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19 pages, 901 KiB  
Article
Scale and Determinants of Non-Agricultural Business Activity Among Farmers in Poland
by Ryszard Kata, Małgorzata Wosiek and Agnieszka Brelik
Sustainability 2025, 17(15), 6956; https://doi.org/10.3390/su17156956 (registering DOI) - 31 Jul 2025
Viewed by 68
Abstract
Non-agricultural business activity of farmers is crucial not only for stabilizing farm income but also for the multifunctional development of rural areas. Capturing changes in the level and nature of this activity supports the development of sustainable agricultural and rural policy. In this [...] Read more.
Non-agricultural business activity of farmers is crucial not only for stabilizing farm income but also for the multifunctional development of rural areas. Capturing changes in the level and nature of this activity supports the development of sustainable agricultural and rural policy. In this context, this study aimed to identify the scale and types of non-agricultural business activity and to recognize the main determinants of such business activities undertaken by farmers in Poland between 2002 and 2022. Sectoral-level data from the Agricultural Censuses and cyclical studies of the structure of farms and household budgets were used to approximate underlying motivations for running non-agricultural business (opportunity vs. necessity entrepreneurship). The findings indicate that, in Poland, the impact of regressive factors remains strong, pushing farmers to take on additional business activity due to the large share of small and very small farms. However, during the 21st century, a gradual spread of opportunity entrepreneurship among Polish farmers has been observed. This study highlights the rationale for supporting non-agriculture business activity motivated by progressive factors to increase the income resilience of farmer households and the sustainable development of agriculture. The article indicates the need for further research on the motives for undertaking non-agricultural economic activities by farmers and the impact of this activity on the allocation of farm resources. Full article
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20 pages, 1088 KiB  
Article
The Nexus Between Natural Resources, Renewable Energy and Economic Growth in the Gulf Cooperation Council Countries
by Jamal Alnsour and Farah Mohammad AlNsour
Resources 2025, 14(8), 124; https://doi.org/10.3390/resources14080124 - 30 Jul 2025
Viewed by 244
Abstract
In sustainable development studies, a key question is how the abundance of natural resources influences long-run economic growth. However, there is no consensus on this issue. Some literature suggests a negative impact, while other studies find no effect at all, and other research [...] Read more.
In sustainable development studies, a key question is how the abundance of natural resources influences long-run economic growth. However, there is no consensus on this issue. Some literature suggests a negative impact, while other studies find no effect at all, and other research indicates a positive impact. This study aims to examine the relationship between natural resource rents, renewable energy, and economic growth in the Gulf Cooperation Council (GCC) countries over the period from 1990 to 2023. The study utilizes the Method of Moments Quantile Regression (MMQR) to provide reliable findings across different quantiles. We also incorporate a series of control variables, including capital, labor force participation, non-renewable energy, and trade openness. The findings indicate that natural resources rent enhances economic growth in GCC countries, supporting the Rostow hypothesis. Although renewable energy has a positive impact on economic growth, it does not have an effect on natural resource rents. Additionally, capital, labor force participation, non-renewable energy, and trade openness play a critical role in raising economic growth in these countries. Based on the empirical results, this study provides several valuable recommendations for policymakers to enhance the management of natural resources in GCC countries. Full article
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26 pages, 2486 KiB  
Review
Sports in Natural Forests: A Systematic Review of Environmental Impact and Compatibility for Readability
by Iulian Bratu, Lucian Dinca, Ionut Schiteanu, George Mocanu, Gabriel Murariu, Mirela Stanciu and Miglena Zhiyanski
Sports 2025, 13(8), 250; https://doi.org/10.3390/sports13080250 - 29 Jul 2025
Viewed by 351
Abstract
The intersection of sports and natural forests and green spaces represents an emerging interdisciplinary field with implications for public health, environmental science, and sustainable land management and refers to the variety of cultural ecosystem services demanded by people from ecosystems. This manuscript presents [...] Read more.
The intersection of sports and natural forests and green spaces represents an emerging interdisciplinary field with implications for public health, environmental science, and sustainable land management and refers to the variety of cultural ecosystem services demanded by people from ecosystems. This manuscript presents a systematic bibliometric and thematic analysis of 148 publications for the period 1993–2024 identified through Web of Science and Scopus, aiming to evaluate the current state of research on sports activities conducted in natural forest environments. Findings indicated a marked increase in scientific interest of this topic over the past two decades, with key contributions from countries such as England, Germany, China, and the United States. Researchers most frequently examined sports such as hiking, trail running, mountain biking, and orienteering for their capacity to provide physiological and psychological benefits, reduce stress, and enhance mental well-being. The literature analysis highlights ecological concerns, particularly those associated with habitat disturbance, biodiversity loss, and conflicts between recreation and conservation. Six principal research themes were identified: sports in urban forests, sports tourism, hunting and fishing, recreational sports, health benefits, and environmental impacts. Keyword and co-authorship analyses revealed a multidisciplinary knowledge base with evolving thematic focuses. In conclusion, the need for integrated approaches that incorporate ecological impact assessment, stakeholder perspectives, and adaptive forest governance to ensure sustainable recreational use of natural forest ecosystems is underlined. Full article
(This article belongs to the Special Issue Fostering Sport for a Healthy Life)
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17 pages, 2126 KiB  
Article
Stable Carbon and Nitrogen Isotope Signatures in Three Pondweed Species—A Case Study of Rivers and Lakes in Northern Poland
by Zofia Wrosz, Krzysztof Banaś, Marek Merdalski and Eugeniusz Pronin
Plants 2025, 14(15), 2261; https://doi.org/10.3390/plants14152261 - 22 Jul 2025
Viewed by 184
Abstract
Aquatic plants, as sedentary lifestyle organisms that accumulate chemical substances from their surroundings, can serve as valuable indicators of long-term anthropogenic pressure. In Poland, water monitoring is limited both spatially and temporally, which hampers a comprehensive assessment of water quality. Since the implementation [...] Read more.
Aquatic plants, as sedentary lifestyle organisms that accumulate chemical substances from their surroundings, can serve as valuable indicators of long-term anthropogenic pressure. In Poland, water monitoring is limited both spatially and temporally, which hampers a comprehensive assessment of water quality. Since the implementation of the Water Framework Directive (WFD), biotic elements, including macrophytes, have played an increasingly important role in water monitoring. Moreover, running waters, due to their dynamic nature, are susceptible to episodic pollution inputs that may be difficult to detect during isolated, point-in-time sampling campaigns. The analysis of stable carbon (δ13C) and nitrogen (δ15N) isotope signatures in macrophytes enables the identification of elemental sources, including potential pollutants. Research conducted between 2008 and 2011 encompassed 38 sites along 15 rivers and 108 sites across 21 lakes in northern Poland. This study focused on the isotope signatures of three pondweed species: Stuckenia pectinata, Potamogeton perfoliatus, and Potamogeton crispus. The results revealed statistically significant differences in the δ13C and δ15N values of plant organic matter between river and lake environments. Higher δ15N values were observed in rivers, whereas higher δ13C values were recorded in lakes. Spearman correlation analysis showed a negative relationship between δ13C and δ15N, as well as correlations between δ15N and the concentrations of Ca2+ and HCO3. A positive correlation was also found between δ13C and dissolved oxygen levels. These findings confirm the utility of δ13C and, in particular, δ15N as indicators of anthropogenic eutrophication, including potentially domestic sewage input and its impact on aquatic ecosystems. Full article
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16 pages, 1856 KiB  
Article
Gas in Transition: An ARDL Analysis of Economic and Fuel Drivers in the European Union
by Olena Pavlova, Kostiantyn Pavlov, Oksana Liashenko, Andrzej Jamróz and Sławomir Kopeć
Energies 2025, 18(14), 3876; https://doi.org/10.3390/en18143876 - 21 Jul 2025
Viewed by 524
Abstract
This study investigates the short- and long-run drivers of natural gas consumption in the European Union using an ARDL bounds testing approach. The analysis incorporates GDP per capita, liquid fuel use, and solid fuel use as explanatory variables. Augmented Dickey–Fuller tests confirm mixed [...] Read more.
This study investigates the short- and long-run drivers of natural gas consumption in the European Union using an ARDL bounds testing approach. The analysis incorporates GDP per capita, liquid fuel use, and solid fuel use as explanatory variables. Augmented Dickey–Fuller tests confirm mixed integration orders, allowing valid ARDL estimation. The results reveal a statistically significant long-run relationship (cointegration) between gas consumption and the energy–economic system. In the short run, the use of liquid fuel exerts a strong positive influence on gas demand, while the effects of GDP materialise only after a two-year lag. Solid fuels show a delayed substitutive impact, reflecting the ongoing transition from coal. An error correction model confirms rapid convergence to equilibrium, with 77% of deviations corrected within one period. Recursive residual and CUSUM tests indicate structural stability over time. These findings highlight the responsiveness of EU gas demand to both economic and policy signals, offering valuable insights for energy modelling and strategic planning under the European Green Deal. Full article
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14 pages, 3176 KiB  
Article
Impact of Data Distribution and Bootstrap Setting on Anomaly Detection Using Isolation Forest in Process Quality Control
by Hyunyul Choi and Kihyo Jung
Entropy 2025, 27(7), 761; https://doi.org/10.3390/e27070761 - 18 Jul 2025
Viewed by 296
Abstract
This study investigates the impact of data distribution and bootstrap resampling on the anomaly detection performance of the Isolation Forest (iForest) algorithm in statistical process control. Although iForest has received attention for its multivariate and ensemble-based nature, its performance under non-normal data distributions [...] Read more.
This study investigates the impact of data distribution and bootstrap resampling on the anomaly detection performance of the Isolation Forest (iForest) algorithm in statistical process control. Although iForest has received attention for its multivariate and ensemble-based nature, its performance under non-normal data distributions and varying bootstrap settings remains underexplored. To address this gap, a comprehensive simulation was performed across 18 scenarios involving log-normal, gamma, and t-distributions with different mean shift levels and bootstrap configurations. The results show that iForest substantially outperforms the conventional Hotelling’s T2 control chart, especially in non-Gaussian settings and under small-to-medium process shifts. Enabling bootstrap resampling led to marginal improvements across classification metrics, including accuracy, precision, recall, F1-score, and average run length (ARL)1. However, a key limitation of iForest was its reduced sensitivity to subtle process changes, such as a 1σ mean shift, highlighting an area for future enhancement. Full article
(This article belongs to the Section Multidisciplinary Applications)
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23 pages, 2494 KiB  
Article
Polyoxometalates Surrounded by Organic Cations or Immobilized on Functionalized Merrifield Resin as Catalysts for Oxidation of β-Myrcene and β-Caryophyllene
by Ali Al Hadi Haidar, Pascal Guillo and Dominique Agustin
Appl. Sci. 2025, 15(14), 7981; https://doi.org/10.3390/app15147981 - 17 Jul 2025
Viewed by 574
Abstract
Polyoxometalates (POMs) surrounded by organic cations and related systems composed of POMs immobilized on functionalized Merrifield resin (MR) were synthesized, characterized and tested as catalysts for the oxidation of two natural terpenes, β-myrcene and β-caryophyllene, using H2O2 and TBHP as [...] Read more.
Polyoxometalates (POMs) surrounded by organic cations and related systems composed of POMs immobilized on functionalized Merrifield resin (MR) were synthesized, characterized and tested as catalysts for the oxidation of two natural terpenes, β-myrcene and β-caryophyllene, using H2O2 and TBHP as green oxidants. The ionic immobilization enabled easy catalyst recovery and reuse. The results showed high conversion and selectivity, with some catalysts maintaining their efficiency for at least three runs without leaching. The catalytic performances of both homogeneous and heterogeneous systems, along with the necessary characterizations, are discussed. Full article
(This article belongs to the Special Issue Advances and Challenges in Biomass and Carbon Materials)
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26 pages, 2715 KiB  
Systematic Review
Hepatitis E Virus (HEV) Infection in the Context of the One Health Approach: A Systematic Review
by Sophie Deli Tene, Abou Abdallah Malick Diouara, Sarbanding Sané and Seynabou Coundoul
Pathogens 2025, 14(7), 704; https://doi.org/10.3390/pathogens14070704 - 16 Jul 2025
Viewed by 414
Abstract
Hepatitis E virus (HEV) is a pathogen that has caused various epidemics and sporadic localized cases. It is considered to be a public health problem worldwide. HEV is a small RNA virus with a significant genetic diversity, a broad host range, and a [...] Read more.
Hepatitis E virus (HEV) is a pathogen that has caused various epidemics and sporadic localized cases. It is considered to be a public health problem worldwide. HEV is a small RNA virus with a significant genetic diversity, a broad host range, and a heterogeneous geographical distribution. HEV is mainly transmitted via the faecal–oral route. However, some animals are considered to be natural or potential reservoirs of HEV, thus elucidating the zoonotic route of transmission via the environment through contact with these animals or consumption of their by-products. Other routes of human-to-human transmission are not negligible. The various human–animal–environment entities, taken under one health approach, show the circulation and involvement of the different species (mainly Paslahepevirus balayani and Rocahepevirus ratti) and genotypes in the spreading of HEV infection. Regarding P. balayani, eight genotypes have been described, of which five genotypes (HEV-1 to 4 and HEV-7) are known to infect humans, while six have been reported to infect animals (HEV-3 to HEV-8). Furthermore, the C1 genotype of the rat HEV strain (HEV-C1) is known to be more frequently involved in human infections than the HEV-C2 genotype, which is known to infect mainly ferrets and minks. Contamination can occur during run-off, flooding, and poor sanitation, resulting in all of these genotypes being disseminated in the environment, contaminating both humans and animals. This systematic review followed the PRISMA guidelines and was registered in PROSPERO 2025 CRD420251071192. This research highlights the importance of investigating the transmission routes and major circulating HEV genotypes in order to adopt a holistic approach for controlling its emergence and preventing future outbreaks. In addition, this article outlines the knowledge of HEV in Africa, underlining the absence of large-scale studies at the environmental, human, and animal levels, which could improve HEV surveillance on the continent. Full article
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27 pages, 3562 KiB  
Article
Automated Test Generation and Marking Using LLMs
by Ioannis Papachristou, Grigoris Dimitroulakos and Costas Vassilakis
Electronics 2025, 14(14), 2835; https://doi.org/10.3390/electronics14142835 - 15 Jul 2025
Cited by 1 | Viewed by 479
Abstract
This paper presents an innovative exam-creation and grading system powered by advanced natural language processing and local large language models. The system automatically generates clear, grammatically accurate questions from both short passages and longer documents across different languages, supports multiple formats and difficulty [...] Read more.
This paper presents an innovative exam-creation and grading system powered by advanced natural language processing and local large language models. The system automatically generates clear, grammatically accurate questions from both short passages and longer documents across different languages, supports multiple formats and difficulty levels, and ensures semantic diversity while minimizing redundancy, thus maximizing the percentage of the material that is covered in the generated exam paper. For grading, it employs a semantic-similarity model to evaluate essays and open-ended responses, awards partial credit, and mitigates bias from phrasing or syntax via named entity recognition. A major advantage of the proposed approach is its ability to run entirely on standard personal computers, without specialized artificial intelligence hardware, promoting privacy and exam security while maintaining low operational and maintenance costs. Moreover, its modular architecture allows the seamless swapping of models with minimal intervention, ensuring adaptability and the easy integration of future improvements. A requirements–compliance evaluation, combined with established performance metrics, was used to review and compare two popular multilingual LLMs and monolingual alternatives, demonstrating the system’s effectiveness and flexibility. The experimental results show that the system achieves a grading accuracy within a 17% normalized error margin compared to that of human experts, with generated questions reaching up to 89.5% semantic similarity to source content. The full exam generation and grading pipeline runs efficiently on consumer-grade hardware, with average inference times under 30 s. Full article
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16 pages, 2607 KiB  
Article
Deep Learning-Based Detection and Assessment of Road Damage Caused by Disaster with Satellite Imagery
by Jungeun Cha, Seunghyeok Lee and Hoe-Kyoung Kim
Appl. Sci. 2025, 15(14), 7669; https://doi.org/10.3390/app15147669 - 8 Jul 2025
Viewed by 544
Abstract
Natural disasters can cause severe damage to critical infrastructure such as road networks, significantly delaying rescue and recovery efforts. Conventional road damage assessments rely heavily on manual inspection, which is labor-intensive, time-consuming, and infeasible in large-scale disaster-affected areas. This study aims to propose [...] Read more.
Natural disasters can cause severe damage to critical infrastructure such as road networks, significantly delaying rescue and recovery efforts. Conventional road damage assessments rely heavily on manual inspection, which is labor-intensive, time-consuming, and infeasible in large-scale disaster-affected areas. This study aims to propose a deep learning-based framework to automatically detect and quantitatively assess road damage using high-resolution pre- and post-disaster satellite imagery. To achieve this, the study systematically compares three distinct change detection approaches: single-timeframe overlay, difference-based segmentation, and Siamese feature fusion. Experimental results, validated over multiple runs, show the difference-based model achieved the highest overall F1-score (0.594 ± 0.025), surpassing the overlay and Siamese models by approximately 127.6% and 27.5%, respectively. However, a key finding of this study is that even this best-performing model is constrained by a low detection recall (0.445 ± 0.051) for the ‘damaged road’ class. This reveals that severe class imbalance is a fundamental hurdle in this domain for which standard training strategies are insufficient. This study establishes a crucial benchmark for the field, highlighting that future research must focus on methods that directly address class imbalance to improve detection recall. Despite its quantified limitations, the proposed framework enables the visualization of damage density maps, supporting emergency response strategies such as prioritizing road restoration and accessibility planning in disaster-stricken areas. Full article
(This article belongs to the Special Issue Remote Sensing Image Processing and Application, 2nd Edition)
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25 pages, 3312 KiB  
Article
In Silico Evaluation of Terpene Interactions with Inflammatory Enzymes: A Blind Docking Study Targeting Arachidonic Acid Metabolism
by Djeni Cherneva, Kaloyan Mihalev, Ivelin Iliev, Nadya Agova, Galina Yaneva, Tsonka Dimitrova and Svetlana Georgieva
Appl. Sci. 2025, 15(13), 7536; https://doi.org/10.3390/app15137536 - 4 Jul 2025
Viewed by 294
Abstract
Terpenes represent a structurally diverse class of natural compounds with increasing scientific interest due to their potential anti-inflammatory properties. This study investigates the in silico binding behavior of six plant-derived terpenes—α-pinene, β-pinene, menthol, camphor, limonene, and linalool—against four key enzymes in the arachidonic [...] Read more.
Terpenes represent a structurally diverse class of natural compounds with increasing scientific interest due to their potential anti-inflammatory properties. This study investigates the in silico binding behavior of six plant-derived terpenes—α-pinene, β-pinene, menthol, camphor, limonene, and linalool—against four key enzymes in the arachidonic acid (AA) metabolic pathway: cyclooxygenase-1 (COX-1), cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), and phospholipase A2 (PLA2). AA serves as a reference for binding energy comparison. Blind rigid-body molecular docking is performed using AutoDock 4.2 and the Lamarckian Genetic Algorithm, with 100 runs per ligand–enzyme pair and the energy-based selection of optimal poses. The analysis includes binding energy (ΔG), inhibition constants (Ki), root-mean-square deviation (RMSD), and residue-level interactions. Several terpenes exhibit favorable binding energies and inhibition constants across the evaluated enzymes. For COX-1 and COX-2, menthol and camphor show low Ki values, indicating stable binding. Menthol and limonene also show the strongest affinities for PLA2, exceeding AA. The focus is on compounds with potential to modulate arachidonic acid metabolism. In this context, β-pinene engages the catalytic site of PLA2, linalool forms multiple contacts within key regions of 5-LOX, and menthol, α-pinene, and β-pinene align with functionally important regions in both COX isoforms. These targeted interactions suggest that the highlighted compounds may selectively interfere with enzymatic activity in inflammation-related pathways. By modulating key steps in AA metabolism, these terpenes may influence the biosynthesis of pro-inflammatory mediators, offering a promising avenue for the development of safer, plant-derived anti-inflammatory agents. The findings lay the groundwork for further experimental validation and the structure-based optimization of terpene-derived modulators. Full article
(This article belongs to the Section Biomedical Engineering)
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24 pages, 2987 KiB  
Article
Optimization of Engine Piston Performance Based on Multi-Method Coupling: Sensitivity Analysis, Response Surface Model, and Application of Genetic Algorithm
by Bin Zheng, Qintao Shui, Zhecheng Luo, Peihao Hu, Yunjin Yang, Jilin Lei and Guofu Yin
Materials 2025, 18(13), 3043; https://doi.org/10.3390/ma18133043 - 26 Jun 2025
Viewed by 388
Abstract
This paper focuses on the use of advanced optimization design strategies to improve the performance and service life of engine pistons, with emphasis on enhancing their stiffness, strength, and dynamic characteristics. As a core component of the engine, the structural design and optimization [...] Read more.
This paper focuses on the use of advanced optimization design strategies to improve the performance and service life of engine pistons, with emphasis on enhancing their stiffness, strength, and dynamic characteristics. As a core component of the engine, the structural design and optimization of the piston are of great significance to its efficiency and reliability. First, a three-dimensional (3D) model of the piston was constructed and imported into ANSYS Workbench for finite element modeling and high-quality meshing. Based on the empirical formula, the actual working environment temperature and heat transfer coefficient of the piston were accurately determined and used as boundary conditions for thermomechanical coupling analysis to accurately simulate the thermal and deformation state under complex working conditions. Dynamic characteristic analysis was used to obtain the displacement–frequency curve, providing key data support for predicting resonance behavior, evaluating structural strength, and optimizing the design. In the optimization stage, five geometric dimensions are selected as design variables. The deformation, mass, temperature, and the first to third natural frequencies are considered as optimization goals. The response surface model is constructed by means of the design of the experiments method, and the fitted model is evaluated in detail. The results show that the models are all significant. The adequacy of the model fitting is verified by the “Residuals vs. Run” plot, and potential data problems are identified. The “Predicted vs. Actual” plot is used to evaluate the fitting accuracy and prediction ability of the model for the experimental data, avoiding over-fitting or under-fitting problems, and guiding the optimization direction. Subsequently, the sensitivity analysis was carried out to reveal the variables that have a significant impact on the objective function, and in-depth analysis was conducted in combination with the response surface. The multi-objective genetic algorithm (MOGA), screening, and response surface methodology (RSM) were, respectively, used to comprehensively optimize the objective function. Through experiments and analysis, the optimal solution of the MOGA algorithm was selected for implementation. After optimization, the piston mass and deformation remained relatively stable, and the working temperature dropped from 312.75 °C to 308.07 °C, which is conducive to extending the component life and improving the thermal efficiency. The first to third natural frequencies increased from 1651.60 Hz to 1671.80 Hz, 1656.70 Hz to 1665.70 Hz, and 1752.90 Hz to 1776.50 Hz, respectively, significantly enhancing the dynamic stability and vibration resistance. This study integrates sensitivity analysis, response surface models, and genetic algorithms to solve multi-objective optimization problems, successfully improving piston performance. Full article
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33 pages, 9434 KiB  
Article
Structure-Based Discovery of Orthosteric Non-Peptide GLP-1R Agonists via Integrated Virtual Screening and Molecular Dynamics
by Mansour S. Alturki, Reem A. Alkhodier, Mohamed S. Gomaa, Dania A. Hussein, Nada Tawfeeq, Abdulaziz H. Al Khzem, Faheem H. Pottoo, Shmoukh A. Albugami, Mohammed F. Aldawsari and Thankhoe A. Rants’o
Int. J. Mol. Sci. 2025, 26(13), 6131; https://doi.org/10.3390/ijms26136131 - 26 Jun 2025
Viewed by 743
Abstract
The development of orally bioavailable non-peptidomimetic glucagon-like peptide-1 receptor agonists (GLP-1RAs) offers a promising therapeutic avenue for the treatment of type 2 diabetes mellitus (T2DM) and obesity. An extensive in silico approach combining structure-based drug design and ligand-based strategies together with pharmacokinetic properties [...] Read more.
The development of orally bioavailable non-peptidomimetic glucagon-like peptide-1 receptor agonists (GLP-1RAs) offers a promising therapeutic avenue for the treatment of type 2 diabetes mellitus (T2DM) and obesity. An extensive in silico approach combining structure-based drug design and ligand-based strategies together with pharmacokinetic properties and drug-likeness predictions is implemented to identify novel non-peptidic GLP-1RAs from the COCONUT and Marine Natural Products (CMNPD) libraries. More than 700,000 compounds were screened by shape-based similarity filtering in combination with precision docking against the orthosteric site of the GLP-1 receptor (PDB ID: 6X1A). The docked candidates were further assessed with the molecular mechanics MM-GBSA tool to check the binding affinities; the final list of candidates was validated by running a 500 ns long MD simulation. Twenty final hits were identified, ten from each database. The hits contained compounds with reported antidiabetic effects but with no evidence of GLP-1 agonist activity, including hits 1, 6, 7, and 10. These findings proposed a novel mechanism for these hits through GLP-1 activity and positioned the other hits as potential promising scaffolds. Among the studied compounds—especially hits 1, 5, and 9—possessed strong and stable interactions with critical amino acid residues such as TRP-203, PHE-381, and GLN-221 at the active site of the 6X1A-substrate along with favorable pharmacokinetic profiles. Moreover, the RMSF and RMSD plots further suggested the possibility of stable interactions. Specifically, hit 9 possessed the best docking score with a ΔG_bind value of −102.78 kcal/mol, surpassing even the control compound in binding affinity. The ADMET profiling also showed desirable drug-likeness and pharmacokinetic characteristics for hit 9. The pipeline of computational integration underscores the potential of non-peptidic alternatives in natural product libraries to pursue GLP-1-mediated metabolic therapy into advanced preclinical validation. Full article
(This article belongs to the Special Issue Small Molecule Drug Design and Research: 3rd Edition)
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21 pages, 3247 KiB  
Article
An Improved YOLOP Lane-Line Detection Utilizing Feature Shift Aggregation for Intelligent Agricultural Machinery
by Cundeng Wang, Xiyuan Chen, Zhiyuan Jiao, Shuang Song and Zhen Ma
Agriculture 2025, 15(13), 1361; https://doi.org/10.3390/agriculture15131361 - 25 Jun 2025
Viewed by 285
Abstract
Agricultural factories utilize advanced facilities and technologies to cultivate crops in a controlled environment, enhancing operational yields and reducing reliance on natural resources. This is crucial for ensuring a stable supply of agricultural products year-round and plays a significant role in the transformation [...] Read more.
Agricultural factories utilize advanced facilities and technologies to cultivate crops in a controlled environment, enhancing operational yields and reducing reliance on natural resources. This is crucial for ensuring a stable supply of agricultural products year-round and plays a significant role in the transformation of agricultural modernization. Automated Guided Vehicles (AGVs) are commonly employed in agricultural factories due to their low ownership costs and high efficiency. However, small embedded devices on AGVs face significant challenges in managing multiple tasks while maintaining the required timeliness. Multi-task learning (MTL) is increasingly employed to enhance the efficiency and performance of detection models in joint detection tasks, such as lane-line detection, pedestrian detection, and obstacle detection. The YOLOP (You Only Look for Panoptic Driving Perception) model demonstrates strong performance in simultaneously addressing these tasks; detecting lane lines in changeable agricultural factory scenarios is yet a challenging task, limiting the subsequent accurate planning and control of AGVs. This paper proposes a feedback-based network for joint detection tasks (MTNet) that simultaneously detects pedestrians, automated guided vehicles (AGVs), and QR codes, while also performing lane-line segmentation. This approach addresses the challenge faced by using embedded devices mounted on AGVs, which are unable to run multiple models for different tasks in parallel due to limited computational resources. For lane-line detection tasks, we also propose an improved YOLOP lane-line detection algorithm based on feature shift aggregation. Homemade datasets were used for training and testing. Comparative experiments of our model with different models in the target-detection and lane-line detection tasks, respectively, show the progressiveness of our model. Surprisingly, we also obtained a significant improvement in the model’s processing speed. Furthermore, we conducted ablation experiments to assess the effectiveness of our improvements in lane-line detection, all of which outperformed the original detection model. Full article
(This article belongs to the Section Agricultural Technology)
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22 pages, 13795 KiB  
Article
The Nucleation and Degradation of Pothole Wetlands by Human-Driven Activities and Climate During the Quaternary in a Semi-Arid Region (Southern Iberian Peninsula)
by A. Jiménez-Bonilla, I. Expósito, F. Gázquez, J. L. Yanes and M. Rodríguez-Rodríguez
Geographies 2025, 5(3), 27; https://doi.org/10.3390/geographies5030027 - 24 Jun 2025
Viewed by 304
Abstract
In this study, we selected a series of pothole wetlands to investigate their nucleation, evolution, and recent anthropogenic degradation in the Alcores Depression (AD), southern Iberian Peninsula, where over 100 closed watersheds containing shallow, ephemeral water bodies up to 2 hm2 have [...] Read more.
In this study, we selected a series of pothole wetlands to investigate their nucleation, evolution, and recent anthropogenic degradation in the Alcores Depression (AD), southern Iberian Peninsula, where over 100 closed watersheds containing shallow, ephemeral water bodies up to 2 hm2 have been identified. We surveyed the regional geological framework, utilized digital elevation models (DEMs), orthophotos, and aerial images since 1956. Moreover, we analyzed precipitation and temperature data in Seville from 1900 to 2024, collected hydrometeorological data since 1990 and modelled the water level evolution from 2002 to 2025 in a representative pothole in the area. Our observations indicate a flooded surface reduction by more than 90% from the 1950s to 2025. Climatic data reveal an increase in annual mean temperatures since 1960 and a sharp decline in annual precipitation since 2000. The AD’s inception due to tectonic isolation during the Quaternary favoured the formation of pothole wetlands in the floodplain. The reduction in the hydroperiod and wetland degradation was primarily due to agricultural expansion since 1950, which followed an increase in groundwater extraction and altered the original topography. Recently, decreased precipitation has exponentially accelerated the degradation and even the complete disappearance of many potholes. This study underscores the fragility of small wetlands in the Mediterranean basin and the critical role of human management in their preservation. Restoring these ecosystems could be a highly effective nature-based solution, especially in semi-arid climates like southern Spain. These prairie potholes are crucial for enhancing groundwater recharge, which is vital for maintaining water availability in regions with limited precipitation. By facilitating rainwater infiltration into the aquifer, recharge potholes increase groundwater levels. Additionally, they capture and store run-off during heavy rainfall, reducing the risk of flooding and soil erosion. Beyond their hydrological functions, these wetlands provide habitats that support biodiversity and promote ecological resilience, reinforcing the need for their protection and recovery. Full article
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