Sign in to use this feature.

Years

Between: -

Subjects

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Journals

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Article Types

Countries / Regions

remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline
remove_circle_outline

Search Results (327)

Search Parameters:
Keywords = Lsi1

Order results
Result details
Results per page
Select all
Export citation of selected articles as:
17 pages, 1345 KB  
Article
Functional Symmetry of Upper Limbs in Young Adults: An Analysis of Muscle Strength and Mobility
by Piotr Osial, Michalina Błażkiewicz, Dagmara Iwańska and Jacek Wąsik
Appl. Sci. 2026, 16(8), 3874; https://doi.org/10.3390/app16083874 - 16 Apr 2026
Viewed by 282
Abstract
Background: Upper limb functional performance depends on the interaction of strength, mobility, and neuromuscular control, while inter-limb asymmetries may increase injury risk. However, comprehensive analyses integrating these factors remain limited. This study aimed to evaluate sex differences and identify functional phenotypes in young [...] Read more.
Background: Upper limb functional performance depends on the interaction of strength, mobility, and neuromuscular control, while inter-limb asymmetries may increase injury risk. However, comprehensive analyses integrating these factors remain limited. This study aimed to evaluate sex differences and identify functional phenotypes in young adults using a multidimensional assessment approach. Methods: Forty-six healthy young adults (23 women, 23 men) underwent a comprehensive battery of upper limb assessments, including anthropometric measurements, maximal handgrip strength, isometric elbow flexion and extension torque, postural stability via the Fall Risk Index (FRI), and functional reach using the Upper Quarter Y-Balance Test (YBT-UQ). Inter-limb symmetry was calculated using the Limb Symmetry Index (LSI). K-means clustering was applied to standardized variables to identify latent functional phenotypes. Results: Men demonstrated significantly greater body mass, height, limb length, and absolute strength (p < 0.01), while functional performance (YBT-UQ composite scores) and inter-limb symmetry were similar between sexes. Strength asymmetry was most prevalent for elbow flexion and handgrip strength (up to 89%), whereas stability asymmetry was less frequent (≈54%). Three functional clusters were identified: Cluster 1—high strength and moderate stability, Cluster 2—lower anthropometry and strength, Cluster 3—high strength but reduced stability and increased asymmetry. Despite phenotypic differences, composite functional performance was comparable across clusters. Conclusions: Upper limb function reflects the interaction of morphological and neuromuscular factors rather than strength alone. Observed asymmetries should be interpreted within a functional context, as moderate asymmetries may represent normal variation in motor control, while larger asymmetries may indicate potential functional imbalance; however, due to the cross-sectional design of this study, no causal inferences regarding injury risk can be made. Functional phenotyping provides a framework for individualized training, screening, and rehabilitation strategies. Full article
Show Figures

Figure 1

12 pages, 2290 KB  
Article
Automated Annuloplasty with VirtuoSEW® in microInvasive Mitral Valve Repair (μMVr)
by Nermir Granov, Farhad Bakhtiary, Armin Šljivo and Jude S. Sauer
Med. Sci. 2026, 14(2), 187; https://doi.org/10.3390/medsci14020187 - 9 Apr 2026
Viewed by 292
Abstract
Background/Objectives: Totally endoscopic mitral valve repair reduces surgical trauma and accelerates recovery but can be technically challenging, particularly for precise annuloplasty suturing. The VirtuoSEW® (LSI Solutions, Victor, NY 14564m, USA) automated annular suturing system was developed to standardize and simplify suture [...] Read more.
Background/Objectives: Totally endoscopic mitral valve repair reduces surgical trauma and accelerates recovery but can be technically challenging, particularly for precise annuloplasty suturing. The VirtuoSEW® (LSI Solutions, Victor, NY 14564m, USA) automated annular suturing system was developed to standardize and simplify suture placement. This study was an early evaluation of this technology’s safety, efficacy, and feasibility in totally endoscopic microInvasive mitral valve repair (µMVr). Methods: We conducted a retrospective observational study of 20 patients with severe mitral valve disease of various etiologies. All patients underwent mitral valve repair using the VirtuoSEW® system for automated placement of annuloplasty sutures, combined with leaflet resection or chordal management as appropriate. Postoperative outcomes were assessed at one month using echocardiography and clinical evaluation. Perioperative and postoperative complications and early mortality were systematically recorded. Results: VirtuoSEW®-assisted mitral valve repair was safe and effective, achieving complete elimination of severe mitral regurgitation in all patients (N = 20, 100%). Annuloplasty rings included Physio-ring (N = 12, 60%), Memo 3D (N = 4, 20%), and Memo 4D (N = 4, 20%), combined with leaflet repair techniques: leaflet plication (N = 5, 25%), neochordae implantation (N = 7, 35%), sliding plasty (N = 2, 10%), commissural repair (N = 1, 5%), and hemibutterfly repair (N = 1, 5%). Concomitant procedures included: tricuspid valve repair (N = 1, 5%) and atrial septal defect closure (N = 1, 5%). Mitral annulus diameter decreased from 42.0 ± 5.3 mm to 34.2 ± 2.2 mm (p = 0.001). Mean total surgery, cardiopulmonary bypass, and aortic cross-clamp times were 170.3 ± 21.3, 143.4 ± 21.5, and 80.4 ± 7.9 min, respectively. ICU stay was 1.0 ± 0.2 days, with a hospital stay of 8.0 ± 1.9 days. No perioperative complications—including bleeding (N = 0, 0%), stroke (N = 0, 0%), infections (N = 0, 0%), or 30-day mortality (N = 0, 0%)—occurred. Conclusions: µMVR invasive mitral valve repair using the VirtuoSEW® system is safe, effective, and reproducible, as well as compatible with almost all repair techniques, providing complete restoration of valve competence with no early device-related complications. To our knowledge, this is the first clinical study reporting outcomes with this device, supporting its potential to streamline mitral repair and improve procedural efficiency. Full article
(This article belongs to the Section Cardiovascular Disease)
Show Figures

Figure 1

17 pages, 1622 KB  
Article
Comparison of Limb Symmetry Index Values Across Different Knee Flexor Strength Testing Conditions in Healthy Male Recreational Athletes
by Natalia Urban and Aleksandra Królikowska
Appl. Sci. 2026, 16(7), 3440; https://doi.org/10.3390/app16073440 - 1 Apr 2026
Viewed by 455
Abstract
Background/Objectives: Restoring lower-limb strength and symmetry is crucial after ACL injury and reconstruction. The limb symmetry index (LSI) is often used to assess strength symmetry for return-to-sport decisions, but various assessment methods can influence outcomes. This study aimed to compare LSI across [...] Read more.
Background/Objectives: Restoring lower-limb strength and symmetry is crucial after ACL injury and reconstruction. The limb symmetry index (LSI) is often used to assess strength symmetry for return-to-sport decisions, but various assessment methods can influence outcomes. This study aimed to compare LSI across common knee flexor testing methods in healthy male athletes and to examine associations between absolute strength outcomes, thereby establishing baseline reference values for LSI in a healthy population. Methods: Twenty-two healthy recreationally active males participated in this prospective cross-sectional study. Knee flexor strength was assessed bilaterally using three force plate isometric tests, a static dynamometer-based test (isometric), and isokinetic dynamometer-based tests. Absolute strength values were normalized to body mass. LSI values were calculated for each testing condition. Differences in LSI across modalities were analyzed with repeated-measures ANOVA, and associations between normalized strength outcomes were assessed using Pearson correlation coefficients. Results: LSI values ranged from 96.69 to 101.83 across the testing conditions, with no significant differences observed between measures. Normalized absolute strength outcomes demonstrated very strong correlations within the same measurement category (r = 0.86–0.94 for force plate tests and r = 0.88–0.96 for isokinetic tests). In contrast, correlations between isometric and isokinetic strength outcomes were moderate (r = 0.41–0.67). Conclusions: LSI values were consistent across knee flexor strength testing modalities, suggesting that symmetry assessment was relatively consistent across different measurement methods in the studied group. In contrast, normalized absolute strength outcomes showed only moderate and variable associations across modalities, indicating that different testing approaches assess related but not interchangeable aspects of muscle strength. Full article
Show Figures

Figure 1

12 pages, 473 KB  
Article
Limb Strength and Power Asymmetries in Professional Team Sport Athletes at Return-to-Sport Testing Following ACL Reconstruction
by Marko D. M. Stojanović, Nikola Andrić, Tatjana Jezdimirovic Stojanovic, Šime Veršić and Julio Calleja Gonzalez
Medicina 2026, 62(4), 654; https://doi.org/10.3390/medicina62040654 - 29 Mar 2026
Viewed by 553
Abstract
Background and Objectives: Present assessment methods have not effectively mitigated the risk of recurrent anterior cruciate ligament (ACL) injury following reconstruction (ACLR), suggesting that critical neuromuscular deficits may be underdiagnosed. This study aimed to compare limb asymmetries across strength, concentric and eccentric [...] Read more.
Background and Objectives: Present assessment methods have not effectively mitigated the risk of recurrent anterior cruciate ligament (ACL) injury following reconstruction (ACLR), suggesting that critical neuromuscular deficits may be underdiagnosed. This study aimed to compare limb asymmetries across strength, concentric and eccentric power, and deceleration metrics during return-to-sport (RTS) testing in professional athletes post-ACLR. Materials and Methods: Forty-four participants (33 males, 11 females; age 22.5 ± 5.8 years, body mass 75.9 ± 13.0 kg, height 180.5 ± 8.38 cm) (mean ± SD) with a unilateral reconstructed ACL (BTB = 33, HT = 11 graft) were included. They underwent isokinetic testing of knee flexor and extensor strength and bilateral countermovement jump (CMJ) assessments to measure concentric and eccentric peak power and deceleration metrics. Limb symmetry indices (LSI) were calculated for each parameter. Welch’s ANOVA and Games–Howell post hoc tests were used to compare LSIs among parameters. Results: Welch’s ANOVA showed that limb symmetry differed significantly across the measured neuromuscular parameters (F = 12,59, p < 0.001). Knee flexor strength LSI was significantly higher than knee extensor strength LSI (p = 0.003; d = 1.18), concentric peak power LSI (p < 0.001, d = 1.44), eccentric peak power LSI (p = 0.001, d = 1.71), and deceleration LSI (p = 0.001, d = 2.09). In addition, deceleration LSI was significantly lower than knee extensor strength LSI (p = 0.001, d = 1.34) and concentric peak power LSI (p = 0.007, d = 1.10). No significant difference was found between concentric and eccentric peak power, nor between knee extensor strength and either concentric or eccentric peak power LSIs. Conclusions: The findings of this study revealed significantly greater asymmetries in load absorption capacity compared to strength and concentric power measures at return-to-sport time frame in professional athletes post-ACLR. Full article
(This article belongs to the Special Issue ACL: From Injury to Return to Sport)
Show Figures

Figure 1

15 pages, 2531 KB  
Article
Pilot Study on Nanofiltration Process for Surface Water Treatment and Optimization in Northern Jiangsu Region
by Jiaming Jin, Sicheng He, Tao Zhang and Shengji Xia
Membranes 2026, 16(4), 117; https://doi.org/10.3390/membranes16040117 - 27 Mar 2026
Viewed by 499
Abstract
Nanofiltration (NF) is increasingly applied for advanced drinking water treatment, but achieving stable operation at high recovery rates remains challenging for surface waters with high scaling potential. This pilot study investigated the performance and optimization of a three-stage NF270 system (4:2:1 tapered array) [...] Read more.
Nanofiltration (NF) is increasingly applied for advanced drinking water treatment, but achieving stable operation at high recovery rates remains challenging for surface waters with high scaling potential. This pilot study investigated the performance and optimization of a three-stage NF270 system (4:2:1 tapered array) for treating coagulated surface water in northern Jiangsu, China, aiming to identify sustainable operating conditions for high-recovery applications. The NF system was operated at recoveries of 80–90% with a feed flux of 20–23 LMH, and the effects of forward flushing frequency, acid dosing location, and concentrate recirculation on fouling behavior were evaluated. The NF270 membrane achieved consistent removal of organic matter (effluent chemical oxygen demand (CODMn) < 0.5 mg/L), hardness (40–60% rejection), and alkalinity (~20% rejection), meeting Jiangsu Province drinking water standards. However, operation at 90% recovery resulted in rapid third-stage fouling, with permeate flow declining by >60% within 2.5 h. Osmotic pressure analysis (local concentrate osmotic pressure: 3.8–4.2 bar; net driving pressure: 0.8–2.2 bar) confirmed physical scaling rather than hydraulic limitation as the dominant mechanism. Stage-wise concentration factor calculations (CF1 = 1.6, CF2 = 2.9, CF3 = 4.4) revealed local Langelier Saturation Index (LSI) values of 1.8–2.2 in the third stage, identifying CaCO3 supersaturation as the primary scaling cause. Reducing recovery to 85% and flux to 20 LMH with 2 h forward flushing extended stable operation. Acid addition effectively mitigated scaling, but dosing location was critical: first-stage addition (pH 8.1 → 7.6) reduced third-stage LSI to 0.7–0.9 and stabilized performance, whereas third-stage addition (pH 8.0 → 7.3) inadvertently promoted Al(OH)3 precipitation from residual coagulant (feed Al: 0.07–0.11 mg/L). Concentrate recirculation (90% ratio) did not alleviate fouling. These findings demonstrate that for aluminum-rich coagulated surface waters, optimizing recovery, flushing frequency, and acid dosing location is essential for sustainable NF operation, and provide engineering guidance for full-scale applications. Full article
(This article belongs to the Special Issue Membrane-Based Technology for Drinking Water Treatment)
Show Figures

Figure 1

14 pages, 1570 KB  
Article
Lifestyle Intervention Therapy Modulates Global DNA Methylation and Adipogenic Gene Expression in Severely Obese Hypogonadal Men
by Siresha Bathina, Virginia Fuenmayor Lopez, Mia Prado, Salina Biene Teo, Dennis T. Villareal, Rui Chen, Clifford Qualls and Reina Armamento-Villareal
Metabolites 2026, 16(3), 198; https://doi.org/10.3390/metabo16030198 - 16 Mar 2026
Viewed by 758
Abstract
Background/Objectives: Previous studies have suggested that lifestyle intervention (LSI) therapies involving diet and exercise can modulate DNA methylation; however, whether this occurs in severely obese hypogonadal men undergoing weight loss from diet and exercise remains unclear. Methods: In this study, we investigated the [...] Read more.
Background/Objectives: Previous studies have suggested that lifestyle intervention (LSI) therapies involving diet and exercise can modulate DNA methylation; however, whether this occurs in severely obese hypogonadal men undergoing weight loss from diet and exercise remains unclear. Methods: In this study, we investigated the effects of weight loss from diet and exercise on global DNA methylation as well as on the mRNA expression of specific demethylation enzymes, DNMT1, DNMT3A, and DNMT3B—in peripheral blood mononuclear cells (PBMCs) and DNA methylation markers in DNA of severely obese hypogonadal men. This is a secondary analysis of samples of severely obese (body mass index of ≥35 kg/m2) hypogonadal men undergoing weight loss from diet and exercise in addition to an aromatase inhibitor (anastrozole) or placebo for a total of 12 months. Results: LSI therapy significantly reduced global DNA methylation and 5-methylcytosine (5-mC) levels, decreased DNMT1, DNMT3A, and DNMT3B (p < 0.05) mRNA levels and markedly decreased CEBPα, FTO, and PPARγ mRNA expression. The reduction in global methylation was independent of aromatase inhibitor use. Conclusions: In summary, our findings suggest that LSI induces epigenetic modifications in leukocytes, possibly through the regulation of DNMT gene expression. Future studies are warranted to clarify the mechanistic pathways linking lifestyle-induced epigenetic alterations to metabolic health outcomes. Full article
(This article belongs to the Special Issue Interactions Between Exercise Physiology and Metabolism)
Show Figures

Figure 1

20 pages, 7877 KB  
Article
Quantifying the Relationship Between Blue–Green Landscape Spatial Patterns and Carbon Storage: A Case Study of theZhengzhou Metropolitan Area
by Longfei Liu, Yonghua Li, Wangxin Su, Yihang Wang and Yang Liu
Sustainability 2026, 18(6), 2771; https://doi.org/10.3390/su18062771 - 12 Mar 2026
Viewed by 251
Abstract
Against the backdrop of global warming and the urgent demand for sustainable development, blue–green spaces (BGSs) play a vital role in carbon reduction and sequestration, yet the multi-scale spatial mechanisms by which blue–green space patterns (BGSPs) regulate carbon storage (CS) remain unclear. Taking [...] Read more.
Against the backdrop of global warming and the urgent demand for sustainable development, blue–green spaces (BGSs) play a vital role in carbon reduction and sequestration, yet the multi-scale spatial mechanisms by which blue–green space patterns (BGSPs) regulate carbon storage (CS) remain unclear. Taking the Zhengzhou Metropolitan Area as the study area, this research clarifies the BGSP-CS correlations at both class and landscape levels and quantifies their spatial interaction mechanisms, providing scientific support for integrated BGS planning that aligns with sustainable development objectives. Using the InVEST model coupled with regional carbon density correction, the total CS of the area is estimated at 1112.27 × 106 t. Spearman’s correlation analysis shows that at the class level, area–edge and shape complexity indicators (e.g., Landscape Shape Index, LSI: r = −0.427) are negatively correlated with CS, while connectivity indicators exert no significant effect. At the landscape level, Shannon’s Diversity Index (SHDI: r = −0.635) and area–edge indicators inhibit CS, whereas Shannon’s Evenness Index (SHEI: r = 0.602), Largest Patch Index (LPI: r = 0.618) and shape complexity indicators exert positive effects. A comparative analysis of three regression models reveals that the multi-scale geographically weighted regression (MGWR) model outperforms the ordinary least squares (OLS) and geographically weighted regression (GWR) models, with R2 values of 0.505 (class level) and 0.484 (landscape level). It effectively captures the “west–strong and east–weak” spatial heterogeneity of BGSP impacts on CS. This study identifies key BGSP indicators regulating CS and their spatial mechanisms, providing scientific support for integrated BGS planning, regional carbon sink enhancement, the achievement of “dual carbon” goals, and the promotion of sustainable development in metropolitan areas. Future research may optimize model parameters through field surveys and explore the coupling mechanism between BGSPs, land surface temperature and CS to better align BGS management with sustainable development agendas. Full article
Show Figures

Figure 1

19 pages, 1022 KB  
Review
Clearance Criteria for Determining Eligibility for Force Plate Testing After Anterior Cruciate Ligament Reconstruction: A Scoping Review
by Landon Christoffel, Lauren Beaupre, Stephanie Nathanail, Wasim Labban, Mark Sommerfeldt, Lindsey Westover and Gail M. Thornton
Medicina 2026, 62(3), 503; https://doi.org/10.3390/medicina62030503 - 9 Mar 2026
Viewed by 584
Abstract
Background and Objectives: Throughout the return-to-play process after anterior cruciate ligament reconstruction (ACLR), clearance criteria and limb symmetry indices (LSI) play an important role in clinical decision-making by helping evaluate patient readiness and informing safe activity progressions, with the goal of reducing [...] Read more.
Background and Objectives: Throughout the return-to-play process after anterior cruciate ligament reconstruction (ACLR), clearance criteria and limb symmetry indices (LSI) play an important role in clinical decision-making by helping evaluate patient readiness and informing safe activity progressions, with the goal of reducing re-injury risk. How clearance criteria are implemented in research studies to evaluate patient readiness, specifically in force plate jumping studies, is currently unknown. This scoping review was a focused examination of clearance criteria and limb symmetry indices in studies performing force plate-based jumping assessments with ACLR patients. The research questions guiding this scoping review were as follows: (1) What clearance criteria are reported in studies involving primary ACLR patients who participate in jumping assessments on force plates? (2) What LSI are reported in force plate studies, and what level of symmetry is deemed acceptable to allow for safe participation of ACLR patients who participate in jumping assessments of force plates? Materials and Methods: Nine databases were searched on 7 or 8 September 2024 for three concepts: ACLR, force plates, and movement properties. Inclusion criteria were as follows: (a) primary ACLR patients at least 6 months post-surgery; (b) performing a countermovement or drop jump; (c) collecting at least one kinetic parameter using a force plate. Clearance criteria was operationally defined as a time from surgery boundary, functional or performance-based testing criteria, medical evaluation, or completion/participation in a rehabilitation program. Results: Thirty-five studies were included. Time from surgery was the most frequently reported clearance criteria (26/35; 74.3%), followed by medical evaluation (18/35; 51.4%), and completion of rehabilitation (10/35; 28.6%). Use of LSI as clearance criteria was limited (5/35; 14.3%). Minimum required LSI ranged from 85 to 90% in quadriceps strength and hop testing. Conclusions: Clearance criteria varied by jump type and post-surgical time frame when the participant was tested. Standardized rehabilitation was common prior to 2 years post-surgery, whereas medical clearance was common after 2 years post-surgery. Single leg jumps typically required 2–3 clearance criteria, whereas double leg jumps required 1–2 clearance criteria. Limb symmetry indices were used in combination with two other clearance criteria in studies with single-leg countermovement or drop jumps. Improvements in clearance criteria and adverse event reporting may help improve patient safety and interpretation of findings across studies. Full article
(This article belongs to the Special Issue Anterior Cruciate Ligament (ACL) Injury)
Show Figures

Figure 1

15 pages, 6743 KB  
Article
Comparative Transcriptomic Analysis Reveals Key Pathways and Genes Involved in Late-Acting Self-Incompatibility in Akebia trifoliata
by Huai Yang, Jie Li, Rui Han, Xiaoxiao Yi, Chen Chen and Peigao Luo
Curr. Issues Mol. Biol. 2026, 48(3), 245; https://doi.org/10.3390/cimb48030245 - 26 Feb 2026
Viewed by 473
Abstract
Self-incompatibility (SI) is a key reproductive mechanism in angiosperms that prevents self-fertilization and promotes genetic diversity while limiting breeding efficiency. Akebia trifoliata is a recently domesticated economic crop native to East Asia with medicinal, edible, and oil-producing value. However, its late-acting self-incompatibility (LSI) [...] Read more.
Self-incompatibility (SI) is a key reproductive mechanism in angiosperms that prevents self-fertilization and promotes genetic diversity while limiting breeding efficiency. Akebia trifoliata is a recently domesticated economic crop native to East Asia with medicinal, edible, and oil-producing value. However, its late-acting self-incompatibility (LSI) severely limits genetic improvement and commercial development. To investigate the molecular basis of LSI, we conducted comparative transcriptomic analyses of pistils at 48, 96, 144, 192, and 240 h after self- and cross-pollination, identifying 1552, 2954, 1302, 814, and 1978 differentially expressed genes (DEGs), respectively. DEGs were consistently enriched in mitogen-activated protein kinase (MAPK) signaling, plant hormone signal transduction, and ubiquitin-mediated proteolysis pathways, with clear transcriptional differences before and after 96 h. Compared with cross-pollinated pistils, self-pollinated pistils showed restricted pollen tube spread, and genes related to pollen recognition and tube development showed differential expression at 48 and 96 h, indicating that LSI probably occurs within the pollen tube. Collectively, these results indicate that pistils of A. trifoliata exhibit distinct early responses to self- and cross-pollination, and that DEG-enriched pathways are similar to those involved in S-RNase-mediated SI. These results provide new insights into the molecular basis of LSI and suggest potential targets for overcoming the SI barrier. Full article
(This article belongs to the Section Molecular Plant Sciences)
Show Figures

Figure 1

22 pages, 3115 KB  
Article
Assessing Nonlinear Effects of Landscape Patterns on Habitat Quality in the Yellow River Basin: An Integrated Framework Combining Interpretable Machine Learning and Spatial Autocorrelation
by Faming Li, Kaiting Yang, Tianming Sun, Yuming Shao, Yanhong Huo and Yiqing Liu
Sustainability 2026, 18(4), 1779; https://doi.org/10.3390/su18041779 - 9 Feb 2026
Viewed by 443
Abstract
In the context of accelerating worldwide urbanization and ecosystem decline, deciphering the interactions between landscape patterns and habitat quality is essential for biodiversity preservation, particularly within ecologically sensitive zones like the Yellow River Basin. This research investigates the spatiotemporal dynamics, spatial linkages, and [...] Read more.
In the context of accelerating worldwide urbanization and ecosystem decline, deciphering the interactions between landscape patterns and habitat quality is essential for biodiversity preservation, particularly within ecologically sensitive zones like the Yellow River Basin. This research investigates the spatiotemporal dynamics, spatial linkages, and nonlinear relationships connecting landscape patterns and habitat quality across the basin. Utilizing land use datasets spanning 1980–2023, we combined the InVEST model, landscape pattern indices, spatial autocorrelation analysis, the XGBoost algorithm, and SHAP interpretability methods. The results show that: (1) Landscape patterns underwent a clear transition around 1995, shifting from regularization and connectivity toward fragmentation and heterogeneity, evidenced by increases in PD, LSI, and SHEI, alongside decreases in LPI and CONTAG. (2) Mean habitat quality progressively declined, exhibited a spatial distribution characterized by “higher in the west, lower in the east.” Low-quality habitat areas expanded from 2.12% to 3.76%, whereas high-quality areas decreased from 23.12% to 22.45%, with better habitats largely maintained in western headwaters and the Qinling Mountains. (3) Significant spatial correlations were observed: LPI positively correlated with habitat quality, while PD, LSI, SHEI, and CONTAG showed negative correlations. Two dominant spatial aggregations emerged—namely “high connectivity–high quality” in the west and “high fragmentation–low quality” in the east. (4) CONTAG was identified as the dominant factor influencing habitat quality, with all landscape indices exhibiting distinct threshold effects. The proposed framework, which integrates spatial statistics, machine learning, and interpretability methods, offers a novel approach for deciphering complex ecological processes. Moreover, the identified thresholds and zonal management strategies offer a scientific foundation for ecological conservation and spatial planning in the Yellow River Basin and other vulnerable river systems worldwide. Full article
Show Figures

Figure 1

13 pages, 1050 KB  
Article
Isokinetic Strength Recovery and Fear of Re-Injury After ACL Reconstruction in Male Soccer Players: A Retrospective Cohort Study
by Matteo Interlandi, Luca Santini, Sebastiano Zuppardo, Franco Merlo, Giovanni Grazzini and Gilberto Martelli
J. Clin. Med. 2026, 15(3), 1243; https://doi.org/10.3390/jcm15031243 - 4 Feb 2026
Viewed by 905
Abstract
Background/Objectives: Persistent strength deficits and psychological impairments may compromise return to sport (RTS) after anterior cruciate ligament reconstruction (ACLR). We investigate the relationship between thigh muscle isokinetic strength recovery at six months after ACLR and long-term psychological outcomes related to RTS in [...] Read more.
Background/Objectives: Persistent strength deficits and psychological impairments may compromise return to sport (RTS) after anterior cruciate ligament reconstruction (ACLR). We investigate the relationship between thigh muscle isokinetic strength recovery at six months after ACLR and long-term psychological outcomes related to RTS in competitive male soccer players. Methods: Sixty male soccer players who underwent primary ACLR with bone–patellar tendon–bone autograft were retrospectively analyzed. Isokinetic testing of quadriceps and hamstrings was performed one week before surgery and six months post-surgery at 90°/s and 180°/s. Limb symmetry index (LSI) was calculated both pre- and post-operatively. At long-term follow-up (mean ≈ 4 years after RTS), athletes completed questionnaires assessing RTS status, ACL re-injuries, sport-related perceptions, and kinesiophobia using the Tampa Scale for Kinesiophobia (TSK). Statistical analyses were conducted to explore associations between post-operative LSI and TSK scores and to compare psychological and neuromuscular outcomes between athletes with and without ACL re-injury. Results: Absolute quadriceps and hamstring peak torque values significantly increased from pre- to post-surgery, with quadriceps strength deficits persisting only in the operated limb. However, quadriceps LSI significantly decreased post-operatively, while hamstring LSI remained stable. Pearson correlation analysis revealed a weak positive association between post-operative quadriceps LSI at 90°/s and TSK scores (r = 0.34). Overall, RTS rate was 91.7%, but a second ACL injury occurred in 18.2% of athletes. No significant differences were observed between re-injured and non-re-injured athletes in TSK scores or post-operative LSI values at either angular velocity (all p > 0.29). High kinesiophobia (TSK ≥ 37) was present in 56.7% of the cohort at long-term follow-up. Conclusions: Despite significant strength gains, quadriceps limb symmetry worsened six months after ACLR, with deficits confined to the operated limb, suggesting persistent neuromuscular inhibition. These physical deficits coexist with long-term kinesiophobia despite high RTS rates. The weak associations between strength symmetry and psychological outcomes highlight the multifactorial nature of RTS and support the need for an integrated physical, psychological, and neuro-cognitive approach to rehabilitation and RTS decision-making. Full article
Show Figures

Figure 1

22 pages, 5527 KB  
Article
Comparative DFT Study of Lignocellulosic Binders on N- and S-Monodoped Graphene for Sustainable Li-Ion Battery Electrodes
by Joaquín Alejandro Hernández Fernández, Juan Carrascal and Jose Alfonso Prieto Palomo
J. Compos. Sci. 2026, 10(2), 70; https://doi.org/10.3390/jcs10020070 - 31 Jan 2026
Cited by 2 | Viewed by 485
Abstract
Heteroatom functionalization of graphene is an effective strategy for designing more sustainable lithium-ion battery electrodes, as it can tune both interfacial adhesion and the electronic features of the carbon lattice. In this work, we investigated the interfacial compatibility between three graphene sheets—pristine graphene, [...] Read more.
Heteroatom functionalization of graphene is an effective strategy for designing more sustainable lithium-ion battery electrodes, as it can tune both interfacial adhesion and the electronic features of the carbon lattice. In this work, we investigated the interfacial compatibility between three graphene sheets—pristine graphene, graphene doped with one nitrogen atom (Graphene–N), and graphene doped with one sulfur atom (Graphene–S)—and three lignocellulosic binders (carboxymethylcellulose (CMC); coniferyl alcohol (LcnA); and sinapyl alcohol (LsiA)) using density functional theory (DFT). Geometries were optimized using CAM-B3LYP and M06-2X in combination with the LANL2DZ basis set, while ωB97X-D/LANL2DZ was employed for dispersion-consistent single-point refinements. The computed adsorption energies indicate that all binder–surface combinations are thermodynamically favorable within the present finite-model framework (ΔEint ≈ −22.6 to −31.1 kcal·mol−1), with LSiA consistently showing the strongest stabilization across surfaces. Nitrogen doping produces a modest but systematic strengthening of adsorption relative to pristine graphene for all binders and is accompanied by electronic signatures consistent with localized donor/basic sites while preserving the delocalized π framework. In contrast, sulfur doping yields a more binder-dependent response: it maintains strong stabilization for LSiA but weakens LCnA relative to pristine/N-doped sheets, consistent with an S-induced local distortion/polarizability pattern that can alter optimal π–π registry depending on the adsorption geometry. A combined interpretation of adsorption energies, electronic descriptors (including ΔEgap as a model-dependent HOMO–LUMO separation), and topological analyses (AIM, ELF, LOL, and MEP) supports that Graphene–N provides the best overall balance between electronic continuity and chemically active interfacial sites, whereas Graphene–S can enhance localized anchoring but introduces more heterogeneous, lone-pair–dominated domains that may partially perturb electronic connectivity. Full article
(This article belongs to the Section Composites Applications)
Show Figures

Figure 1

9 pages, 836 KB  
Communication
Test–Retest Reliability of Single-Arm Closed Kinetic Chain Upper Extremity Stability Test
by Andy Waldhelm, Mareli Klopper, Matthew Paul Gonzalez, Stephanie Flynn, Edward Austin and Ron Masri
J. Funct. Morphol. Kinesiol. 2026, 11(1), 46; https://doi.org/10.3390/jfmk11010046 - 21 Jan 2026
Viewed by 591
Abstract
Background: The original Closed Kinetic Chain Upper Extremity Stability Test (CKCUEST) is a simple assessment tool but does not account for individual differences in hand starting position and fails to provide information on limb asymmetries. The purpose of the study is to evaluate [...] Read more.
Background: The original Closed Kinetic Chain Upper Extremity Stability Test (CKCUEST) is a simple assessment tool but does not account for individual differences in hand starting position and fails to provide information on limb asymmetries. The purpose of the study is to evaluate the test–retest reliability of a new single-arm CKCUEST as well as the reliability of the limb symmetry index (LSI). This version normalizes the test based on the participant’s arm length and allows for the assessment of limb symmetry since it is performed one arm at a time. Methods: Twelve healthy young adults provided both verbal and written consent to participate. Participants were excluded if they had sustained an injury in the past three months requiring medical attention and/or resulting in decreased activity for more than three days. Testing was conducted in the push-up position with participants’ thumbs placed parallel and at a distance equal to the length of their dominant arm (measured from the acromion to the tip of the middle finger), and feet positioned shoulder-width apart. Participants were instructed to keep the testing hand stable on the floor while the opposite hand reached across the body to touch the stationary hand and then return to the starting position marked with athletic tape. The goal was to complete as many touches as possible in 15 s, with each touch counted only if the participant touched the stationary hand, returned to the starting position, and maintained the shoulder-width stance. The average number of touches from the three trials was used for analysis. Intraclass Correlation Coefficients (ICC(3,1)) were computed to determine test–retest reliability. Results: Test–retest reliability of the single-arm CKCUEST individual tests was good to excellent. The ICC(3,1) was 0.88 (95% CI: 0.74–0.95) for all tests, 0.89 (95% CI: 0.66–0.96) for the dominant arm, and 0.93 (95% CI: 0.78–0.98) for the non-dominant arm. In contrast, the reliability of the Limb Symmetry Index (LSI) was questionable, showing substantial variability with an ICC(3,1) of 0.53 (95% CI: −0.03–0.83) between Day 1 and Day 2, despite similar mean values (Day 1: 93.6 ± 8.46; Day 2: 94.8 ± 5.77). The Kappa coefficient suggested a substantial level of agreement for the direction of the asymmetry (preferred limb) (Kappa coefficient = 0.62). Conclusions: The new single-arm CKCUEST, which personalizes the hand starting position and measures limb symmetry, demonstrates high reliability among healthy young adults. Full article
(This article belongs to the Section Kinesiology and Biomechanics)
Show Figures

Figure 1

17 pages, 2808 KB  
Article
Comparative Analysis of Machine Learning Models for Prediction of Langelier Saturation Index in Groundwater of a River Basin
by Jelena Vesković, Milica Lučić, Andrijana Miletić, Marija Vesković and Antonije Onjia
Sustain. Chem. 2026, 7(1), 7; https://doi.org/10.3390/suschem7010007 - 20 Jan 2026
Viewed by 860
Abstract
Accurate prediction of the Langelier Saturation Index (LSI), an indicator of water’s scaling and corrosive potential, is vital for water treatment and infrastructure maintenance. In this study, five machine learning models (Ridge Regression, Support Vector Machine, Random Forest, Deep Neural Network, and XGBoost) [...] Read more.
Accurate prediction of the Langelier Saturation Index (LSI), an indicator of water’s scaling and corrosive potential, is vital for water treatment and infrastructure maintenance. In this study, five machine learning models (Ridge Regression, Support Vector Machine, Random Forest, Deep Neural Network, and XGBoost) were applied to predict the LSI from physicochemical characteristics of groundwater in the Morava River basin (Serbia). Rigorous data preprocessing (outlier removal, missing data handling, z-score normalization) and feature selection were performed to ensure robust model training. Models were optimized via 10-fold cross-validation on a 70/30 train–test split. All models achieved high predictive accuracy, with ensemble methods outperforming others. XGBoost yielded the best performance (R2 = 0.98; RMSE = 0.06), followed closely by Random Forest (R2 = 0.95). The linear Ridge model showed the lowest (yet still strong) performance (R2 = 0.90) and larger errors at extreme LSI values. Feature importance analysis consistently identified pH as the most influential predictor of the LSI, followed by alkalinity and calcium. Partial dependence plots confirmed that the models captured established nonlinear LSI behavior. The LSI rises steeply with increasing pH and moderately with mineral content. Overall, this comparative study demonstrates that modern machine learning models can predict the LSI accurately, providing interpretable insights through feature importance and dependence plots. These results underscore the potential of data-driven approaches to complement traditional water stability indices for proactive water quality management. Full article
Show Figures

Graphical abstract

24 pages, 7504 KB  
Article
Historical Trajectories of the Evolved Cropland Features and Their Reshaped Influences on Agricultural Landscapes and Ecosystem Services in China’s Sanjiang Commodity Grain Base
by Tao Pan, Kun Liu, Zherui Yin, Zexian Li and Lin Shi
Land 2026, 15(1), 175; https://doi.org/10.3390/land15010175 - 16 Jan 2026
Viewed by 375
Abstract
Drastic cropland expansion and its internal structural changes have had an obvious impact on agricultural landscapes and ecosystem services. However, a prolonged investigation of this effect is still lacking in China’s grain-producing bases, such as Sanjiang Plain. To address this issue, half a [...] Read more.
Drastic cropland expansion and its internal structural changes have had an obvious impact on agricultural landscapes and ecosystem services. However, a prolonged investigation of this effect is still lacking in China’s grain-producing bases, such as Sanjiang Plain. To address this issue, half a century of study on the ‘land trajectory migration–landscape evolution–ecological effect,’ covering the period 1970–2020, was elucidated using the synergistic methodology of spatial analysis technology, the reclamation rate algorithm, the landscape indicator, and the newly established ecosystem service improvement model. Satellite observation results indicate that the cropland area exhibited a substantial expansion trend from 23,672.69 km2 to 42,856.17 km2 from 1970 to 2020, representing a net change of +19,183.48 km2 and a huge growth rate of 81.04%, which led to an obvious improvement in the level of agricultural cultivation. Concurrently, the internal structure of the cropland underwent dramatic restructuring, with rice fields increasing from 6.46% to 53.54%, while upland fields decreased from 93.54% to 46.46%. In different regions, spatially heterogeneous improvements of 2.64–52.47% in agricultural cultivation levels across all cities were observed. From 1970 to 2020, the tracked cropland center of gravity trajectories exhibited a distinct biphasic pattern, initially shifting westward and then followed by a southward transition, accumulating a displacement of 19.39 km2. As for the evolved agricultural landscapes, their integrity has improved (SHDI = −0.08%), accompanied by increased connectivity (CON = +8.82%) and patch edge integrity (LSI = −15.71%) but also by reduced fragmentation (PD = −48.14%). Another important discovery was that the evaluated ecosystem services continuously decreased from 2337.84 × 108 CNY in 1970 to 1654.01 × 108 CNY in 2020, a net loss of −683.84 × 108 CNY and a huge loss rate of 33.65%, accompanied by a center–periphery gradient pattern whereby degradation propagated from the low-value central croplands to the high-value surrounding natural covers. These discoveries will play a significant role in guiding farmland structure reformation, landscape optimization, and ecosystem service improvement. Full article
(This article belongs to the Special Issue Monitoring Ecosystem Services and Biodiversity Under Land Use Change)
Show Figures

Figure 1

Back to TopTop