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41 pages, 12580 KB  
Article
Visualization of the Reverse Side of Cathode and Anode Spots in a Welding Arc
by Yulia I. Karlina, Andrey E. Balanovskiy, Georgy E. Kurdyumov, Vitaliy A. Gladkikh, Vladimir Yu. Konyukhov, Tatiana A. Oparina, Roman V. Kononenko and Viktor V. Kondratiev
Appl. Sci. 2026, 16(7), 3385; https://doi.org/10.3390/app16073385 - 31 Mar 2026
Viewed by 318
Abstract
Improving the quality of welded joints, as well as the advancement of equipment and materials, inevitably requires deep theoretical knowledge of the physical phenomena occurring in the arc column and in the cathode and anode regions. Achievements in the field of controlling metal [...] Read more.
Improving the quality of welded joints, as well as the advancement of equipment and materials, inevitably requires deep theoretical knowledge of the physical phenomena occurring in the arc column and in the cathode and anode regions. Achievements in the field of controlling metal transfer at the micro- and nanoscale through the regulation of current and voltage in welding power sources have encountered the problem of the formation of cathode and anode spots, which affect the stability of welding arcs and the quality of the weld. Under short current pulses and pauses, the stability of the arc discharge depends on the ability to form a cathode spot, melt the wire metal, and transfer it through the arc column. In this article, based on the generalization of known experimental facts and studies performed using a high-speed camera, it is shown that the current-carrying channel of the electric arc has a discrete structure consisting of a multitude of thin channels through which the main discharge current flows. The cathode spot of the arc discharge represents a highly heated and brightly luminous region on the cathode surface. Electron emission sustaining the discharge and the removal of cathode material occur from this region. A new method is proposed for investigating the reverse side of the cathode spot, which makes it possible to identify a structure consisting of individual cells or fragments of the cathode spot. For the first time, anode spots recorded with a high-speed camera are presented. An analysis of the spot structure is carried out. The parameters influencing the mobility of cathode and anode spots are determined. Based on the obtained experimental facts, a hypothesis is proposed regarding the non-uniform structure of cathode and anode spots in the arc discharge. Full article
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24 pages, 11322 KB  
Article
Hydrodynamic Influence of Circular Piles with a Surface Patterned with Hexagonal Dimples
by Angelica Lizbeth Álvarez-Mejia, Humberto Salinas-Tapia, Carlos Díaz-Delgado, Juan Manuel Becerril-Lara, Jesús Ramiro Félix-Félix, Boris Miguel López-Rebollar and Juan Antonio García-Aragón
Water 2026, 18(7), 807; https://doi.org/10.3390/w18070807 - 28 Mar 2026
Viewed by 385
Abstract
The interaction between circular piers and turbulent open-channel flow generates complex three-dimensional structures, including horseshoe vortices at the pier base and wake vortices downstream. These structures increase vertical velocities, pressure fluctuations, and shear stresses, contributing to erosion and structural instability. Although these phenomena [...] Read more.
The interaction between circular piers and turbulent open-channel flow generates complex three-dimensional structures, including horseshoe vortices at the pier base and wake vortices downstream. These structures increase vertical velocities, pressure fluctuations, and shear stresses, contributing to erosion and structural instability. Although these phenomena have been widely studied, limited attention has been given to surface geometric modifications as a flow-control strategy. This study employs Large Eddy Simulation (LES) to evaluate the influence of a hexagonal dimple pattern on circular piles in a free-surface channel. The dimples were defined by varying diameter, depth, and spacing to reduce vertical velocity and alter vortex formation. The computational domain represents a 0.40 m wide, 12 m long, and 1.2 m high rectangular channel, with an inlet mass flow of 9.4 kg/s and 0.10 m water depth. Model validation against particle image velocimetry (PIV) data showed 99% correlation, confirming numerical accuracy. Results demonstrate that textured surfaces modify flow dynamics by enhancing kinetic energy dissipation and generating micro-vortices that weaken dominant structures. The optimal configuration (6 mm diameter, 2 mm depth, 1 mm spacing) reduced downward vertical velocity by 42% and wake vortex shedding frequency by 24%, indicating improved hydraulic stability and erosion mitigation potential. Full article
(This article belongs to the Topic Advances in Environmental Hydraulics, 2nd Edition)
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14 pages, 4096 KB  
Article
Biochar-Enhanced Inorganic Gel for Water Plugging in High-Temperature and High-Salinity Fracture-Vuggy Reservoirs
by Shiwei He and Tengfei Wang
Processes 2026, 14(6), 1014; https://doi.org/10.3390/pr14061014 - 21 Mar 2026
Viewed by 353
Abstract
With the expansion of global oil and gas resource exploration and development into deep and ultra deep layers, the efficient development of deep carbonate rock fracture cave reservoirs has become the key to ensuring energy security. However, this type of reservoir commonly faces [...] Read more.
With the expansion of global oil and gas resource exploration and development into deep and ultra deep layers, the efficient development of deep carbonate rock fracture cave reservoirs has become the key to ensuring energy security. However, this type of reservoir commonly faces high temperatures, high salinity, and extremely strong heterogeneity, leading to increasingly severe water content spikes caused by dominant water flow channels. Although the existing traditional inorganic plugging agent has good temperature resistance, it has the defects of great brittleness and easy cracking, while the organic polymer gel is prone to degradation failure under high temperature and high salt environments. In order to solve the above problems, a new biochar-enhanced inorganic composite gel system was constructed by using biochar prepared from agricultural and forestry waste pyrolysis as a functional enhancement component. Through rheological testing, high-temperature and high-pressure mechanical experiments, long-term thermal stability evaluation, and dynamic sealing experiments of fractured rock cores, the reinforcement and toughening laws and rheological control mechanisms of biochar on inorganic matrices were systematically studied. Research has found that a biochar content of 0.5 wt% can significantly improve the micro pore structure of the matrix. By utilizing its micro aggregate filling effect and interfacial chemical bonding, the compressive strength of the solidified body can be increased to over 2 MPa, and there is no significant decline in strength after aging at 130 °C for 30 days. More importantly, the unique “adsorption slow-release” mechanism of biochar effectively stabilizes the hydration reaction kinetics at high temperatures, extending the solidification time of the system to 15 h and solving the problem of flash condensation in deep well pumping. This system exhibits excellent shear thinning characteristics and crack sealing ability, and presents a unique “yield reconstruction” toughness sealing feature. This study elucidates the multidimensional strengthening mechanism of biochar in inorganic cementitious materials, providing technical reference for stable oil and water control in deep fractured reservoirs. Full article
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29 pages, 3082 KB  
Article
Multi-Objective Optimization of Thermal and Mechanical Performance of Prismatic Aluminum Shell Lithium Battery Module with Integrated Biomimetic Liquid Cooling Plate
by Yi Zheng and Xu Zhang
Batteries 2026, 12(3), 106; https://doi.org/10.3390/batteries12030106 - 19 Mar 2026
Viewed by 418
Abstract
Addressing the thermal management challenges of prismatic aluminum shell lithium battery modules in electric vehicles under high-rate charge–discharge conditions, this study proposes a multi-objective optimization design method for integrated biomimetic liquid cooling plates. By integrating various highly efficient heat transfer structures from nature, [...] Read more.
Addressing the thermal management challenges of prismatic aluminum shell lithium battery modules in electric vehicles under high-rate charge–discharge conditions, this study proposes a multi-objective optimization design method for integrated biomimetic liquid cooling plates. By integrating various highly efficient heat transfer structures from nature, including fractal-tree-like networks, leaf vein branching systems, and spider web radial distribution, a novel biomimetic liquid cooling plate topology was constructed. A multi-physics coupled numerical model considering electrochemical heat generation, thermal conduction, convective heat transfer, and thermal stress deformation was established. The NSGA-II algorithm was employed to globally optimize 12 design variables including channel geometric parameters, operating conditions, and structural dimensions, achieving collaborative optimization objectives of maximum temperature minimization, temperature uniformity maximization, pressure drop minimization, and structural lightweighting. The weight coefficients for the four optimization objectives were determined through the Analytic Hierarchy Process (AHP) with verified consistency (CR = 0.02 < 0.10), ensuring rational priority allocation aligned with automotive safety standards. The optimization results demonstrated that compared to the initial design, the optimal solution reduced the maximum temperature under 3C discharge conditions by 9.9% to 34.7 °C, decreased the temperature difference by 31.3% to 3.3 °C, lowered the pressure drop by 24.6% to 2150 Pa, reduced structural mass by 4.0%, and decreased maximum stress by 16.7%. Quantitative comparison with single biomimetic structures under identical boundary conditions showed that the integrated design achieved a 3.3% lower maximum temperature and 25.7% better flow uniformity than the best-performing single structure, demonstrating the synergistic advantages of multi-biomimetic integration. These synergistic performance improvements can be attributed to the hierarchical multi-scale architecture where fractal networks provide macro-scale flow distribution, leaf vein branches ensure meso-scale coverage, and spider web radials achieve micro-scale thermal matching. Long-term cycling tests conducted at 1C/1C rate with 25 ± 1 °C ambient temperature showed that the optimized design maintained a capacity retention rate of 92.3% after 1000 charge–discharge cycles, demonstrating excellent durability. The complex biomimetic channel structure can be fabricated using selective laser melting technology with minimum feature sizes below 0.3 mm, indicating promising manufacturing feasibility. The research findings provide theoretical guidance and technical support for the engineering design of high-performance battery thermal management systems. Full article
(This article belongs to the Section Battery Modelling, Simulation, Management and Application)
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20 pages, 3077 KB  
Article
Research on the Main Causes of Water Channeling in High-Pressure Water Injection of Low-Permeability Reservoirs and the Regulation Strategies of the Seepage Field
by Kai Yang, Hualei Xu, Jianyu Li, Ziqi Chen, Jie Wang and Houshun Jiang
Processes 2026, 14(6), 893; https://doi.org/10.3390/pr14060893 - 11 Mar 2026
Viewed by 271
Abstract
High-pressure water injection (HPWI) can rapidly replenish the formation energy of low-permeability reservoirs, but it may trigger multi-scale fractures, leading to premature water breakthrough between injection and production wells. To identify the main causes and regulate the mainstream line (i.e., the preferential flow [...] Read more.
High-pressure water injection (HPWI) can rapidly replenish the formation energy of low-permeability reservoirs, but it may trigger multi-scale fractures, leading to premature water breakthrough between injection and production wells. To identify the main causes and regulate the mainstream line (i.e., the preferential flow path with the highest streamline density/flow rate), a two-zone and five-point numerical model was developed. This model couples the static damage zone (dominated by micro-fractures) and the fracture development zone (dominated by macro-fractures). Through sensitivity analysis, the ways in which micro-fracture damage and macro-fracture geometry control the evolution of seepage patterns and the risk of water breakthrough were quantified. The results show that in the representative scenarios of this paper, micro-fracture damage is mainly associated with an increased risk of water breakthrough by forming equivalent weakening zones and enhancing the directional extension trend of main fractures. The scale of macro-fractures has the strongest correlation with the water breakthrough response. When the fracture scale increases to a certain proportion close to the well spacing, the seepage mode changes from “fracture + matrix cooperation” to “main-fracture-dominated short-circuit channel”. Based on this, a design and verification of a combined control scheme of “chemical profile control + cyclic water injection” was proposed and carried out in well groups with high water cut and strong channeling. Simulations show that this combination helps to weaken the flow conductivity of preferential channels and improve the uniformity of the flow field. This paper can provide technical support for the prevention, control, and early warning of water breakthrough and the regulation of main flow lines in the high-pressure water injection development of similar low-permeability reservoirs. Full article
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21 pages, 3553 KB  
Article
Synergistic Effects of Biomimetic Structures on Heat Transfer Enhancement and Flow Resistance Reduction
by Kaichen Wang, Yan Shi, Junjie Chen and Yuchi Dai
Biomimetics 2026, 11(3), 198; https://doi.org/10.3390/biomimetics11030198 - 9 Mar 2026
Viewed by 454
Abstract
This study numerically investigated the thermal performance of a rectangular channel incorporating scale-inspired biomimetic protrusion structures with micro-grooves on their surfaces. A three-dimensional numerical model was established and validated against experimental data under identical geometric parameters and boundary conditions, demonstrating good agreement in [...] Read more.
This study numerically investigated the thermal performance of a rectangular channel incorporating scale-inspired biomimetic protrusion structures with micro-grooves on their surfaces. A three-dimensional numerical model was established and validated against experimental data under identical geometric parameters and boundary conditions, demonstrating good agreement in terms of outlet temperature and pressure drop over a wide range of Reynolds numbers. The effects of groove depth on friction factor, Colburn factor, and overall performance evaluation criterion (PEC) were systematically analyzed to elucidate the underlying flow and heat transfer mechanisms. The results indicated that the introduction of biomimetic grooves significantly modified the flow structure and thermal boundary layer development, thereby enhancing fluid mixing and heat transfer. However, excessive groove depth intensified flow separation and pressure loss, leading to performance deterioration. An optimal groove depth of 0.6 mm (approximately 40% of the fin height) was identified, which achieved the best balance between heat transfer enhancement and flow resistance. The findings provide theoretical guidance for the biomimetic surface design of high-efficiency heat exchangers. Full article
(This article belongs to the Section Biomimetics of Materials and Structures)
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28 pages, 1758 KB  
Review
Research Progress on Superhydrophobic Surface Technology for Air-Source Heat Pump Frosting Control: Mechanisms, Fabrication, and Applications
by Bin Liu and Zhiping Yuan
Energies 2026, 19(5), 1185; https://doi.org/10.3390/en19051185 - 27 Feb 2026
Viewed by 334
Abstract
As a key technology for achieving building heating electrification and decarbonization, the air-source heat pump (ASHP) has long been constrained by outdoor heat exchanger frosting in cold and humid regions. Frosting leads to increased thermal resistance, a sharp rise in air-side pressure drop, [...] Read more.
As a key technology for achieving building heating electrification and decarbonization, the air-source heat pump (ASHP) has long been constrained by outdoor heat exchanger frosting in cold and humid regions. Frosting leads to increased thermal resistance, a sharp rise in air-side pressure drop, and the attenuation of heating capacity, while traditional active defrosting methods, such as reverse-cycle defrosting, suffer from high energy consumption and heating interruption. This review aims to systematically present the recent research progress of superhydrophobic surfaces (SHSs) as a highly efficient passive anti-frosting strategy. First, the complex phase-change dynamics of frosting and key influencing factors such as environment and surface characteristics are deeply analyzed. Second, it elucidates how superhydrophobic surfaces achieve delayed frosting and sloughing off defrosting by delaying nucleation, promoting droplet self-removal, and reducing ice adhesion. Furthermore, fabrication processes suitable for complex fin structures are systematically reviewed from the perspectives of subtractive manufacturing, in situ growth, and additive coatings, and their industrialization prospects are compared. Finally, the practical effects of this technology in improving heat transfer coefficients, reducing fan energy consumption, and improving defrosting efficiency are evaluated. Although superhydrophobic technology has significant energy-saving potential, it still faces challenges such as poor long-term durability, wettability failure under extreme conditions, and residual micro-droplets. Future research should focus on the development of highly durable materials, the matching design of micro–nano structures with macro flow channels, and active–passive synergistic anti-frosting strategies. Full article
(This article belongs to the Section J: Thermal Management)
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13 pages, 2804 KB  
Article
Selective Capture and Continuous Recovery of Sulfur-Containing Molecules from Flowing Wastewater Using a Capillary Ag2Mo3O10·1.8H2O/Carbon Fiber Membrane System
by Lei-Yang Xue, Chu-Ya Luo, Han-Mei Xu, Jia-Xin Hua, Xue Zhang, Lian-Wen Zhu and Jun Wu
Membranes 2026, 16(3), 84; https://doi.org/10.3390/membranes16030084 - 26 Feb 2026
Viewed by 504
Abstract
This work presents a novel, membrane-inspired hybrid framework composed of Ag2Mo3O10·1.8H2O nanowires grown in situ on carbon fiber cloth (CFC) for the continuous and selective recovery of high-value sulfur-containing molecules from organic wastewater. The framework [...] Read more.
This work presents a novel, membrane-inspired hybrid framework composed of Ag2Mo3O10·1.8H2O nanowires grown in situ on carbon fiber cloth (CFC) for the continuous and selective recovery of high-value sulfur-containing molecules from organic wastewater. The framework forms an integrated hierarchical porous network rich in micro-/nano-channels, which facilitates efficient, capillary-driven water transport. Owing to its mesoporous texture and specific Ag–S coordination affinity, the material shows exceptional selectivity toward sulfur-containing dyes, enabling rapid adsorption (>94% removal of methylene blue within 10 min) and high specificity in mixed solutions. The hybrid also exhibits excellent reusability, maintaining high recovery efficiency over repeated adsorption–desorption cycles. When configured into a continuous-flow system, the framework operates without external pressure and achieves a water transport rate of 1875 mL·h−1·m−2. These findings underscore the potential of the Ag2Mo3O10·1.8H2O/CFC hybrid as an efficient, scalable, and sustainable platform for resource-oriented wastewater treatment. Full article
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21 pages, 3430 KB  
Article
Comparative Evaluation of Brine Leakage Models in Legacy Wells: Analytical, Transient, and Mechanistic Approaches for CO2 Storage Integrity
by Ahmed Alsubaih, Bruno Fernande, Mojdeh Delshad and Kamy Sepehrnoori
Energies 2026, 19(5), 1154; https://doi.org/10.3390/en19051154 - 26 Feb 2026
Viewed by 285
Abstract
Geologic carbon storage (GCS) is expanding rapidly as a cornerstone decarbonization option, but its climate value depends on maintaining long-term containment of CO2 and displaced formation brine. Legacy wells—many drilled and abandoned before modern barrier standards—remain one of the most credible and [...] Read more.
Geologic carbon storage (GCS) is expanding rapidly as a cornerstone decarbonization option, but its climate value depends on maintaining long-term containment of CO2 and displaced formation brine. Legacy wells—many drilled and abandoned before modern barrier standards—remain one of the most credible and controllable pathways for unintended upward migration. To support transparent, fit-for-purpose risk screening, this study benchmarks three leakage-modeling philosophies across a common six-layer scenario: (i) a reservoir-scale analytical solution for layered aquifers, (ii) a semi-analytical pressure-transient model that captures rock–fluid compressibility and breakthrough time, and (iii) a new mechanistic wellbore-scale model that explicitly represents dominant annular failure pathways (micro-annuli, cement fractures, casing breaches, and cement–formation interface flow) with pathway-specific hydraulic losses. Results show that model choice and physics assumptions drive order-of-magnitude differences in predicted brine rates: after 1000 days, the analytical model predicts ~1.7 bbls/day, the pressure-transient model exceeds 8 bbls/day, whereas the mechanistic model yields damage-dependent outcomes (~0.2–0.4 bbls/day for moderate–severe cement damage and up to ~3.5 bbls/day for open-channel conditions). These findings demonstrate that neglecting wellbore hydraulic resistance can systematically overstate leakage risk, while mechanistic pathway representation enables more realistic, condition-dependent screening. Future work will focus on model calibration to field/monitoring data, probabilistic parameterization of defect geometries, and extension to multiphase/reactive leakage to support operational decision-making and regulatory assurance. Full article
(This article belongs to the Section A: Sustainable Energy)
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17 pages, 2303 KB  
Article
Semi-Analytical Modelling of Evaporating Power-Law Thin Films in Inclined Micro-Channels
by Husain Mustafa Nakara and Nilanjan Chakraborty
Fluids 2026, 11(3), 61; https://doi.org/10.3390/fluids11030061 - 26 Feb 2026
Viewed by 429
Abstract
The evaporation of a thin liquid film representative of power-law rheology flowing along an inclined channel wall under the combined influence of gravity and surface tension is investigated using a semi-analytical modelling framework. The evolution of film thickness, heat transfer characteristics, and dry-out [...] Read more.
The evaporation of a thin liquid film representative of power-law rheology flowing along an inclined channel wall under the combined influence of gravity and surface tension is investigated using a semi-analytical modelling framework. The evolution of film thickness, heat transfer characteristics, and dry-out behaviour are examined as functions of the power-law exponent, Weber number, and inlet film thickness. The results show that a decrease in the power-law exponent leads to a slower reduction in film thickness, resulting in a significant increase in the dry-out length for a fixed value of consistency. This behaviour is attributed to the large effective viscosity developing near the free surface for shear-thinning fluids, in contrast to the negligible surface viscosity observed for shear-thickening fluids. The local Nusselt number increases gradually along the flow direction, followed by a sharp terminal rise marking the onset of dry-out. The mean Nusselt number decreases with increasing power-law exponent, which is consistent with the dry-out length variation with the power-law exponent. The dry-out length is found to be largely insensitive to surface tension for a fixed normalised inlet film thickness, while exhibiting an approximately linear dependence on the inlet film thickness that is nearly independent of the power-law index. Overall, the study establishes a hierarchy of controlling parameters for evaporating power-law films in inclined micro-channels, demonstrating that inlet film thickness primarily governs the dry-out location, while rheology and surface tension exert secondary influences within the parameter ranges considered. Full article
(This article belongs to the Topic Heat and Mass Transfer in Engineering)
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18 pages, 4617 KB  
Article
Numerical and Experimental Investigation of Mixing Enhancement in a Zigzag Passive Micromixer with D-Shaped Obstacles
by Bingyang Yuan, Shuai Yuan and Hao Wang
Micromachines 2026, 17(2), 190; https://doi.org/10.3390/mi17020190 - 30 Jan 2026
Cited by 1 | Viewed by 532
Abstract
Micromixers are crucial for rapid and homogeneous mixing in lab-on-a-chip systems. This study presents a novel passive micromixer that synergistically combines a Zigzag channel with D-shaped obstacles to enhance mixing across a broad Reynolds number (Re) range of 0.1–50. The design leverages flow [...] Read more.
Micromixers are crucial for rapid and homogeneous mixing in lab-on-a-chip systems. This study presents a novel passive micromixer that synergistically combines a Zigzag channel with D-shaped obstacles to enhance mixing across a broad Reynolds number (Re) range of 0.1–50. The design leverages flow splitting, recombination, and the generation of localized high-velocity streams to effectively disrupt laminar flow. A comprehensive parametric study optimized key geometric parameters, including obstacle dimensions (b2, a2) and the number of mixing units (n). Results show that optimizing b2 to 500 μm and increasing a2 to 250 μm significantly enhances mixing efficiency. Mechanistic analysis reveals that centrifugal forces in the Zigzag channel work synergistically with obstacle-induced perturbations to stretch and fold the fluid interface, promoting transverse transport. The optimized mixer, fabricated and experimentally validated, achieves a high mixing index (>0.85) under all Re conditions. This work provides valuable design insights for developing efficient, compact micromixers for micro-total analysis systems. Full article
(This article belongs to the Section C:Chemistry)
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19 pages, 1037 KB  
Review
Cystic Fibrosis of the Pancreas: In Vitro Duct Models for CFTR-Targeted Translational Research
by Alessandra Ludovico, Martina Battistini and Debora Baroni
Int. J. Mol. Sci. 2026, 27(3), 1279; https://doi.org/10.3390/ijms27031279 - 27 Jan 2026
Viewed by 893
Abstract
Cystic fibrosis (CF) is caused by loss-of-function variants in the cystic fibrosis transmembrane conductance regulator (CFTR) chloride and bicarbonate channel and affects multiple organs, with pancreatic involvement showing very high penetrance. In pancreatic ducts, CFTR drives secretion of alkaline, bicarbonate-rich fluid that maintains [...] Read more.
Cystic fibrosis (CF) is caused by loss-of-function variants in the cystic fibrosis transmembrane conductance regulator (CFTR) chloride and bicarbonate channel and affects multiple organs, with pancreatic involvement showing very high penetrance. In pancreatic ducts, CFTR drives secretion of alkaline, bicarbonate-rich fluid that maintains intraductal patency, neutralises gastric acid and permits safe delivery of digestive enzymes. Selective impairment of CFTR-dependent bicarbonate transport, even in the presence of residual chloride conductance, is strongly associated with exocrine pancreatic insufficiency, recurrent pancreatitis and cystic-fibrosis-related diabetes. These clinical manifestations are captured by pharmacodynamic anchors such as faecal elastase-1, steatorrhoea, pancreatitis burden and glycaemic control, providing clinically meaningful benchmarks for CFTR-targeted therapies. In this review, we summarise the principal mechanisms underlying pancreatic pathophysiology and the current approaches to clinical management. We then examine in vitro pancreatic duct models that are used to evaluate small molecules and emerging therapeutics targeting CFTR. These experimental systems include native tissue, primary cultures, organoids, co-cultures and microfluidic devices, each of which has its own advantages and limitations. Intact micro-perfused ducts provide the physiological benchmark for studying luminal pH control and bicarbonate (HCO3) secretion. Primary pancreatic duct epithelial cells (PDECs) and pancreatic ductal organoids (PDO) preserve ductal identity, patient-specific genotype and key regulatory networks. Immortalised ductal cell lines grown on permeable supports enable scalable screening and structure activity analyses. Co-culture models and organ-on-chip devices incorporate inflammatory, stromal and endocrine components together with flow and shear and provide system-level readouts, including duct-islet communication. Across this complementary toolkit, we prioritise bicarbonate-relevant endpoints, including luminal and intracellular pH and direct measures of HCO3 flux, to improve alignment between in vitro pharmacology and clinical pancreatic outcomes. The systematic use of complementary models should facilitate the discovery of next-generation CFTR modulators and adjunctive strategies with the greatest potential to protect both exocrine and endocrine pancreatic function in people with CF. Full article
(This article belongs to the Special Issue Molecular Mechanisms Underlying the Pathogenesis of Genetic Diseases)
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21 pages, 12162 KB  
Article
Thermal Displacement with CO2 for E-CBM Recovery: Mechanisms and Efficacy of Temperature–Pressure Synergy in Permeability Enhancement
by Xiaohu Xu, Tengze Ge, Ersi Gao, Shuguang Li, Kai Wei, Yulong Liu and Ao Wang
Energies 2026, 19(2), 496; https://doi.org/10.3390/en19020496 - 19 Jan 2026
Viewed by 263
Abstract
The efficient development of coalbed methane (CBM) faces persistent challenges due to low recovery rates. While CO2 thermal displacement offers a promising approach, the pore–fracture structure (PFC) evolution and gas displacement mechanisms under temperature–pressure coupling remain insufficiently clear. To address this knowledge [...] Read more.
The efficient development of coalbed methane (CBM) faces persistent challenges due to low recovery rates. While CO2 thermal displacement offers a promising approach, the pore–fracture structure (PFC) evolution and gas displacement mechanisms under temperature–pressure coupling remain insufficiently clear. To address this knowledge gap, the in situ, dynamic quantification of pore–fracture evolution during CO2 displacement was achieved by an integrated system with NMR and CT scanning, revealing the expansion, connection, and reconfiguration of coal PFC under temperature–pressure synergy and establishing the intrinsic relationship between supercritical CO2 (ScCO2)-induced permeability enhancement and methane displacement efficiency. Experimental results identify an observed transition in permeability near 80 °C under the tested conditions as a critical permeability transition point: below this value, permeability declines from 0.61 mD to 0.49 mD, reflecting pore structure adjustment; above it, permeability rises markedly to 1.18 mD, indicating a structural shift toward fracture-dominated flow. A “pressure-dominated, temperature-assisted” mechanism is elucidated, wherein pressure acts as the primary driver in creating macro-fractures and forming percolation pathways, while temperature—mainly via thermal stress—promotes micro-fracture development and assists gas desorption, offering only limited direct contribution to permeability. Although elevated injection pressure enhances permeability and establishes fracture networks, displacement efficiency eventually reaches a physical limit. To transcend this constraint, a synergistic production mechanism is proposed in which pressure builds flow channels while temperature activates microporous desorption. This study provides an integrated, in situ quantification of the pore–fraction evolution under high-temperature ScCO2 conditions. The elucidated synergy between pressure and temperature offers insights and an experimental basis for the design of deep CBM recovery and CO2 storage strategies. Full article
(This article belongs to the Special Issue Advances in Unconventional Reservoirs and Enhanced Oil Recovery)
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21 pages, 7900 KB  
Article
Mechanisms and Multi-Field-Coupled Responses of CO2-Enhanced Coalbed Methane Recovery in the Yanchuannan and Jinzhong Blocks Toward Improved Sustainability and Low-Carbon Reservoir Management
by Hequn Gao, Yuchen Tian, Helong Zhang, Yanzhi Liu, Yinan Cui, Xin Li, Yue Gong, Chao Li and Chuncan He
Sustainability 2026, 18(2), 765; https://doi.org/10.3390/su18020765 - 12 Jan 2026
Viewed by 351
Abstract
Supercritical CO2 modifies deep coal reservoirs through the coupled effects of adsorption-induced deformation and geochemical dissolution. CO2 adsorption causes coal matrix swelling and facilitates micro-fracture propagation, while CO2–water reactions generate weakly acidic fluids that dissolve minerals such as calcite [...] Read more.
Supercritical CO2 modifies deep coal reservoirs through the coupled effects of adsorption-induced deformation and geochemical dissolution. CO2 adsorption causes coal matrix swelling and facilitates micro-fracture propagation, while CO2–water reactions generate weakly acidic fluids that dissolve minerals such as calcite and kaolinite. These synergistic processes remove pore fillings, enlarge flow channels, and generate new dissolution pores, thereby increasing the total pore volume while making the pore–fracture network more heterogeneous and structurally complex. Such reservoir restructuring provides the intrinsic basis for CO2 injectivity and subsequent CH4 displacement. Both adsorption capacity and volumetric strain exhibit Langmuir-type growth characteristics, and permeability evolution follows a three-stage pattern—rapid decline, slow attenuation, and gradual rebound. A negative exponential relationship between permeability and volumetric strain reveals the competing roles of adsorption swelling, mineral dissolution, and stress redistribution. Swelling dominates early permeability reduction at low pressures, whereas fracture reactivation and dissolution progressively alleviate flow blockage at higher pressures, enabling partial permeability recovery. Injection pressure is identified as the key parameter governing CO2 migration, permeability evolution, sweep efficiency, and the CO2-ECBM enhancement effect. Higher pressures accelerate CO2 adsorption, diffusion, and sweep expansion, strengthening competitive adsorption and improving methane recovery and CO2 storage. However, excessively high pressures enlarge the permeability-reduction zone and may induce formation instability, while insufficient pressures restrict the effective sweep volume. An optimal injection-pressure window is therefore essential to balance injectivity, sweep performance, and long-term storage integrity. Importantly, the enhanced methane production and permanent CO2 storage achieved in this study contribute directly to greenhouse gas reduction and improved sustainability of subsurface energy systems. The multi-field coupling insights also support the development of low-carbon, environmentally responsible CO2-ECBM strategies aligned with global sustainable energy and climate-mitigation goals. The integrated experimental–numerical framework provides quantitative insight into the coupled adsorption–deformation–flow–geochemistry processes in deep coal seams. These findings form a scientific basis for designing safe and efficient CO2-ECBM injection strategies and support future demonstration projects in heterogeneous deep coal reservoirs. Full article
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25 pages, 1399 KB  
Article
Coupled Mechanisms of Shale Oil Occurrence and Spontaneous Imbibition in the Chang 7 Member: Pore Structure Response and Evolution
by Tao Fan, Yufeng Zhou, Dongpo Shi, Yu Zhang, Shuobin Xiong and Hujun Gong
Processes 2026, 14(1), 46; https://doi.org/10.3390/pr14010046 - 22 Dec 2025
Viewed by 405
Abstract
Lacustrine shale oil in the Chang 7 Member of the Ordos Basin is controlled by a multi-scale pore–throat system in which oil occurrence, spontaneous imbibition, and pore-structure evolution are tightly coupled. In this study, nitrogen adsorption and micro-computed tomography (μCT) were employed to [...] Read more.
Lacustrine shale oil in the Chang 7 Member of the Ordos Basin is controlled by a multi-scale pore–throat system in which oil occurrence, spontaneous imbibition, and pore-structure evolution are tightly coupled. In this study, nitrogen adsorption and micro-computed tomography (μCT) were employed to characterize pore-size distribution and connectivity, whereas nuclear magnetic resonance (NMR) T2 relaxation was utilized to classify oil occurrence states, and X-ray diffraction (XRD) and total organic carbon (TOC) analyses were performed to determine mineralogical and organic compositions. Spontaneous imbibition experiments were conducted at 60 °C and subsequently extended to temperature–pressure sequence tests. The Chang 7 shale exhibits a stratified pore system in which micropores, mesopores, and macropores jointly define a three-tier “micropore adsorption–mesopore confinement–macropore mobility” pattern. As pore size and connectivity increase, the equilibrium imbibed mass and initial imbibition rate both rise, while enhanced wettability (contact angle decreasing from 81.2° to 58.7°) further strengthens capillary uptake. Temperature elevation promotes imbibition, whereas increasing confining pressure suppresses it, revealing a “thermal enhancement–pressure suppression” behavior. μCT-based network analysis shows that imbibition activates previously ineffective pore–throat elements, increasing coordination number and connectivity and reducing tortuosity, which collectively represents a capillary-driven structural reconfiguration of the pore network. When connectivity exceeds a threshold of about 0.70, the flow regime shifts from interface-dominated to channel-dominated. Building on these observations, a multi-scalecoupling framework and a three-stage synergistic mechanism of “pore-throat activation–energy conversion–structural reconstruction” are established. These results provide a quantitative basis for predicting imbibition efficiency and optimizing capillary-driven development strategies in deep shale oil reservoirs. Full article
(This article belongs to the Topic Petroleum and Gas Engineering, 2nd edition)
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