Search Results (10)

The building sector is a critical component of the European Union’s strategy to achieve climate neutrality, as it accounts for 30–40% of total energy consumption and significant greenhouse gas emissions. While sustainability certification systems like BREEAM, LEED, DGNB, and HQE have established frameworks for environmental assessment, their widespread adoption in the residential sector faces challenges related to complexity and technical barriers. This paper provides a state-of-the-art literature review on streamlining sustainability certification for residential buildings in the EU. It examines the transition from established private schemes to harmonised frameworks such as Level(s), alongside the integration of Building Information Modelling (BIM) and Life Cycle Assessment (LCA). The review identifies key obstacles, including data interoperability issues, the need for automated quantity extraction, and the lack of technical expertise among stakeholders. Findings suggest that streamlining requires advancing semantic data models and digital twins to enable real-time performance monitoring and automated compliance checking. Furthermore, the alignment of national building codes with the Energy Performance of Buildings Directive (EPBD) and the European Green Deal is essential for fostering a more cohesive certification landscape. The study concludes by outlining pathways for reducing the administrative and technical burden of certification to support the EU’s decarbonisation and renovation goals. Full article

Background: Gastric cancer (GC) is the fifth most common malignancy worldwide. Early detection of precancerous conditions—atrophic gastritis (AG), intestinal metaplasia (IM), and dysplasia—is vital for surveillance. Objectives: To assess the accuracy of single high-quality endoscopy (HQE) in detecting advanced GPCs and to identify risk factors for AG, IM, and dysplasia. Methods: A retrospective review of 442 gastroscopies (2017–2022) at a single center. Endoscopic findings were compared with histology, including OLGA/OLGIM staging, dysplasia, and Helicobacter pylori (H. pylori) status. Results: The study population comprised 319 women (72.17%) and 123 men (27.83%), with a mean age of 59 years (SD: 12.53). AG, as defined by OLGA and OLGIM staging, was identified in 90 patients (20.36%) and 50 patients (11.31%), respectively. A total of 44 cases of de novo gastric dysplasia were observed, while HP infection was confirmed in 37 individuals (8.37%). We observed similar low sensitivity for detection of advanced OLGA (32.5%), OLGIM (40%), and dysplasia (19.7%) with relatively high specificity (~89%). Advanced AG and IM peaked at ages 51–53. Risk factors for advanced OLGIM included male sex (OR 2.26; p < 0.001) and presence of dysplasia (OR 2.09; p = 0.02). Dysplasia was positively associated with AG (OR 2.03; p < 0.001) and IM (OR 2.21; p < 0.001) but inversely associated with a family history of GC (OR 0.44; p < 0.001). Conclusions: A single HQE can help exclude advanced GPCs, but due to low sensitivity, gastric mapping biopsies remain crucial. Males are at increased risk of extensive IM. Family history of GC was linked to lower OLGA/OLGIM stages. Full article

Utilizing data from 282 prefecture-level cities in China from 2005 to 2021, this study constructs an evaluation index system for high-quality economic development across the following five dimensions: innovation, coordination, green, openness, and sharing. A continuous difference-in-differences approach is employed for regression analysis to empirically examine the impact of high-speed rail on high-quality economic development, further exploring its mechanisms and spatial spillover effects. The findings reveal that (1) HSR significantly promotes high-quality economic development; (2) with the development of HSR, from 2005 to 2021, China’s high-quality economic development showed an evolutionary trend of overall improvement, with a gradual optimization of spatial patterns; (3) it facilitates high-quality economic development by enhancing capital and labor mobility, strengthening industrial chain resilience, and advancing industrial structure upgrading; (4) high-speed rail development in neighboring regions generates positive spatial spillover effects on local urban economic quality; and (5) the impact of high-speed rail on high-quality economic development exhibits significant heterogeneity across cities with different regions, tiers, scales, and resource endowments. These results confirm the positive role of high-speed rail in fostering high-quality economic development. Full article

The quality of the housing environment (HE) is an important issue that has a direct impact on the life of inhabitants. Aiming for quality in residential architecture begins with a well-designed HE, with the designing process being a value that is difficult to evaluate. Nowadays, a well-designed HE takes into account the energy efficiency of a building. An appropriate degree of thermal comfort, which is required by inhabitants, needs to be considered at the design stage. Designers can use building certification programs and multi-criteria analysis to motivate investors to construct buildings in accordance with energy efficiency requirements. These systems respond to the needs of energy efficiency, thermal comfort, sustainable heating, and ventilation. Defining ways and methods to evaluate quality in architectural projects will allow the value of the HE to be improved. For this purpose, a multi-criteria analysis of five systems that can be used to evaluate HE quality and energy efficiency in a temperate climate was conducted: (1) Building For Life 12, (2) Home Quality Mark, (3) Housing Quality Indicators, (4) Système D’évaluation De Logements (Sel), and (5) NF Habitat-NF Habitat HQE. This analysis concerned information about the systems, their applicability in practice, and the applied assessment measures. The article shows that the quality of the HE consists of specific factors that can be distinguished and indicated by evaluation systems. As a result of the carried out assessment of the housing environment, 13 original categories of building assessment criteria were defined. The results of the conducted analysis indicated that it is possible to: (i) identify factors for the improvement of HE quality; (ii) prepare objective systems for the measurement of the HE; and (iii) use such systems in practice, e.g., in the design industry, real estates, and public administration. Moreover, the systems can be used in legal regulations for updating urban policies. Full article

Due to the occurrence of THz-excited vibrational modes in biomacromolecules, the THz frequency range has been identified as particularly suitable for developing and applying new bioanalytical methods. We present a scalable THz metamaterial-based biosensor being utilized for the multifrequency investigation of single- and double-stranded DNA (ssDNA and dsDNA) samples. It is demonstrated that the metamaterial resonance frequency shift by the DNA’s presence depends on frequency. Our experiments with the scalable THz biosensors demonstrate a major change in the degree of the power function for dsDNA by 1.53 ± 0.06 and, in comparison, 0.34 ± 0.11 for ssDNA as a function of metamaterial resonance frequency. Thus, there is a significant advantage for dsDNA detection that can be used for increased sensitivity of biomolecular detection at higher frequencies. This work represents a first step for application-specific biosensors with potential advantages in sensitivity, specificity, and robustness. Full article

The decarbonisation of buildings is a crucial milestone if European cities mean to reach their mitigation targets. The construction sector was responsible for 38% of the GHG emissions in 2020. From these emissions, 11% is calculated to be currently embodied in building materials. In this context, an evaluation from a life cycle perspective is becoming increasingly necessary to achieve the objectives set. Currently, there are different building rating systems (BRS) at European level that allow the evaluation of the degree of sustainability of buildings. During this study, the authors have evaluated to what extent and how the most extended five BRS (NF Habitat HQE, VERDE, DGNB, BREEAM, and HPI systems) in the European framework have integrated the life cycle methodology during their evaluation process. Four methodologies have been used in the research in order to analyse these five systems: quantitative assessment, multi-level perspective, mapping–gap analysis, and expert interviews. Although each methodology has produced different results, the need to harmonise the evaluation criteria at the European level, the insufficient consistency of data software, and the availability of skilled LCA professionals for wider LCA market penetration, among others, should be highlighted. The quality and harmonised data of construction products is required for LCA to give aggregated and transformative results. Full article

Saponins or their aglycone form, sapogenin, have recently gained interest as bioactive agents due to their biological activities, their antitumoral effects being among them. Metabolic reprogramming has been recognized as a hallmark of cancer and, together with the increased aerobic glycolysis and glutaminolysis, the altered lipid metabolism is considered crucial to support cancer initiation and progression. The purpose of this study was to assess and compare the inhibitory effects on colorectal cancer cell lines of saponin-rich extracts from fenugreek and quinoa (FE and QE, respectively) and their hydrolyzed extracts as sapogenin-rich extracts (HFE and HQE, respectively). By mean of the latest technology in the analysis of cell bioenergetics, we demonstrate that FE and HFE diminished mitochondrial oxidative phosphorylation and aerobic glycolysis; meanwhile, quinoa extracts did not show relevant activities. Distinct molecular mechanisms were identified for fenugreek: FE inhibited the expression of TYMS1 and TK1, synergizing with the chemotherapeutic drug 5-fluorouracil (5-FU); meanwhile, HFE inhibited lipid metabolism targets, leading to diminished intracellular lipid content. The relevance of considering the coexisting compounds of the extracts or their hydrolysis transformation as innovative strategies to augment the therapeutic potential of the extracts, and the specific subgroup of patients where each extract would be more beneficial, are discussed in the frame of precision nutrition. Full article

Saponin-rich extracts from edible seeds have gained increasing interest and their hydrolysis to sapogenin-rich extracts may be an effective strategy to enhance their potential bioactivity. However, it remains necessary to study the resulting chemical modifications of the extracts after hydrolysis as well as their impact on the subsequent bioaccessibility of bioactive compounds. The chemical composition of non-hydrolyzed and hydrolyzed extracts from fenugreek (FE, HFE) and quinoa (QE, HQE), and the bioaccessibility of saponins, sapogenins and other bioactive compounds after an in vitro gastrointestinal digestion was assessed. In general, FE mainly contained saponins (31%), amino acids (6%) and glycerides (5.9%), followed by carbohydrates (3.4%), fatty acids (FFA) (2.3%), phytosterols (0.8%), tocols (0.1%) and phenolics (0.05%). HFE consisted of FFA (35%), sapogenins (8%) and partial glycerides (7%), and were richer in phytosterols (1.9%) and tocols (0.3%). QE mainly contained glycerides (33%), FFA (19%), carbohydrates (16%) and saponins (7.9%), and to a lesser extent alkylresorcinols (1.8%), phytosterols (1.5%), amino acids (1.1%), tocols (0.5%) and phenolics (0.5%). HQE mainly consisted of FFA (57%), partial glycerides (23%) and sapogenins (5.4%), were richer in phytosterols (2.4%), phenolics (1.2%) and tocols (0.7%) but poorer in alkylresorcinols (1%). After in vitro digestion, saponins from FE and QE were fully bioaccessible, sapogenins from HFE displayed a good bioaccessibility (76%) and the sapogenin from HQE was moderately bioaccesible (38%). Digestion of saponin and sapogenin standards suggested that other components of the extracts were enhancing the bioaccessibility. Other minor bioactive compounds (phytosterols, alkylresorcinols, tocols and some phenolics) also displayed optimal bioaccessibility values (70–100%). Full article

Increasing problems regarding pollution and climate change have long been demonstrated by scientific evidence. An important portion of carbon emissions are produced by the building sector. These emissions are directly related not only to the building’s energy consumption, but also other building attributes affecting the construction and operation of existing buildings: materials selection, waste management, transportation, water consumption, and others. To help reduce these emissions, several green building rating system (GBRSs) have appeared during the last years. This has made it difficult for stakeholders to identify which GBRSs could be more suitable to a specific project. The heterogeneity of the GRBS scenario requires the creation of a transparent and robust indicator framework that can be used in any country within the European Union (EU), which is a common EU framework of core sustainability indicators for office and residential buildings Level(s) with the goal to provide a solid structure for building sustainability certification across all countries of the EU. This paper provides a comprehensive review of the most common GBRSs within the EU: Building Research Establishment Assessment Method (BREEAM), Deutsche Gesellschaft für Nachhaltiges Bauen (DGNB), Haute Qualité Environnementale (HQE), and Leadership in Energy & Environmental Design (LEED), and a bottom up comparison of the influence in the final score produced by the indicators stated by Level(s). The indicators studied show a different influence of Level(s) indicators on every GBRS, where LEED and BREEAM were most affected while HQE and DGNB were less so. This paper demonstrates the heterogeneity of current GRBSs in the EU scenario and the difference between sustainability assessments, where DGNB seems to be more aligned to the current EU framework. Finally, the paper concludes with the need to work to achieve alignment between the GBRS and Level(s). Full article

Rating systems for assessing the environmental impact of buildings are technical instruments that aim to evaluate the environmental impact of buildings and construction projects. In some cases, these rating systems can also cover urban-scale projects, community projects, and infrastructures. These schemes are designed to assist project management in making the projects more sustainable by providing frameworks with precise criteria for assessing the various aspects of a building’s environmental impact. Given the growing interest in sustainable development worldwide, many rating systems for assessing the environmental impact of buildings have been established in recent years, each one with its peculiarities and fields of applicability. The present work is motivated by an interest in emphasizing such differences to better understand these rating systems and extract the main implications to building design. It also attempts to summarize in a user-friendly form the vast and fragmented assortment of information that is available today. The analysis focuses on the six main rating systems: the Building Research Establishment Environmental Assessment Methodology (BREEAM), the Comprehensive Assessment System for Built Environment Efficiency (CASBEE), the Deutsche Gesellschaft für Nachhaltiges Bauen (DGNB), the Haute Qualité Environnementale (HQE^TM), the Leadership in Energy and Environmental Design (LEED), and the Sustainable Building Tool (SBTool). Full article