PARK2 mutations are the most common cause of early-onset Parkinson’s disease. No genotype-phenotype correlation exists, and phenotypic variability is quite common. We report two siblings with confirmed identical compound heterozygous mutations in the...
Parkin and α-synuclein are two key proteins involved in the pathophysiology of Parkinson’s disease (PD). Neurotoxic alterations of α-synuclein that lead to the formation of toxic oligomers and fibrils contribute to PD through synapt...
The main goal of the present study was the identification of cellular phenotypes in attention-deficit-/hyperactivity disorder (ADHD) patient-derived cellular models from carriers of rare copy number variants (CNVs) in the PARK2 locus that have been p...
This study aimed to explore the intricate relationship between mitochondrial dysfunction, infection, and neuroinflammation, focusing specifically on the impact of pathogenic epitopes of the Epstein–Barr Virus (EBV) nuclear antigen 1 (EBNA1) in...
The PARK2 gene is located on 6q26, encodes ubiquitin-E3- ligase, and is a transcriptional repressor of p53. It contains 12 exons. PARK2 copy number variants has been reported in various types of neurodevelopmental disorders, namely schizophrenia, Par...
Mitophagy plays an important role in maintaining mitochondrial homeostasis by clearing damaged mitochondria. Sphingosine kinase 2 (SK2), a type of sphingosine kinase, is an important metabolic enzyme involved in generating sphingosine-1-phosphate. It...
Appertaining parking lots of public buildings provide a large proportion of parking supply in cities. However, these parking lots mainly serve the parking demands of public buildings, leading to a low utilization ratio of parking spaces. It is theref...
Parkinson’s disease (PD) is the second most common neurodegenerative diseases characterized by progressive loss of midbrain dopaminergic neurons in the substantia nigra. Mutations in the PARK2 gene are a frequent cause of familial forms of PD....
This study mainly focuses on the estimation calculation of urban parking space. Urban parking has always been a problem that plagues governments worldwide. Due to limited parking space, if the parking space is not controlled correctly, with the city&...
Among various types of external space, a park, which is a critical urban public infrastructure, must be planned and redeveloped as a smart park that can reflect new technologies rather than being designed and managed in a traditional way. This study...
The population of Dubai has increased dramatically in the last 40 years. Along with social changes, neighborhood parks are becoming increasingly important for enhancing the residents’ quality of life. This study aims to evaluate the physical en...
At present, the realization of autonomous valet parking (AVP) technology does not achieve information interaction between the parking spaces and vehicles, and accurate parking spaces information perception cannot be obtained when the accuracy of the...
According to the vehicle dynamics model and the requirements of reliable safety and minimal time, the path planning problem of parking in different types of parking spaces is solved by obstacle avoidance analysis and motion analysis in the case of th...
The provision of high-quality national park tourism services depends on an understanding of the role of the national park brand in visitors’ decision-making on visiting parks. The consideration of forest recreation and park brand awareness not...
The induction motor (IM) is considered to be one of the most important types of motors used in industries. A sudden failure in this machine can lead to unwanted downtime, with consequences in costs, product quality, and safety. Over the last decade,...
Shared parking is an effective means to alleviate the shortage of parking spaces in urban central areas during the morning peak hours. Meanwhile, walking time cost and parking fees are two critical factors affecting shared parking efficiency. Firstly...
According to the existing mainstream automatic parking system (APS), a parking path is first planned based on the parking slot detected by the sensors. Subsequently, the path tracking module guides the vehicle to track the planned parking path. Howev...
This study proposes geometric path plans composed of two stages to automatically perform perpendicular and parallel parking with a reverse path in a narrow space. In perpendicular parking, the minimum width of the available parking spot is computed b...
The pollution and congestion caused by the shortage of parking spaces are threatening the sustainable development of cities. Smart parking platforms are one of the major tools to solve the problem by providing the efficient usage of parking resources...
Urban complexes on top of subways as a function of intensive building groups, including residential, office, business, and other types nature of land use where parking time differences are obvious, can implement shared parking spaces, thereby reducin...
With the expansion of urban scale and the popularization of multi-modal transportation, transportation hubs, as the link of multi-modal travel, are becoming increasingly important in urban development and residents’ lives. In situations of high...
Automatic parking system has been widely equipped on manual driving vehicles for decades. Due to the limited environment sensing ability and not-accurate-enough positioning system, however, it usually requires a very large redundant space for a car t...
There are significant differences in the utilization efficiency of parking spaces in different spatial locations within the complex parking lots, which reduces the utilization efficiency of parking resources. For the above problem, a parking spaces s...
Questions about park–people relationships and the understanding and handling of the conflicts that may result from the creation and management of national parks in the surrounding area are prerequisites for both successful park management and sustain...
With the continuous increase in the number of vehicles worldwide, parking challenges have become more severe, making it a shared goal for governments to alleviate parking difficulties in urban centers. Shared parking has emerged as an effective solut...
The proximity of urban green spaces to residential areas has become a central principle in contemporary urban planning, with cities worldwide adopting “15-minute city” concepts that prioritize walking-distance access to parks. This study...
22 August 2019
Aims: The present study aimed to examine and compare the socioecological correlates of park-based physical activity (PA) among Hong Kong and Leipzig older adults in terms of types of activity areas, perceived park environment, psychosocial factors, a...
Suburban areas connect the city and the natural land. This kind of area is subject to high ecological sensitivity. To give full play to the ecological value of spontaneous plants, it was applied to the construction of suburban parks. We need to explo...
The parking assist system (PAS) provides information of parking slots around the vehicle. As the demand for an autonomous system is increasing, intelligent PAS has been developed to park the vehicle without the driver’s intervention. To locate...
Parks, as essential elements of urban green public spaces, play a crucial role in sustainable urban development. Their features have features confirmed to significantly affect park vitality. Prior research has indirectly indicated that park features...
2 November 2017
Introduction: Parks in the US and Australia are generally underutilised, and park visitors typically engage in low levels of physical activity (PA). Better understanding park features that may encourage visitors to be active is important. This study...
A singular and modest activist action, a temporary park created in San Francisco, grew into the global urban Park(ing) Day (PD) phenomenon. This tactical urbanism event not only expanded to be annually celebrated in thousands of parking lots all over...
This paper presents a comprehensive study on autonomous vehicle parking challenges, focusing on kinematic and reverse parking models. The research develops models for various scenarios, including turning, reverse, vertical, and parallel parking while...
This study highlights the importance of social sustainability in the context of urban parks and evaluates its performance using a specific case study. It proposes a comprehensive measurement scale focused on eight dimensions: identity, sense of place...
This paper introduces an automatic parking method using an around view monitoring system. In this method, parking lines are extracted from the camera images, and a route to a targeted parking slot is created. The vehicle then tracks this route to par...
Parking is a problem in many cities. Usually, it is not possible to build new parking lots due to insufficient available areas. This paper focuses on the parking situation in Slovak city Žilina. The authors carried out an extensive traffic survey in...
The parking assist system is an essential application of the car’s active collision avoidance system in low-speed and complex urban environments, which has been a hot research topic in recent years. Parking space detection is an important step...
Neuroinflammation is considered to be one of the driving factors in Parkinson’s disease (PD). This study was conducted using neuronal and glial cell cultures differentiated from induced pluripotent stem cells (iPSC) of healthy donors (HD) and P...
The COVID-19 pandemic has limited people’s visitation to public places because of social distancing and shelter-in-place orders. According to Google’s community mobility reports, some countries showed a decrease in park visitation during...
With the cultivation of the shared economy, shared parking provides a new solution to the urban parking resource shortage problem. In this paper, the shared parking mode is taken as the research object to improve the utilization efficiency of parking...
This study investigates the institutional dynamics behind the phenomenon of apartment construction within urban parks in South Korea, using the Policy Arrangement Approach (PAA) as an analytical framework. By comparing two landmark policies—the...
Urban parks deliver vital ecosystem services and enhance residents’ well-being globally, yet equitable access remains challenging in high-density cities. The prevailing planning paradigms predominantly rely on proximity-based metrics, overlooki...
Both academics and practitioners concur that parking restraints should be actively introduced in urban centers and job-intensive areas, to prevent overdependence on automobiles. Many Chinese metropolises have reduced the level of parking minimums for...
The city of Lviv faces a scarcity of parking lots, especially in its central zone. A comparison of the results of the in situ studies carried out in 2016 and 2021 in the city center showed the efficiency of the planning activities, due to which the n...
Narrow parking spaces pose difficulties in path planning and spot turning caused by sudden changes and discontinuities in path curvature. To address these problems, this paper investigates the performance of three path-planning algorithms and propose...
For cities, the problem of “difficult parking and chaotic parking” increases carbon emissions and reduces quality of life. Accurately and efficiently predicting the availability of vacant parking spaces (VPSs) can help motorists reduce th...
Contemporary cities generally lack the balance between the development of the spatial structure and the communication possibilities of the inhabitants. The high motorisation rate in Poland, as well as in other European countries, and the preferred ch...
The cooling effects of urban parks, which form “Park Cool Island” (PCI), can help decrease land surface temperature (LST) and mitigate urban heat island (UHI) effects. PCI intensity largely depends on the characteristics of urban parks. The relations...
21 January 2020
We conducted secondary data analyses of pooled data from a clinical trial that prescribed park visits to children and their caregivers in a low-income, urban setting. Data were collected at the prescribing visit (baseline) and at one and three months...
This paper explores the minimum lateral parking distance and parking acceleration/deceleration distance of vehicles to improve the efficiency of automated valet parking (AVP) lots and save urban land. Specifically, the paper focuses on designing park...
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