Search Results (98)

A modular strategy for the molecular design of silicone-based antifoaming agents was developed by precisely controlling the architecture of poly (methylhydrosiloxane) (PMHS). Sixteen PMHS variants were synthesized by systematically varying the siloxane chain length (L1–L4), backbone composition (D₃T₁ vs. D₃₀T₁), and terminal group chemistry (H- vs. M-type). These structural modifications resulted in a broad range of Si-H functionalities, which were quantitatively analyzed and correlated with defoaming performance. The PMHS matrices were integrated with high-viscosity PDMS, a nonionic surfactant, and covalently grafted fumed silica—which was chemically matched to each PMHS backbone—to construct formulation-specific defoaming systems with enhanced interfacial compatibility and colloidal stability. Comprehensive physicochemical characterization via FT-IR, ¹H NMR, GPC, TGA, and surface tension analysis revealed a nonmonotonic relationship between Si-H content and defoaming efficiency. Formulations containing 0.1–0.3 wt% Si-H achieved peak performance, with suppression efficiencies up to 96.6% and surface tensions as low as 18.9 mN/m. Deviations from this optimal range impaired performance due to interfacial over-reactivity or reduced mobility. Furthermore, thermal stability and molecular weight distribution were found to be governed by repeat unit architecture and terminal group selection. Compared with conventional EO/PO-modified commercial defoamers, the PMHS-based systems exhibited markedly improved suppression durability and formulation stability in high-viscosity environments. These results establish a predictive structure–property framework for tailoring antifoaming agents and highlight PMHS-based formulations as advanced foam suppressors with improved functionality. This study provides actionable design criteria for high-performance silicone materials with strong potential for application in thermally and mechanically demanding environments such as coating, bioprocessing, and polymer manufacturing. Full article

Background/Objectives: This study explores the perspectives of mental health professionals on tailoring the Mentis Plus intervention to enhance positive mental health (PMH) in individuals experiencing First-Episode Psychosis (FEP). Although the Mentis Plus Program has been previously implemented in other contexts, it has not yet been applied to FEP care. Therefore, this study aimed to adapt the intervention for future implementation through expert consultation. Methods: A qualitative exploratory-descriptive design was employed. Data were collected via three focus groups comprising multidisciplinary professionals experienced in FEP care. Qualitative content analysis was used to examine the data. Results: Participants viewed the tailored Mentis Plus intervention as a valuable, recovery-oriented tool. Key recommendations included a flexible, group-based format with eight weekly sessions. Suggested intervention components encompassed gratitude journaling, emotional regulation techniques, and collaborative problem-solving exercises. Group delivery was highlighted as essential for mitigating isolation and promoting peer support. Practical implementation strategies included phased session structures and routine emotional check-ins. Identified barriers to implementation included the need for specialized training, limited therapeutic spaces, and the heterogeneity of participant needs. Facilitators included a person-centered approach, institutional backing, and sufficient resources. Conclusions: The findings support the feasibility and clinical relevance of a tailored Mentis Plus FEP Program—Brief Version. Expert-informed insights provide a foundation for adapting mental health interventions to early-psychosis care and inform future research and implementation strategies. Full article

Background: Adolescence is a key period of development characterized by emotional, cognitive, and social changes that impact positive mental health (PMH). While social support is a well-established protective factor, cognitive and emotional processes, such as cognitive fusion and regulation of distress, also play a critical role. Objective: This study aimed to examine the relationship among various cognitive (i.e., cognitive fusion), emotional (i.e., regulation of distress), and social determinants (i.e., social support) in adolescents’ PMH, as their interplay could reflect theoretical models highlighting how these factors jointly shape adolescents’ mental health. Methods. A cross-sectional study was conducted with 505 adolescents (aged 13–15 years) in Spain. Participants completed online questionnaires assessing sociodemographic variables, cognitive fusion, regulation of distress, PMH, and social support from friends. Descriptive statistics, correlation analyses, and mediation and moderated mediation models were conducted, adjusting for relevant covariates. Results: Cognitive fusion was negatively correlated with regulation of distress, PMH, and social support, whereas regulation of distress showed a positive association with both PMH and social support. Mediation analysis indicated that regulation of distress significantly mediated the relationship between cognitive fusion and PMH. Furthermore, peer support moderated this mediated relationship: higher levels of support mitigated the negative impact of regulation of distress on PMH. Sociodemographic analyses revealed that girls, non-national students, and those receiving educational support showed less favorable outcomes. Conclusions: Cognitive, emotional, and social variables jointly influence adolescents’ PMH. Emotional regulation serves as a mediator of cognitive fusion and PMH, while social support from peers mediates the impact of psychological distress. Targeted interventions should prioritize emotional regulation strategies and enhancing peer support, especially among more vulnerable groups. Full article

Background/Objectives: The Jackson/Cubbin scale is a recommended tool to assess the risk of pressure injury in intensive care unit (ICU) patients. This scale is deemed to have superior predictive validity compared to the Braden scale. Many Italian nurses struggle with reading and applying the tool in English. This language barrier results in a lack of use of the Jackson/Cubbin scale clinically, meaning that patients potentially experience worse outcomes. This study aims to translate the original English version of the Jackson/Cubbin scale into the Italian language, conduct a cultural adaptation, and verify its content validity. Methods: An observational study was conducted using Beaton’s five-step methodology: (1) forward translation, (2) synthesis, (3) back-translation, (4) expert committee approval using Fleiss’ Kappa (κ) index, and (5) pre-testing, where participants assessed item clarity on a dichotomous scale (clear/unclear). Items deemed unclear by 20% or more of the sample were revised. Content validity was assessed using the Content Validity Index (CVI). Results: Fleiss’ κ index was 0.74. Item 3 “PMH-affecting condition” was unclear to 36% of the sample and required revision. The item-level CVI (I-CVI) was >0.78 for each item. The scale-level CVI (S-CVI) and the scale-level CVI using the average method (S-CVI-Ave) were 0.92 and 0.94, respectively. Conclusions: The translation process resulted in a linguistically accurate scale requiring content modifications to reflect current evidence and reduce inter-rater variability. This may improve implementation of the Jackson/Cubbin scale in clinical practice for Italian nurses and reduce the incidence of pressure injury for ICU patients. Full article

Resol phenol–formaldehyde (PF) resin was modified with 2.5 and 5.0 wt% polymethylhydrosiloxane (PMHS). This study characterizes the modified resin and its subsequently fabricated glass fiber (GF)-reinforced composites (30–60 wt% GF). Formation of an organic–inorganic hybrid network, via reaction between Si-H groups of PMHS and hydroxyl (-OH) groups of the resol resin, was confirmed by FTIR and ¹H NMR. DSC and TGA/DTG revealed enhanced thermal stability for PMHS-modified resin: the decomposition temperature of Resol–PMHS 5.0% increased to 483 °C (neat resin: 438 °C), and char yield at 800 °C rose to 57% (neat resin: 38%). The 60 wt% GF-reinforced Resol–PMHS 5.0% composite exhibited tensile, flexural, and impact strengths of 145 ± 7 MPa, 160 ± 7 MPa, and 71 ± 5 kJ/m², respectively, superior to the unmodified resin composite (136 ± 6 MPa, 112 ± 6 MPa, and 51 ± 5 kJ/m²). SEM observations indicated improved fiber–matrix interfacial adhesion and reduced delamination. These results demonstrate that PMHS modification effectively enhances the thermo-mechanical properties of the PF resin and its composites, highlighting potential for industrial applications. Full article

Rising workloads and institutional pressures in higher education threaten lecturers’ mental health, yet few studies explore how university climate and self-efficacy contribute to their positive mental health (PMH). This study employed a cross-sectional survey to investigate the mediating role of lecturers’ self-efficacy in the relationship between university climate and lecturers’ PMH. A total of 357 responses were collected from English major lecturers in Chinese higher education institutions through an online survey with convenience sampling. Data were collected via an online questionnaire using validated scales: the School Climate Inventory (SCI-5) for school climate, the General Self-Efficacy Scale (GSES) for self-efficacy, and the Positive Mental Health Scale (PMH) for mental health. The results indicated that all five dimensions of university climate—Collaboration (β = 0.122, p < 0.05), Student Relations (β = 0.163, p < 0.01), School Resources (β = 0.12, p < 0.05), Decision-Making (β = 0.11, p < 0.05), and Instructional Innovation (β = 0.325, p < 0.001)—positively influenced lecturers’ self-efficacy, with instructional innovation having the most significant impact. Moreover, self-efficacy significantly enhanced lecturers’ PMH (β = 0.27, p < 0.001) and partially mediated the relationship between university climate and lectures’ PMH (VAF = 20–80%). The findings highlighted the importance of fostering an innovative and supportive university climate while enhancing self-efficacy to promote faculty well-being. Future studies can further extend the results of this study through institutional and individual development strategies. Full article

This study investigates occupant kinematic and injury responses in zero-gravity seats under rear impacts at 16 km/h, 40 km/h, and 56 km/h and evaluates the protective performance of a conventional three-point seat belt system and a four-point seat belt system. First, a THUMS (Total Human Model for Safety)-based finite element assembly consisting of a regular seat model and a conventional three-point seat belt system was verified by comparing the kinematic responses and time-history curves of head acceleration, head rotation, and the T1 acceleration of PMHS (Postmortem Human Subject) tests. Then, a THUMS-based finite element assembly in a zero-gravity seat with a three-point seat belt system was created, and computational biomechanical analyses revealed that at low-to-medium impact speeds (16 and 40 km/h), the occupant exhibited backward sliding in the zero-gravity seat along the seatback with lower limb rotation and did not experience head and neck injury. However, a 56 km/h impact induced an excessive seatback rotation and caused the head to become out of position. The neck collided with the upper part of the headrest and caused a surge in the contact force between the neck and the headrest. The head injury and neck injury were comprehensively analyzed via the head injury metrics and neck injury metrics, including cervical spine injury metrics and cervical ligament injury metrics. Further, a four-point seat belt system was adopted and demonstrated better and more balanced restraining effects by reducing the relative displacement between the occupant’s head and chest in the x- and y-directions by 26% and 84%, respectively. Therefore, the occupant’s head remains in position and the collision between the neck and the headrest can be avoided. Maximum reductions in the head and neck injury metrics reached 70% and 57%, respectively. The current study illustrates the disadvantages of the traditional three-point seat belt system in restraining the occupant in a zero-gravity seat under rear impact and shows the four-point seat belt to be a better alternative. This study sheds light on seat belt system design and optimization towards future zero-gravity seats under rear impact. Full article

Promethazine hydrochloride (PMH) is a first-generation antipsychotic drug created from phenothiazine derivatives that is widely employed to treat psychiatric disorders in human healthcare systems. However, an overdose or long-term intake of PMH can lead to severe health issues in humans. Hence, establishing a sensitive, accurate, and efficient detection approach to detect PMH in human samples is imperative. In this study, we designed orthorhombic copper molybdate microspheres decorated on reduced graphene oxide (Cu₃Mo₂O₉/RGO) composite via the effective one-pot hydrothermal method. The structural and morphological features of the designed hybrid were studied using various spectroscopic methods. Subsequently, the electrochemical activity of the composite-modified screen-printed carbon electrode (Cu₃Mo₂O₉/RGO/SPCE) was assessed by employing voltammetric methods for PMH sensing. Owing to the uniform composition and structural benefits, the combination of Cu₃Mo₂O₉ and RGO has not only improved electrochemical properties but also enhanced the electron transport between PMH and Cu₃Mo₂O₉/RGO. As a result, the Cu₃Mo₂O₉/RGO/SPCE exhibited a broad linear range of 0.4–420.8 µM with a low limit of detection (LoD) of 0.015 µM, highlighting excellent electrocatalytic performance to PMH. It also demonstrated good cyclic stability, reproducibility, and selectivity in the presence of chlorpromazine and biological and metal compounds. Furthermore, the Cu₃Mo₂O₉/RGO/SPCE sensor displayed satisfactory recoveries for real-time monitoring of PMH in human urine and serum samples. This study delivers a promising electrochemical sensor for the efficient analysis of antipsychotic drug molecules. Full article

The human neck is highly vulnerable in motor vehicle crashes, and cervical spine response data are essential to improve injury prediction tools (e.g., crash test dummies, human body models). This feasibility study aimed to implement the use of pressure sensors in whole-body post-mortem human subject (PMHS) cervical spine intervertebral discs (IVDs) to confirm the feasibility and repeatability of cervical IVD pressure response to biomechanic research. Two fresh frozen whole-body PMHSs were instrumented with miniature pressure sensors (Model 060S, Precision Measurement Company, Ann Arbor, MI, USA) at three cervical IVD levels (C3/C4, C5/C6, and C7/T1) using minimally invasive surgical insertion techniques. Each PMHS underwent three quasistatic motion test trials, and each trial included multiple head/neck motions (i.e., gentle traction, flexion/extension, lateral bending, axial rotation, and forced tension/compression). Results showed marked pressure differences between both the cervical level assessed and the motion undertaken as well as successful intra-subject repeatability between the three motion trials. This study demonstrates that changes in cervical IVD pressure are associated with motion events of the cervical spine. Cervical IVD response data could be utilized to assess and supplement the characterization of the head/neck complex motion, and data could facilitate the continued improvement of injury prediction tools. Full article

Pseudomyogenic haemangioendotheliomas (PMH) are exceedingly rare, mostly occurring in soft tissue, with malignant cases even more uncommon. In this report, we present a case of a 28-year-old male initially suspected of having a fibroblastic osteosarcoma of the right femur, which was then correctly diagnosed as a primary pseudomyogenic hemangioendothelioma of the bone with synchronous metastases to other skeletal segments. Molecular analysis through targeted RNA sequencing confirmed the correct diagnosis, revealing a fusion transcript ACTB::FOSB. To our knowledge, this is one of the few reported cases of suffering from multiple pathological fractures. The rapid skeletal progression and the onset of distant metastases in this case is highly unusual considering the typically indolent clinical course commonly reported in the literature for this tumor. Full article

Hydrogels with tunable properties are of great interest for the development of advanced drug delivery systems. In this study, novel hydrogels with an interpenetrating polymer network (IPN) structure were obtained from the pH-responsive poly(methacrylic acid) (PMAA) and the neutral poly(N,N-dimethylacrylamide) (PDMAM). The newly synthesized IPN hydrogels were shown to be pH responsive with a 1.5 to 2.5 fold increase in their equilibrium swelling ratio at a pH above 5 which makes them appropriate for targeted intestine drug delivery. Moreover, their pH responsiveness was found to be strongly influenced by the IPN’s composition. The IPN hydrogels were loaded with PMH via swelling and the drug entrapment efficiency was found to depend on their swelling characteristic varying with the IPN’s composition from 20% to 60%. The drug release profiles were investigated under conditions resembling the oral route of drug application. The PMH release profiles appeared to follow Fickian diffusion at a stomach-like pH = 1.2 and sub-diffusion mechanism at an intestine-like pH = 6.8. The results from this study reveal that IPN hydrogels of PMAA and PDMAM are promising candidates for oral delivery of promethazine hydrochloridee demonstrating pH responsiveness and controllable swelling dependent on their composition. Further investigations are planned to fully reveal their potential as smart drug delivery systems. Full article

The concept of positive mental health (PMH) and therefore mental well-being (MWB) have taken center stage over the last few decades. The Mental Health Continuum—Short Form (MHC-SF) is one of the most important tools for assessing MWB. This study aims to assess the psychometric properties and dimensionality of the Portuguese version of the MHC-SF by comparing three competing models. Methods: Between January and March of 2021, a survey was conducted with a convenience sample of 495 Portuguese adolescents aged 12 to 18 years, enrolled in grades 7 to 12. Descriptive statistics and bivariate statistical tests and measures associated with confirmatory factor analysis (CFA) were calculated. Results: The results of the CFA support the idea that the bifactor model fits the data better than the other competing models. The indices support unidimensionality, namely the explained common variance (ECV = 0.81), the Percentage of Uncontaminated Correlations (PUC = 0.69), and the omega hierarchical (ωH = 0.89), and point to the existence of a general MHC-SF factor. The scale showed high reliability (ω = 0.95) in the general factor. The MHC-SF has concurrent validity, correlating with other scales that assess aspects related to mental health and well-being. Conclusion: The results point to the adequacy of the bifactor model and suggest the existence of a general factor of PMH, confirming that the total score of the scale can be used. Full article

In this paper, polymethylhydrosiloxane (PMHS) and ethanol were used as raw materials to synthesize the ceramic precursor of side ethoxy polysiloxane (PESO) using dehydration and a dealcoholization reaction, which had a ceramic yield of 87.15% and a very low residual carbon content. With the quartz fiber as a reinforcer, the silica matrix composites (SiO_2f/SiO₂) with a double-layer interface (PyC-SiO₂/BNNSs) coating were manufactured using precursor impregnation pyrolysis (PIP). The as-prepared SiO_2f/SiO₂ possessed an excellent mechanical property, which exhibited obvious fiber pull-out and debonding phenomena from a fracture morphology. The flexural strength and fracture toughness of SiO_2f/SiO₂ reached 63.3 MPa and 2.52 MPa·m^1/2, respectively. Moreover, the SiO_2f/SiO₂ had suitable dielectric properties, with a dielectric constant of about 2.5 and a dielectric loss of less than 0.01. This work provides an important concept for the enhancement of the dielectric properties and mechanical properties of quartz fiber-reinforced ceramic matrix composites, as well as in the preparation of wave-transmissivity composites. Full article

Background: Student-athletes and competitive dancers experience significant physical, psychological, and emotional stress, often coupled with academic and social pressures. These stressors may lead to unhealthy coping mechanisms, negatively impacting mental health, quality of life, and athletic performance. While assessing mental illness is important, measuring positive mental health (PMH) can offer valuable insights into overall well-being and resilience. The positive mental health Instrument (PMHI) was developed to assess PMH, but its psychometric properties in student-athletes and competitive athletes have not been explored. Methods: Collegiate student-athletes and competitive dancers completed a survey, including the PMHI-19 and a demographic questionnaire. Confirmatory factor analysis (CFA) was conducted to assess the factor structure of the PMHI-19. An exploratory factor analysis (EFA) was then conducted to identify a more parsimonious structure. Results: The CFA of the PMHI-19 did not meet recommended model fit indices. EFA resulted in two different parsimonious models: a 4-factor, 11-item model (PMHI-11) and a 3-factor, 9-item model (PMHI-9), both meeting recommended fit indices. Conclusions: The condensed PMHI-11 and PMHI-9 models may be more suitable for use in collegiate athletic populations. Further research is needed to refine these instruments and explore their applicability across diverse athletic groups. Full article

Comminution is performed by using two main types of machines: grinders and chippers. Grinders are commonly used to treat contaminated wood biomass. In South Korea, cut-to-length harvesting is the main salvage logging method, and felled trees and residues often become dirtied during extraction, where logs are moved from the stump to the roadside using a small shovel. Therefore, grinders are preferred for the comminution of wood biomass for conversion into hog fuel. This study aimed to evaluate productivity and hog fuel quality as outcomes of wood biomass sorting. The productivities for unsorted residues and logs were 11.2 ± 1.48 ton/PMH₀ and 12.4 ± 1.73 ton/PMH₀ at a moisture content of 24%, respectively. Between 33.5% and 46.0% of the total hog fuel mass passed through the screen and reached an acceptable size (3.15 mm to 63 mm). The bulk densities of the two materials ranged from 132.4 kg/m³ to 148.8 kg/m³ on a dry basis. The results of this study suggest that sorting the feedstock has the potential to reduce the number of oversized particles in the hog fuel without screening. Full article