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Keywords = Pontryagin maximum principle

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14 pages, 1539 KB  
Article
Optimal Control of Orbit Rendezvous with Low-Thrust on Near-Circular Orbits Using Pontryagin’s Maximum Principle
by Xiao Zhou, Hongbin Deng, Yaxuan Li and Yigao Gao
Mathematics 2026, 14(2), 294; https://doi.org/10.3390/math14020294 - 13 Jan 2026
Viewed by 184
Abstract
This paper investigates the optimal control problem of orbital rendezvous for spacecraft in near-circular orbits with a low-thrust propulsion system. Two optimality criteria are considered: time-optimal and motor-time-optimal control. A linearized mathematical model of relative motion between the active and passive spacecraft is [...] Read more.
This paper investigates the optimal control problem of orbital rendezvous for spacecraft in near-circular orbits with a low-thrust propulsion system. Two optimality criteria are considered: time-optimal and motor-time-optimal control. A linearized mathematical model of relative motion between the active and passive spacecraft is employed, which is formulated in dimensionless variables that characterize secular, periodic, and lateral motion components of the relative motion. By applying Pontryagin’s Maximum Principle, the equations governing the optimal relative motion of the spacecraft are derived. To address the discontinuities associated with the bang–bang switching function inherent in the motor-time-optimal problem, and the lack of a suitable initial guess, a homotopy method is adopted, in which the solution to the rendezvous time-optimal problem is used as an initial guess and is gradually deformed into the motor-time-optimal control. Considering the errors introduced by the linearization of the relative motion model, the obtained control law is validated via numerical simulations based on the original nonlinear dynamics of the system. Simulation results demonstrate that the proposed trajectory optimization methodology achieves high success rates and rapid convergence, providing valuable theoretical support and practical guidance for mission scenarios with similar trajectory design requirements. Full article
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35 pages, 901 KB  
Article
Modeling the Dynamic of Herpes Simplex Virus II Incorporating Voluntary Laboratory Test and Medical Treatment
by Abdulfatai Atte Momoh, Salaudeen Yusuf, Goni Umar Modu, Ali Inalegwu Michael, Idris Ahmed and Jessada Tariboon
Symmetry 2026, 18(1), 86; https://doi.org/10.3390/sym18010086 - 3 Jan 2026
Viewed by 205
Abstract
This study develops a mathematical model to investigate the transmission dynamics of HSV-II within the framework of symmetry in dynamical systems. The basic reproduction number (R0HSV<1) of the model was determined using the next generation [...] Read more.
This study develops a mathematical model to investigate the transmission dynamics of HSV-II within the framework of symmetry in dynamical systems. The basic reproduction number (R0HSV<1) of the model was determined using the next generation method (NGM). The stability of the disease-free equilibrium point was also investigated using the Routh–Hurwitz Criterion and was found to be locally asymptotically stable (LAS) when R0HSV<1 but not globally asymptotically stable (GAS). To help ensure that the control variables were included correctly, sensitivity analysis was performed on the fundamental reproduction number parameters. Four control variables were applied for the model: HSV-II vaccination, effective condom use, laboratory test, and treatment. The optimality system was solved using Pontryagin’s maximum principle (PMP) to establish the optimal control strategy for combating the spread of the disease. Numerical solution was obtained by using the forward-backward Runge–Kutta fourth-order approach. The most effective approach to help eradicate HSV-II disease in the system is to combine the HSV-II vaccine, effective condom use, laboratory testing, and HSV therapy (strategy D). Full article
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15 pages, 406 KB  
Article
Decentralized Control for Interrelated Systems with Asymmetric Information Architecture
by Yixing Wang, Yirun Wang, Boqun Tan, Xinghua Li and Xiao Liang
Electronics 2026, 15(1), 96; https://doi.org/10.3390/electronics15010096 - 24 Dec 2025
Viewed by 149
Abstract
This paper focuses on finite-horizon optimum state feedback control problems for interconnected systems of two players involved with asymmetric one-step delay information. For the finite horizon optimum decentralized control problem, a crucial and adequate condition is derived by using Pontryagin’s maximum principle. Under [...] Read more.
This paper focuses on finite-horizon optimum state feedback control problems for interconnected systems of two players involved with asymmetric one-step delay information. For the finite horizon optimum decentralized control problem, a crucial and adequate condition is derived by using Pontryagin’s maximum principle. Under this framework, player 1 transmits its state and control input data with a one-step delay to the controller of player 2, while player 1’s controller does not have access to the real-time or delayed states and control inputs of player 2, resulting in an asymmetric information structure characterized by a one-step delay Then, the solutions to the forward and backward stochastic difference equations are derived. A target tracking system is given in numerical examples to verify the proposed algorithm. Full article
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19 pages, 1281 KB  
Article
The Optimal Frequency Control Problem of a Nonlinear Oscillator
by Victor Ilyutko, Dmitrii Kamzolkin and Vladimir Ternovski
Mathematics 2026, 14(1), 37; https://doi.org/10.3390/math14010037 - 22 Dec 2025
Viewed by 188
Abstract
We study a minimum-time (time-optimal) control problem for a nonlinear pendulum-type oscillator, in which the control input is the system’s natural frequency constrained to a prescribed interval. The objective is to transfer the oscillator from a given initial state to a prescribed terminal [...] Read more.
We study a minimum-time (time-optimal) control problem for a nonlinear pendulum-type oscillator, in which the control input is the system’s natural frequency constrained to a prescribed interval. The objective is to transfer the oscillator from a given initial state to a prescribed terminal state in the shortest possible time. Our approach combines Pontryagin’s maximum principle with Bellman’s principle of optimality. First, we decompose the original problem into a sequence of auxiliary problems, each corresponding to a single semi-oscillation. For every such subproblem, we obtain a complete analytical solution by applying Pontryagin’s maximum principle. These results allow us to reduce the global problem of minimizing the transfer time between the prescribed states to a finite-dimensional optimization problem over a sequence of intermediate amplitudes, which is then solved numerically by dynamic programming. Numerical experiments reveal characteristic features of optimal trajectories in the nonlinear regime, including a non-periodic switching structure, non-uniform semi-oscillation durations, and significant deviations from the behavior of the corresponding linearized system. The proposed framework provides a basis for the synthesis of fast oscillatory regimes in systems with controllable frequency, such as pendulum and crane systems and robotic manipulators. Full article
(This article belongs to the Section E: Applied Mathematics)
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23 pages, 359 KB  
Article
Pontryagin’s Maximum Principle for Optimal Control Problems Governed by Integral Equations with State and Control Constraints
by Hugo Leiva and Marcial Valero
Symmetry 2025, 17(12), 2088; https://doi.org/10.3390/sym17122088 - 5 Dec 2025
Viewed by 530
Abstract
This paper proves a new lemma that characterizes controllability for linear Volterra control systems and shows that the usual controllability assumption for the variational linearized system near an optimal pair is superfluous. Building on this, it establishes a Pontryagin-type maximum principle for Volterra [...] Read more.
This paper proves a new lemma that characterizes controllability for linear Volterra control systems and shows that the usual controllability assumption for the variational linearized system near an optimal pair is superfluous. Building on this, it establishes a Pontryagin-type maximum principle for Volterra optimal control with general control and state constraints (fixed terminal constraints and time-dependent state bounds), where the cost combines a terminal term with a state-dependent and integral term. Using the Dubovitskii–Milyutin framework, we construct conic approximations for the cost, dynamics, and constraints and derive necessary optimality conditions under mild regularity: (i) a classical adjoint system when only terminal constraints are present and (ii) a Stieltjes-type adjoint with a non-negative Borel measure when pathwise state constraints are active. Furthermore, under convexity of the cost functional and linear Volterra dynamics, the maximum principle becomes a sufficient criterion for global optimality (recovering the classical sufficiency in the differential case). The differential case recovers the classical PMP, and an SIR example illustrates the results. A key theme is symmetry/duality: the adjoint differentiates in the state while the maximum condition differentiates in the control, reflecting operator transposition and the primal–dual geometry of Dubovitskii–Milyutin cones. Full article
30 pages, 877 KB  
Article
Fractional Optimal Control of Anthroponotic Cutaneous Leishmaniasis with Behavioral and Epidemiological Extensions
by Asiyeh Ebrahimzadeh, Amin Jajarmi and Mehmet Yavuz
Math. Comput. Appl. 2025, 30(6), 122; https://doi.org/10.3390/mca30060122 - 6 Nov 2025
Viewed by 397
Abstract
Sandflies spread the neglected vector-borne disease anthroponotic cutaneous leishmaniasis (ACL), which only affects humans. Despite decades of control, asymptomatic carriers, vector pesticide resistance, and low public awareness prevent eradication. This study proposes a fractional-order optimal control model that integrates biological and behavioral aspects [...] Read more.
Sandflies spread the neglected vector-borne disease anthroponotic cutaneous leishmaniasis (ACL), which only affects humans. Despite decades of control, asymptomatic carriers, vector pesticide resistance, and low public awareness prevent eradication. This study proposes a fractional-order optimal control model that integrates biological and behavioral aspects of ACL transmission to better understand its complex dynamics and intervention responses. We model asymptomatic human illnesses, insecticide-resistant sandflies, and a dynamic awareness function under public health campaigns and collective behavioral memory. Four time-dependent control variables—symptomatic treatment, pesticide spraying, bed net use, and awareness promotion—are introduced under a shared budget constraint to reflect public health resource constraints. In addition, Caputo fractional derivatives incorporate memory-dependent processes and hereditary effects, allowing for epidemic and behavioral states to depend on prior infections and interventions; on the other hand, standard integer-order frameworks miss temporal smoothness, delayed responses, and persistence effects from this memory feature, which affect optimal control trajectories. Next, we determine the optimality conditions for fractional-order systems using a generalized Pontryagin’s maximum principle, then solve the state–adjoint equations numerically with an efficient forward–backward sweep approach. Simulations show that fractional (memory-based) dynamics capture behavioral inertia and cumulative public response, improving awareness and treatment efforts. Furthermore, sensitivity tests indicate that integer-order models do not predict the optimal allocation of limited resources, highlighting memory effects in epidemiological decision-making. Consequently, the proposed method provides a realistic and flexible mathematical basis for cost-effective and sustainable ACL control plans in endemic settings, revealing how memory-dependent dynamics may affect disease development and intervention efficiency. Full article
(This article belongs to the Special Issue Mathematics and Applied Data Science)
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24 pages, 1707 KB  
Article
Differential Game Analysis of Green Technology Investment in the Food Industry Under a Governmental Coordination Mechanism
by Enquan Luo, Shuwen Xiang and Yanlong Yang
Axioms 2025, 14(11), 821; https://doi.org/10.3390/axioms14110821 - 6 Nov 2025
Viewed by 310
Abstract
This study constructs a Stackelberg differential game model for green technology invest-ment in the food industry under a governmental coordination mechanism. The optimal dynamic strategies for local governments and enterprises are derived using Pontryagin’s maximum principle. The backward differential equation method is employed [...] Read more.
This study constructs a Stackelberg differential game model for green technology invest-ment in the food industry under a governmental coordination mechanism. The optimal dynamic strategies for local governments and enterprises are derived using Pontryagin’s maximum principle. The backward differential equation method is employed in this study. It is used to analyze the impact of shadow prices on the optimal decisions of both parties. Furthermore, the study examines how social welfare benefits influence the food quality levels within the jurisdiction of local governments. Based on these findings, optimal strategy pathways are proposed to achieve social welfare and enterprise profit maximization in the green transition process of both government and enterprises. The results indicate that a local government’s investment in food quality improvement significantly enhances the food quality levels within their jurisdictions—greater government investment leads to higher food quality. At the same time, food quality levels are positively correlated with the enterprises’ green technology capital investment. Additionally, consumer price sensitivity and sensitivity to price differences have a notable impact on product pricing. As consumers become more price-sensitive, product prices decrease accordingly, which, in turn, helps increase the market share of the enterprises’ products. Full article
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24 pages, 891 KB  
Article
Stability and Controllability of Nonlinear Dynamic Systems with Neural Networks: An Application to Financial Data
by Lamiae Seddati, Touria Karite, Ahmed Aberqi and Nuno R. O. Bastos
Axioms 2025, 14(11), 808; https://doi.org/10.3390/axioms14110808 - 30 Oct 2025
Viewed by 563
Abstract
This paper presents a novel approach to the controllability of nonlinear dynamic systems using recurrent neural networks (RNNs). We develop a comprehensive theoretical framework that integrates controllability analysis, stability verification via Lyapunov functions, and the derivation of optimal control laws based on Pontryagin’s [...] Read more.
This paper presents a novel approach to the controllability of nonlinear dynamic systems using recurrent neural networks (RNNs). We develop a comprehensive theoretical framework that integrates controllability analysis, stability verification via Lyapunov functions, and the derivation of optimal control laws based on Pontryagin’s Maximum Principle. Our methodology not only ensures theoretical soundness but also offers practical effectiveness. To demonstrate its applicability, we conduct simulations using real-world data from the AAPL stock database. The proposed RNN-based control framework significantly reduces the deviation between predicted system outputs and actual observations. We further enhance performance through two complementary strategies, a direct control method and a parameter optimization approach, both of which contribute to the accuracy and adaptability of the control system. These results confirm the potential of neural network-based control in managing complex nonlinear dynamics Full article
(This article belongs to the Special Issue Mathematical Methods in the Applied Sciences, 2nd Edition)
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38 pages, 2445 KB  
Article
Optimal Control and Tumour Elimination by Maximisation of Patient Life Expectancy
by Byron D. E. Tzamarias, Annabelle Ballesta and Nigel John Burroughs
Mathematics 2025, 13(19), 3080; https://doi.org/10.3390/math13193080 - 25 Sep 2025
Viewed by 544
Abstract
We propose a life-expectancy pay-off function (LEP) for determining optimal cancer treatment within a control theory framework. The LEP averages life expectancy over all future outcomes, outcomes that are determined by key events during therapy such as tumour elimination (cure) and patient death [...] Read more.
We propose a life-expectancy pay-off function (LEP) for determining optimal cancer treatment within a control theory framework. The LEP averages life expectancy over all future outcomes, outcomes that are determined by key events during therapy such as tumour elimination (cure) and patient death (including treatment related mortality). We analyse this optimisation problem for tumours treated with chemotherapy using tumour growth models based on ordinary differential equations. To incorporate tumour elimination we draw on branching processes to compute the probability distribution of tumour population extinction. To demonstrate the approach, we apply the LEP framework to simplified one-compartment models of tumour growth that include three possible outcomes: cure, relapse, or death during treatment. Using Pontryagin’s maximum principle (PMP) we show that the best treatment strategies fall into three categories: (i) continuous treatment at the maximum tolerated dose (MTD), (ii) no treatment, or (iii) treat-and-stop therapy, where the drug is given at the MTD and then halted before the treatment (time) horizon. Optimal treatment strategies are independent of the time horizon unless the time horizon is too short to accommodate the most effective (treat-and-stop) therapy. For sufficiently long horizons, the optimal solution is either no treatment (when treatment yields no benefit) or treat-and-stop. Patients, thus, split into an untreatable class and a treatable class, with patient demographics, tumour size, tumour response, and drug toxicity determining whether a patient benefits from treatment. The LEP is in principle parametrisable from data, requiring estimation of the rates of each event and the associated life expectancy under that event. This makes the approach suitable for personalising cancer therapy based on tumour characteristics and patient-specific risk profiles. Full article
(This article belongs to the Section E3: Mathematical Biology)
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36 pages, 6566 KB  
Article
Algorithmic Optimal Control of Screw Compressors for Energy-Efficient Operation in Smart Power Systems
by Kassym Yelemessov, Dinara Baskanbayeva, Leyla Sabirova, Nikita V. Martyushev, Boris V. Malozyomov, Tatayeva Zhanar and Vladimir I. Golik
Algorithms 2025, 18(9), 583; https://doi.org/10.3390/a18090583 - 14 Sep 2025
Cited by 2 | Viewed by 1476
Abstract
This work presents the results of a research study focused on the development and evaluation of an algorithmic optimal control framework for energy-efficient operation of screw compressors in smart power systems. The proposed approach is based on the Pontryagin maximum principle (PMP), which [...] Read more.
This work presents the results of a research study focused on the development and evaluation of an algorithmic optimal control framework for energy-efficient operation of screw compressors in smart power systems. The proposed approach is based on the Pontryagin maximum principle (PMP), which enables the synthesis of a mathematically grounded regulator that minimizes the total energy consumption of a nonlinear electromechanical system composed of a screw compressor and a variable-frequency induction motor. Unlike conventional PID controllers, the developed algorithm explicitly incorporates system constraints, nonlinear dynamics, and performance trade-offs into the control law, allowing for improved adaptability and energy-aware operation. Simulation results obtained using MATLAB/Simulink confirm that the PMP-based regulator outperforms classical PID solutions in both transient and steady-state regimes. Experimental tests conducted in accordance with standard energy consumption evaluation methods showed that the proposed PMP-based controller provides a reduction in specific energy consumption of up to 18% under dynamic load conditions compared to a well-tuned basic PID controller, while maintaining high control accuracy, faster settling, and complete suppression of overshoot under external disturbances. The control system demonstrates robustness to parametric uncertainty and load variability, maintaining a statistical pressure error below 0.2%. The regulator’s structure is compatible with real-time execution on industrial programmable logic controllers (PLCs), supporting integration into intelligent automation systems and smart grid infrastructures. The discrete-time PLC implementation of the regulator requires only 103 arithmetic operations per cycle and less than 102 kB of RAM for state, buffers, and logging, making it suitable for mid-range industrial controllers under 2–10 ms task cycles. Fault-tolerance is ensured via range and rate-of-change checks, residual-based plausibility tests, and safe fallbacks (baseline PID or torque-limited speed hold) in case of sensor faults. Furthermore, the proposed approach lays the groundwork for hybrid extensions combining model-based control with AI-driven optimization and learning mechanisms, including reinforcement learning, surrogate modeling, and digital twins. These enhancements open pathways toward predictive, self-adaptive compressor control with embedded energy optimization. The research outcomes contribute to the broader field of algorithmic control in power electronics, offering a scalable and analytically justified alternative to heuristic and empirical tuning approaches commonly used in industry. The results highlight the potential of advanced control algorithms to enhance the efficiency, stability, and intelligence of energy-intensive components within the context of Industry 4.0 and sustainable energy systems. Full article
(This article belongs to the Special Issue AI-Driven Control and Optimization in Power Electronics)
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25 pages, 1496 KB  
Article
Mathematical Analysis and Optimal Control of a Transmission Model for Respiratory Syncytial Virus
by Zakaria S. Al Ajlan, Moustafa El-Shahed and Yousef Alnafisah
Mathematics 2025, 13(18), 2929; https://doi.org/10.3390/math13182929 - 10 Sep 2025
Viewed by 626
Abstract
In this study, we develop a mathematical model to describe the transmission dynamics of the Respiratory Syncytial Virus (RSV), incorporating the coexistence of two distinct strains. The global stability of the disease-free and endemic equilibria is analyzed. Bifurcation analysis reveals the occurrence of [...] Read more.
In this study, we develop a mathematical model to describe the transmission dynamics of the Respiratory Syncytial Virus (RSV), incorporating the coexistence of two distinct strains. The global stability of the disease-free and endemic equilibria is analyzed. Bifurcation analysis reveals the occurrence of a forward bifurcation. To control the spread of the infection, Pontryagin’s maximum principle is applied within the framework of optimal control theory, considering intervention strategies such as isolation, treatment, and vaccination. A detailed evaluation of the effectiveness of these control strategies is conducted for a specific population based on a nonlinear optimal control model. Moreover, a cost-effectiveness analysis is performed to identify the most economically viable intervention. The findings indicate that, among the studied interventions, isolation is the most cost-effective strategy for reducing RSV prevalence. The model is numerically solved using the fourth-order Runge–Kutta method, coupled with the forward–backward sweep algorithm, to assess the impact of various control combinations on the transmission dynamics of RSV. Full article
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21 pages, 1311 KB  
Article
Optimal Control Strategies for a Mathematical Model of Pneumonia Infection
by Nuwayyir Almutairi and Moustafa El-Shahed
Computation 2025, 13(9), 204; https://doi.org/10.3390/computation13090204 - 23 Aug 2025
Viewed by 1362
Abstract
In this study, we formulate and analyze a deterministic mathematical model describing the transmission dynamics of pneumonia. A comprehensive stability analysis is conducted for both the disease-free and endemic equilibrium points. The disease-free equilibrium is locally and globally asymptotically stable when the basic [...] Read more.
In this study, we formulate and analyze a deterministic mathematical model describing the transmission dynamics of pneumonia. A comprehensive stability analysis is conducted for both the disease-free and endemic equilibrium points. The disease-free equilibrium is locally and globally asymptotically stable when the basic reproduction number R0 < 1, while the endemic equilibrium is locally and globally asymptotically stable when R0 > 1. To evaluate effective intervention strategies, an optimal control problem is formulated by introducing time-dependent control variables representing awareness campaigns, screening of carriers, and treatment of infected individuals. Applying Pontryagin’s Maximum Principle, the simulation results confirm the effectiveness of the proposed control strategies in reducing the number of infections and mitigating the overall disease burden. The findings offer valuable insights into the control of pneumonia and highlight the potential impact of strategic public health interventions. Full article
(This article belongs to the Section Computational Biology)
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23 pages, 3747 KB  
Article
Mathematical Modeling of the Impact of Desert Dust on Asthma Dynamics
by Zakaria S. Al Ajlan and Moustafa El-Shahed
Axioms 2025, 14(8), 639; https://doi.org/10.3390/axioms14080639 - 16 Aug 2025
Viewed by 660
Abstract
This study presents a mathematical model to describe the transmission dynamics of asthma, explicitly accounting for the impact of dust waves and airborne particulate matter in the environment, recognized as key triggers of asthma exacerbations. The model incorporates a single endemic equilibrium point, [...] Read more.
This study presents a mathematical model to describe the transmission dynamics of asthma, explicitly accounting for the impact of dust waves and airborne particulate matter in the environment, recognized as key triggers of asthma exacerbations. The model incorporates a single endemic equilibrium point, which is shown to be locally asymptotically stable. To mitigate the burden of asthma, we employed the Pontryagin Maximum Principle within an optimal control framework, incorporating three time-dependent intervention strategies: vaccination, treatment, and avoidance of environmental triggers such as dust exposure. The model was numerically solved using the fourth-order Runge–Kutta method in conjunction with a forward–backward sweep algorithm to investigate the effects of various control combinations on the prevalence of asthma. Additionally, a comprehensive cost-effectiveness analysis was conducted to evaluate the economic viability of each strategy. The results indicate that the combined application of vaccination and treatment is the most cost-effective approach among the strategies analyzed, significantly reducing the number of asthma cases at minimal cost. All simulations and numerical experiments were performed to validate the theoretical findings and quantify the effectiveness of the proposed interventions under realistic environmental conditions driven by dust activity. The model highlights the importance of integrated medical and environmental control policies in mitigating asthma outbreaks, particularly in regions frequently exposed to dust storms. Full article
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19 pages, 476 KB  
Article
Modeling and Optimal Control of Liquidity Risk Contagion in the Banking System with Delayed Status and Control Variables
by Hamza Mourad, Said Fahim and Mohamed Lahby
AppliedMath 2025, 5(3), 107; https://doi.org/10.3390/appliedmath5030107 - 15 Aug 2025
Viewed by 687
Abstract
The application of contagion risk spread modeling within the banking sector is a relatively recent development, emerging as a response to the persistent threat of liquidity risk that has affected financial institutions globally. Liquidity risk is recognized as one of the most destructive [...] Read more.
The application of contagion risk spread modeling within the banking sector is a relatively recent development, emerging as a response to the persistent threat of liquidity risk that has affected financial institutions globally. Liquidity risk is recognized as one of the most destructive financial threats to banks, capable of causing severe and irreparable damage if overlooked or underestimated. This study aims to identify the most effective control strategy for managing financial contagion using a Susceptible–Infected–Recovered (SIR) epidemic model, incorporating time delays in both state and control variables. The proposed strategy seeks to maximize the number of resilient (vulnerable) banks while minimizing the number of infected institutions at risk of bankruptcy. Our goal is to formulate intervention policies that can curtail the propagation of financial contagion and mitigate associated systemic risks. Our model remains a simplification of reality. It does not account for strategic interactions between banks (e.g., panic reactions, network coordination), nor for adaptive regulatory mechanisms. The integration of these aspects will be the subject of future work. We establish the existence of an optimal control strategy and apply Pontryagin’s Maximum Principle to characterize and analyze the control dynamics. To numerically solve the control system, we employ a discretization approach based on forward and backward finite difference approximations. Despite the model’s simplifications, it captures key dynamics relevant to major European banks. Simulations performed using Python 3.12 yield significant results across three distinct scenarios. Notably, in the most severe case (α3=1.0), the optimal control strategy reduces bankruptcies from 25% to nearly 0% in Spain, and from 12.5% to 0% in France and Germany, demonstrating the effectiveness of timely intervention in containing financial contagion. Full article
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19 pages, 1769 KB  
Article
Dynamics of a Fractional-Order Within-Host Virus Model with Adaptive Immune Responses and Two Routes of Infection
by Taofeek O. Alade, Furaha M. Chuma, Muhammad Javed, Samson Olaniyi, Adekunle O. Sangotola and Gideon K. Gogovi
Math. Comput. Appl. 2025, 30(4), 80; https://doi.org/10.3390/mca30040080 - 2 Aug 2025
Cited by 1 | Viewed by 903
Abstract
This paper introduces a novel fractional-order model using the Caputo derivative operator to investigate the virus dynamics of adaptive immune responses. Two infection routes, namely cell-to-cell and virus-to-cell transmissions, are incorporated into the dynamics. Our research establishes the existence and uniqueness of positive [...] Read more.
This paper introduces a novel fractional-order model using the Caputo derivative operator to investigate the virus dynamics of adaptive immune responses. Two infection routes, namely cell-to-cell and virus-to-cell transmissions, are incorporated into the dynamics. Our research establishes the existence and uniqueness of positive and bounded solutions through the application of the generalized mean-value theorem and Banach fixed-point theory methods. The fractional-order model is shown to be Ulam–Hyers stable, ensuring the model’s resilience to small errors. By employing the normalized forward sensitivity method, we identify critical parameters that profoundly influence the transmission dynamics of the fractional-order virus model. Additionally, the framework of optimal control theory is used to explore the characterization of optimal adaptive immune responses, encompassing antibodies and cytotoxic T lymphocytes (CTL). To assess the influence of memory effects, we utilize the generalized forward–backward sweep technique to simulate the fractional-order virus dynamics. This study contributes to the existing body of knowledge by providing insights into how the interaction between virus-to-cell and cell-to-cell dynamics within the host is affected by memory effects in the presence of optimal control, reinforcing the invaluable synergy between fractional calculus and optimal control theory in modeling within-host virus dynamics, and paving the way for potential control strategies rooted in adaptive immunity and fractional-order modeling. Full article
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