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826 Results Found

  • Article
  • Open Access
7 Citations
3,314 Views
12 Pages

The Two-Component System CpxRA Affects Antibiotic Susceptibility and Biofilm Formation in Avian Pathogenic Escherichia coli

  • Kai Ma,
  • Hui Wang,
  • Zhenfei Lv,
  • Yutong Hu,
  • Hongli Wang,
  • Fang Shu,
  • Chengfeng Zhu and
  • Ting Xue

23 January 2023

Avian pathogenic Escherichia coli (APEC) is one of the common extraintestinal infectious disease pathogens in chickens, geese, and other birds. It can cause a variety of infections, and even the death of poultry, causing enormous economic losses. How...

  • Article
  • Open Access
56 Citations
6,830 Views
30 Pages

24 September 2019

Prefabrication (PC) projects have many advantages, such as cost and energy savings and waste reduction. However, some problems still exist that hamper the development of prefabrication projects. To improve PC project performance and advance innovatio...

  • Article
  • Open Access
12 Citations
4,474 Views
19 Pages

Experimental Study for Improving the Repair of Magnesium–Aluminium Hybrid Parts by Turning Processes

  • Eva María Rubio,
  • María Villeta,
  • José Luis Valencia and
  • José Manuel Sáenz de Pipaón

16 January 2018

One of the lightest metallic materials used in the aeronautics, aerospace, and automotive industries, among others, is magnesium, due to its excellent weight/strength ratio. Most parts used in these industries need to be made of materials that are ri...

  • Article
  • Open Access
3 Citations
4,350 Views
14 Pages

30 November 2024

Fine particulate matter (PM) 2.5 is the main component of air pollution causing pathological responses primarily in the respiratory and cardiovascular systems. Therefore, it is urgent to explore valid strategies to inhibit the adverse reactions induc...

  • Review
  • Open Access
5 Citations
5,961 Views
39 Pages

25 October 2024

A recirculating aquaculture system (RAS) represents a forward-looking form of aquaculture. A RAS consists of fish tanks and water treatment processes in a closed loop to sustain the environmental conditions for fish production. However, the rapid ind...

  • Article
  • Open Access
7 Citations
1,814 Views
16 Pages

26 December 2024

This study analyzed the activity concentrations of various radionuclides in irrigation water, rice components, and corresponding soil samples from eleven paddy fields, revealing significant findings with potential environmental and health implication...

  • Article
  • Open Access
10 Citations
4,262 Views
19 Pages

7 August 2018

Drilling is one of the most common machining operations in the aeronautic and aerospace industries. For assembling parts, a large number of holes are usually drilled into the parts so that they can be joined later by rivets. As these holes are subjec...

  • Article
  • Open Access
9 Citations
3,556 Views
22 Pages

Repairing Hybrid Mg–Al–Mg Components Using Sustainable Cooling Systems

  • David Blanco,
  • Eva María Rubio,
  • Marta María Marín and
  • Joao Paulo Davim

15 January 2020

This paper focused on the maintenance or repair of holes made using hybrid Mg–Al–Mg components by drilling, using two sustainable cooling techniques (dry machining and cold compressed air) and taking surface roughness on the inside of the...

  • Article
  • Open Access
7 Citations
6,617 Views
17 Pages

Potential Quality Evaluation Method for Radix Astragali Based on Sweetness Indicators

  • Ke Li,
  • Fanrong Gao,
  • Zhenyu Li,
  • Xuemei Qin,
  • Haifeng Sun,
  • Jie Xing,
  • Lizeng Zhang and
  • Guanhua Du

13 February 2015

Sweetness is a traditional sensory indicator used to evaluate the quality of the popular Chinese herb Radix Astragali (RA). RA roots with strong sweetness are considered to be of good quality. However, neither a thorough analysis of the component(s)...

  • Article
  • Open Access
970 Views
14 Pages

Expression of the Renin-Angiotensin System in the Heart, Aorta, and Perivascular Adipose Tissue in an Animal Model of Type 1 Diabetes

  • Beatriz Martín-Carro,
  • Sara Fernández-Villabrille,
  • Paula Calvó-García,
  • Nerea González-García,
  • Francisco Baena-Huerta,
  • Angie Hospital-Sastre,
  • Pedro Pujante,
  • Francisco José López-Hernández,
  • Manuel Naves-Díaz and
  • José Luis Fernández-Martín
  • + 3 authors

29 September 2025

This study examined the expression of the renin-angiotensin system (RAS) and inflammatory markers in cardiovascular complications associated with long-term type 1 diabetes (T1D) using a rat model. After 24 weeks of streptozotocin-induced T1D, the ani...

  • Article
  • Open Access
15 Citations
3,779 Views
14 Pages

Expression of Components of the Renin-Angiotensin System by Cancer Stem Cells in Renal Clear Cell Carcinoma

  • Sam Siljee,
  • Bridget Milne,
  • Helen D. Brasch,
  • Nicholas Bockett,
  • Josie Patel,
  • Paul F. Davis,
  • Andrew Kennedy-Smith,
  • Tinte Itinteang and
  • Swee T. Tan

7 April 2021

This study investigated the expression of components of the renin-angiotensin system (RAS) by cancer stem cells (CSCs) we have recently demonstrated in renal clear cell carcinoma (RCCC). Fifteen RCCC tissue samples underwent immunohistochemical stain...

  • Feature Paper
  • Review
  • Open Access
210 Citations
13,342 Views
17 Pages

An Update on the Tissue Renin Angiotensin System and Its Role in Physiology and Pathology

  • Ali Nehme,
  • Fouad A. Zouein,
  • Zeinab Deris Zayeri and
  • Kazem Zibara

In its classical view, the renin angiotensin system (RAS) was defined as an endocrine system involved in blood pressure regulation and body electrolyte balance. However, the emerging concept of tissue RAS, along with the discovery of new RAS componen...

  • Article
  • Open Access
12 Citations
2,794 Views
15 Pages

Renin-Angiotensin System in Huntington′s Disease: Evidence from Animal Models and Human Patients

  • Lucas M. Kangussu,
  • Natalia P. Rocha,
  • Priscila A. C. Valadão,
  • Thatiane C. G. Machado,
  • Kívia B. Soares,
  • Julliane V. Joviano-Santos,
  • Leigh B. Latham,
  • Gabriela D. Colpo,
  • Ana Flávia Almeida-Santos and
  • Cristina Guatimosim
  • + 4 authors

The Renin-Angiotensin System (RAS) is expressed in the central nervous system and has important functions that go beyond blood pressure regulation. Clinical and experimental studies have suggested that alterations in the brain RAS contribute to the d...

  • Feature Paper
  • Article
  • Open Access
6 Citations
1,962 Views
12 Pages

Metabolic Syndrome and Its Components Have a Different Presentation and Impact as Cardiovascular Risk Factors in Psoriatic and Rheumatoid Arthritis

  • Fabiola Atzeni,
  • Laura La Corte,
  • Mariateresa Cirillo,
  • Manuela Giallanza,
  • James Galloway and
  • Javier Rodríguez-Carrio

31 July 2023

Patients with chronic inflammatory arthritis have a higher cardiovascular (CV) risk than the general population. Traditional CV risk factors are clearly implicated, while the impact of metabolic syndrome (MetS) is less defined. The aim of this study...

  • Article
  • Open Access
29 Citations
5,266 Views
16 Pages

Quantifying Renin-Angiotensin-System Alterations in COVID-19

  • Fabrizio Pucci,
  • Filippo Annoni,
  • Robson Augusto Souza dos Santos,
  • Fabio Silvio Taccone and
  • Marianne Rooman

14 October 2021

The renin-angiotensin system (RAS) plays a pivotal role in a wide series of physiological processes, among which inflammation and blood pressure regulation. One of its key components, the angiotensin-converting enzyme 2, has been identified as the en...

  • Article
  • Open Access
4 Citations
5,155 Views
31 Pages

21 January 2025

Smart car parking management systems (SPMSs) have gained an ever-increasing popularity for the digital management of car parking processes. While various techniques and technologies have been proposed for SPMSs, the literature lacks in any generic so...

  • Article
  • Open Access
2 Citations
2,051 Views
25 Pages

25 March 2024

In this study, proportional response addition (Prop-RA), a model for predicting response from chemical mixture exposure, is demonstrated and evaluated by statistically analyzing data on all possible binary combinations of the four regulated trihalome...

  • Review
  • Open Access
21 Citations
5,870 Views
18 Pages

Rheumatoid arthritis (RA) is an autoimmune inflammatory disease characterized by chronic synovitis and the progressive destruction of cartilage and bone. RA is commonly accompanied by extra-articular comorbidities. The pathogenesis of RA and its como...

  • Article
  • Open Access
31 Citations
7,635 Views
15 Pages

On the Applicability of ATR-FTIR Microscopy to Evaluate the Blending between Neat Bitumen and Bituminous Coating of Reclaimed Asphalt

  • Alexandros Margaritis,
  • Giorgio Tofani,
  • Geert Jacobs,
  • Johan Blom,
  • Serge Tavernier,
  • Cedric Vuye and
  • Wim Van den bergh

The utilization of Reclaimed Asphalt (RA) in the road construction sector induces considerable economic and ecological benefits. The blending of the recycled material with new components is believed to be of great importance for the mixture’s p...

  • Review
  • Open Access
10 Citations
11,500 Views
23 Pages

The Renin-Angiotensin System: The Challenge behind Autoimmune Dermatological Diseases

  • Minela Aida Maranduca,
  • Mihai Andrei Cosovanu,
  • Andreea Clim,
  • Alin Constantin Pinzariu,
  • Nina Filip,
  • Ilie Cristian Drochioi,
  • Vlad Ionut Vlasceanu,
  • Daniel Vasile Timofte,
  • Roxana Nemteanu and
  • Ionela Lacramioara Serban
  • + 2 authors

7 November 2023

Autoimmune dermatological diseases (AIDD) encompass a diverse group of disorders characterized by aberrant immune responses targeting the skin and its associated structures. In recent years, emerging evidence suggests a potential involvement of the r...

  • Article
  • Open Access
4 Citations
3,226 Views
16 Pages

An Efficient Adaptive Data-Link-Layer Architecture for LoRa Networks

  • Micael Coutinho,
  • Jose A. Afonso and
  • Sérgio F. Lopes

17 August 2023

LoRa is one of the most popular low-power wireless network technologies for implementation of the Internet of Things, with the advantage of providing long-range communication, but lower data rates, when compared with technologies such as Zigbee or Bl...

  • Article
  • Open Access
15 Citations
3,301 Views
18 Pages

Effects of Interferometric Radar Altimeter Errors on Marine Gravity Field Inversion

  • Xiaoyun Wan,
  • Shuanggen Jin,
  • Bo Liu,
  • Song Tian,
  • Weiya Kong and
  • Richard Fiifi Annan

27 April 2020

The traditional altimetry satellite, which is based on pulse-limited radar altimeter, only measures ocean surface heights along tracks; hence, leads to poorer accuracy in the east component of the vertical deflections compared to the north component,...

  • Article
  • Open Access
24 Citations
5,234 Views
21 Pages

LoRaWAN Behaviour Analysis through Dataset Traffic Investigation

  • Pietro Spadaccino,
  • Francesco Giuseppe Crinó and
  • Francesca Cuomo

23 March 2022

The large development of Internet of Things technologies is increasing the use of smart-devices to solve and support several real-life issues. In many cases, the aim is to move toward systems that, even if significant demands are not required in term...

  • Review
  • Open Access
4 Citations
3,548 Views
14 Pages

2 February 2022

Although a recent genomic survey revealed its ancient evolutionary origin in the animal kingdom, retinoic acid (RA) signaling was previously thought to be unique to chordates. Echinoderms are of critical interest in researching the evolutionary histo...

  • Article
  • Open Access
518 Views
36 Pages

3 January 2026

Smart charging management systems for electric vehicles (SCMSs) enable the effective management of electric vehicle (EV) charging processes using smart technologies. Numerous SCMS technologies have been available for different stakeholders, e.g., EV...

  • Article
  • Open Access
11 Citations
4,005 Views
9 Pages

Depression in Rheumatoid Arthritis: Prevalence and Effects on Disease Activity

  • Cătălina-Elena Ionescu,
  • Claudiu Costinel Popescu,
  • Mihaela Agache,
  • Georgiana Dinache and
  • Cătălin Codreanu

2 April 2024

Background:The primary objective of this study was to estimate depression’s prevalence in a cohort of rheumatoid arthritis (RA) patients, and the secondary objective was to evaluate the impact of depression on disease activity over time. Method...

  • Article
  • Open Access
32 Citations
5,097 Views
17 Pages

Network Pharmacology-Based Investigation of Protective Mechanism of Aster tataricus on Lipopolysaccharide-Induced Acute Lung Injury

  • Yijun Chen,
  • Jiaojiao Dong,
  • Jie Liu,
  • Wenjuan Xu,
  • Ziyi Wei,
  • Yueting Li,
  • Hao Wu and
  • Hongbin Xiao

Acute lung injury (ALI) is a common clinical condition that badly influences people’s health. Recent studies indicated that Aster tataricus (RA) had potential effects on ALI, but the effective components and their mechanism is not clear. In thi...

  • Abstract
  • Open Access
1,114 Views
2 Pages

When recycling reclaimed asphalt (RA) in new hot-mix asphalt (HMA), the temperature of the mix components (mainly virgin aggregate, RA, and virgin bitumen) can vary in a wide range [...]

  • Article
  • Open Access
15 Citations
3,837 Views
26 Pages

Dysregulated Retinoic Acid Signaling in the Pathogenesis of Pseudoexfoliation Syndrome

  • Matthias Zenkel,
  • Ursula Hoja,
  • Andreas Gießl,
  • Daniel Berner,
  • Bettina Hohberger,
  • Julia M. Weller,
  • Loretta König,
  • Lisa Hübner,
  • Thomas A. Ostermann and
  • Ursula Schlötzer-Schrehardt
  • + 3 authors

Pseudoexfoliation (PEX) syndrome, a stress-induced fibrotic matrix process, is the most common recognizable cause of open-angle glaucoma worldwide. The recent identification of PEX-associated gene variants uncovered the vitamin A metabolic pathway as...

  • Article
  • Open Access
2 Citations
1,488 Views
15 Pages

26 June 2025

In the domain of agricultural machinery, the utilization of carbon fiber-reinforced plastics (CFRP) for structural components, such as the chassis, facilitates substantial weight reduction. To integrate additional components, stainless-steel connecti...

  • Article
  • Open Access
54 Citations
8,194 Views
18 Pages

Expression of Renin-Angiotensin System Components in the Taste Organ of Mice

  • Noriatsu Shigemura,
  • Shingo Takai,
  • Fumie Hirose,
  • Ryusuke Yoshida,
  • Keisuke Sanematsu and
  • Yuzo Ninomiya

19 September 2019

The systemic renin-angiotensin system (RAS) is an important regulator of body fluid and sodium homeostasis. Angiotensin II (AngII) is a key active product of the RAS. We previously revealed that circulating AngII suppresses amiloride-sensitive salt t...

  • Article
  • Open Access
279 Views
13 Pages

3 February 2026

As a pivotal component of the global carbon cycle, the spatial variation in soil respiration (Rs) is crucial for forecasting climate change trajectories. Despite extensive research on the spatial patterns of total Rs, the distinct drivers of its two...

  • Review
  • Open Access
60 Citations
11,128 Views
19 Pages

Diet as a Modulator of Intestinal Microbiota in Rheumatoid Arthritis

  • Eduardo Dourado,
  • Margarida Ferro,
  • Catarina Sousa Guerreiro and
  • João Eurico Fonseca

14 November 2020

Rheumatoid arthritis (RA) is a chronic immune-driven inflammatory disease characterised by synovial inflammation, leading to progressive cartilage and bone destruction, impacting patients’ functional capacity and quality of life. Patients with...

  • Review
  • Open Access
24 Citations
4,301 Views
17 Pages

30 September 2021

The lipid-anchored RAS (Rat sarcoma) small GTPases (guanosine triphosphate hydrolases) are highly prevalent in human cancer. Traditional strategies of targeting the enzymatic activities of RAS have been shown to be difficult. Alternatively, RAS funct...

  • Article
  • Open Access
29 Citations
3,956 Views
13 Pages

21 August 2019

Many studies have shown that Orthosiphon stamineus extract (OE) has antioxidant activity, and we previously reported that OE protects the intestine against injury from a high-fat diet. However, the molecular mechanism underlying this protective effec...

  • Article
  • Open Access
1 Citations
1,821 Views
10 Pages

28 July 2023

Interstitial expansion is associated with glomerular filtration rate (GFR) loss in many renal diseases, including diabetic nephropathy. The Renin–Angiotensin System Study (RASS) tested whether a 5-year renin–angiotensin system (RAS) block...

  • Article
  • Open Access
4 Citations
2,521 Views
15 Pages

4 February 2023

The PKA pathway is a signaling pathway involved in virulence in Candida albicans. This mechanism can be activated via addition of glucose and activation involves at least two proteins, namely Cdc25 and Ras1. Both proteins are involved in specific vir...

  • Article
  • Open Access
15 Citations
4,757 Views
15 Pages

29 June 2020

Recently, novelty detection with reconstruction along projection pathway (RaPP) has made progress toward leveraging hidden activation values. RaPP compares the input and its autoencoder reconstruction in hidden spaces to detect novelty samples. Never...

  • Article
  • Open Access
18 Citations
5,677 Views
19 Pages

7 February 2021

Background: To date, few studies have compared the dietary quality of US adults with diabetes mellitus (DM), osteoarthritis (OA), and rheumatoid arthritis (RA) by age groups. Methods: This study used cross-sectional data from adult participants from...

  • Article
  • Open Access
7 Citations
3,265 Views
16 Pages

Anti-Inflammatory Effects of Ang-(1-7) Bone-Targeting Conjugate in an Adjuvant-Induced Arthritis Rat Model

  • Sana Khajeh pour,
  • Arina Ranjit,
  • Emma L. Summerill and
  • Ali Aghazadeh-Habashi

17 September 2022

Rheumatoid arthritis (RA) is a chronic inflammatory condition of synovial joints that causes disability and systemic complications. Ang-(1-7), one of the main peptides in the renin-angiotensin (Ang) system (RAS), imposes its protective effects throug...

  • Article
  • Open Access
1 Citations
4,075 Views
25 Pages

Software-Defined Radio Implementation of a LoRa Transceiver

  • João Pedro de Omena Simas,
  • Daniel Gaetano Riviello and
  • Roberto Garello

25 July 2024

The number of applications of low-power wide-area networks (LPWANs) has been growing quite considerably in the past few years and so has the number of protocol stacks. Despite this fact, there is still no fully open LPWAN protocol stack available to...

  • Review
  • Open Access
22 Citations
5,022 Views
30 Pages

Impact of the Renin-Angiotensin System on the Pathogeny and Pharmacotherapeutics of Neurodegenerative Diseases

  • Walther Bild,
  • Alexandru Vasincu,
  • Răzvan-Nicolae Rusu,
  • Daniela-Carmen Ababei,
  • Aurelian Bogdan Stana,
  • Gabriela Dumitrița Stanciu,
  • Bogdan Savu and
  • Veronica Bild

6 October 2022

Brain neurodegenerative diseases (BND) are debilitating conditions that are especially characteristic of a certain period of life and considered major threats to human health. Current treatments are limited, meaning that there is a challenge in devel...

  • Review
  • Open Access
15 Citations
6,060 Views
11 Pages

17 November 2021

RAS (rat sarcoma virus) mutant cancers remain difficult to treat despite the advances in targeted therapy and immunotherapy. Targeted therapies against the components of mitogen-activated protein kinase (MAPK) pathways, including RAS, RAF, MEK, and E...

  • Article
  • Open Access
1 Citations
1,992 Views
11 Pages

Exhaled Nitric Oxide Reflects the Immune Reactions of the Airways in Early Rheumatoid Arthritis

  • Tomas Weitoft,
  • Johan Rönnelid,
  • Anders Lind,
  • Charlotte de Vries,
  • Anders Larsson,
  • Barbara Potempa,
  • Jan Potempa,
  • Alf Kastbom,
  • Klara Martinsson and
  • Marieann Högman
  • + 1 author

Patients with rheumatoid arthritis (RA) have altered levels of exhaled nitric oxide (NO) compared with healthy controls. Here, we investigated whether the clinical features of and immunological factors in RA pathogenesis could be linked to the NO lun...

  • Review
  • Open Access
20 Citations
4,021 Views
13 Pages

Towards Better Sinomenine-Type Drugs to Treat Rheumatoid Arthritis: Molecular Mechanisms and Structural Modification

  • Cuili Zhang,
  • Shujie Zhang,
  • Jingjing Liao,
  • Zipeng Gong,
  • Xin Chai and
  • Haining Lyu

7 December 2022

Sinomenine is the main component of the vine Sinomenium acutum. It was first isolated in the early 1920s and has since attracted special interest as a potential anti-rheumatoid arthritis (RA) agent, owing to its successful application in traditional...

  • Review
  • Open Access
27 Citations
5,839 Views
18 Pages

DNA Methylation-Governed Gene Expression in Autoimmune Arthritis

  • Barbara Brandt,
  • Shima Rashidiani,
  • Ágnes Bán and
  • Tibor A. Rauch

12 November 2019

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease hallmarked by progressive and irreversible joint destruction. RA pathogenesis is a T cell-regulated and B cell-mediated process in which activated lymphocyte-produced chemokines a...

  • Review
  • Open Access
106 Citations
10,493 Views
27 Pages

The Role of Reactive Oxygen Species in the Rheumatoid Arthritis-Associated Synovial Microenvironment

  • Xing Wang,
  • Danping Fan,
  • Xiaoxue Cao,
  • Qinbin Ye,
  • Qiong Wang,
  • Mengxiao Zhang and
  • Cheng Xiao

Rheumatoid arthritis (RA) is an inflammatory disease that begins with a loss of tolerance to modified self-antigens and immune system abnormalities, eventually leading to synovitis and bone and cartilage degradation. Reactive oxygen species (ROS) are...

  • Review
  • Open Access
45 Citations
7,323 Views
18 Pages

26 October 2020

The renin-angiotensin system (RAS) is a peptidic system known mainly for its roles in the maintenance of blood pressure and electrolyte and fluid homeostasis. However, several tissues and cells have been described to possess an intrinsic RAS that act...

  • Article
  • Open Access
7 Citations
4,020 Views
13 Pages

18 July 2023

Rosmarinus officinalis leaves (ROLs) are widely used in the food and cosmetics industries due to their high antioxidant activity and fascinating flavor properties. Carnosic acid (CA) and rosmarinic acid (RA) are regarded as the characteristic antioxi...

  • Article
  • Open Access
1 Citations
2,598 Views
31 Pages

Investigating the Mechanism of Action of Ipomoea pes-caprae in the Treatment of Rheumatoid Arthritis Based on Serum Metabolomics and Network Pharmacology

  • Fangfei Zhong,
  • Siwei Li,
  • Xianglong Pan,
  • Juan Wen,
  • Jinling Xie,
  • Zhengcai Du,
  • Erwei Hao,
  • Jiagang Deng and
  • Xiaotao Hou

7 March 2025

Ipomoea pes-caprae (L.) Sweet (Convolvulaceae) is a commonly used marine Chinese medicine in the coastal areas of southern China. Traditionally, it has been used in the treatment of rheumatoid arthritis (RA). However, the mechanism of action against...

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