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48 Results Found

  • Article
  • Open Access
11 Citations
2,887 Views
16 Pages

30 September 2022

In the thermal processes of fossil fuel and biomass combustion, organic compounds are formed, belonging to the family of so-called Persistent Organic Pollutants. Among them, polycyclic aromatic hydrocarbons (PAHs) are of particular importance. Due to...

  • Article
  • Open Access
3 Citations
3,383 Views
15 Pages

17 March 2025

The potential migration of chemical compounds from plastic food packaging poses significant health risks, necessitating continuous monitoring and enhanced safety protocols. This study aimed to investigate the migration of nine chemical groups, includ...

  • Article
  • Open Access
7 Citations
1,560 Views
11 Pages

Effect of Composting Ashes from Biomass Combustion on Polycyclic Aromatic Hydrocarbon Content

  • Paweł Cwalina,
  • Małgorzata Krasowska,
  • Marzena Ewa Smolewska and
  • Kinga Koziak

9 February 2024

The safe management of waste from biomass combustion is a global problem, as the use of biomass for energy purposes is increasing around the world. Many rapidly developing countries in Asia, Africa, and South America have weak legal regulations regar...

  • Article
  • Open Access
2 Citations
3,206 Views
20 Pages

30 December 2022

Compliance with the legal limits set at the European level for the content of polycyclic aromatic hydrocarbons (PAH), which are harmful to human health and the environment, is of central importance for the recycling of rubber, particularly end-of-lif...

  • Article
  • Open Access
7 Citations
6,487 Views
12 Pages

17 August 2022

Petroleum spills and land contamination are becoming increasingly common around the world. Polycyclic aromatic hydrocarbons (PAHs) and other pollutants found in petroleum are constantly migrating underground, making their migration in soil a hot rese...

  • Article
  • Open Access
8 Citations
3,522 Views
14 Pages

Non-Muscle MLCK Contributes to Endothelial Cell Hyper-Proliferation through the ERK Pathway as a Mechanism for Vascular Remodeling in Pulmonary Hypertension

  • Mariam Anis,
  • Janae Gonzales,
  • Rachel Halstrom,
  • Noman Baig,
  • Cat Humpal,
  • Regaina Demeritte,
  • Yulia Epshtein,
  • Jeffrey R. Jacobson and
  • Dustin R. Fraidenburg

7 November 2022

Pulmonary arterial hypertension (PAH) is characterized by endothelial dysfunction, uncontrolled proliferation and migration of pulmonary arterial endothelial cells leading to increased pulmonary vascular resistance resulting in great morbidity and po...

  • Article
  • Open Access
3 Citations
1,928 Views
12 Pages

Behaviour of FITC-Labeled Polyallylamine in Polyelectrolyte Microcapsules

  • Alexey V. Dubrovskii,
  • Alexey V. Berezhnov,
  • Aleksandr L. Kim and
  • Sergey A. Tikhonenko

8 August 2023

There are many studies devoted to the application of polyelectrolyte microcapsules (PMC) in various fields; however, there are significantly fewer studies devoted to the study of the polyelectrolyte microcapsules themselves. The study examined the mu...

  • Review
  • Open Access
50 Citations
6,296 Views
28 Pages

21 February 2021

Pulmonary arterial hypertension (PAH) is a progressive and fatal disease without a cure. The exact pathogenic mechanisms of PAH are complex and poorly understood, yet a number of abnormally expressed genes and regulatory pathways contribute to sustai...

  • Article
  • Open Access
9 Citations
2,802 Views
9 Pages

Microrna-486-5P Regulates Human Pulmonary Artery Smooth Muscle Cell Migration via Endothelin-1

  • Ting-An Yen,
  • Hsin-Chung Huang,
  • En-Ting Wu,
  • Heng-Wen Chou,
  • Hung-Chieh Chou,
  • Chien-Yi Chen,
  • Shu-Chien Huang,
  • Yih-Sharng Chen,
  • Frank Lu and
  • Mei-Hwan Wu
  • + 2 authors

8 September 2022

Pulmonary arterial hypertension (PAH) is a fatal or life-threatening disorder characterized by elevated pulmonary arterial pressure and pulmonary vascular resistance. Abnormal vascular remodeling, including the proliferation and phenotypic modulation...

  • Article
  • Open Access
18 Citations
4,981 Views
18 Pages

Genome-Wide Transcriptional and Functional Analysis of Human T Lymphocytes Treated with Benzo[α]pyrene

  • Marie Liamin,
  • Hélène Le Mentec,
  • Bertrand Evrard,
  • Laurence Huc,
  • Frédéric Chalmel,
  • Elisa Boutet-Robinet,
  • Eric Le Ferrec and
  • Lydie Sparfel

17 November 2018

Polycyclic aromatic hydrocarbons (PAHs) are widely distributed environmental contaminants, known to affect T lymphocytes. However, the molecular targets and pathways involved in their immunotoxic effects in human T lymphocytes remain unknown. Here, w...

  • Article
  • Open Access
4 Citations
3,003 Views
15 Pages

Transformation and Degradation of PAH Mixture in Contaminated Sites: Clarifying Their Interactions with Native Soil Organisms

  • Xiaoyu Li,
  • Shengnan Zhang,
  • Ruixue Guo,
  • Xuejing Xiao,
  • Boying Liu,
  • Rehab Khaled Mahmoud,
  • Mostafa R. Abukhadra,
  • Ruijuan Qu and
  • Zunyao Wang

13 May 2024

Soil contamination of polycyclic aromatic hydrocarbons (PAHs), especially caused by the mixture of two or more PAHs, raised great environmental concerns. However, research on the migration and transformation processes of PAHs in soils and their inter...

  • Article
  • Open Access
57 Citations
3,979 Views
13 Pages

Polycyclic aromatic hydrocarbons (PAHs) are organic pollutants widely present in industrial sites. Microbial degradation is an effective method of removing PAHs. The identification of microorganisms that have important ecological functions at the sit...

  • Feature Paper
  • Article
  • Open Access
2 Citations
2,434 Views
16 Pages

In Situ Passive Sampling to Monitor Long Term Cap Effectiveness at a Tidally Influenced Shoreline

  • Alex V. Smith,
  • Xiaolong Shen,
  • Uriel Garza-Rubalcava,
  • William Gardiner and
  • Danny Reible

23 February 2022

Polydimethylsiloxane solid-phase microextraction passive samplers were used to evaluate long-term performance of a sand/gravel cap placed in 2005 in a tidally influenced shoreline in Puget Sound to reduce polycyclic aromatic hydrocarbon (PAH) transpo...

  • Review
  • Open Access
24 Citations
5,284 Views
24 Pages

Contemporary Research Progress on the Detection of Polycyclic Aromatic Hydrocarbons

  • Yan Zhang,
  • Limin Yuan,
  • Shuli He,
  • Huilin Tao,
  • Wenlian Xie,
  • Xinyu Zhang,
  • Xiaolu Ren,
  • Tao Jiang,
  • Lihong Li and
  • Zhiqiang Zhu

Polycyclic aromatic hydrocarbons (PAHs) are a class of the most common and widespread contaminants. The accumulation of PAHs has made a certain impact on the environment and is seriously threatening human health. Numerous general analytical methods s...

  • Article
  • Open Access
859 Views
23 Pages

Silty seabed sediments in the subaqueous delta of the Yellow River are heavily contaminated with petroleum-derived polycyclic aromatic hydrocarbons (PAHs). Storm-induced sediment resuspension and liquefaction are key mechanisms responsible for the re...

  • Review
  • Open Access
5 Citations
5,255 Views
20 Pages

Role of the Purinergic P2Y2 Receptor in Pulmonary Hypertension

  • Mazen Shihan,
  • Tatyana Novoyatleva,
  • Thilo Lehmeyer,
  • Akylbek Sydykov and
  • Ralph T. Schermuly

Pulmonary arterial hypertension (PAH), group 1 pulmonary hypertension (PH), is a fatal disease that is characterized by vasoconstriction, increased pressure in the pulmonary arteries, and right heart failure. PAH can be described by abnormal vascular...

  • Article
  • Open Access
12 Citations
2,853 Views
19 Pages

25 May 2023

To clarify the impact of coking industry activities on the soil-groundwater Polycyclic aromatic hydrocarbon (PAH) occurrence, a typical coking site in Shanxi Province was taken as the study area, and soil and groundwater samples were collected to ana...

  • Article
  • Open Access
11 Citations
3,800 Views
19 Pages

Soluble Receptor for Advanced Glycation End Products (sRAGE) Is a Sensitive Biomarker in Human Pulmonary Arterial Hypertension

  • Franziska Diekmann,
  • Philippe Chouvarine,
  • Hannes Sallmon,
  • Louisa Meyer-Kobbe,
  • Moritz Kieslich,
  • Brian D. Plouffe,
  • Shashi K. Murthy,
  • Ralf Lichtinghagen,
  • Ekaterina Legchenko and
  • Georg Hansmann

10 August 2021

Pulmonary arterial hypertension (PAH) is a progressive condition with an unmet need for early diagnosis, better monitoring, and risk stratification. The receptor for advanced glycation end products (RAGE) is activated in response to hypoxia and vascu...

  • Article
  • Open Access
6 Citations
9,275 Views
14 Pages

TRAIL Deficient Mice Are Protected from Sugen/Hypoxia Induced Pulmonary Arterial Hypertension

  • Sarah H. Dawson,
  • Nadine D. Arnold,
  • Josephine A. Pickworth,
  • Sheila E. Francis and
  • Allan Lawrie

31 July 2014

Pulmonary arterial hypertension (PAH) is a progressive lung disease diagnosed by an increase in pulmonary arterial blood pressure that is driven by a progressive vascular remodelling of small pulmonary arterioles. We have previously reported that tum...

  • Article
  • Open Access
3 Citations
2,265 Views
14 Pages

4 October 2020

Long-term wastewater and reclaimed water irrigation systems constitute the major processes in local water circulation, which concomitantly introduce plenty of undesirable substances that can threaten water quality, ecosystem functions and human healt...

  • Article
  • Open Access
48 Citations
10,810 Views
7 Pages

Genotoxicity in child populations exposed to Polycyclic Aromatic Hydrocarbons (PAHs) in the air from Tabasco, Mexico

  • Rodríguez T. Gamboa,
  • Aldeco R. Gamboa,
  • Alvarez H. Bravo and
  • Wegman P. Ostrosky

The economy of the state of Tabasco is based on oil extraction. However, this imposes major effects to the environment and communities. Examples are the Polycyclic Aromatic Hydrocarbons (PAHs) that may be found in the soil, water and sediment of the...

  • Article
  • Open Access
12 Citations
3,647 Views
12 Pages

Silibinin Upregulates CXCR4 Expression in Cultured Bone Marrow Cells (BMCs) Especially in Pulmonary Arterial Hypertension Rat Model

  • Tingting Zhang,
  • Nanako Kawaguchi,
  • Kunikazu Tsuji,
  • Emiko Hayama,
  • Yoshiyuki Furutani,
  • Hisashi Sugiyama and
  • Toshio Nakanishi

21 May 2020

Previously we reported that silibinin ameliorated pulmonary arterial hypertension (PAH) in rat PAH models, possibly through the suppression of the CXCR4/SDF-1, until the point where PAH became a severe and irreversible condition. To further investiga...

  • Article
  • Open Access
16 Citations
2,703 Views
15 Pages

6 September 2022

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental and processing contaminants generated by both spontaneous and anthropogenic incomplete combustion processes of organic matter. Contamination of PAHs in vegetable oils can result fro...

  • Review
  • Open Access
26 Citations
6,517 Views
26 Pages

24 November 2020

Pulmonary artery hypertension (PAH) is a rare chronic disease with high impact on patients’ quality of life and currently no available cure. PAH is characterized by constant remodeling of the pulmonary artery by increased proliferation and migr...

  • Article
  • Open Access
4 Citations
2,834 Views
20 Pages

Unraveling the Impact of miR-146a in Pulmonary Arterial Hypertension Pathophysiology and Right Ventricular Function

  • Joana Santos-Gomes,
  • Pedro Mendes-Ferreira,
  • Rui Adão,
  • Carolina Maia-Rocha,
  • Beatriz Rego,
  • Manu Poels,
  • Anaïs Saint-Martin Willer,
  • Bastien Masson,
  • Steeve Provencher and
  • Sébastien Bonnet
  • + 5 authors

Pulmonary arterial hypertension (PAH) is a chronic disorder characterized by excessive pulmonary vascular remodeling, leading to elevated pulmonary vascular resistance and right ventricle (RV) overload and failure. MicroRNA-146a (miR-146a) promotes v...

  • Review
  • Open Access
21 Citations
4,926 Views
18 Pages

Role of Long Non-Coding RNAs in Pulmonary Arterial Hypertension

  • Yun Han,
  • Md Khadem Ali,
  • Kamal Dua,
  • Edda Spiekerkoetter and
  • Yuqiang Mao

26 July 2021

Pulmonary arterial hypertension (PAH) is a debilitating condition of the pulmonary circulatory system that occurs in patients of all ages and if untreated, eventually leads to right heart failure and death. Despite existing medical treatment options...

  • Article
  • Open Access
36 Citations
4,884 Views
18 Pages

23 July 2021

Particulate matter from forest fires (PMFF) is an environmental pollutant causing oxidative stress, inflammation, and cancer cell metastasis due to the presence of polycyclic aromatic hydrocarbons (PAHs). Perilla seed meal contains high levels of pol...

  • Article
  • Open Access
15 Citations
2,894 Views
19 Pages

Specificity Protein 1-Mediated Promotion of CXCL12 Advances Endothelial Cell Metabolism and Proliferation in Pulmonary Hypertension

  • Evan R. DeVallance,
  • Christopher M. Dustin,
  • Daniel Simoes de Jesus,
  • Imad Al Ghouleh,
  • John C. Sembrat,
  • Eugenia Cifuentes-Pagano and
  • Patrick J. Pagano

29 December 2022

Pulmonary arterial hypertension (PAH) is a rare yet devastating and incurable disease with few treatment options. The underlying mechanisms of PAH appear to involve substantial cellular proliferation and vascular remodeling, causing right ventricular...

  • Article
  • Open Access
2,385 Views
11 Pages

3 December 2021

Graphene/poly-(sodium-4-styrene sulfonate)(PSS)/poly-(allylamine hydrochloride) (PAH) composite is a frequently adopted system for fabricating polyelectrolyte multilayer films. Swelling is the bottleneck limiting its applications, and its effects on...

  • Article
  • Open Access
3 Citations
1,879 Views
17 Pages

21 July 2023

With their unique geographical characteristics, semi-closed narrow bays are important places for human survival but vulnerable to pollution. Because pollutants (polycyclic aromatic hydrocarbons, PAHs) migrate and undergo transformation through a dyna...

  • Review
  • Open Access
3 Citations
2,959 Views
33 Pages

29 November 2024

Treatment options for pulmonary arterial hypertension (PAH) have improved substantially in the last 30 years, but there is still a need for novel molecules that can regulate the excessive accumulation of pulmonary artery smooth muscle cells (PASMCs)...

  • Article
  • Open Access
3 Citations
2,883 Views
11 Pages

24 December 2022

The antifogging coating based on super-hydrophilic polymer is regarded as the most promising strategy to avoid fogging but suffers from short-term effectiveness due to antifogging failure induced by water invasion. In this study, a black phosphorus n...

  • Article
  • Open Access
14 Citations
5,736 Views
13 Pages

Willows Used for Phytoremediation Increased Organic Contaminant Concentrations in Soil Surface

  • Maxime Fortin Faubert,
  • Dominic Desjardins,
  • Mohamed Hijri and
  • Michel Labrecque

26 March 2021

The Salix genus includes shrub species that are widely used in phytoremediation and various other phytotechnologies due to their advantageous characteristics, such as a high evapotranspiration (ET) rate, in particular when cultivated in short rotatio...

  • Article
  • Open Access
61 Citations
7,026 Views
15 Pages

Glucagon-Like Peptide-1 Receptor Agonist Attenuates Autophagy to Ameliorate Pulmonary Arterial Hypertension through Drp1/NOX- and Atg-5/Atg-7/Beclin-1/LC3β Pathways

  • Yi-Chia Wu,
  • Wei-Ting Wang,
  • Su-Shin Lee,
  • Yur-Ren Kuo,
  • Ya-Chin Wang,
  • Shih-Jung Yen,
  • Mei-Yueh Lee and
  • Jwu-Lai Yeh

Mitochondrial dysfunction is associated with cardiovascular diseases and diabetes. Pulmonary arterial hypertension (PAH) is characterized by pulmonary vascular remodeling, and the abnormal proliferation, apoptosis and migration of pulmonary arterial...

  • Article
  • Open Access
20 Citations
4,278 Views
21 Pages

Proteomic Analysis of KCNK3 Loss of Expression Identified Dysregulated Pathways in Pulmonary Vascular Cells

  • Hélène Le Ribeuz,
  • Florent Dumont,
  • Guillaume Ruellou,
  • Mélanie Lambert,
  • Thierry Balliau,
  • Marceau Quatredeniers,
  • Barbara Girerd,
  • Sylvia Cohen-Kaminsky,
  • Olaf Mercier and
  • Stéphanie Yen-Nicolaÿ
  • + 4 authors

7 October 2020

The physiopathology of pulmonary arterial hypertension (PAH) is characterized by pulmonary artery smooth muscle cell (PASMC) and endothelial cell (PAEC) dysfunction, contributing to pulmonary arterial obstruction and PAH progression. KCNK3 loss of fu...

  • Article
  • Open Access
16 Citations
3,073 Views
11 Pages

18 June 2019

In this paper, we discuss the effect sewage sludge (SS) application has on the contamination of polycyclic aromatic hydrocarbons in fertilized soils and groundwater. Morver, the contents of these compounds in plant biomass was analyzed. For six month...

  • Article
  • Open Access
3 Citations
2,726 Views
20 Pages

Microcapsule-Based Dose-Dependent Regulation of the Lifespan and Behavior of Adipose-Derived MSCs as a Cell-Mediated Delivery System: In Vitro Study

  • Igor Khlusov,
  • Kristina Yurova,
  • Valeria Shupletsova,
  • Olga Khaziakhmatova,
  • Vladimir Malashchenko,
  • Valeriya Kudryavtseva,
  • Marina Khlusova,
  • Gleb Sukhorukov and
  • Larisa Litvinova

24 December 2022

The development of “biohybrid” drug delivery systems (DDS) based on mesenchymal stem/stromal cells (MSCs) is an important focus of current biotechnology research, particularly in the areas of oncotheranostics, regenerative medicine, and t...

  • Article
  • Open Access
42 Citations
8,575 Views
17 Pages

8 August 2014

Bone morphogenetic protein-4 (BMP4), a member of the transforming growth factor β (TGF-β) family of growth factors, is activated and increased under hypoxic conditions, which plays an important role in the progression of pulmonary arterial hypertensi...

  • Review
  • Open Access
16 Citations
3,701 Views
12 Pages

A Short Review of Simple Analytical Methods for the Evaluation of PAHs and PAEs as Indoor Pollutants in House Dust Samples

  • Santino Orecchio,
  • Diana Amorello,
  • Roberta Indelicato,
  • Salvatore Barreca and
  • Silvia Orecchio

30 October 2022

Studies on indoor air quality are indispensable when considering that people spend approximately 85% of their time in confined environments. This short review mostly takes into consideration research that uses passive samplers to evaluate the quality...

  • Review
  • Open Access
33 Citations
6,450 Views
25 Pages

3 September 2020

Pulmonary arterial hypertension (PAH) is a vascular disease that is characterized by elevated pulmonary arterial pressure (PAP) due to progressive vascular remodeling. Extracellular matrix (ECM) deposition in pulmonary arteries (PA) is one of the key...

  • Article
  • Open Access
3 Citations
1,763 Views
14 Pages

24 July 2025

In the context of increasing concern over long-term environmental impacts of closed landfill sites, this study investigates the composition of groundwater and leachate at a municipal waste landfill in southwestern Poland, two decades after its closur...

  • Article
  • Open Access
12 Citations
3,023 Views
14 Pages

15 December 2021

The results of the study of hydrocarbons (HCs): aliphatic (AHCs) and polycyclic aromatic hydrocarbons (PAHs) in bottom sediments (2019 and 2020, cruises 75 and 80 of the R/V Akademik Mstislav Keldysh) in the Norwegian-Barents Sea basin: Mohns Ridge,...

  • Article
  • Open Access
18 Citations
3,696 Views
10 Pages

Evaluation of the Toxicity on Lung Cells of By-Products Present in Naphthalene Secondary Organic Aerosols

  • Yuri Lima de Albuquerque,
  • Emmanuelle Berger,
  • Sophie Tomaz,
  • Christian George and
  • Alain Géloën

6 April 2021

In 2018, seven million people died prematurely due to exposure to pollution. Polycyclic aromatic hydrocarbons (PAHs) are a significant source of secondary organic aerosol (SOA) in urban areas. We investigated the toxic effects of by-products of napht...

  • Article
  • Open Access
8 Citations
4,538 Views
15 Pages

Therapeutic Potential of Regorafenib—A Multikinase Inhibitor in Pulmonary Hypertension

  • Swathi Veeroju,
  • Baktybek Kojonazarov,
  • Astrid Weiss,
  • Hossein Ardeschir Ghofrani,
  • Norbert Weissmann,
  • Friedrich Grimminger,
  • Werner Seeger,
  • Tatyana Novoyatleva and
  • Ralph Theo Schermuly

2 February 2021

Pulmonary hypertension (PH) is characterized by a progressive elevation of mean arterial pressure followed by right ventricular failure and death. Previous studies have indicated that numerous inhibitors of receptor tyrosine kinase signaling could be...

  • Article
  • Open Access
8 Citations
2,496 Views
17 Pages

Performance Evaluation of Modified Biochar as a Polycyclic Aromatic Hydrocarbon Adsorbent and Microbial-Immobilized Carrier

  • Shuying Geng,
  • Shushuai Mao,
  • Guangming Xu,
  • Aizhong Ding,
  • Feiyong Chen,
  • Junfeng Dou and
  • Fuqiang Fan

23 December 2024

Herein, biochars derived from corn stalks, rice husks, and bamboo powder were modified by nitric acid oxidation and sodium hydroxide alkali activation to identify efficient and cost-effective polycyclic aromatic hydrocarbon-adsorbent and microbial-im...

  • Article
  • Open Access
2 Citations
2,121 Views
16 Pages

Airborne fine dust pollution poses a significant threat to both respiratory and skin health, yet the skin’s physiological response to such exposure has been underexplored. This study investigates the impact of fine dust on skin cells, focusing...

  • Article
  • Open Access
34 Citations
4,419 Views
21 Pages

Monitoring Moroccan Honeys: Physicochemical Properties and Contamination Pattern

  • Abir Massous,
  • Tarik Ouchbani,
  • Vincenzo Lo Turco,
  • Federica Litrenta,
  • Vincenzo Nava,
  • Ambrogina Albergamo,
  • Angela Giorgia Potortì and
  • Giuseppa Di Bella

24 February 2023

The physicochemical traits and an array of organic and inorganic contaminants were monitored in monofloral honeys (i.e., jujube [Ziziphus lotus], sweet orange [Citrus sinensis], PGI Euphorbia [Euphorbia resinifera] and Globularia alyphum) from the Mo...

  • Article
  • Open Access
8 Citations
3,565 Views
12 Pages

Multicellular Cell Seeding on a Chip: New Design and Optimization towards Commercialization

  • Trieu Nguyen,
  • Linh Ho,
  • Sakib M. Moinuddin,
  • Tanoy Sarkar,
  • Dipongkor Saha and
  • Fakhrul Ahsan

1 August 2022

This paper shows both experimental and in-depth theoretical studies (including simulations and analytical solutions) on a microfluidic platform to optimize its design and use for 3D multicellular co-culture applications, e.g., creating a tissue-on-ch...