Search Results (8,178)

Accurately characterizing the kinematics of slow-moving urban landslides remains a major scientific and operational challenge, because no single monitoring technique can simultaneously provide spatially continuous deformation patterns and reliable three-dimensional displacement measurements. This study investigates the spatial and temporal evolution of a slow-moving landslide affecting the University of Azuay campus in Cuenca (Ecuador), where ongoing ground deformation has caused structural damage to several buildings. An integrated monitoring strategy combining GNSS measurements, Sentinel-1 multi-temporal DInSAR analysis, and geophysical investigations (ERT and seismic profiling) was adopted to characterize landslide kinematics and constrain subsurface conditions. GNSS observations revealed that the north–south displacement component was dominant, with cumulative displacements exceeding 20 cm during the monitoring period (from July 2021 to June 2024), while east–west displacements were on the order of 10 cm. MT-DInSAR analysis delineated the spatial extent of the unstable area and identified mean deformation rates of up to approximately −1.5 cm/year in the central sector of the landslide. The combined interpretation of geodetic and geophysical data indicates that slope instability is controlled by saturated fine-grained layers and mechanical contrasts, with the basal sliding zone associated with weak levels of the Mangan Formation. Overall, the results demonstrate the value of a multi-sensor, component-wise monitoring strategy for improving the reliability of deformation estimates and for supporting landslide risk assessment and land-use planning in complex urban environments. Full article

Dynamic stretching (DS) comprises repetitive movements throughout the joint range of motion, and DS speed is known to affect athletic performance. However, it is unclear how DS speed affects musculotendinous stiffness (MTS). This study aimed to compare the DS effects at three different speeds on the maximum ankle dorsiflexion angle, maximum passive torque, and MTS. Based on sample size calculation (f = 0.25, α = 0.05, power = 0.80), 12 participants were needed, and 12 healthy university male athletes enrolled. DS to ankle plantar flexors was performed under the following conditions: low-speed (30 reps/min), moderate-speed (60 reps/min), high-speed (120 reps/min), and control (no DS). DS was performed for 15 reps × four sets with a 30 s rest. To assess musculotendinous extensibility, the maximum ankle dorsiflexion angle, maximum passive torque, and MTS were measured before and after DS. The maximum ankle dorsiflexion angle significantly increased after all DS (p = 0.001–0.006, d_z = 0.98–1.38) and was significantly larger in the high-speed DS than in the control condition (p = 0.039). MTS significantly increased after high-speed DS (p = 0.038, d = 0.68) but significantly decreased after moderate-speed DS (p = 0.025, d_z = −0.75) compared to baseline values. Maximal passive torque significantly increased after low-, moderate-, and high-speed DS (p < 0.001 to p = 0.011, d_z = 0.89–1.89) and was significantly higher after high-speed DS than after control (p = 0.004, d = 0.58). These results indicate that DS increases the ankle dorsiflexion angle regardless of speed and is effective in decreasing MTS at moderate speed. Full article

Static magnetic fields (SMFs) are underexplored as biophysical tools for transplant immunomodulation. This study investigated a 300 mT SMF as a non-pharmacological adjuvant to enhance graft survival in parathyroid xenotransplantation. Human parathyroid tissues were transplanted into Sprague-Dawley rats (n = 20) across four groups: control (G1), SMF-only (G2), transplantation-only (G3), and SMF-assisted transplantation (G4). Following 30-day continuous SMF exposure, functional and immunological assessments were performed. G4 achieved the highest systemic PTH recovery (p = 0.009) without altering intrinsic secretory capacity. Systemic cytokine profiling revealed significant IFN-gamma suppression in G4 (p = 0.0024), suggesting downregulation of Th1-mediated rejection pathways. While G2 showed pro-inflammatory increases (TNF-alpha, GM-CSF), G4 maintained baseline levels, confirming biocompatibility. IHC confirmed that SMF exposure sequestered lymphocytes to the graft periphery, preventing the diffuse infiltration observed in G3. In conclusion, continuous SMF exposure modulates the immune microenvironment by altering lymphocyte migration and IFN-gamma signaling. This biophysical strategy provides localized immunoprotection, potentially offering a drug-free alternative to systemic immunosuppression in endocrine tissue transplantation. Full article

Melatonin, a well-known antioxidant, has been widely used in sperm cryopreservation of various animals, but its regulatory mechanism in fish remains unclear. This first study on teleosts suggests a potential molecular mechanism by which melatonin may improve post-thaw sperm quality of Epinephelus fuscoguttatus via targeting mitochondrial function. Compared with the melatonin group, the MT1 receptor-inhibited group showed slightly higher sperm motility (77.09 ± 3.41% vs. 76.50 ± 1.10%), significantly inhibited mitochondrial permeability transition pore (mPTP) opening (12.64 ± 1.05% vs. 18.29 ± 1.38%), and maintained higher mitochondrial membrane potential (MMP; 85.86 ± 0.18% vs. 81.81 ± 0.69%), with both groups performing better than the control. In contrast, the MT2-inhibited and MT1/2 dual-inhibited groups exhibited reduced sperm quality compared with the MT group, suggesting that MT2 may serve as the core receptor for melatonin to regulate mitochondrial homeostasis in teleosts. Mechanistically, melatonin-activated MT2 potentially inhibits mPTP opening via the PI3K/Akt/GSK-3β pathway, and this protective effect was abrogated by the PI3K and GSK-3β inhibitors. This receptor-mediated process synergized with melatonin’s direct antioxidant effect, as ROS levels in all melatonin-treated groups were significantly lower than the control. This study is the first to find pharmacological evidence for the melatonin–MT2/PI3K/GSK-3β axis in maintaining teleost sperm mitochondrial function; it also reveals potential mechanistic differences between teleosts and mammals and fills a critical knowledge gap regarding this signaling cascade in teleost reproductive biology. Full article

Archaeological evidence for prehistoric placer tin mining is rare due to the ephemeral nature of the workings and the associated tools in the dynamic setting of active river systems. Here, we report an additional line of evidence for metallurgical activities at stream tin mining in Serbia at Mt. Cer and Bukulja. Rivers at these locations contain Pb-rich-glass grains, many of which are also enriched in Cu and Sn. Compositionally, the detrital grains of glass are similar to the vitreous infillings on a bleached ceramic sherd found at Spasovine, an archaeological site situated on the bank of the tin-rich Milinska River. The high-Pb-bearing (average 42 wt%) and Sn-bearing (average 0.7 wt%) composition of the glass, along with the inclusions of secondary cassiterite, indicate that the slag was derived from the refinement of leaded bronze (i.e., lead removal). Although the detrital glass slag grains lack direct archaeological context, broader archaeological observations limit their production to either the Roman or Medieval Periods. The presence of Pb-Cu-Sn metallurgical glass grains in a river at Bukulja provides the first concrete evidence of prehistoric tin mining at this locality, which demonstrates that sluicing for crushed glassy residues is a viable means to prospect for as yet undiscovered sites of ancient metallurgical activities. Full article

The Xinqiao Cu-S polymetallic deposit is located in the Tongling ore concentration area of the Middle-Lower Yangtze River metallogenic belt. The orebodies consist of skarn orebodies and stratiform sulfide orebodies, but the genetic link between them remains controversial. In this study, magnetite was used as a proxy to systematically constrain the hydrothermal evolution from the intrusion to the contact zone and further to the stratiform orebodies. A representative drill hole (E603) was logged, and samples were systematically collected from the Jitou pluton outward to the contact zone. Composite samples from the 8–28 m interval were crushed and prepared as resin mounts for integrated TIMA automated mineralogy, BSE textural observation, and in situ LA-ICP-MS trace element analysis. Five types of magnetite (Mt1 to Mt5) were systematically identified. Mt1 occurs as inclusions within feldspar in the quartz monzodiorite. It exhibits typical magmatic magnetite characteristics and contains grid-like ilmenite exsolution, indicating crystallization during the late magmatic stage. Mt2 is distributed in the interstices of magmatic minerals, commonly showing hematitization and replacement of ilmenite exsolution lamellae by titanite. Its trace element geochemistry displays magmatic–hydrothermal transitional features. Mt3–Mt5 in the skarn and stratiform orebodies are paragenetic with retrograde alteration minerals (e.g., epidote, chlorite, and actinolite) and sulfides, and are characterized by low Ti, Al, and V contents and high Mg, Mn, and Sn contents, indicating a hydrothermal origin. From Mt3 to Mt5, (Ti + V) and (Al + Mn) decrease, while Zn and Mn increase, accompanied by a decrease in the (Si + Al)/(Mg + Mn) ratio. This reflects a trend of decreasing fluid temperature and progressively enhanced wall-rock buffering. The Mg-in-magnetite geothermometer yields relatively consistent results for Mt1–Mt3, but anomalously high temperatures for Mt4–Mt5. This suggests that the elevated Mg activity in the fluid, caused by reaction with carbonate wall rocks, can significantly influence the calculated temperatures. Therefore, this geothermometer should be used cautiously for magnetite in the outer skarn zone and interpreted in combination with other temperature constraints. The textures, paragenetic mineral assemblages, and trace element characteristics of magnetite collectively reveal a continuous mineralization process linking the skarn and stratiform orebodies at Xinqiao, providing robust mineralogical and geochemical evidence for the contribution of Yanshanian magmatic–hydrothermal activity to the stratiform mineralization. Full article

Northeast China, situated in the eastern Central Asian Orogenic Belt (CAOB), marks the terminal closure zone of the Paleo-Asian Ocean (PAO) (eastern segment). At present, due to extensive Quaternary cover, the structural deformation characteristics and deep structure of the Solonker Suture Zone in the east of the Nenjiang–Balihan fault remain poorly constrained, which limits our understanding of the tectonic evolution of the PAO. This study integrates deep seismic reflection (DSR) and magnetotelluric (MT) sounding profiles to investigate the crustal structural, sedimentary framework, and tectonic evolution of the oceanic and continental crusts along the western slope of the Songliao Basin. Two regional detachment surfaces (D1 and D2) were identified. The D2 interface demarcates the upper crust’s basal boundary, overlain by multiple high-amplitude monoclinic reflections. The area below the D2 interface exhibits a network structure of arcuate and variably oriented reflections, indicating a dual-layered orogenic structure. The upper crust exhibits distinct structural domains defined by strongly contrasting monoclinal reflections: north-dipping, low-resistivity zones in the southern sector and south-dipping, high-resistivity zones in the northern sector. These oppositely oriented reflections have been interpreted as marking an Early Paleozoic accretionary wedge and oceanic island arc, respectively. Interposed between these opposing structural domains, the Paleozoic to Early Mesozoic forearc basin sequences are preserved, with a pre-Middle Permian oceanic basin identified north of the study area. By integrating characteristics of seismic reflection sequences with regional geological data, this paper clarifies the processes of closure and collision at the northern margin of the PAO (Eastern Segment). Full article

Mountain Social–Ecological Systems (MtSES) are global assets, providing essential ecosystem services to nearly half of humanity, yet they are disproportionately vulnerable to global change, experiencing “polytraps” of depopulation, poverty, and environmental degradation. Despite the inherent human dimension in sustainability, the social pillar remains conceptually chaotic, forming a highly fragmented “publication labyrinth”, and is often neglected in favor of more easily quantifiable environmental and economic metrics. These oversights leave mountain communities in a precarious state, underscoring an urgent need for robust, context-specific assessment tools. This paper addresses this critical gap by employing a two-step methodology: first, a literature review identifies prevailing social sustainability issues in mountain contexts; second, a comparative analysis evaluates prominent frameworks and indicator-based tools against these themes, using Ostrom’s multi-tier Social–Ecological Systems (SES) framework as the theoretical lens. Our findings reveal a persistent environmental bias in MtSES research and highlight the necessity for frameworks that integrate local knowledge, address power imbalances, and support bottom-up governance. A tool is proposed with indicators specifically for mountainous contexts. This study contributes to theory by offering a structured approach to unpack the elusive “social” in SES and to practice by providing a model and tool for developing actionable, context-sensitive social sustainability assessments, thereby fostering resilience and equitable development in vulnerable mountain regions. Ultimately, by operationalizing these social dimensions, this research provides a direct roadmap for achieving key United Nations Sustainable Development Goals in marginalized high-altitude contexts, particularly focusing on No Poverty (SDG 1), Good Health and Well-being (SDG 3), Reduced Inequalities (SDG 10), Sustainable Communities (SDG 11), and Peace, Justice, and Strong Institutions (SDG 16). Full article

Background: The aminosteroid RM-581 exhibits strong antiproliferative activity against cell lines from more than 10 solid tumor cancers, including some with poor prognoses. However, RM-581’s impact has never been assessed on leukemia. Methods: Cellular responses to RM-581 were evaluated using complementary approaches. Cytotoxicity was quantified using MTS-based viability assays and drug interactions were analyzed according to the Chou-Talalay method. Flow cytometry was employed to assess apoptosis, cell cycle distribution and effects on lymphocytes subpopulations. The transcriptomic profile was investigated by mRNA sequencing to identify differentially expressed genes and associated pathways. Results: Its evaluation on six leukemia cell lines (HL-60, THP-1, JURKAT, K-562, HG-3 and JVM-2) showed that RM-581 efficiently blocked the proliferation of leukemia cells. In healthy peripheral blood lymphocytes, flow cytometry revealed a significant impact on T lymphocytes (CD3+), particularly cytotoxic T cells (CD8+), at 50 µM. In THP-1 cells, an acute monocytic leukemia cell line, RM-581 triggered apoptosis and induced G0/G1 cell cycle arrest, which was confirmed with a transcriptomic analysis of enriched pathways. The role of RM-581 as an endoplasmic reticulum (ER) stress aggravator was confirmed by observing an increase in ER stress markers, such as BIP (GRP-78), CHOP and HERP, and in unfolded protein response (UPR) effectors (PERK, IRE1α and ATF6). Conclusions: This study demonstrates that RM-581 could be a promising candidate to treat leukemia, notably through the induction of ER-stress mediated apoptosis. Full article

Background: The aim of this study was to derive and internally validate a prescriptive clinical prediction rule (CPR) for identifying baseline factors associated with short-term clinical improvement in patients with neck pain (NP) undergoing a manual therapy (MT)-based physiotherapy program. Methods: A prospective cohort study was conducted, including 71 patients with NP (18–65 years). Participants received six MT-based sessions over three weeks. Baseline assessments included Pain Intensity Numeric Rating Scale (PI-NRS), Neck Disability Index (NDI), Body Mass (BM), Body Mass Index (BMI), International Physical Activity Questionnaire-Short Form (IPAQ-SF), Hospital Anxiety and Depression Scale (HADS), Minnesota Satisfaction Questionnaire-Short Form (MSQ), and Craniovertebral Angle (CVA). Clinical improvement was defined using the Global Perceived Effect Scale (GPES-7). Univariate analyses, receiver operating characteristic (ROC) curve analysis, and forward stepwise logistic regression were performed to derive the predictive model. Results: Fifty-six participants (78.9%) reported moderate to complete improvement. BM ≥ 76.5 kg and MSQ score ≤ 42.5 were retained in the final regression model. When both predictors were present, the probability of clinical improvement increased to 96.43% (positive likelihood ratio = 7.58). The model demonstrated adequate fit (Nagelkerke R² = 0.247; Hosmer–Lemeshow p = 0.804). Internal validation yielded an optimism-corrected AUC of 0.741, suggesting minimal overfitting. Conclusions: Higher BM and lower MSQ score were associated with greater short-term improvement following MT in patients with NP. These findings highlight the relevance of integrating physical and psychosocial factors in prescriptive rehabilitation approaches. External validation of this CPR is required before clinical implementation. Full article

Porphyromonas gingivalis (P. gingivalis), a keystone pathogen in periodontitis, has been increasingly implicated in compromising hepatic health and exacerbating the pathogenesis of liver diseases, including metabolic dysfunction-associated steatotic liver disease (MASLD), chronic hepatitis, and cirrhosis. Current studies have identified three well-established pathways through which periodontitis contributes to chronic liver disease progression: systemic inflammatory responses, liver cells dysfunction, and gut microbiota dysbiosis. This review systematically elucidates the associations between periodontitis and chronic liver disorders, consolidates evidence on the canonical molecular mechanisms involved, and further proposes potential yet understudied pathways such as ferroptosis, immune evasion, and endothelial–mesenchymal transition (EndMT). By integrating these insights, this work aims to provide novel perspectives for mitigating the systemic adverse effects of periodontitis while offering a theoretical foundation for future research and clinical therapeutic strategies. Full article

Hydrophobicity has limited the efficiency of many drugs. To improve this, gold–silver alloy nanocomposites covered with carbon-based quantum dots were synthesized as a platform to reduce the drugs’ hydrophobicity. Using the hydrophobic drug Andrographolide as a model, it was demonstrated that these nanocomposites can decrease Andrographolide’s hydrophobicity (Log P from 2.632 to 0.56) without encapsulating the drug. Entry within prostate cancer (PC-3) cells and in vitro localization of the nanocomposites and Andrographolide was observed qualitatively via confocal microscopy and their identity confirmed by SERS inside the PC-3 cells. MTS assays demonstrated the carbon-based quantum dot layer covering the metal core of the nanocomposites stabilizes the oxidation rate of the nanocomposite’s core metals. This was observed by a decrease in cytotoxicity in PC-3 cells when compared to other gold or silver nanosystems for similar timeframes published in the literature. Full article

Magnetotelluric (MT) inversion models are widely used to interpret crustal conductivity structures related to fluid pathways, deformation zones, and mineralization processes; however, evaluating the reliability of inversion-derived anomalies remains challenging when datasets contain subtle station-dependent distortions or residual cultural noise. We present a jackknife-inspired, model-space diagnostic framework based on leave-one-station-out (LOSO) inversion to quantify station influence and improve interpretation reliability. The workflow consists of (1) generating a LOSO inversion ensemble using identical inversion settings, (2) computing ensemble statistics and standardized perturbation metrics to identify sensitive zones, and (3) applying distribution-based diagnostics to classify station influence and guide construction of an ensemble-refined model. Synthetic experiments demonstrate that the framework distinguishes localized station-controlled artifacts from broadly supported structural responses, allowing targeted correction without altering robust features. Application to a field MT dataset acquired in a noise-affected environment shows that a mid-crustal conductive structure remains stable across the LOSO ensemble, while some shallow anomalies exhibit strong station dependence. The resulting ensemble-refined model introduces only localized modifications, demonstrating that ensemble-based model-space diagnostics provide a practical and reproducible strategy for validating MT inversion results and improving confidence in exploration-oriented conductivity interpretations. Full article

The comprehension of the complex dynamics of degassing is critical for volcano monitoring and assessing volcanic hazards. In this study, we apply visibility graph analysis (VGA) to a decadal, high-resolution time series of daily soil CO₂ flux recorded by a standardized monitoring network at Mt. Etna volcano (Italy). By mapping these time series into complex networks, we demonstrate that the connectivity degree distributions follow a power law described by the exponent $\gamma$, which reveals a self-similar behavior of gas emissions. We introduce the $\gamma$-deviation, namely the variation of the scaling exponent from its long-term site-specific baseline, as a novel proxy for degassing efficiency. The long-term baseline is interpreted as a site-specific measure of flux efficiency, while its variations are attributed to other factors, such as fluctuations in the sources or changes in the efficiency of fluids transport pathways. Our results identify a transition from a period of discordance across the monitoring sites (pre-2016) to a phase of network-wide concordance (after 2016). The striking correlation between topological $\gamma$-deviations and the established normalized network signal (${\Phi }_{norm}$) validates the methodology, suggesting that VGA is able to capture the same underlying magmatic drivers. This study establishes VGA as a robust and reliable tool for medium- and long-term monitoring, potentially capable of identifying the occurrence of large-scale magmatic processes and refining the characterization of fluid transport dynamics in active volcanic systems. Full article

Identifying suitable habitats for ecosystem restoration is critical for conserving globally threatened biodiversity. Baseline data on the distribution and range of biogenic habitat-forming species at high spatial resolution are essential for informing habitat management strategies and preserving ecosystem integrity. We identified suitable sites for habitat restoration by integrating community ecological data for Quercus mongolica Fisch. ex Turcz., a valuable restoration tree species, with insights from ensemble modeling. Habitat suitability was predicted using an ensemble species distribution model. A total of 89 occurrence records and nine environmental variables were used to develop the single algorithm models. Model performance was assessed using the Receiver Operating Characteristic (ROC) curve and the True Skill Statistic (TSS). Future habitat suitability was evaluated using projected climate change scenarios. Under more extreme climate change scenarios, the future suitable habitat of Q. mongolica is projected to gradually contract toward the high-altitude areas of Mt. Gariwang. The primary environmental variable is elevation, and rising temperatures due to climate change negatively impact habitat suitability for Q. mongolica. Therefore, adaptation measures must be established to mitigate these impacts, such as protecting the reference ecosystems of Q. mongolica. This integrated approach offers a nature-based solution for guiding climate change-integrated restoration programs in Mt. Gariwang and globally. Full article