Search Results (16)

Background: Neurological immune related adverse events (N-irAEs) following immune checkpoint inhibitor (ICI) therapy are associated with significant morbidity and mortality. The early involvement of neurological services is therefore recommended to assist diagnosis and guide management. However, the practical experience of specialist neurology involvement is poorly understood. Methods: A multi-centre, retrospective case note review was performed in a unified healthcare setting in the United Kingdom via predetermined proforma to investigate the involvement and impact of neurology services in this setting. Results: One hundred and nine patients with N-irAE were identified with a median time from ICI treatment to symptom onset of 52 days. Neurology service models, reasons for referral and referral rates varied by centre. Overall, eighty-seven (79.8%) patients (range 52.9–100% by centre) had neurology involvement. Neurology input was associated with younger age (median 67.2 vs. 72.8 years), anatomical location (Central > Peripheral) and severity of neurotoxicity (p < 0.001, q < 0.004). Patients with neurology involvement were more likely to undergo specialist investigations: MR imaging (p = 0.041, q = 0.043), lumbar puncture (p < 0.001, q < 0.004), and neurophysiology (p = 0.005, q = 0.007) resulting in a broader range of specific N-irAE diagnoses. Steroids were appropriately prescribed, with second line treatment (Intravenous immunoglobulins/Plasma exchange) associated with neurology involvement. At lower grades (CTCAE ≤ 2), resolution rates were similar in those with or without neurology involvement. At grades 3–4, one-third of patients with neurology involvement had resolution. In a centre with a model of early neurology involvement for all possible N-irAEs the aetiology of the neurological presentation was changed in 63.7%. Conclusions: This study highlights the potential to improve diagnosis and treatment algorithms and therefore patient outcomes through development of uniform N-irAE models of care to support this area of growing clinical need. Full article

Scholarship in Buddhist Studies, particularly among philologists and philosophers, often overlooks cosmology, karma, and rebirth. This neglect is a legacy of a deep and long-standing anti-metaphysical spirit that pervades the empirical and philosophical frameworks employed in the discipline. This study engages in a philological close reading of four manuscripts of an unedited and untranslated Pali commentary on the Cha-gati-dīpanī “Light on the Six Realms”, a work on karma and rebirth composed possibly in Pagan, Myanmar, in the early second millennium. This text is particularly significant as one of the oldest Pali works from the region, drawing on now-lost Sanskrit (or possibly Prakrit) sources and offering unique insights into broader Buddhist debates, such as the ontological status of hell guardians. I examine the text’s depiction of the hell and animal realms and reassess some of our scholarly paradigms that often frame the kind of ideas the commentary presents as irrational, figurative, or “folk”. Ultimately, this study calls for greater attention to such works and their perspectival horizons to enrich our understanding of the intellectual life of medieval Buddhism beyond the constraints of modern empirical and philosophical assumptions. Full article

This paper investigates the complex causal relationships within Jain narrative literature (prathamānuyoga/dharmakathānuyoga), specifically focusing on the examination of the Sītā abandonment narrative across Prakrit, Sanskrit, and Apabhramsha textual traditions. By employing textual analysis and philosophical interpretation, the study explores the intricate causative mechanisms in narratives by Vimalasūri, Raviṣeṇa, and Svayambhūdeva. The paper addresses critical research questions examining the multifaceted nature of causality: the root causes of Sītā’s abandonment, the identification of precursory causal signs like dreams, cravings during pregnancy and omens, an analysis of Sītā’s philosophical response to her circumstances, and the complex interplay between external and internal instrumental causes (bahiraṅga- and antaraṅga-nimitta-kāraṇa). Through rigorous textual comparison and philosophical analysis of the Paümacariyaṃ, Padmapuraṇa, and Paümacariü, the study reveals that Jain narrative literature predominantly employs instrumental causality as its primary explanatory framework. The paper demonstrates how external and internal instrumental causes interplay, and explores the role of Sītā’s bad or good karma in shaping her narrative trajectory. The paper contributes to the ongoing scholarship on Jain narratives by analyzing causality in religious narratives, offering philosophical insights into narrative causation, providing an interdisciplinary perspective that bridges literary analysis with philosophical interpretation, and illuminating the ways Jain narratives employ causality to explain complex human experiences and ethical dilemmas, ultimately revealing how narrative structures reflect deeper metaphysical and philosophical concepts within the Jain textual tradition. Full article

Used to mark devotion to the main propagators of Jainism, namely the Jina (arhat), the Liberated Souls (siddha), the Teachers (ācārya), the spiritual Guides (guru), the Preceptors (upādhyāya), and the monks (muṇi), the formula of homage to the five supreme entities (pañcanamaskāra) underwent a significant development in the medieval period where it became a mantra protecting against all evils and violence and symbolising Jainism in its entirety and its respect for life in all its forms amidst the various Indian religions. In the present paper, I intend to investigate how the formula was used in largely unknown romance poems composed in the Prakrit language by Jaina scholar monks in medieval North India between the 8th and 12th centuries. Particular attention will be paid to how the writer monks used the formula of homage in the narrative to avoid the use of violence. The analysis will also focus on the development of the formula in the hymns of praise of the romance poems and study its significance in the context of the spread of Jainism at the turn of the first millennium, a period that led to the advent of King Kumārapāla, who has remained famous in history not only for the imposing monuments he left behind, but also for his conversion to Jainism and his governance according to principles of non-violence. Full article

Microplastics are widespread in coastal and marine environments, and sediments serve as a sink for microplastics. In this study, four sediment cores were collected from the Kuala Gula Mangrove area. The abundance of microplastics in mangrove sediments ranged from 25–130 items/kg dry weight. The highest abundance of microplastic was observed at the KG04 site near the mouth of the river. The number of microplastics by sampling site was significantly different (p < 0.01), with station KG04 having the highest fiber content. The dominant color of microplastics was blue, and the main shape was fiber. Rayon, cotton, Polyethylene terephthalate (PET), and azlon were observed from FT-IR, indicating that the potential sources of microplastic and fiber could come from household laundry wastewater. Microplastics tended to accumulate in deeper depths at KG01 (p < 0.01), whereas other stations showed no significant difference (p > 0.05). However, this study provides evidence that mangroves can be a trap for microplastics and can be used as baseline data for future studies. Full article

Microplastics have been found to accumulate in freshwater, marine ecosystems, and biological organisms. The frequency of studies on microplastic contamination in organs has increased recently, although there have been relatively fewer investigations on fish eggs in Thailand. To extract microplastics from catfish samples for laboratory analysis (Osteogeneiosus militaris), we used 10% potassium hydroxide in the digestion process. A needle penetrated the fish eggs to investigate microplastic contamination. We examined microplastics under a stereomicroscope and used Fourier transform infrared spectroscopy to determine the type of polymer. We found microplastic contamination in organs, most commonly in the stomach (0.91 ± 0.13 items/g), followed by tissue (0.53 ± 0.09 items/g), and gills (0.30 ± 0.03 items/g) at the level of significance p < 0.01. We found a total of 349 fish eggs with 27 items of microplastic. The dominant microplastic we found in the stomach, tissue, and gills of the fish, as well as in fish eggs, was of fiber shape. We noted that fragments were found only in the stomach and tissue of fish. The dominant color of microplastics was black in organs and blue in fish eggs. The common polymer types in organs and fish eggs were polyethylene terephthalate, polypropylene, and cellulosic fiber. Full article

Absolute sea-level rise has become an important topic globally due to climate change. In addition, relative sea-level rise due to the vertical land motion in coastal areas can have a big societal impact. Vertical land motion (VLM) in Southeast Asia includes a tectonically induced component: uplift and subsidence in plate boundary zones where both Peninsular and East Malaysia are located. In this paper, the relative sea-level trends and (seismic cycle-induced) temporal changes across Malaysia were investigated. To do so, the data (1984–2019) from 21 tide gauges were analyzed, along with a subset (1994–2021) of nearby Malaysian GNSS stations. Changes in absolute sea level (ASL) at these locations (1992–2021) were also estimated from satellite altimetry data. As a first for Peninsular and East Malaysia, the combination ASL minus VLM was robustly used to validate relative sea-level rise from tide-gauge data and provide relative sea-level trend estimates based on a common data period of 25+ years. A good match between both the remote and in situ sea-level rise estimations was observed, especially for Peninsular Malaysia (differences < 1 mm/year), when split trends were estimated from the tide gauges and GNSS time series to distinguish between the different VLM regimes that exist due to the 2004 Sumatra–Andaman megathrust earthquake. As in the south of Thailand, post-seismic-induced negative VLM has increased relative sea-level rise by 2–3 mm/year along the Andaman Sea and Malacca Strait coastlines since 2005. For East Malaysia, the validation shows higher differences (bias of 2–3 mm/year), but this poorer match is significantly improved by either not including data after 1 January 2014 or applying a generic jump to all East Malay tide gauges from that date onwards. Overall, the present relative sea-level trends range from 4 to 6 mm/year for Malaysia with a few regions showing up to 9 mm/year due to human-induced land subsidence. Full article

Microplastic (MP) contamination in the marine environment has received growing attention. In 2022, the surface water of the U-Taphao River was sampled four times, in February, April, June, and August. The surface water samples were taken at seven different locations, ranging from upstream to downstream parts of the river. The results reveal that the number of MPs detected at the U-Taphao River in February, April, June, and August were 0.41 ± 0.08, 0.25 ±0.06, 0.24 ± 0.11, and 0.26 ± 0.06 particles/L, respectively. The MPs in the U-Taphao River each month were not statistically different (p = 0.190). The trend of the number of MPs found declined from upstream to downstream. Fibers were the most commonly found MPs in the U-Taphao River in this study and were found at more than 80% of all stations during all sample collection periods. Our results indicate that MP contamination is present in the river water, but it is noted that slightly different polymer types were found during each collection month. MPs can be transferred through the food chain and potentially to humans. Regular monitoring of MPs in the riverine system is, therefore, important, for which the findings of the present study can be used as a baseline for the number of MPs in the river water in the region. Full article

The concentration and distribution of trace metals were determined in sediment cores from the Khuan Khi Sian wetland, Thailand. The sediment cores were collected from seven stations in the dry and wet seasons in 2022. The concentration of Pb, As, and Cd in the dry season were in the range 0.00–60.16, 0.00–6.68, and 0.00–0.92 mg/kg (dry weight), respectively. Meanwhile, the concentration of Pb, As, and Cd in the wet season were in the range 0.00–12.12, 0.00–3.86, and 0.00–0.92 mg/kg (dry weight), respectively. The vertical profiles of metal concentrations in core sediment show a general increase from bottom to top. Average concentrations of heavy metals in the sediments of the Khuan Khi Sian wetland are found to be lower than the sediment quality guideline. In the sediment cores, only As in the dry season exceeded the U.S. EPA standard. The calculated enrichment factor (EF) and the geoaccumulation index (Igeo) indicate that the sediments were moderately polluted with As in some locations. According to the Ri analysis, Pb was low risk but the criteria of ecological risk of As and Cd are considerable and they are considered high risk. This is potentially due to agricultural activities and land use around the wetland areas and municipalities. The concentration of As and Cd should be of concern and subject to regular monitoring. Full article

Temporal changes in vertical land motion (VLM) in and around Phuket Island in southern Thailand following the great 2004 Sumatra–Andaman megathrust earthquake have impacted the relative sea-level change estimates based on tide-gauge (TG) records. To better monitor the VLM, two new continuous global navigation satellite system (GNSS) stations have been installed in the past 5 years, situated on bedrock both near and at the Koh Taphao Noi Island TG in Phuket, which together with older global positioning system (GPS) data provides a clear insight in the VLM of Phuket Island from 1994 onward. In addition, satellite altimetry (SALT) data has been analyzed since 1992. The VLM (GPS) position and relative (TG) and absolute (SALT) sea-level change time series were successfully combined in pairs to validate each independent result (e.g., SALT − GNSS = TG): prior to the 2004 earthquake, the relative sea-level rise in Phuket was 1.0 ± 0.7 mm/yr, lower by 2.4 ± 0.2 mm/yr than the absolute sea-level rise caused by VLM. After the earthquake, nonlinear post-seismic subsidence has caused the VLM to drop by 10 cm in the past 17 years, resulting, by the end of 2020, in a relative sea-level rise by up to 16 cm. During the same period, other TG stations in south Thailand recorded similar sea-level increases. Combination with SALT further suggests that, prior to 2005, uplift (5.3 ± 1.4 mm/yr) of the coastal region of Ranong (north of Phuket) resulted in a relative sea-level fall, but since then, post-seismic-induced negative VLM may have significantly increased coastal erosion along the entire Andaman Sea coastline. Full article

The use of arbuscular mycorrhizal fungi (AMF) as biofertilizer in agriculture is a sustainable approach to fertilization. The first step in the production of AMF biofertilizer is inoculation of mycotrophic plants with a composite of soil and native plant roots, containing potentially viable AMF spores from natural habitats, to a trap culture. A single host plant or a consortium of host plants can be used to propagate AMF spores. However, the difference in the comparative efficiency of mono- and co-cultivated host plants used for the production of AMF spores and the maintenance of original AMF community composition has not been well elucidated. Here, we prepared trap culture with nutrient-poor soil from coastal sand dune vegetation collected during the dry season when the AMF spore density and relative abundance of Glomeromycota ITS2 sequences were significantly higher (p = <0.05) than in the wet season. The AMF communities in the soil were mainly composed of Glomus spp. Maize (Zea mays L.) and/or Sorghum (Sorghum bicolor (L.). Moench) were grown in trap cultures in the greenhouse. Our results demonstrated that co-cultivation of the host plants increased the production of AMF spores but, compared to mono-cultivation of host plants, did not better sustain the native AMF community compositions in the coastal sand dune soil. We propose that the co-cultivation of host plants in a trap culture broadens AMF-host plant compatibilities and thus sustains the symbiotic association of the natively diverse AMF. Therefore, the results of this study suggest that further research is needed to confirm whether the co-culturing of more than one host plant is as efficient a strategy as using a monoculture of a single host plant. Full article

Mangroves are areas that connect the land and sea, and are important to the ecosystem. They are important places for food sources and the habitat of aquatic fauna in the tidal areas. However, the existence of plastic debris poses a risk to the aquatic environment. This study aimed to investigate the accumulation of microplastics (MPs) in sediment cores from two mangrove areas. The first mangrove area is in the outer section of the Songkhla lagoon (SK), while the second is in the coastal area of Pattani province (PN). Sediment core sampling was performed from SK = 8 stations and PN = 5 stations. Surface enrichment of MP was observed, especially in sediments of 0–4 cm. MPs were found throughout the depth in both areas, while fewer MPs were found in deeper sediment core layers (p < 0.05) at some stations inside the mangrove zone. Simple linear regression of the observed MPs and distance in the horizontal were found to be significant at SK within the mangrove zone with r² = 0.79 (p < 0.05). MP fibers were the most commonly found MP type in both areas and were less than 1 mm. Blue and black MPs were the most abundant colors found in both areas. The six polymer types reported in this study comprised polyethylene, rayon, rubber, styrene, Poly (vinyl acetate), and paint. The findings of the present study suggest that long-term monitoring of marine debris along coastlines is necessary to help improve national policies and measures related to marine plastic debris. Full article

The Apabhraṃśa dohā is a literary medium from Indian antiquity, with early examples appearing in Kālidāsa’s plays around the 5th century and continuing in later Hindi-language Jain and Bhakti works in the early modern period. However, it was within Tantric Buddhist texts and traditions that the dohā truly came into its own as a literary genre. Particularly within the “Yoginī Tantra” strata of the Tantric Buddhist canon, Apabhraṃśa dohās appear in notable and formulaic ways, used within ritual contexts and other significant junctures, signaling the underexamined use of this literary form and its language of composition. This paper examines the use of dohās attributed to the mahāsiddha Saraha as they are used in the Hevajra Tantra, the Buddhakapāla Tantra, and some associated texts. In doing so, this paper demonstrates that as a literary genre, Apabhraṃśa dohās perform a similar function to mantras and dhāraṇīs, but are unique in their attention to phonology and discursive meaning. By examining the uses of these dohās during particular moments of Tantric Buddhist ritual syntax, this paper will then reflect on the later trajectory of these verses after the death of institutional Buddhism in India, and the reasons for their survival. Full article

The presence of Apabhraṃśa in tantric Buddhist texts has long been noted by scholars, overwhelmingly explained away as an example of “Twilight language” (saṃdhā-bhāṣā). However, when one looks closer at the vast number of Apabhraṃśa verses in this canon, one finds recurring patterns, themes, and even tropes. This begs for deeper study, as well as establishing a taxonomy of these verses based on their place and use. This paper focuses on a specific subset of Apabhraṃśa verses: “goddess songs” in maṇḍala visualization rituals. These verses are sung by yoginīs at specific moments in esoteric Buddhist ritual syntax; while the sādhaka is absorbed in enstatic emptiness, four yoginīs call out to him with sexually charged appeals, begging him to return to the world and honor their commitments to all sentient beings. When juxtaposed with other Apabhraṃśa verses in tantric Buddhist texts, these songs express an immediacy and intimacy that stands out in both form and content from the surrounding text. This essay argues that Apabhraṃśa is a conscious stylistic choice for signaling intimate and esoteric passages in tantric literature, and so the vast number of Apabhraṃśa verses in this corpus should be reexamined in this light. Full article

Jain narrative literature in Sanskrit, Prakrit, and Apabhraṃśa is rightly recognised as one of South Asia’s great cultural heritages and a vital source of material for insight into premodern Jain teachings, practices, and everyday life. However, Jain studies is yet to fully engage with the rich archive of Jain narrative literature in Brajbhāṣā, and a wealth of untapped manuscript material is waiting to be explored. In this article, I argue that by going beyond the too-broad moniker of “Jain Hindī literature” to recognise Jain narrative literature in Brajbhāṣā as a distinct category, we may better understand the Jains of early modern North India as partakers of a wider literary and religious culture. More particularly, by comparing the form and religious outlook of Rāmcand Bālak’s Sītācarit, a seventeenth-century Rāmāyaṇa treatment, with the works of the more well-known Banārsīdās, we see that even amongst the Jains who used Brajbhāṣā, considerable variety of outlooks and approaches existed. Full article