Search Results (23,158)

Several chronic inflammatory processes are currently being studied in relation to other systems to better understand the regulation mechanisms and identify potential therapeutic targets. A significant body of evidence supports the role of the nervous system in regulating various immunological processes. This study investigates the relationship between pterygia and the sympathetic nervous system, focusing on their interaction in the inflammatory response and fibrogenic process. Sixteen surgical specimens of primary pterygia and four conjunctival tissue samples were examined, and their morphology was analyzed using hematoxylin–eosin and Masson’s trichrome stains. The gene expression of adrenergic receptors, as well as inflammatory and fibrogenic cytokines, was also assessed. Additionally, both adrenergic receptors and tyrosine hydroxylase were found to be localized within the tissues according to immunohistochemistry and immunofluorescence techniques. Increased expression of proinflammatory, fibrogenic, and adrenergic genes was observed in the pterygium compared to the healthy conjunctiva. Adrenergic receptors and tyrosine hydroxylase were localized in the basal region of the epithelium and within blood vessels, closely associated with immune cells. Neuroimmunomodulation plays a key role in the pathogenesis of pterygia by activating the sympathetic nervous system. At the intravascular level, norepinephrine promotes the migration of immune cells, thereby sustaining inflammation. Additionally, sympathetic nerve fibers located at the subepithelial level contribute to epithelial growth and the fibrosis associated with pterygia. Full article

With the rapid proliferation of Internet of Things (IoT) devices and mobile applications and the growing demand for low-latency services, edge computing has emerged as a transformative paradigm that brings computation and storage closer to end users. However, the dynamic nature and limited resources of edge networks bring challenges such as load imbalance and high latency while satisfying user requests. Service migration, the dynamic redeployment of service instances across distributed edge nodes, has become a key enabler for solving these challenges and optimizing edge network characteristics. Moreover, the low-latency nature of edge computing requires that service migration strategies must be in real time in order to ensure latency requirements. Thus, this paper presents a systematic survey of real-time service migration in edge networks. Specifically, we first introduce four network architectures and four basic models for real-time service migration. We then summarize four research motivations for real-time service migration and the real-time guarantee introduced during the implementation of migration strategies. To support these motivations, we present key techniques for solving the task of real-time service migration and how these algorithms and models facilitate the real-time performance of migration. We also explore latency-sensitive application scenarios, such as smart cities, smart homes, and smart manufacturing, where real-time service migration plays a critical role in sustaining performance and adaptability under dynamic conditions. Finally, we summarize the key challenges and outline promising future research directions for real-time service migration. This survey aims to provide a structured and in-depth theoretical foundation to guide future research on real-time service migration in edge networks. Full article

Background: The role of collagen membrane fixation during guided bone regeneration (GBR) remains debatable, particularly in post-extraction sockets with buccal defects and concomitant immediate implant placement. This study evaluated whether or not fixation with titanium pins improved regenerative outcomes. Methods: Six adult Beagle dogs received bilateral extractions of the fourth mandibular premolars. An implant was immediately placed in both the distal alveoli, and standardized buccal bone defects (5 mm height, 3–2 mm width) were prepared. All defects were filled with a slowly resorbing equine xenograft and covered by a resorbable pericardium membrane. At the test sites, the membrane was apically fixed with pins, while no fixation was applied to the control sites. After 3 months of healing, histomorphometric analyses were performed. Results: The vertical bone gain of the buccal crest was 3.2 mm in the test sites (pin group) and 2.9 mm in the control sites (no-pin) (p > 0.754). No significant difference was found in terms of bone-to-implant contact (BIC). However, residual graft particles were located significantly more coronally in the pin group compared to the no-pin group (p = 0.021). Morphometric analyses revealed similar new bone formation within the groups, but with higher amounts of residual xenograft and soft tissue in the pin group. Conclusions: Membrane fixation did not significantly enhance vertical bone gain, and although the slightly higher regeneration in the pin group (3.2 mm vs. 2.9 mm) may hold clinical relevance in esthetically sensitive areas and osseointegration, it appeared to limit coronal migration of the grafting material. Full article

Burn injuries are complex and require effective wound management strategies. Traditional treatments, such as dermal templates, are limited by simplified extracellular matrix (ECM) composition (e.g., collagen-elastin or collagen-glycosaminoglycan), sheet-based formats, and frequent use of animal-derived materials. These limitations can reduce wound conformity, biocompatibility, and integration with host tissue. Functional hydrogels are being explored as alternatives due to properties such as high water content, biodegradability, adhesiveness, antimicrobial activity, and support for angiogenesis. Unlike standard templates, hydrogels can adapt to irregular wound shapes as in burn wounds and reach deeper tissue layers, supporting moisture retention, cell migration, and controlled drug delivery. These features may improve the wound environment and support healing in burns of varying severity. This review outlines recent developments in functional hydrogel technologies and compares them to current clinical treatments for burn care. Emphasis is placed on the structural and biological features that influence performance, including material composition, bioactivity, and integration capacity. Through an exploration of key mechanisms of action and clinical applications, this review highlights the benefits and challenges associated with hydrogel technology, providing insights into its future role in burn care. Full article

This study systematically investigates the homogenization-induced Laves phase dissolution kinetics and recrystallization mechanisms in laser powder bed fusion (L-PBF) processed IN718 superalloy. The as-built material exhibits a characteristic fine dendritic microstructure with interdendritic Laves phase segregation and high dislocation density, featuring directional sub-grain boundaries aligned with the build direction. Laves phase dissolution demonstrates dual-stage kinetics: initial rapid dissolution (0–15 min) governed by bulk atomic diffusion, followed by interface reaction-controlled deceleration (15–60 min) after 1 h at 1150 °C. Complete dissolution of the Laves phase is achieved after 3.7 h at 1150 °C. Recrystallization initiates preferentially at serrated grain boundaries through boundary bulging mechanisms, driven by localized orientation gradients and stored energy differentials. Grain growth kinetics obey a fourth-power time dependence, confirming Ostwald ripening-controlled boundary migration via grain boundary diffusion. Such a study is expected to be helpful in understanding the microstructural development of L-PBF-built IN718 under heat treatments. Full article

The accurate identification of seismic faults, which serve as crucial fluid migration pathways in hydrocarbon reservoirs, is of paramount importance for reservoir characterization. Traditional interpretation is inefficient. It also struggles with complex geometries, failing to meet the current exploration demands. Deep learning boosts fault identification significantly but struggles with edge accuracy and noise robustness. To overcome these limitations, this research introduces SwiftSeis-AWNet, a novel lightweight and high-precision network. The network is based on an optimized MedNeXt architecture for better fault edge detection. To address the noise from simple feature fusion, a Semantics and Detail Infusion (SDI) module is integrated. Since the Hadamard product in SDI can cause information loss, we engineer an Attention-Weighted Semantics and Detail Infusion (AWSDI) module that uses dynamic multi-scale feature fusion to preserve details. Validation on field seismic datasets from the Netherlands F3 and New Zealand Kerry blocks shows that SwiftSeis-AWNet mitigates challenges like the loss of small-scale fault features and misidentification of fault intersection zones, enhancing the accuracy and geological reliability of automated fault identification. Full article

The high pH and heavy metal leaching of argon oxygen decarburization (AOD) slag limit its application in agriculture. Slag carbonation can aid in decreasing slag alkalinity and inhibit heavy metal release; the environmental safety of utilizing carbonated AOD slag (CAS) as a fertilizer remains a topic of significant debate, however. In this work, pakchoi (Brassica chinensis L.) was planted in CAS-fertilized soil to investigate the accumulation and migration behavior of heavy metals in the soil–plant system and perform an associated risk assessment. Our results demonstrated that CAS addition increases Ca, Si, and Cr concentrations but decreases Mg and Fe concentrations in soil leachates. Low rates (0.25–1%) of CAS fertilization facilitate the growth of pakchoi, resulting in the absence of soil contamination and posing no threat to human health. At the optimal slag addition rate of 0.25%, the pakchoi leaf biomass, stem biomass, leaf area, and seedling height increased by 34.2%, 17.2%, 26.3%, and 8.7%, respectively. The accumulation of heavy metals results in diverging characteristics in pakchoi. Cr primarily accumulates in the roots; in comparison, Pb, Cd, Ni, and Hg preferentially accumulate in the leaves. The migration rate of the investigated heavy metals from the soil to pakchoi follows the order of Cr > Cd > Hg > Ni > Pb; in comparison, that from the roots to the leaves follows the order Cd > Ni > Hg > Cr > Pb. Appropriate utilization of CAS as a mineral fertilizer can aid in improving pakchoi yield, achieving sustainable economic benefits, and preventing environmental pollution. Full article

Against the backdrop of China’s fast-growing digital economy and its financial inclusion agenda, there is still little city-level evidence on whether the e-CNY pilot accelerates financial deepening at the grassroots. Using a balanced panel of 271 prefecture-and-above cities for 2016–2022, this study employs a staggered difference-in-differences (SDID) design augmented by the synthetic control method (SCM) to rigorously identify the policy effect of the e-CNY pilot. The results show that the pilot program significantly improves urban financial inclusion, contributing to more equitable access to financial services and supporting inclusive socio-economic development. Mechanism analysis suggests that the effect operates mainly through two channels, a merchant-coverage channel and a transaction-scale channel, with the former contributing the majority of the overall effect. Incorporating a migration-based mobility index shows that most studies’ focus on the merchant-coverage effect is amplified in cities under tight mobility restrictions but wanes where commercial networks are already saturated, whereas the transaction-scale channel is largely insensitive to mobility shocks. Heterogeneity tests further indicate stronger gains in non-provincial capital cities and in the eastern and central regions. Overall, the study uncovers a “penetration-inclusion” network logic and provides policy insights for advancing sustainable financial inclusion through optimized terminal deployment, merchant incentives, and diversified scenario design. Full article

Cellulose acetate (CA), commercially produced from natural cellulose, is one of the promising candidates to solve the microplastic issue. In this study, attempts were made to prepare CA microparticles by means of melt extrusion of incompatible polymer blends comprising CA with plasticizer (triacetin (TA)) and polyvinyl alcohol (PVA) followed by selective removable of TA and PVA. As implied by semi-theoretical equation previously established by Wu (Wu’s equation), particle size decreased with increasing shear rate or decreasing viscosity ratio of polymers. CA microparticles with a controlled size of 2–8 μm, narrow particle size distribution, and smooth surface were successfully obtained. Efforts were made to determine the numerical solution of Wu’s equation to compare them with observed particle size. To this end, interfacial tension between dispersed and matrix phases to be incorporated in the equation was determined by group contribution methods. The root mean squared error (RMSE) between the observed and calculated particle size was unsatisfactorily large, 4.46 μm. It was found that one of the possible reasons for the limited prediction accuracy was migration of TA from the dispersed to matrix phase affecting the viscosity ratio. Further efforts will be required to achieve a better prediction. Full article

The adrenal medulla and organs of Zuckerkandl consist of chromaffin cells that produce, store, and secrete catecholamines. In humans, the adrenal medulla is known to function throughout postnatal life, while the organs of Zuckerkandl degenerate by 2–3 years of postnatal life. Although the history of investigation of chromaffin cells goes back more than a century, little is known about the reciprocal organogenesis of the adrenal glands and organs of Zuckerkandl during human fetal development. In the current study, we compared these two organs using serial sectioning, routine histological staining, and immunohistochemical reactions in human embryos, prefetuses, and fetuses from 8 to 26 gestational weeks. In our study, we used antibodies for tyrosine hydroxylase, dopamine beta-hydroxylase, and phenylethanolamine N-methyltransferase, which are enzymes of catecholamine synthesis, β-III tubulin, and S100. We found two morphological cell types (large and small) in the developing ganglia, organs of Zuckerkandl, and adrenal medulla, and two migration patterns of large cells and small cells. The immunohistochemical characteristics of these cells were determined. We revealed that the number of small cells increased significantly at the ages from 16 to 21–22 gestational weeks, followed by a decrease at 22.5–26 gestational weeks. The presence of two large cell subpopulations was suggested—those that migrate primarily from organs of the Zuckerkandl region and those that differentiate later from the small cells. We also determined that 12 gestational weeks was the age of the first appearance of phenylethanolamine N-methyltransferase reactivity in developing chromaffin cells, temporally correlating with synaptogenesis events. This is important data in the light of the controversial glucocorticoid theory of phenylethanolamine N-methyltransferase induction in humans. Full article

Idiopathic pulmonary fibrosis (IPF) is characterized by excessive extracellular matrix (ECM) deposition driven by aberrant fibroblast-to-myofibroblast transition (FMT). However, the upstream regulators and downstream effectors of this process remain incompletely understood. Here, we identify acyl-CoA synthetase long-chain family member 4 (ACSL4), a lipid metabolic enzyme, as a critical mediator linking complement component 5a (C5a)/C5a receptor 1 (C5aR1) signaling to FMT via calcium signaling. In bleomycin (BLM)-induced pulmonary fibrosis of C57BL/6JGpt mice, and in C5a-stimulated primary lung fibroblasts, the expression of ACSL4 was markedly upregulated. Pharmacological inhibition of ACSL4 (PRGL493) or C5aR1 (PMX53) attenuated the deposition of ECM and suppressed the expression of fibrotic markers in vivo and in vitro. Mechanistically, the activation of C5a/C5aR1 signaling increased intracellular calcium levels and promoted the expression of ACSL4, while inhibition of calcium signaling (FK506) reversed the upregulation of ACSL4 and FMT-related changes, including the expression of α-smooth muscle actin (αSMA) and the migration of fibroblasts. Notably, inhibition of ACSL4 did not affect the proliferation of fibroblasts, suggesting its specific role in phenotypic transition. These findings demonstrate that ACSL4 functions downstream of C5a/C5aR1-induced calcium signaling to promote FMT and the progression of pulmonary fibrosis. Targeting ACSL4 may therefore offer a novel therapeutic strategy for IPF. Full article

Coronavirus disease 2019 (COVID-19) causes cardiovascular complications, which contributes to the high mortality rate of the disease. Emerging evidence indicates that aberrant vascular smooth muscle cell (SMC) function is a key driver of vascular disease in COVID-19. While antivirals alleviate the symptoms of COVID-19, it is not known whether these drugs directly affect SMCs. Accordingly, the present study investigated the ability of three approved COVID-19 antiviral drugs to influence SMC function. Treatment of SMCs with remdesivir (RDV), but not molnupiravir or nirmatrelvir, inhibited cell proliferation, DNA synthesis, and migration without affecting cell viability. RDV also stimulated an increase in heme oxygenase-1 (HO-1) expression that was not observed with molnupiravir or nirmatrelvir. The induction of HO-1 by RDV was abolished by mutating the antioxidant responsive element of the promoter, overexpressing dominant-negative NF-E2-related factor-2 (Nrf2), or treating cells with an antioxidant. Finally, silencing HO-1 partly rescued the proliferative and migratory response of RDV-treated SMCs, and this was reversed by carbon monoxide and bilirubin. In conclusion, the induction of HO-1 via the oxidant-sensitive Nrf2 signaling pathway contributes to the antiproliferative and antimigratory actions of RDV by generating carbon monoxide and bilirubin. These pleiotropic actions of RDV may prevent occlusive vascular disease in COVID-19. Full article

Traps are central to petroleum exploration, where hydrocarbons accumulate during migration. Reservoirs are likewise an essential petroleum system element and serve as the primary medium for hydrocarbon storage. The buried hill is a geological formation highly favorable for reservoir development. However, the factors influencing hydrocarbon accumulation in buried hill reservoirs are highly diverse, especially in areas with complex, active fault systems. Fault systems play a dual role, both in the formation of reservoirs and in the migration of hydrocarbons. Therefore, understanding the impact of complex fault systems helps enhance the exploration success rate of buried hill traps and guide drilling deployment. In the Beibuwan Basin in the South China Sea, buried hill traps are key targets for deep-buried hydrocarbon exploration in this faulted basin. The low level of exploration and research in buried hills globally limits the understanding of hydrocarbon accumulation conditions, thereby hindering large-scale hydrocarbon exploration. By using drilling data, logging data, and seismic data, stress fields and tectonic faults were restored. There are two types of buried hills developed in the Beibuwan Basin, which were formed during the Late Ordovician-Silurian period and Permian-Triassic period, respectively. The tectonic genesis of the Late Ordovician-Silurian period buried hills belongs to magma diapirism activity, while the tectonic genesis of the Permian-Triassic period buried hills belongs to reverse thrust activity. The fault systems formed by two periods of tectonic activity were respectively altered into basement buried hills and limestone buried hills. The negative structural inversion controls the distribution and interior stratigraphic framework of the deformed Carboniferous strata in the limestone buried hill. The faults and derived fractures of the Late Ordovician-Silurian period and Permian-Triassic period promoted the diagenesis and erosion of these buried hills. The faults formed after the Permian-Triassic period are not conducive to calcite cementation, thus facilitating the preservation of the reservoir space formed earlier. The control of hydrocarbon accumulation by the fault system is reflected in two aspects: on the one hand, the early to mid-Eocene extensional faulting activity directly controlled the depositional process of lacustrine source rocks; on the other hand, the Late Eocene-Oligocene, which is closest to the hydrocarbon expulsion period, is the most effective fault activity period for connecting Eocene source rocks and buried hill reservoirs. This study contributes to understanding of the role of complex fault activity in the formation of buried hill traps within hydrocarbon-bearing basins. Full article

Chloride ion penetration is one of the most aggressive threats to reinforced concrete, as it triggers the electrochemical corrosion of steel reinforcement, compromising structural integrity and durability. Chloride ingress occurs through the porous structure of concrete, making permeability control crucial for enhancing structural longevity. Fiber-reinforced concrete (FRC) is widely used to improve durability; however, the effects of different fiber types on chloride resistance remain unclear. This study examines the influence of glass and polypropylene fibers on concrete’s microstructure and chloride penetration resistance. Cylindrical specimens were prepared, including a reference mix without fibers and mixes with 0.25% and 0.50% fiber content by volume. Both fiber types were tested for chloride resistance. The accelerated non-steady-state migration method was employed to determine the resistance coefficients to chloride ion penetration, while X-ray macrofluorescence (MacroXRF) mapped the chlorine infiltration depth in the samples. Compressive strength decreased in all fiber-reinforced samples, with 0.50% glass fiber leading to a 56% reduction in strength. Nevertheless, the XRF results showed that a 0.25% fiber content significantly reduced chloride penetration, with polypropylene fibers outperforming glass fibers. These findings highlight the critical role of fiber type and volume in improving concrete durability, offering insights for designing long-lasting FRC structures in chloride-rich environments. Full article

Background: The 2022 conflict in Ukraine triggered mass migration, leading to a significant influx of Ukrainian refugee children into Poland. This situation raises concerns about hepatitis B virus immunity, as Ukraine’s hepatitis B vaccination coverage has been inconsistent compared to Poland’s high vaccination rates. Objective: To evaluate hepatitis B immunity and infection prevalence among Ukrainian refugee children residing in Southern Poland and to assess implications for vaccination strategies in the host country. Methods: A prospective cross-sectional study was conducted on 1322 Ukrainian refugee children (0–18 years) presenting to a pediatric infectious diseases department in Southern Poland between February 2022 and March 2024. Data on vaccination history, demographic characteristics, and selected laboratory parameters, including hepatitis B surface antigen and anti-HBs antibody levels, were collected. Protective immunity was defined as anti-HBs antibody levels ≥10 IU/L. Results: Among the participants (mean age 9.9 years; 50.2% female), 83.2% were reported as vaccinated according to national immunization programs, but only 64.9% demonstrated protective anti-HBs antibody levels. Protective antibody prevalence declined significantly with age, with less than half of adolescents aged 15–18 years showing immunity. Five children (0.4%) were diagnosed with chronic hepatitis B, four of whom were unvaccinated. Conclusions: This study identifies a significant gap in hepatitis B immunity among Ukrainian adolescent refugees residing in Southern Poland, with less than half possessing protective anti-HBs antibody levels. This immunity gap and the high risk of sexual transmission of the hepatitis B virus in adolescents highlight the urgent need for comprehensive surveillance, screening, and catch-up vaccination programs. Full article