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Search Results (783)

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Keywords = Hierarchical Linear Modeling

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14 pages, 397 KB  
Article
Red Cell Distribution Width-Standard Deviation Is Associated with Cumulative Metabolic Burden but Not Independently with Metabolic Syndrome
by Kemal Ozan Lule, Nezihe Otay Lule, Mert Deniz Savcilioglu and Hamit Yildiz
Medicina 2026, 62(4), 647; https://doi.org/10.3390/medicina62040647 (registering DOI) - 28 Mar 2026
Abstract
Background and Objectives: Red cell distribution width (RDW) has been associated with adverse cardiometabolic outcomes; however, whether RDW—particularly RDW standard deviation (RDW-SD)—represents an independent determinant of metabolic syndrome (MetS) or reflects cumulative metabolic burden remains unclear. This study evaluated the association between [...] Read more.
Background and Objectives: Red cell distribution width (RDW) has been associated with adverse cardiometabolic outcomes; however, whether RDW—particularly RDW standard deviation (RDW-SD)—represents an independent determinant of metabolic syndrome (MetS) or reflects cumulative metabolic burden remains unclear. This study evaluated the association between RDW-SD and MetS presence and examined its relationship with the quantitative accumulation of MetS components. Materials and Methods: In this single-center observational study, 222 adults undergoing evaluation for MetS were consecutively recruited. Participants with overt anemia, extreme mean corpuscular volume values, or acute inflammation were excluded. MetS was defined according to revised NCEP ATP-III criteria. Associations between RDW-SD and MetS were assessed using hierarchical multivariable logistic regression models. The relationship between RDW-SD and the number of MetS components was examined using multivariable linear regression. Discriminative performance was evaluated by receiver operating characteristic (ROC) curve analysis. Results: MetS was present in 68.0% of participants. RDW-SD levels were significantly higher in individuals with MetS and increased progressively across quartiles. RDW-SD was independently associated with the number of MetS components (standardized β = 0.226, p < 0.001). However, RDW-SD was not independently associated with MetS presence in fully adjusted logistic models (OR = 1.07, 95% CI: 0.97–1.18, p = 0.198). The addition of RDW-SD provided minimal incremental explanatory value (Nagelkerke R2 increase from 0.348 to 0.356). ROC analysis demonstrated poor discriminatory ability (area under the curve [AUC] = 0.611, 95% CI: 0.535–0.687), supporting limited standalone diagnostic utility. Conclusions: RDW-SD was independently associated with cumulative metabolic burden but not with the independent presence of MetS after adjustment for established cardiometabolic factors. Given the cross-sectional design, these findings should be interpreted as associative rather than causal. Full article
(This article belongs to the Section Endocrinology)
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24 pages, 4739 KB  
Article
Hierarchical Cooperative Control of Trajectory Tracking and Stability for Distributed Drive Electric Vehicles Under Extreme Conditions
by Guosheng Wang, Jian Liu and Gang Liu
Actuators 2026, 15(4), 182; https://doi.org/10.3390/act15040182 - 26 Mar 2026
Abstract
To enhance the trajectory tracking accuracy and lateral stability of distributed-drive electric vehicles, a hierarchical cooperative control strategy optimized by the Genetic–Firefly Algorithm (G-FA) is proposed. First, bottom-level controllers for trajectory tracking utilizing a Linear Quadratic Regulator (LQR) and stability relying on Sliding [...] Read more.
To enhance the trajectory tracking accuracy and lateral stability of distributed-drive electric vehicles, a hierarchical cooperative control strategy optimized by the Genetic–Firefly Algorithm (G-FA) is proposed. First, bottom-level controllers for trajectory tracking utilizing a Linear Quadratic Regulator (LQR) and stability relying on Sliding Mode Control (SMC) are jointly optimized offline using the G-FA to address the limitations of empirical parameter tuning and effectively mitigate chattering. Compared to traditional Nonlinear Model Predictive Control (NMPC), which relies on computationally demanding dynamic programming, the proposed G-FA acts as an efficient approximate optimization method that significantly reduces the online computational burden while maintaining high control accuracy. Second, an adaptive cooperative mechanism based on desired yaw rate correction is introduced. By constructing two reference benchmarks—“tracking-oriented” and “stability-oriented”—a cooperative weighting coefficient adapts the fusion of control objectives based on the vehicle’s stability state. Hardware-in-the-loop (HIL) simulation results demonstrate that, under high-adhesion double lane change maneuvers, the proposed strategy reduces peak lateral error and sideslip angle by 31.53% and 28.08%, respectively, compared to traditional LQR. In low-adhesion S-curve limit maneuvers, where traditional LQR fails, the proposed strategy outperforms the NMPC benchmark, further reducing these indices by 61.98% and 8.33%, respectively, significantly improving control performance under extreme conditions. Full article
(This article belongs to the Section Actuators for Surface Vehicles)
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16 pages, 4249 KB  
Article
Analysis Method for the Grid at the Sending End of Renewable Energy Scale Effect Under Typical AC/DC Transmission Scenarios
by Zheng Shi, Yonghao Zhang, Yao Wang, Yan Liang, Jiaojiao Deng and Jie Chen
Electronics 2026, 15(7), 1382; https://doi.org/10.3390/electronics15071382 - 26 Mar 2026
Abstract
In the context of the coordinated development of high-proportion renewable energy integration and alternating current/direct current (AC/DC) hybrid transmission, the sending-end power grid faces challenges such as decreased system strength, contracted stability boundaries, and difficulties in covering high-risk operating conditions. This paper proposes [...] Read more.
In the context of the coordinated development of high-proportion renewable energy integration and alternating current/direct current (AC/DC) hybrid transmission, the sending-end power grid faces challenges such as decreased system strength, contracted stability boundaries, and difficulties in covering high-risk operating conditions. This paper proposes a new renewable energy scale impact analysis method that integrates “typical scenario construction-scale ladder comparison–prediction-driven time series injection” in response to the operational constraints of AC/DC transmission. In terms of method implementation, firstly, a two-layer typical scenario system is constructed under unified transmission constraints and fixed grid boundaries: A regular benchmark scenario covers the main operating range, and a set of high-risk scenarios near the boundaries is obtained through multi-objective intelligent search, which is then refined through clustering to form a computable stress-test scenario library. Here, the boundary scenarios are generated by a multi-objective search that simultaneously drives multiple key section load rates towards their limits, subject to AC power-flow feasibility and operational constraints, and the resulting Pareto candidates are reduced into a compact stress-test library by clustering. Secondly, a ladder scenario with increasing renewable energy scale is constructed, and cross-scale comparisons are carried out within the same scenario system to extract the scale effect and critical laws of key safety indicators. Finally, data resampling and Gated Recurrent Unit multi-step prediction are introduced to generate wind power output time series, enabling the temporal mapping of prediction results to scenario injection quantities, and constructing a closed-loop input interface of “prediction–scenario–grid indicators”. The results demonstrate that the proposed hierarchical framework, under unified AC/DC export constraints, can effectively construct a compact stress-test scenario library with enhanced boundary-risk coverage and can reveal how transient voltage security evolves across renewable expansion scales. By coupling boundary-oriented scenario construction, cross-scale comparable assessment, and forecasting-driven time series injection, the framework improves engineering interpretability and practical applicability compared with conventional scenario sampling/reduction workflows. For the forecasting module, the Gated Recurrent Unit (GRU) model achieves MAPE = 8.58% and RMSE = 104.32 kW on the test set, outperforming Linear Regression (LR)/Random Forest (RF)/Support Vector Regression (SVR) in multi-step ahead prediction. Full article
(This article belongs to the Special Issue Applications of Computational Intelligence, 3rd Edition)
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25 pages, 6659 KB  
Article
MDS3-Net: A Multiscale Spectral–Spatial Sequence Hybrid CNN–Transformer Model for Hyperspectral Image Classification
by Taonian Bian, Bin Yang, Yuanjiang Chen, Xuan Zhou, Li Yue and Shunshi Hu
Remote Sens. 2026, 18(7), 977; https://doi.org/10.3390/rs18070977 - 25 Mar 2026
Viewed by 204
Abstract
Hyperspectral image (HSI) classification faces significant challenges due to the spatial–spectral heterogeneity of land covers and the geometric rigidity of standard convolutions. Although Transformers offer powerful global modeling capabilities, their quadratic computational complexity limits practical efficiency. To address these limitations, this paper proposes [...] Read more.
Hyperspectral image (HSI) classification faces significant challenges due to the spatial–spectral heterogeneity of land covers and the geometric rigidity of standard convolutions. Although Transformers offer powerful global modeling capabilities, their quadratic computational complexity limits practical efficiency. To address these limitations, this paper proposes a novel hierarchical framework named MDS3-Net (Multiscale Deformable Spectral–Spatial Sequence Network). Specifically, we design a Multiscale Spectral-Deformable Convolution (MSDC) module that adopts a cascaded strategy to sequentially extract discriminative spectral features and adaptively align spatial receptive fields with irregular object boundaries. To capture long-range dependencies efficiently, a Spectral–Spatial Sequence (S3) Encoder is introduced based on a gated large-kernel convolution mechanism, achieving global context modeling with linear complexity. Furthermore, a Dual-Path Feature Extraction (DPFE) module is proposed to perform semantics-preserving dimension reduction via spectral reorganization and spatial attention. Experimental results on four public datasets demonstrate that the proposed MDS3-Net achieves state-of-the-art classification performance and exhibits superior robustness under limited training samples compared to existing methods. Full article
(This article belongs to the Section Remote Sensing Image Processing)
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18 pages, 3126 KB  
Article
SS-AdaMoE: Spatio-Spectral Adaptive Mixture of Experts with Global Structural Priors for Graph Node Classification
by Xilin Kang, Tianyue Yu, Letao Wang, Yutong Guo and Fengjun Zhang
Entropy 2026, 28(3), 355; https://doi.org/10.3390/e28030355 - 21 Mar 2026
Viewed by 130
Abstract
Graph Neural Networks (GNNs) have emerged as the standard for learning representations from graph-structured data. While traditional architectures relying on message-passing mechanisms excel in homophilic settings, they essentially function as fixed low-pass filters. However, this smoothing operation limits their ability to generalize to [...] Read more.
Graph Neural Networks (GNNs) have emerged as the standard for learning representations from graph-structured data. While traditional architectures relying on message-passing mechanisms excel in homophilic settings, they essentially function as fixed low-pass filters. However, this smoothing operation limits their ability to generalize to heterophilic graphs, where connected nodes often exhibit dissimilar labels and high-frequency signals are crucial for discrimination. Furthermore, existing Mixture-of-Experts (MoE) methods for graphs often suffer from local-view routing, failing to capture global structural context during expert selection. To address these challenges, this paper proposes SS-AdaMoE, a novel Spatio-Spectral Adaptive Mixture of Experts framework designed for robust node classification across diverse graph patterns. Specifically, a Dual-Domain Expert System is constructed, integrating heterogeneous spatial aggregators with learnable spectral filters based on Bernstein polynomials. This allows the model to adaptively capture arbitrary frequency responses—including high-pass and band-pass signals—which are overlooked by standard GNNs. To resolve the locality bias, a Hierarchical Global-Prior Gating Network augmented by a Linear Graph Transformer is introduced, ensuring that expert selection is guided by both local node features and global topological awareness. Extensive experiments are conducted on five benchmark datasets spanning both homophilic and heterophilic networks. The results demonstrate that SS-AdaMoE consistently outperforms baselines, achieving accuracy improvements of up to 2.65% on Chameleon and 1.41% on Roman-empire over the strongest MoE baseline, while surpassing traditional GCN architectures by margins exceeding 28% on heterophilic datasets such as Texas. These findings validate that the synergy of learnable spectral priors and global gating effectively bridges the gap between spatial aggregation and spectral filtering. Full article
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19 pages, 3171 KB  
Article
Beyond Time: Divergent Successional Trajectories Driven by Legacies and Edaphic Filters in a Tropical Karst Forest of Yucatan Peninsula, Mexico
by Aixchel Maya-Martinez, Josué Delgado-Balbuena, Ligia Esparza-Olguín, Yameli Guadalupe Aguilar-Duarte, Eduardo Martínez-Romero and Teresa Alfaro Reyna
Forests 2026, 17(3), 386; https://doi.org/10.3390/f17030386 - 20 Mar 2026
Viewed by 197
Abstract
Secondary succession in tropical forests is traditionally described as a linear process driven by time since disturbance. However, growing evidence suggests that recovery pathways depend strongly on historical and environmental contexts. We evaluated how disturbance legacies and edaphic constraints interact to shape successional [...] Read more.
Secondary succession in tropical forests is traditionally described as a linear process driven by time since disturbance. However, growing evidence suggests that recovery pathways depend strongly on historical and environmental contexts. We evaluated how disturbance legacies and edaphic constraints interact to shape successional trajectories in a tropical karst landscape of the Maya Forest, Mexico. We sampled 100 plots along a chronosequence, quantifying vegetation structure, floristic diversity, biomass (NDVI), disturbance legacies, and soil properties. Using unsupervised clustering (K-means) and multivariate ordination, we identified four contrasting ecological typologies that represent distinct successional states rather than transient stages. Our results show a pronounced dichotomy in vegetation dynamics following the abandonment of land-use practices: while some sites are experiencing diverse development due to positive forest legacies (Typology B), others remain stalled (Typology C), dominated by lianas, where biotic barriers inhibit tree regeneration despite decades of abandonment. Additionally, we documented an asynchronous recovery between floristic recovery and vertical development; in sites with edaphic constraints, forests reach high diversity and biomass but exhibit stunted growth (Typology D). This suggests that severe abiotic constraints—specifically high rockiness and shallow soils—limit the dominance of highly competitive species, thereby acting as a filter that maintains high levels of diversity despite structural limitations. Edaphic analysis confirmed that chemical fertility and physical constraints (rockiness and shallow depth) act as orthogonal filters. This explains the persistence of structurally constrained yet functionally mature forests as stable, edaphically determined outcomes. Overall, secondary succession in tropical karst is nonlinear and path-dependent, governed by a hierarchical filtering model where historical land use dictates community identity and physical substrate limits structural architecture. These findings highlight the need for trajectory-specific management and the abandonment of uniform expectations of forest recovery in karst landscapes. Full article
(This article belongs to the Special Issue Secondary Succession in Forest Ecosystems)
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18 pages, 469 KB  
Article
Profiling Personality to Predict Athletes’ Academic Achievement: Cross-Cultural Analysis
by Aleksandra M. Rogowska, Cezary Kuśnierz and Iuliia Pavlova
Behav. Sci. 2026, 16(3), 461; https://doi.org/10.3390/bs16030461 - 20 Mar 2026
Viewed by 344
Abstract
Research using latent profile analysis (LPA) has yielded inconsistent results regarding the number of personality profiles among athletes, the specific configuration of the Big Five traits, and their interpretation. This study seeks to explore personality types by excluding additional variables from the LPA [...] Read more.
Research using latent profile analysis (LPA) has yielded inconsistent results regarding the number of personality profiles among athletes, the specific configuration of the Big Five traits, and their interpretation. This study seeks to explore personality types by excluding additional variables from the LPA model, aiming to assess how well personality profiles are universal (independent of gender and cultural context) and can predict academic achievement in student athletes. A cross-sectional study was conducted using a paper-and-pencil questionnaire among 424 student athletes from two universities in Poland and Ukraine. The average age of participants was 20 years old (M = 20.01; SD = 2.48), 62% were male, 53% lived in Poland, and 58% studied Sports Sciences vs. 42% Physical Education. The Mini-International Personality Item Pool (Mini-IPIP) was used to assess the Big Five personality traits, and grade point average (GPA) was used to measure students’ academic achievements in the last semester. The LPA identified four personality profiles: (1) Restrained Neurotic (Profile 1, 32%), Open Extravert (Profile 2, 42%), Competitive Neurotic (Profile 3, 17%), and Cooperative Perfectionist (Profile 4, 8%). Profiles 1, 3, and 4 showed similarly low levels of emotional stability, extraversion, and intellect but differed significantly in agreeableness and conscientiousness. Gender and country differences across athletes representing specific profiles were also noted. Profile 2 showed the strongest link with academic achievement. Hierarchical multiple linear regression showed that LPA profiles explained only 2% of GPA variance, compared to Big Five personality traits (9%) and demographic variables, such as sex, country, and study major (8%), which were also included in the following steps in the regression model, explaining only 9% and 8%, respectively. Most student athletes (52%) with personality profiles 1 (Restrained Neurotic), 3 (Competitive Neurotic), and 4 (Cooperative Perfectionist) may require psychological training to better cope with negative emotions and stress arising in competitive and academic settings. Profile 2 (Open Extravert) seems to be the most adaptive and potentially successful personality type. Personality types are, at least to some extent, related to gender and country of residence. More cross-cultural research is required to further verify the types of athletic personalities. Full article
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13 pages, 604 KB  
Article
An Evidence-Based Tiered Intervention Strategy for Student Physical Health: Design and Implementation
by Xiongce Lv and Yang Xue
Appl. Sci. 2026, 16(6), 2988; https://doi.org/10.3390/app16062988 - 20 Mar 2026
Viewed by 146
Abstract
The physical and mental health of adolescents is a cornerstone of national future. However, traditional “one-size-fits-all” school health interventions often fail to address the diverse needs of students. To overcome this limitation, this research introduces an evidence-based, tiered intervention model designed to provide [...] Read more.
The physical and mental health of adolescents is a cornerstone of national future. However, traditional “one-size-fits-all” school health interventions often fail to address the diverse needs of students. To overcome this limitation, this research introduces an evidence-based, tiered intervention model designed to provide personalized health support. This study constructs and validates a dynamic ‘Dynamic Weighting-based Asset-Condition-Resource Allocation-Evaluation-Feedback’ (DWA-CRISPR) tiered intervention model, moving from a “triage-driven” to a “needs-driven” service delivery framework. The model is built upon a Response to Intervention (RTI)/Multi-Tiered System of Support (MTSS) three-tier structure and integrates ecological systems theory, social cognitive theory, and the health belief model. Using a quasi-experimental design with propensity score matching (PSM), the intervention’s effectiveness was evaluated on a final matched cohort of 470 students. Difference-in-differences (DID) analysis was then employed to assess the outcomes. The results demonstrate that the tiered intervention significantly reduced the BMI Z-scores of at-risk students compared to the control group. Furthermore, by employing XGBoost and SHAP, the study identified key risk factors, such as cardiorespiratory fitness and baseline BMI, enabling precise and early risk identification. Hierarchical linear models (HLMs) further clarified the multi-level factors influencing intervention outcomes. In conclusion, the DWA-CRISPR tiered model proves to be more effective than traditional approaches, providing a scientific, efficient, and personalized pathway for improving the physical health of primary and secondary school students. Full article
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19 pages, 1232 KB  
Article
Network-Level Modeling of Pavement Surface Macrotexture Degradation Using Linear Mixed-Effects Models
by Raul Almeida, Adriana Santos, Susana Faria and Elisabete Freitas
Infrastructures 2026, 11(3), 101; https://doi.org/10.3390/infrastructures11030101 - 18 Mar 2026
Viewed by 153
Abstract
Surface texture plays a key role in pavement safety and performance, yet its degradation is influenced by multiple interacting factors that vary across road networks. This study developed statistical models to characterize and predict surface texture evolution on Portuguese highways using linear mixed-effects [...] Read more.
Surface texture plays a key role in pavement safety and performance, yet its degradation is influenced by multiple interacting factors that vary across road networks. This study developed statistical models to characterize and predict surface texture evolution on Portuguese highways using linear mixed-effects modeling. Texture measurements collected on 7204 pavement sections, each 100 m in length, over three monitoring cycles were analyzed alongside traffic, climatic, pavement structural, geometric, and spatial variables. The hierarchical structure of the data, with repeated measurements nested within pavement sections, was explicitly accounted for via random intercepts and random slopes. At the same time, temporal correlation was modeled via an autoregressive error structure. Two model specifications were evaluated: a model including only traffic and climatic variables and an extended model incorporating pavement and geometric characteristics. Results indicate that texture evolution is statistically associated with cumulative traffic loading, temperature-related indicators, precipitation, surface course type, lane position, vertical alignment, and altitude. The extended model showed a significantly better fit and superior predictive performance, as confirmed by information criteria and cross-validation metrics. The findings highlight the importance of accounting for section-level heterogeneity and roadway characteristics when modeling texture degradation. The proposed modeling framework provides a statistically scalable and robust tool for texture prediction, accounting for regional-specificities and long-term pavement management decisions. Full article
(This article belongs to the Special Issue Sustainable Road Design and Traffic Management)
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24 pages, 996 KB  
Article
Predictors of Psychological Well-Being Among Pre-Service Teachers: Emotional Intelligence and Occupational Anxiety
by Ümit İzgi Onbaşılı
J. Intell. 2026, 14(3), 49; https://doi.org/10.3390/jintelligence14030049 - 17 Mar 2026
Viewed by 330
Abstract
This study examined psychological well-being as the outcome and its associations with emotional intelligence and occupational anxiety in a sample of pre-service teachers (n = 360) from 74 universities in Türkiye. Participants completed the Trait Emotional Intelligence Questionnaire-Short Form (TEIQue-SF), the Ryff [...] Read more.
This study examined psychological well-being as the outcome and its associations with emotional intelligence and occupational anxiety in a sample of pre-service teachers (n = 360) from 74 universities in Türkiye. Participants completed the Trait Emotional Intelligence Questionnaire-Short Form (TEIQue-SF), the Ryff Psychological Well-Being Scale (PWBS), and the Occupational Anxiety Scale (OAS). After descriptive statistics and Pearson correlations, multiple linear regression was conducted; incremental validity was examined with a two-block hierarchical model. Emotional intelligence was positively associated with psychological well-being, whereas occupational anxiety showed a negative association. In the regression model, emotional intelligence (Beta = 0.66) and occupational anxiety (Beta = −0.28) jointly explained 71% of the variance in psychological well-being (R = 0.84, R2 = 0.71, F(2, 357) = 426.18, p < 0.001). Mediation analysis (PROCESS Model 4, 5000 bootstrap resamples) further supported an indirect association whereby higher emotional intelligence was related to lower occupational anxiety, which in turn was related to higher psychological well-being, while the direct association remained significant. These findings suggest that strengthening socio-emotional competencies and integrating anxiety regulation strategies within teacher education may support well-being outcomes. The principal limitations are the cross-sectional design and reliance on self-report measures, so inferences are correlational rather than causal. Future research should include longitudinal or quasi-experimental evaluations of interventions targeting emotional intelligence and anxiety regulation, using multi-method measurement and tests of moderation and multilevel models. Full article
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30 pages, 3316 KB  
Article
A Novel Hybrid CNN-ViT-Based Bi-Directional Cross-Guidance Fusion-Driven Breast Cancer Detection Model
by Abdul Rahaman Wahab Sait and Yazeed Alkhurayyif
Life 2026, 16(3), 474; https://doi.org/10.3390/life16030474 - 14 Mar 2026
Viewed by 278
Abstract
Accurate and early identification of breast cancer from mammography is key to reducing breast cancer mortality, and automated analysis is challenging due to subtle lesion appearances, heterogeneous breast density, and the variance caused by modality. Standard Convolutional Neural Networks (CNNs) are excellent at [...] Read more.
Accurate and early identification of breast cancer from mammography is key to reducing breast cancer mortality, and automated analysis is challenging due to subtle lesion appearances, heterogeneous breast density, and the variance caused by modality. Standard Convolutional Neural Networks (CNNs) are excellent at capturing localized textures, whereas Vision Transformers (ViTs) capture long-range dependencies; however, both often struggle to produce a unified representation that consistently supports diagnostic decision-making. To address these limitations, this study presents a dual-stream framework integrating ConvNeXt for high-fidelity local feature extraction with Swin Transformer V2 for hierarchical global context modeling. A Bi-Directional Cross-Guidance (BDCG) mechanism is added to harmonize interactions between the two feature domains and ensure mutual information learning in the representations. Furthermore, a Prototype-Anchored Similarity Head (PASH) is used to stabilize classification using distance-based reasoning instead of using linear separation. Comprehensive experiments show the effectiveness of the proposed method using two benchmark datasets. On Dataset 1, the model achieves accuracy: 98.8%, precision: 98.7%, recall: 98.6%, and F1 score: 97.2%, outperforming existing models based on CNN, ViTs, and hybrid architectures, and provides a lower inference time (8.3 ms/image). On the more heterogeneous Dataset 2, the model maintains strong performance, with an accuracy of 97.0%, precision of 95.4%, recall of 94.8%, and F1-score of 95.1%, demonstrating its resilience to domain shift and imaging variability. These results underscore the value of structural multi-scale feature interaction and prototype-driven classification for robust mammographic analysis. The consistent performance across internal and external evaluations indicates the potential for the proposed framework to be reliably applied in computer-aided screening systems. Full article
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19 pages, 3586 KB  
Article
Exploratory Multivariate Analysis of Mediator Organization in Canine Platelet-Rich Gel Under NSAID Exposure
by Jorge U. Carmona, Julián Ospina and Catalina López
Gels 2026, 12(3), 246; https://doi.org/10.3390/gels12030246 - 14 Mar 2026
Viewed by 231
Abstract
Platelet-rich gel (PRG) is a fibrin-based biobased biomaterial generated by activating platelet-rich plasma (PRP), yet its biological characterization has commonly relied on univariate measurements of isolated mediators. This study aimed to define the multivariate biological organization of PRG and related hemocomponents (PRP, chemically [...] Read more.
Platelet-rich gel (PRG) is a fibrin-based biobased biomaterial generated by activating platelet-rich plasma (PRP), yet its biological characterization has commonly relied on univariate measurements of isolated mediators. This study aimed to define the multivariate biological organization of PRG and related hemocomponents (PRP, chemically induced platelet lysate (CIPL), and plasma) in a canine model under single exposure to non-steroidal anti-inflammatory drugs (NSAIDs). In a randomized crossover design (n = 6 dogs), hemocomponents were produced at baseline (0 h) and 6 h after administration of carprofen or firocoxib. Platelet and white blood cell (WBC) counts, growth factors (platelet-derived growth factor-BB (PDGF-BB) and transforming growth factor beta-1 (TGF-β1)), and cytokines (tumor necrosis factor alpha (TNF-α), interleukin-1 beta, and interleukin-10) were integrated using linear mixed-effects modeling, principal component analysis (PCA), and hierarchical clustering. PRG was derived from a leukocyte-poor PRP precursor with moderate platelet enrichment (~1.6-fold vs. whole blood) and a marked WBC reduction (~8–9-fold). In mixed-effects modeling, hemocomponent type significantly influenced the PDGF-BB:TNF-α log-ratio, with PRG (estimate −1.12; 95% CI −1.34 to −0.90) and plasma (−2.06; 95% CI −2.28 to −1.84) lower than PRP, while CIPL did not differ. Time and NSAID effects were not supported. PCA identified two orthogonal axes explaining 61.3% of total variance (PC1 = 43.7%, PC2 = 18.6%), separating a platelet/trophic dimension (log(PDGF-BB), log(TGF-β1), platelet count, PDGF-BB:TNF-α log-ratio) from an inflammatory dimension (log(TNF-α), log(IL-1β)). Overall, hemocomponent composition emerged as the primary determinant of mediator organization, supporting the interpretation of PRG as a structured, biomaterial defined by coordinated mediator networks. Full article
(This article belongs to the Special Issue Biobased Gels for Drugs and Cells (2nd Edition))
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21 pages, 709 KB  
Article
SBT-Rec: A Structured Behavioral Tokenization Framework for LLM-Based Sequential Recommendation
by Langgao Cheng, Yanying Mao, Guowang Li and Honghui Chen
Big Data Cogn. Comput. 2026, 10(3), 86; https://doi.org/10.3390/bdcc10030086 - 10 Mar 2026
Viewed by 340
Abstract
Generative recommendation systems based on Large Language Models leverage their reasoning capabilities to capture users’ latent interests. However, aligning continuous user behavioral embeddings with the discrete semantic space of LLMs remains a challenge. Direct alignment often leads to semantic mismatch and hallucination issues. [...] Read more.
Generative recommendation systems based on Large Language Models leverage their reasoning capabilities to capture users’ latent interests. However, aligning continuous user behavioral embeddings with the discrete semantic space of LLMs remains a challenge. Direct alignment often leads to semantic mismatch and hallucination issues. Furthermore, existing methods typically rely on multi-stage training strategies to adapt to variations in feature distributions, thereby limiting training efficiency. To address the aforementioned issues, we propose SBT-Rec, a structured behavioral tokenization framework. Specifically, we first design a hierarchical discrete structure discovery module, utilizing a recursive residual quantization mechanism to decompose continuous behavioral vectors into discrete behavioral atoms to resolve modality discrepancies. Second, the multi-scale behavioral semantic reconstruction module reconstructs behavioral representations via residual superposition, thereby reducing data noise. Third, a residual-aware modality distribution aligner is introduced to transform behavioral features into input tokens compatible with the LLM via non-linear mapping. Finally, based on structured discrete representations, we propose a single-stage behavioral-semantic adaptive optimization strategy, achieving end-to-end parameter-efficient fine-tuning. Experiments on the MovieLens, LastFM, and Steam datasets demonstrate that SBT-Rec outperforms existing baseline models in terms of recommendation accuracy, training efficiency, and noise robustness. Full article
(This article belongs to the Special Issue Multimodal Deep Learning and Its Applications)
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24 pages, 541 KB  
Article
Entrepreneurial Intentions Among Saudi Sports Education Students: Extending the Theory of Planned Behavior with Entrepreneurial Role Models
by Hayet Jemli, Wassim J. Aloulou and Amal Hassan Alhazmi
Educ. Sci. 2026, 16(3), 406; https://doi.org/10.3390/educsci16030406 - 6 Mar 2026
Viewed by 242
Abstract
This study investigated the determinants of entrepreneurial intentions and behavior among Saudi sports education students using the Theory of Planned Behavior. The study employed a cross-sectional survey of 372 undergraduate and graduate sports science students from Saudi universities. It extended TPB by including [...] Read more.
This study investigated the determinants of entrepreneurial intentions and behavior among Saudi sports education students using the Theory of Planned Behavior. The study employed a cross-sectional survey of 372 undergraduate and graduate sports science students from Saudi universities. It extended TPB by including entrepreneurial role models as an independent variable affecting TPB antecedents—attitudes toward behavior, subjective norms and perceived behavioral control and outcomes (ENTIs and actual entrepreneurial behavior, AEB). Data were analyzed using linear and hierarchical regression with mediation testing using bootstrapping. Results showed that all TPB antecedents significantly predicted ENTI, while only ENTI and PBC influenced AEB. ERMs were significantly associated with SNs but had no direct effect on ATB, PBC, or ENTI. Mediation analyses revealed that ATB and PBC partially mediated SNs’ effect on ENTI, whereas SNs fully mediated ERMs’ influence on ATB and PBC. These findings provide theoretical and practical insights by validating the extension of TPB with role models, challenging assumptions about ERMs’ direct effects, and highlighting the importance of fostering entrepreneurial culture in universities. Integrating exposure to positive ERMs can effectively translate students’ intentions into entrepreneurial behavior, supporting the development of sports entrepreneurs. Full article
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37 pages, 5077 KB  
Article
A Study on Landscape Satisfaction in Micro-Scale Waterfront Spaces: Evidence from the Grand Canal in Wuxi
by Wei Liu, Jizhou Chen, Xiaobin Li, Yueling Xiao, Xuqi Wang and Rong Zhu
Sustainability 2026, 18(5), 2606; https://doi.org/10.3390/su18052606 - 6 Mar 2026
Viewed by 298
Abstract
Micro-scale waterfront spaces play a critical role in contemporary urban regeneration by supporting everyday activities and place-based experiences. However, existing studies often rely on linear evaluation approaches and insufficiently address the asymmetric effects of functional, environmental, and cultural attributes on residents’ landscape satisfaction. [...] Read more.
Micro-scale waterfront spaces play a critical role in contemporary urban regeneration by supporting everyday activities and place-based experiences. However, existing studies often rely on linear evaluation approaches and insufficiently address the asymmetric effects of functional, environmental, and cultural attributes on residents’ landscape satisfaction. This study investigates the satisfaction structure of micro-scale waterfront spaces along the Grand Canal in Wuxi, China, with a particular focus on nonlinear demand mechanisms. A mixed-method framework integrating grounded theory, the Delphi method, and the Kano model was employed to identify key landscape attributes and classify their satisfaction effects. The results reveal a hierarchical satisfaction mechanism characterized by “basic–performance–attractive” attributes. Fundamental functional and environmental factors, such as accessibility, safety, water quality, and cultural authenticity, function as must-be attributes that primarily prevent dissatisfaction. Environmental comfort and social facilities act as one-dimensional attributes that linearly enhance satisfaction, while cultural narratives, memory-related elements, and ecological esthetics emerge as attractive attributes that significantly elevate emotional engagement when present. Sensitivity analysis further identifies priority intervention factors with the greatest impact on satisfaction improvement. These findings demonstrate the asymmetric nature of residents’ landscape satisfaction and provide a phased optimization framework for the sustainable regeneration of heritage-based micro-scale waterfront spaces, emphasizing basic reliability, experiential enhancement, and cultural resonance. Full article
(This article belongs to the Topic Contemporary Waterfronts, What, Why and How?)
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