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1,578 Results Found

  • Review
  • Open Access
106 Citations
12,169 Views
26 Pages

Hydrogen Sulfide in Pharmacotherapy, Beyond the Hydrogen Sulfide-Donors

  • Ewelina Zaorska,
  • Lenka Tomasova,
  • Dominik Koszelewski,
  • Ryszard Ostaszewski and
  • Marcin Ufnal

18 February 2020

Hydrogen sulfide (H2S) is one of the important biological mediators involved in physiological and pathological processes in mammals. Recently developed H2S donors show promising effects against several pathological processes in preclinical and early...

  • Feature Paper
  • Review
  • Open Access
52 Citations
11,663 Views
19 Pages

Nanomaterials for the Selective Detection of Hydrogen Sulfide in Air

  • Eduard Llobet,
  • Jérôme Brunet,
  • Alain Pauly,
  • Amadou Ndiaye and
  • Christelle Varenne

17 February 2017

This paper presents a focused review on the nanomaterials and associated transduction schemes that have been developed for the selective detection of hydrogen sulfide. It presents a quite comprehensive overview of the latest developments, briefly dis...

  • Review
  • Open Access
9 Citations
3,691 Views
17 Pages

The Impact of Drugs on Hydrogen Sulfide Homeostasis in Mammals

  • Asrar Alsaeedi,
  • Simon Welham,
  • Peter Rose and
  • Yi-Zhun Zhu

Mammalian cells and tissues have the capacity to generate hydrogen sulfide gas (H2S) via catabolic routes involving cysteine metabolism. H2S acts on cell signaling cascades that are necessary in many biochemical and physiological roles important in t...

  • Review
  • Open Access
40 Citations
9,538 Views
19 Pages

The chemical challenge of economically splitting water into molecular hydrogen and oxygen requires continuous development of more efficient, less-toxic, and cheaper catalyst materials. This review article highlights the potential of iron sulfide-base...

  • Review
  • Open Access
9 Citations
8,184 Views
19 Pages

In this review article, we discuss and explore the role of bacteria-derived hydrogen sulfide. Hydrogen sulfide is a signaling molecule produced endogenously that plays an important role in health and disease. It is also produced by the gut microbiome...

  • Article
  • Open Access
8 Citations
4,637 Views
22 Pages

Characterization of the Inducible and Slow-Releasing Hydrogen Sulfide and Persulfide Donor P*: Insights into Hydrogen Sulfide Signaling

  • Modesta Trummer,
  • Erwan Galardon,
  • Anita Fischer,
  • Stefan Toegel,
  • Bernd Mayer,
  • Guenter Steiner and
  • Burkhard Kloesch

Hydrogen sulfide (H2S) is an important mediator of inflammatory processes. However, controversial findings also exist, and its underlying molecular mechanisms are largely unknown. Recently, the byproducts of H2S, per-/polysulfides, emerged as biologi...

  • Feature Paper
  • Review
  • Open Access
20 Citations
14,189 Views
45 Pages

Direct Selective Oxidation of Hydrogen Sulfide: Laboratory, Pilot and Industrial Tests

  • Sergei Khairulin,
  • Mikhail Kerzhentsev,
  • Anton Salnikov and
  • Zinfer R. Ismagilov

15 September 2021

This article is devoted to scientific and technical aspects of the direct catalytic oxidation of hydrogen sulfide for the production of elemental sulfur. It includes a detailed description of the Claus process as the main reference technology for hyd...

  • Review
  • Open Access
22 Citations
6,781 Views
10 Pages

Production of Hydrogen Sulfide by Fermentation in Rumen and Its Impact on Health and Production of Animals

  • Ali Mujtaba Shah,
  • Jian Ma,
  • Zhisheng Wang,
  • Rui Hu,
  • Xueying Wang,
  • Quanhui Peng,
  • Felix Kwame Amevor and
  • Naqash Goswami

17 September 2020

Hydrogen sulfide is a Janus-faced molecule with many beneficial and toxic effects on the animal health. In ruminants, rumen fermentation plays a vital role in the digestion and absorption of nutrients. During rumen fermentation, the production of hyd...

  • Review
  • Open Access
91 Citations
9,977 Views
44 Pages

Hydrogen Sulfide Biology and Its Role in Cancer

  • Saadullah Khattak,
  • Mohd Ahmar Rauf,
  • Nazeer Hussain Khan,
  • Qian-Qian Zhang,
  • Hao-Jie Chen,
  • Pir Muhammad,
  • Mohammad Azam Ansari,
  • Mohammad N. Alomary,
  • Muhammad Jahangir and
  • Dong-Dong Wu
  • + 2 authors

Hydrogen sulfide (H2S) is an endogenous biologically active gas produced in mammalian tissues. It plays a very critical role in many pathophysiological processes in the body. It can be endogenously produced through many enzymes analogous to the cyste...

  • Review
  • Open Access
42 Citations
6,942 Views
45 Pages

Chemistry of Hydrogen Sulfide—Pathological and Physiological Functions in Mammalian Cells

  • Celia María Curieses Andrés,
  • José Manuel Pérez de la Lastra,
  • Celia Andrés Juan,
  • Francisco J. Plou and
  • Eduardo Pérez-Lebeña

22 November 2023

Hydrogen sulfide (H2S) was recognized as a gaseous signaling molecule, similar to nitric oxide (-NO) and carbon monoxide (CO). The aim of this review is to provide an overview of the formation of hydrogen sulfide (H2S) in the human body. H2S is synth...

  • Review
  • Open Access
12 Citations
7,163 Views
11 Pages

Anoxygenic Photosynthesis in Photolithotrophic Sulfur Bacteria and Their Role in Detoxication of Hydrogen Sulfide

  • Ivan Kushkevych,
  • Veronika Bosáková,
  • Monika Vítězová and
  • Simon K.-M. R. Rittmann

Hydrogen sulfide is a toxic compound that can affect various groups of water microorganisms. Photolithotrophic sulfur bacteria including Chromatiaceae and Chlorobiaceae are able to convert inorganic substrate (hydrogen sulfide and carbon dioxide) int...

  • Review
  • Open Access
120 Citations
13,352 Views
36 Pages

27 October 2022

Metal-sulfide nanostructures have piqued the interest of researchers for decades due to their intriguing optoelectronic properties. Indeed, significant advances and improvements have been made in various fundamental aspects for cutting-edge applicati...

  • Review
  • Open Access
40 Citations
7,074 Views
37 Pages

Biological Functions of Hydrogen Sulfide in Plants

  • Zhifeng Yang,
  • Xiaoyu Wang,
  • Jianrong Feng and
  • Shuhua Zhu

1 December 2022

Hydrogen sulfide (H2S), which is a gasotransmitter, can be biosynthesized and participates in various physiological and biochemical processes in plants. H2S also positively affects plants’ adaptation to abiotic stresses. Here, we summarize the...

  • Article
  • Open Access
7 Citations
4,150 Views
15 Pages

Hydrogen Sulfide Production with a Microbial Consortium Isolated from Marine Sediments Offshore

  • Roberto Briones-Gallardo,
  • Muriel González-Muñoz,
  • Itza García-Bautista,
  • David Valdés-Lozano,
  • Tanit Toledano-Thompson,
  • Erik Polanco-Lugo,
  • Renata Rivera-Madrid and
  • Ruby Valdez-Ojeda

Hydrogen, electric energy production, and metal toxic bioremediation are some of the biotechnological applications of sulfate-reducing organisms, which potentially depend on the sulfide produced. In this study, offshore of Yucatan, the capacity to pr...

  • Review
  • Open Access
8 Citations
2,979 Views
8 Pages

Implications of Hydrogen Sulfide in Development of Pulmonary Hypertension

  • Yan Sun,
  • Chaoshu Tang,
  • Hongfang Jin and
  • Junbao Du

The pathological mechanisms underlying pulmonary hypertension (PH), as well as its treatment strategy, are crucial issues in this field. This review aimed to summarize the pathological mechanisms by which the hydrogen sulfide (H2S) pathway contribute...

  • Review
  • Open Access
21 Citations
3,445 Views
12 Pages

8 February 2022

Autophagy is a degradative conserved process in eukaryotes to recycle unwanted cellular protein aggregates and damaged organelles. Autophagy plays an important role under normal physiological conditions in multiple biological processes, but it is ind...

  • Review
  • Open Access
41 Citations
6,420 Views
20 Pages

Molecular Functions of Hydrogen Sulfide in Cancer

  • Rodney E. Shackelford,
  • Islam Z. Mohammad,
  • Andrew T. Meram,
  • David Kim,
  • Fawaz Alotaibi,
  • Stavan Patel,
  • Ghali E. Ghali and
  • Christopher G. Kevil

Hydrogen sulfide (H2S) is a gasotransmitter that exerts a multitude of functions in both physiologic and pathophysiologic processes. H2S-synthesizing enzymes are increased in a variety of human malignancies, including colon, prostate, breast, renal,...

  • Proceeding Paper
  • Open Access
1 Citations
3,377 Views
4 Pages

Colorimetric Detection of Hydrogen Sulfide in Ambient Air

  • Laura Engel,
  • Karina R. Tarantik,
  • Carolin Pannek and
  • Jürgen Wöllenstein

21 November 2018

We present a fast method to monitor hydrogen sulfide (H2S) in ambient air based on a visible color change. Therefore, an immobilized copper(II) complex of the azo dye 1-(2-pyridylazo)-2-naphtol (H-PAN) was synthesized and prepared in a matrix for scr...

  • Review
  • Open Access
89 Citations
11,949 Views
23 Pages

Hydrogen Sulfide and Persulfides Oxidation by Biologically Relevant Oxidizing Species

  • Dayana Benchoam,
  • Ernesto Cuevasanta,
  • Matías N. Möller and
  • Beatriz Alvarez

22 February 2019

Hydrogen sulfide (H2S/HS–) can be formed in mammalian tissues and exert physiological effects. It can react with metal centers and oxidized thiol products such as disulfides (RSSR) and sulfenic acids (RSOH). Reactions with oxidized thiol produc...

  • Abstract
  • Open Access
1,585 Views
1 Page

Polyaniline Nanocomposites for Hydrogen Sulfide Detection at ppb Level

  • Caroline Duc,
  • Mohamed-Lamine Boukhenane,
  • Thomas Fagniez,
  • Nathalie Redon and
  • Jean-Luc Wojkiewicz

Coming from natural and anthropogenic sources, hydrogen sulfide gas (H2S) is a smelly hazardous substance at the sub-ppm level, which can lead to poisoning deaths at higher concentrations. New sensors with high metrological properties (detection limi...

  • Article
  • Open Access
43 Citations
8,501 Views
13 Pages

Hydrogen Sulfide Effects on the Survival of Lactobacilli with Emphasis on the Development of Inflammatory Bowel Diseases

  • Ivan Kushkevych,
  • Věra Kotrsová,
  • Dani Dordević,
  • Leona Buňková,
  • Monika Vítězová and
  • Amedeo Amedei

20 November 2019

The gut microbiota is a complex component of humans that depends on diet, host genome, and lifestyle. The background: The study purpose is to find relations between nutrition, intestinal lactic acid bacteria (LAB) from various environments (human, an...

  • Review
  • Open Access
1 Citations
2,141 Views
41 Pages

The gasotransmitter hydrogen sulfide (H2S; also termed sulfide) generally acts as a vasodilator in the systemic vasculature but causes a paradoxical constriction of pulmonary arteries (PAs). In light of evidence that a fall in the partial pressure in...

  • Article
  • Open Access
8 Citations
2,801 Views
21 Pages

Effect of Hydrogen Sulfide on Essential Functions of Polymorphonuclear Leukocytes

  • Sarah Farahat,
  • Salome Kherkheulidze,
  • Stephan Nopp,
  • Alexander Kainz,
  • Margherita Borriello,
  • Alessandra F. Perna and
  • Gerald Cohen

4 March 2023

Impaired polymorphonuclear leukocyte (PMNL) functions contribute to increased infections and cardiovascular diseases in chronic kidney disease (CKD). Uremic toxins reduce hydrogen sulfide (H2S) levels and the anti-oxidant and anti-inflammatory effect...

  • Article
  • Open Access
9 Citations
2,855 Views
15 Pages

Uterine Dysfunction in Diabetic Mice: The Role of Hydrogen Sulfide

  • Emma Mitidieri,
  • Domenico Vanacore,
  • Carlotta Turnaturi,
  • Raffaella Sorrentino and
  • Roberta d’Emmanuele di Villa Bianca

26 September 2020

It is well-known that the physiological uterine peristalsis, related to several phases of reproductive functions, plays a pivotal role in fertility and female reproductive health. Here, we have addressed the role of hydrogen sulfide (H2S) signaling i...

  • Review
  • Open Access
54 Citations
8,011 Views
25 Pages

The Role of Hydrogen Sulfide in Respiratory Diseases

  • Saadullah Khattak,
  • Qian-Qian Zhang,
  • Muhammad Sarfraz,
  • Pir Muhammad,
  • Ebenezeri Erasto Ngowi,
  • Nazeer Hussain Khan,
  • Saqib Rauf,
  • Yi-Zhen Wang,
  • Hui-Wen Qi and
  • Dong-Dong Wu
  • + 3 authors

Respiratory diseases are leading causes of death and disability around the globe, with a diverse range of health problems. Treatment of respiratory diseases and infections has been verified to be thought-provoking because of the increasing incidence...

  • Article
  • Open Access
2 Citations
840 Views
17 Pages

Hydrogen-Sulfide-Mediated PpAOS3-JA Module Provides Insight into Salt Stress Resistance in Peach

  • Xiaolan Gao,
  • Miao Li,
  • Qingtao Gong,
  • Guixiang Li,
  • Haixiang Yu,
  • Xiaomin Dong,
  • Xiaoyou Wang,
  • Zheng Gong,
  • Zhongtang Wang and
  • Anning Zhang
  • + 1 author

15 May 2025

Salt stress is one of the main abiotic stresses that affects peach growth. Hydrogen sulfide has an important role in regulating plant resistance to salt stress. However, the mechanism by which hydrogen sulfide regulates salt stress resistance is curr...

  • Review
  • Open Access
39 Citations
6,579 Views
17 Pages

Hydrogen Sulfide and Carbon Monoxide Tolerance in Bacteria

  • Sofia S. Mendes,
  • Vanessa Miranda and
  • Lígia M. Saraiva

Hydrogen sulfide and carbon monoxide share the ability to be beneficial or harmful molecules depending on the concentrations to which organisms are exposed. Interestingly, humans and some bacteria produce small amounts of these compounds. Since sever...

  • Article
  • Open Access
12 Citations
3,012 Views
10 Pages

A New Ratiometric Fluorescent Probe Based on BODIPY for Highly Selective Detection of Hydrogen Sulfide

  • Huan Xiang,
  • Tianqing Ye,
  • Yanbo Li,
  • Yanfei Lin,
  • Dan Liu,
  • Hongwei Zhou,
  • Jianbo Wang and
  • Lei Li

3 November 2022

Hydrogen sulfide (H2S) as small molecular signal messenger plays key functions in numerous biological processes. The imaging detection of intracellular hydrogen sulfide is of great significance. In this work, a ratiometric fluorescent probe BH based...

  • Article
  • Open Access
77 Citations
6,503 Views
11 Pages

Hydrogen Sulfide as a Toxic Product in the Small–Large Intestine Axis and its Role in IBD Development

  • Ivan Kushkevych,
  • Dani Dordević,
  • Peter Kollar,
  • Monika Vítězová and
  • Lorenzo Drago

19 July 2019

The small–large intestine axis in hydrogen sulfide accumulation and testing of sulfate and lactate in the gut–gut axis of the intestinal environment has not been well described. Sulfate reducing bacteria (SRB) of the Desulfovibrio genus r...

  • Review
  • Open Access
9 Citations
3,756 Views
17 Pages

28 November 2022

Atherosclerosis is the greatest contributor to cardiovascular events and is involved in the majority of deaths worldwide. Plaque rapture or erosion precipitates life-threatening thrombi, resulting in the obstruction blood flow to the heart (acute cor...

  • Review
  • Open Access
30 Citations
4,994 Views
13 Pages

Hydrogen Sulfide as a Potential Therapy for Heart Failure—Past, Present, and Future

  • Kyle B. LaPenna,
  • David J. Polhemus,
  • Jake E. Doiron,
  • Hunter A. Hidalgo,
  • Zhen Li and
  • David J. Lefer

Hydrogen sulfide (H2S) is an endogenous, gaseous signaling molecule that plays a critical role in cardiac and vascular biology. H2S regulates vascular tone and oxidant defenses and exerts cytoprotective effects in the heart and circulation. Recent st...

  • Review
  • Open Access
22 Citations
4,062 Views
14 Pages

Hydrogen sulfide (H2S) has been increasingly recognized as a crucial inflammatory mediator in immune cells, particularly macrophages, due to its direct and indirect effects on cellular signaling, redox homeostasis, and energy metabolism. The intricat...

  • Review
  • Open Access
24 Citations
4,890 Views
15 Pages

Regulation of Mitochondrial Respiration by Hydrogen Sulfide

  • Dandan Huang,
  • Guangqin Jing and
  • Shuhua Zhu

20 August 2023

Hydrogen sulfide (H2S), the third gasotransmitter, has positive roles in animals and plants. Mitochondria are the source and the target of H2S and the regulatory hub in metabolism, stress, and disease. Mitochondrial bioenergetics is a vital process t...

  • Article
  • Open Access
28 Citations
3,774 Views
14 Pages

Hydrogen Sulfide Alleviates Manganese Stress in Arabidopsis

  • Lixia Hou,
  • Zhaoxia Wang,
  • Guangxia Gong,
  • Ying Zhu,
  • Qing Ye,
  • Songchong Lu and
  • Xin Liu

Hydrogen sulfide (H2S) has been shown to participate in various stress responses in plants, including drought, salinity, extreme temperatures, osmotic stress, and heavy metal stress. Manganese (Mn), as a necessary nutrient for plant growth, plays an...

  • Article
  • Open Access
2 Citations
1,057 Views
15 Pages

Interactive Effects of Sulfide Addition and Heat Pretreatment on Hydrogen Production via Dark Fermentation

  • Tae-Hoon Kim,
  • Yun-Ju Jeon,
  • Sungjin Park,
  • Ji-Hye Ahn,
  • Junsu Park and
  • Yeo-Myeong Yun

Despite being recognized as toxic in anaerobic systems, sulfide’s potential to enhance hydrogen fermentation via microbial modulation remains underexplored. This study evaluated the combined effects of sulfide concentration (0–800 mg S/L)...

  • Feature Paper
  • Article
  • Open Access
15 Citations
3,874 Views
14 Pages

6 November 2023

Quantum dots (QDs) are promising semiconductor nanocrystals in photocatalysis due to their unique properties and in contrast to bulk semiconductors. Different from the traditional modification methods of indium phosphide (InP) QDs such as metal dopin...

  • Review
  • Open Access
22 Citations
5,217 Views
27 Pages

Hydrogen Sulfide Metabolism and Pulmonary Hypertension

  • Lukas Roubenne,
  • Roger Marthan,
  • Bruno Le Grand and
  • Christelle Guibert

12 June 2021

Pulmonary hypertension (PH) is a severe and multifactorial disease characterized by a progressive elevation of pulmonary arterial resistance and pressure due to remodeling, inflammation, oxidative stress, and vasoreactive alterations of pulmonary art...

  • Review
  • Open Access
16 Citations
3,803 Views
12 Pages

The Role of Hydrogen Sulfide Regulation of Autophagy in Liver Disorders

  • Xueqin Lu,
  • Yueming Ding,
  • Huiyang Liu,
  • Mengyao Sun,
  • Chaoran Chen,
  • Yihan Yang and
  • Honggang Wang

Autophagy is a complex process of degradation of senescent or dysfunctional organelles in cells. Dysfunctional autophagy is associated with many diseases such as cancers, immune dysfunction, and aging. Hydrogen sulfide (H2S) is considered to be the t...

  • Review
  • Open Access
51 Citations
7,387 Views
19 Pages

24 November 2021

This review focuses on the effects of hydrogen sulfide (H2S) on the unique bioenergetic molecular machines in mitochondria and bacteria—the protein complexes of electron transport chains and associated enzymes. H2S, along with nitric oxide and...

  • Review
  • Open Access
69 Citations
8,394 Views
16 Pages

The Hidden Role of Hydrogen Sulfide Metabolism in Cancer

  • Rong-Hsuan Wang,
  • Yu-Hsin Chu and
  • Kai-Ti Lin

Hydrogen Sulfide (H2S), an endogenously produced gasotransmitter, is involved in various important physiological and disease conditions, including vasodilation, stimulation of cellular bioenergetics, anti-inflammation, and pro-angiogenesis. In cancer...

  • Review
  • Open Access
46 Citations
11,174 Views
20 Pages

Role of Hydrogen Sulfide in Inflammatory Bowel Disease

  • Nathalie Stummer,
  • René G. Feichtinger,
  • Daniel Weghuber,
  • Barbara Kofler and
  • Anna M. Schneider

6 August 2023

Hydrogen sulfide (H2S), originally known as toxic gas, has now attracted attention as one of the gasotransmitters involved in many reactions in the human body. H2S has been assumed to play a role in the pathogenesis of many chronic diseases, of which...

  • Review
  • Open Access
82 Citations
16,774 Views
21 Pages

30 January 2019

Glutathione and aged garlic extract are sulfur-containing products that play important protective and regulatory roles within the immune system and in oxidative processes. Hydrogen sulfide (H2S), an endogenous, gaseous, signaling transmitter, has als...

  • Review
  • Open Access
85 Citations
10,635 Views
17 Pages

Hydrogen Sulfide and Endothelium-Dependent Vasorelaxation

  • Jerzy Bełtowski and
  • Anna Jamroz-Wiśniewska

16 December 2014

In addition to nitric oxide and carbon monoxide, hydrogen sulfide (H2S), synthesized enzymatically from l-cysteine or l-homocysteine, is the third gasotransmitter in mammals. Endogenous H2S is involved in the regulation of many physiological processe...

  • Review
  • Open Access
87 Citations
20,784 Views
26 Pages

17 February 2024

In the oil and gas industry, the corrosion attributed to hydrogen sulfide (H2S) is one of the most significant challenges. This review paper systematically investigates the diverse facets of H2S corrosion, including its sources, corrosion locations,...

  • Article
  • Open Access
16 Citations
3,014 Views
12 Pages

Kinetic Features of the Hydrogen Sulfide Sorption on the Ferro-Manganese Material

  • Elizaveta Cheremisina,
  • Olga Cheremisina,
  • Maria Ponomareva,
  • Viktor Bolotov and
  • Alexander Fedorov

5 January 2021

The kinetics of hydrogen sulfide sorption by the surface of a ferromanganese material containing in its composition a mixture of iron (II) and (III) oxides FeO × Fe2O3, takanelite (Mn, Ca) Mn4O9 × 3H2O and quartz SiO2, and which is sample...

  • Review
  • Open Access
123 Citations
7,246 Views
11 Pages

16 June 2021

Since the first description of hydrogen sulfide (H2S) as a toxic gas in 1713 by Bernardino Ramazzini, most studies on H2S have concentrated on its toxicity. In 1989, Warenycia et al. demonstrated the existence of endogenous H2S in the brain, suggesti...

  • Article
  • Open Access
6 Citations
2,421 Views
13 Pages

Since a large amount of sewage sludge (WSS) is generated daily, exploring effective methods for utilizing WSS is necessary. Although a photo-fermentation system sometimes alters the characteristics of microbial functions, there have been no attempts...

  • Review
  • Open Access
13 Citations
6,068 Views
14 Pages

Hydrogen Sulfide Enhances Plant Tolerance to Waterlogging Stress

  • Yaoqi Li,
  • Da Sun,
  • Ke Xu,
  • Libo Jin and
  • Renyi Peng

16 September 2021

Hydrogen sulfide (H2S) is considered the third gas signal molecule in recent years. A large number of studies have shown that H2S not only played an important role in animals but also participated in the regulation of plant growth and development and...

  • Review
  • Open Access
59 Citations
5,039 Views
18 Pages

8 November 2021

Hydrogen sulfide (H2S) has recently been considered as a crucial gaseous transmitter occupying extensive roles in physiological and biochemical processes throughout the life of plant species. Furthermore, plenty of achievements have been announced re...

  • Article
  • Open Access
17 Citations
5,483 Views
15 Pages

15 August 2019

Lung tissues are frequently exposed to a hyperoxia environment, which leads to oxidative stress injuries. Hydrogen sulfide (H2S) is widely implicated in physiological and pathological processes and its antioxidant effect has attracted much attention....

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