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Measuring the spray parameters and providing feedback on the quality of the spraying is critical to ensuring that the spraying material reaches to the appropriate region. A novel software entitled DropSense was developed to determine spray parameters quickly and accurately compared to DepositScan, ImageJ 1.54d and Image-Pro 10 software. Water-sensitive papers (WSP) were used to determine spray parameters such as deposit coverage, total deposits counted, D_V10, D_V50, D_V90, density, deposit area and relative span values. Upon execution of the developed software, these parameters were displayed on the computer screen and then saved in an Excel spreadsheet file at the end of the image analysis. A conveyor belt system with three different belt speeds (4, 5 and 6 km h⁻¹) and four nozzle types (AI11002, TXR8002, XR11002, TTJ6011002) were used for carrying out the spray experiments. The novel software was developed in the LabVIEW programming language. Compared WSP image results related to the mentioned spray parameters were statistically evaluated. The results showed that the DropSense software had superior speed and ease of use in comparison to the other software for the image analysis of WSPs. The novel software showed mostly similar or more reliable performance compared to the existing software. The core technical innovation of DropSense lay in its integration of advanced morphological operations, which enable the accurate separation and quantification of overlapping droplet stains on WSPs. In addition, it performed fully automated processing of WSP images and significantly reduced analysis time compared to commonly used WSP image analysis software. Full article

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14 pages, 3433 KB

Open AccessArticle

Defect Reduction in HEMT Epilayers on SiC Meta-Substrates

by Vin-Cent Su, Ting-Yu Wei, Meng-Hsin Chen, Chien-Te Ku and Guan-Shian Liu

Nanomaterials 2026, 16(3), 158; https://doi.org/10.3390/nano16030158 (registering DOI) - 23 Jan 2026

Abstract

Dislocation reduction in gallium nitride (GaN) epitaxial layers remains a critical challenge for high-performance GaN-based electronic devices. In this study, GaN epitaxial growth on newly-developed 4H-Silicon Carbide (SiC) meta-substrates was systematically investigated to elucidate the role of surface pattern geometry in modulating dislocation propagation. A series of truncated-hexagonal-pyramid meta-structures with a fixed array period and varying pattern ratios (R) were designed and fabricated to enable controlled tuning of the effective surface morphology. Atomic force microscopy confirmed comparable surface flatness for all samples after epitaxial growth. Cathodoluminescence analysis revealed a non-monotonic dependence of defect density on R, indicating the existence of an optimal pattern geometry. Among all configurations, the outstanding sample exhibited the lowest defect density, achieving a 54.96% reduction in threading dislocations (edge + mixed) compared with a planar reference. Cross-sectional transmission electron microscopy further confirmed a substantially reduced dislocation density and clear evidence of dislocation bending and termination near the meta-structured regions. These results demonstrate that geometry-engineered 4H-SiC meta-substrates provide an effective and scalable strategy for dislocation modulation in GaN epitaxy on SiC meta-substrates, offering a promising pathway toward advanced GaN power and RF devices. Full article

(This article belongs to the Special Issue Nonlinear Optics of Nanostructures and Metasurfaces)

13 pages, 2024 KB

Open AccessArticle

Tuning the Crystal Structure of Amphiphilic 3,4,5-Tris(alkyloxy)benzenesulfonates with Bulky Tetrabutylammonium Cations by Variation in the Aliphatic Chain

by Aleksei Stupnikov, Artem Bakirov, Maxim Shcherbina, Enfeng Song, Uwe Beginn, Martin Möller and Sergei Chvalun

Molecules 2026, 31(3), 401; https://doi.org/10.3390/molecules31030401 (registering DOI) - 23 Jan 2026

Abstract

3,4,5-Tris(alkyloxy)benzenesulfonates constitute a class of wedge-shaped dendrons exhibiting liquid crystalline properties, characterized by a diverse and intricate phase behavior that is predominantly governed by the length of the terminal aliphatic chains and the size and nature of the dendrons’ focal group, which collectively influence their self-organization. In systems comprising both two large counterions—wedge-shaped 3,4,5-tris(alkyloxy)benzenesulfonate anions and tetrabutylammonium (N(C₄H₉)₄⁺) cations—a delicate balance between ionic interactions and microphase segregation drives the formation of giant octupoles that self-assemble subsequently into a remarkably ordered lattice. Such phase behavior is consistently observed across a broad range of compounds, with terminal aliphatic chain lengths varying from six to eighteen methylene units. While the structural configuration of the octupoles and the resulting crystalline lattice remains consistent across most compounds, a distinct transition from quantitative to qualitative changes is observed in tetrabutylammonium 3,4,5-tris(hexadecyloxy)benzenesulfonates and 3,4,5-tris(octadecyloxy)benzenesulfonates that exhibit a unique crystalline lattice structure. Full article

(This article belongs to the Special Issue Crystal Structures of Tricky, Unexpected, Labile or Difficult Molecular Structures by Diffraction Methods)

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27 pages, 2787 KB

Open AccessArticle

Comparative Analysis of Oral Microbiome in Indian Type 2 Diabetes Mellitus (T2DM) and Periodontitis Cohorts

by Meenakshi Murmu, Rajshri Singh, Rajesh Gaikwad, Akshaya Banodkar, Sagar Barage, Preethi Sudhakara and Aruni Wilson Santhosh Kumar

Diseases 2026, 14(2), 38; https://doi.org/10.3390/diseases14020038 (registering DOI) - 23 Jan 2026

Abstract

Background: Type 2 diabetes mellitus (T2DM) and periodontitis are highly prevalent immune-inflammatory diseases that interact bidirectionally. However, how early-onset T2DM, periodontitis, and adverse lifestyle behaviors collectively remodel the gingival plaque microbiome at the ecological network level remains poorly understood in Indian populations. Methods: A cross-sectional 16S rRNA gene (V3–V4) sequencing study was conducted on supragingival and subgingival plaque from 60 adults (30–40 years) recruited in Mumbai. Participants were categorized as healthy (H, n = 10), periodontitis (P, n = 10), T2DM (n = 20), and T2DM with periodontitis (T2DM_P, n = 20). Comprehensive demographic, anthropometric, metabolic, periodontal, dietary, lifestyle, and oral hygiene data were collected. Sequence data were processed using QIIME2–DADA2, followed by diversity, differential abundance, and genus-level co-occurrence network analyses (Spearman |r| ≥ 0.6, FDR < 0.05; core prevalence ≥ 70%). Results: α-diversity showed no marked depletion across groups, whereas Bray–Curtis β-diversity revealed significant global separation, with maximal dissimilarity between H and T2DM_P. Healthy individuals with favorable lifestyle behaviors harbored scaffold-forming taxa such as Corynebacterium matruchotii, Lautropia mirabilis, and Capnocytophaga spp. In contrast, P and T2DM_P groups showed enrichment of proteolytic, inflammation-adapted genera including Porphyromonas, Tannerella, Treponema, Fretibacterium, Peptostreptococcus, and Selenomonas. Network analysis revealed a shift from commensal-rich modular networks to densely connected, keystone-centered disease modules. Conclusion: Early-onset T2DM and periodontitis, particularly under adverse lifestyle behaviors, reorganize plaque microbial composition and interaction architecture rather than depleting diversity, highlighting plaque-based keystone taxa and networks as targets for microbiome-informed risk stratification and integrated medical–dental–lifestyle interventions. Full article

16 pages, 6513 KB

Open AccessArticle

Comparative Analysis of Industrial Fused Magnesia from Natural and Flotation-Processed Magnesite: Associations Among CaO/SiO₂ Ratio, Silicate Phase Formation, and Microcracking

by Chunyan Wang, Jian Luan, Zhitao Yang, Qigang Ma, Gang Wang and Ximin Zang

Materials 2026, 19(3), 463; https://doi.org/10.3390/ma19030463 (registering DOI) - 23 Jan 2026

Abstract

In view of the depletion of high-grade magnesite resources in China, this study presents a comparative analysis of two industrial fused magnesia products produced via a flotation–fusion route. A low-grade magnesite (DSQLM-3, MgO 41.48 wt.%) was upgraded by reverse flotation to a concentrate (FDSQLM-3, MgO 47.55 wt.%) with >97% SiO₂ removal. Two fused magnesia samples (FM-1 from natural high-grade ore DSQLM-1; FFM-3 from concentrate FDSQLM-3) were produced under identical arc-furnace melting (2800 °C, 4 h), followed by natural cooling. Although FFM-3 showed higher MgO (97.61 vs. 97.25 wt.%), its bulk density was comparable to FM-1 (3.45 vs. 3.46 g/cm³). XRD/Rietveld refinement and SEM-EDS indicated that CMS dominated the Ca–silicate assemblage in FM-1, whereas β/γ-C₂S was observed in FFM-3, coinciding with a higher CaO/SiO₂ (C/S) ratio (2.85 vs. 0.68). Image analysis further showed higher grain boundary microcrack metrics in FFM-3. These observations are consistent with reports in the literature stating that the β → γ transformation of C₂S during cooling involves ~12% volume expansion that can contribute to cracking; however, cooling history and composition were not independently controlled in this industrial comparison, so the relationships are interpreted as data-supported associations rather than isolated causality. The results suggest that beneficiation strategies may benefit from managing residual oxide balance (especially C/S ratio) in addition to reducing total impurities. Mechanical and thermomechanical properties were not measured and should be evaluated in future work. Full article

(This article belongs to the Section Advanced and Functional Ceramics and Glasses)

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28 pages, 1484 KB

Open AccessArticle

Rational Design, Synthesis, and Molecular Docking of Novel Terpene Analogues of Imatinib, and Their Inhibition on Downstream BCR-ABL Signaling

by Rositsa Mihaylova, Asine Dailova-Barzeva, Irena Philipova, Georgi Momekov, Irini Doytchinova, Mariyana Atanasova and Georgi Stavrakov

Pharmaceuticals 2026, 19(2), 198; https://doi.org/10.3390/ph19020198 (registering DOI) - 23 Jan 2026

Abstract

Background/Objectives: Imatinib, the first tyrosine kinase inhibitor, marks the beginning of a revolution in clinical oncology. Disrupting oncogenic kinase-dependent signaling pathways represents a key strategy for advancing targeted cancer therapies. Terpene analogues of imatinib were developed to probe the influence of terminal ring modifications on BCR-ABL inhibition and downstream oncogenic signaling. Methods: Nine novel imatinib analogues bearing bulky aliphatic moieties were designed, synthesised, and structurally characterized by ¹H/¹³C NMR spectroscopy and high-resolution mass spectrometry (HRMS). Molecular docking calculations were performed to assess the binding modes and intermolecular interactions. The cytotoxicity of the newly synthesized imatinib derivatives was evaluated across a panel of BCR-ABL+ leukemia cell lines. Results: Molecular docking analyses demonstrated conserved interactions within the ATP-binding site of BCR-ABL for all derivatives, with calculated docking scores ranging between 123 and 128, while modifications at the terminal ring introduced subtle changes in electrostatic and steric profiles. Biological evaluation using MTT-based cytotoxicity assays in BCR-ABL+ leukemic cell lines revealed enhanced antiproliferative activity compared with imatinib, with compounds 6a (flexible cyclohexyl) and 6d (rigid camphane-type (+)-isopinocampheyl) exhibiting the lowest micromolar activity in the AR-230 model (IC₅₀ values of 1.1 and 1.2 μM, respectively). Proteome-wide phosphokinase profiling demonstrated shared suppression of STAT5/3/6, RSK1/2, S6K1/p70, and Pyk2, confirming effective disruption of canonical BCR-ABL pathways. Critically, the terpene moiety dictated downstream pathway bias: 6a preferentially attenuated CREB activation, whereas 6d more effectively suppressed the PI3K/Akt oncogenic axis and strongly activated proapoptotic p53-mediated stress responses. Conclusions: Our findings establish terpene-engineered imatinib analogues as tunable modulators and promising candidates for targeting downstream BCR-ABL signaling pathways in leukemia treatment. Full article

(This article belongs to the Special Issue Targeting Enzymes in Drug Design and Discovery)

32 pages, 3916 KB

Open AccessReview

From Porphyrinic MOFs and COFs to Hybrid Architectures: Design Principles for Photocatalytic H₂ Evolution

by Maria-Chrysanthi Kafentzi, Grigorios Papageorgiou and Kalliopi Ladomenou

Inorganics 2026, 14(2), 32; https://doi.org/10.3390/inorganics14020032 (registering DOI) - 23 Jan 2026

Abstract

Solar-driven hydrogen production via photocatalytic water splitting represents a promising route toward sustainable and low-carbon energy systems. Among emerging photocatalysts, porphyrin-based framework materials, specifically porphyrinic metal–organic frameworks (PMOFs) and porphyrinic covalent organic frameworks (PCOFs), have attracted increasing attention owing to their strong visible-light absorption, tunable electronic structures, permanent porosity, and well-defined catalytic architectures. In these systems, porphyrins function as versatile photosensitizers whose photophysical properties can be precisely tailored through metalation, peripheral functionalization, and integration into ordered frameworks. This review provides a comprehensive, design-oriented overview of recent advances in PMOFs, PCOFs, and hybrid porphyrinic architectures for photocatalytic H₂ evolution. We discuss key structure–activity relationships governing light harvesting, charge separation, and hydrogen evolution kinetics, with particular emphasis on the roles of porphyrin metal centers, secondary building units, linker functionalization, framework morphology, and cocatalyst integration. Furthermore, we highlight how heterojunction engineering through coupling porphyrinic frameworks with inorganic semiconductors, metal sulfides, or single-atom catalytic sites can overcome intrinsic limitations related to charge recombination and limited spectral response. Current challenges, including long-term stability, reliance on noble metals, and scalability, are critically assessed. Finally, future perspectives are outlined, emphasizing rational molecular design, earth-abundant catalytic motifs, advanced hybrid architectures, and data-driven approaches as key directions for translating porphyrinic frameworks into practical photocatalytic hydrogen-generation technologies. Full article

(This article belongs to the Section Inorganic Materials)

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14 pages, 906 KB

Open AccessArticle

Heart Rate Variability Nomogram Predicts Atrial Fibrillation in Patients with Moderate to High Burden of Premature Ventricular Complexes

by Koray Kalenderoglu, Mert Ilker Hayiroglu, Tufan Cinar, Faysal Saylik, Gokcem Ayan Bayraktar, Melih Oz, Miray Ozer Oz, Kadir Gurkan and Tolga Aksu

Medicina 2026, 62(2), 243; https://doi.org/10.3390/medicina62020243 (registering DOI) - 23 Jan 2026

Abstract

Background and Objectives: There is a well-established correlation between premature ventricular contractions (PVCs) and atrial fibrillation (AF), with a higher burden of PVCs increasing the likelihood of new-onset AF. This study aims to investigate the impact of heart rate variability (HRV) on the onset of AF in patients with moderate to high burdens of PVCs, as observed through 24 h ambulatory electrocardiogram (ECG) analysis. Materials and Methods: Our study was a retrospective analysis involving 187 patients at a single tertiary center. We analyzed PVC counts from 24 h ECG recordings, categorizing the patients into groups based on whether they developed AF or not. Additionally, we developed a nomogram to estimate the risk of AF development in these patients. Results: A new-onset AF was detected in 16% of the cohort. Analysis of 24 h ambulatory ECG data revealed statistically significant increases in the SDNN index, RMSSD, PNN50, total power (TP), and low-frequency (LF) values in AF patients. To estimate the risk of AF, a risk prediction nomogram was created using high-frequency (HF), LF, SDNN index, and PNN50. Among these variables, PNN50 was identified as the strongest predictor in the multivariable model. Additionally, a decision curve analysis demonstrated that the nomogram offers a net clinical benefit for detecting AF in patients when the baseline threshold risk exceeds 15%. Conclusions: Our study found that among patients with AF who had a moderate to high burden of PVCs using 24 h ambulatory ECGs, several HRV parameters were elevated. This increased autonomic instability may play a role in the development and persistence of AF episodes. Full article

(This article belongs to the Special Issue Advances in Atrial Fibrillation: Mechanisms, Diagnosis, and Emerging Therapies)

20 pages, 1626 KB

Open AccessArticle

Effect of Harvest Date on Fruit Quality and Post-Harvest Storability of Three Different Peach Cultivars

by Belén Velardo-Micharet, Marisol Duarte-Maya, Ana Cristina Agulheiro-Santos, María Concepción Ayuso-Yuste and María Josefa Bernalte-García

Foods 2026, 15(3), 421; https://doi.org/10.3390/foods15030421 (registering DOI) - 23 Jan 2026

Abstract

Peach consumers demand good quality fruit, but premature harvests result in fruit that does not ripen properly and does not reach the required organoleptic quality, so consumers stop buying this product that does not meet their expectations. In our region, peaches are exported long distances, and it is required that when they reach the destination market their quality is adequate. Therefore, the objective of this study was to determine the storage capacity of commercial and delayed harvest in three peach cultivars. ‘Rich Lady’, ‘Summer Lady’, and ‘Merryl O’Henry’ were harvested at commercial maturity (H1) and, a few days later (H2), packed in passive modified atmosphere (PMA), and stored under refrigeration for up to 40 days to simulate marketing to distant markets. During storage and after three days of shelf-life, the physico-chemical characteristics, damage, and sensory quality of the fruit were analyzed. In general, after cold storage, peaches improve their sensory characteristics after three days at room temperature. PMA with refrigeration was suitable for exporting ‘Rich Lady’ peaches overseas for H1. The late harvest, H2, is recommended for ‘Summer Lady’, as it improves sensory quality without losing storability. ‘Summer Lady’ was the best-rated cultivar by the tasters, and ‘Merryl O’Henry’ the worst, due to its lack of ripening and high incidence of chilling injury. Full article

(This article belongs to the Special Issue Postharvest Quality and Microbiological Control of Fruit and Vegetables)

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14 pages, 1874 KB

Open AccessArticle

Synergistic Effects of mTG-Induced Protein Crosslinking and Methyl Cellulose Polymer in Modulating the Quality Parameters of Hybrid Meat Patties

by Abdul Samad, Ayesha Muazzam, A. M. M. Nurul Alam, Young-Hwa Hwang and Seon-Tea Joo

Appl. Sci. 2026, 16(3), 1187; https://doi.org/10.3390/app16031187 - 23 Jan 2026

Abstract

The demand for healthier and more sustainable meat products is increasing, and hybrid meat products have garnered consumer interest due to their nutritional and environmental benefits. This study aimed to formulate hybrid patties using chicken boneless meat and isolated soy protein (ISP), with varying concentrations of microbial transglutaminase (mTG) and methyl cellulose (CL), to improve physicochemical, textural, and sensory attributes. A secondary objective was to identify an effective mTG–CL combination as a bioadhesive for hybrid and plant-based meat analogs. A two-factor factorial design with mTG (0–3%) and CL (0–3%) was employed to evaluate their individual and combined effects on hybrid patties. The combination of 3% mTG and 2% CL produced the most desirable balance of textural and sensory properties, significantly increasing hardness, chewiness, cohesiveness, and springiness, while maintaining TBARS values within acceptable sensory limits (≈1.10 mg MDA/kg). Increasing CL levels slightly reduced pH and increased lightness and yellowness, whereas redness remained stable across treatments. Sensory evaluation revealed the highest preference for patties containing 3% mTG and 2% CL in terms of texture, surface moisture, and overall quality (p < 0.05). These results demonstrate that enzymatic–hydrocolloid synergy between mTG and CL effectively enhances textural integrity, while color attributes and oxidative stability are primarily governed by additive effects. Full article

(This article belongs to the Special Issue Advanced Food Processing Technologies and Approaches: 2nd Edition)

18 pages, 2758 KB

Open AccessArticle

Synergistic Effects of Coal Gasification Slag-Based Soil Conditioner and Vermicompost on Soil–Microbe–Plant Systems Under Saline–Alkali Stress

by Hang Yang, Longfei Kang, Qing Liu, Qiang Li, Feng Ai, Kaiyu Zhang, Xinzhao Zhao and Kailang Ding

Sustainability 2026, 18(3), 1180; https://doi.org/10.3390/su18031180 - 23 Jan 2026

Abstract

Soil salinization remains a critical constraint on global land sustainability, severely limiting agricultural output and ecosystem resilience. To address this issue, a field trial was implemented to investigate the interactive benefits of vermicompost (VC) and a novel soil conditioner derived from coal gasification slag-based soil conditioner (CGSS) in mitigating saline–alkali stress. The perennial forage grass Leymus chinensis, valued for its ecological robustness and economic potential under adverse soil conditions, served as the test species. Five treatments were established: CK (unamended), T1 (CGSS alone), T2 (VC alone), T3 (CGSS:VC = 1:1), T4 (CGSS:VC = 1:2), and T5 (CGSS:VC = 2:1). Study results indicate that the combined application of CGSS and VC outperformed individual amendments, with the T4 treatment demonstrating the most effective results. Compared to CK, T4 reduced soil electrical conductivity (EC) by 12.00% and pH by 5.17% (p < 0.05), while markedly enhancing key fertility indicators—including soil organic matter and the availability of nitrogen, phosphorus, and potassium. Thus, these improvements translated into superior growth of L. chinensis, reflected in significantly greater dry biomass, expanded leaf area, and increased plant height. Additionally, the T4 treatment increased soil microbial richness (Chao1 index) by 21.5% and elevated the relative abundance of the Acidobacteria functional group by 16.9% (p < 0.05). Hence, T4 treatment (CGSS: 15,000 kg·ha⁻¹; VC: 30,000 kg·ha⁻¹) was identified as the optimal remediation strategy through a fuzzy comprehensive evaluation that integrated multiple soil and plant indicators. From an economic perspective, the T4 treatment (corresponding to a VC-CGSS application ratio of 2: 1) exhibits a lower cost compared to other similar soil conditioners and organic fertilizer combinations for saline–alkali soil remediation. This study not only offers a practical and economically viable approach for reclaiming degraded saline–alkali soils but also advances the circular utilization of coal-based solid waste. Furthermore, it deepens our understanding of how integrated soil amendments modulate the soil–microbe–plant nexus under abiotic stress. Full article

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21 pages, 6679 KB

Open AccessArticle

Influence of Lignosulfonate on the Hydrothermal Interaction Between Pyrite and Cu(II) Ions in Sulfuric Acid Media

by Kirill Karimov, Maksim Tretiak, Uliana Sharipova, Tatiana Lugovitskaya, Oleg Dizer and Denis Rogozhnikov

Metals 2026, 16(2), 137; https://doi.org/10.3390/met16020137 - 23 Jan 2026

Abstract

Hydrometallurgical pretreatment of pyrite-bearing concentrates and tailings by hydrothermal interaction with Cu(II) solutions is a promising route for chemical beneficiation and mitigation of acid mine drainage but is limited by passivation caused by elemental sulfur and secondary copper sulfides. Here, the effect of sodium lignosulfonate (SLS) on the hydrothermal reaction between natural pyrite and CuSO₄ in H₂SO₄ media at 180–220 °C was studied at [H₂SO₄]₀ = 10–30 g/dm³, [Cu]₀ = 6–24 g/dm³, and [SLS]₀ = 0–1.0 g/dm³. Process efficiency was evaluated by Fe extraction into solution and Cu precipitation on the solid phase, and products were characterized by XRD and SEM/EDS. SLS markedly intensified pyrite conversion: at 200 °C and 120 min, Fe extraction increased from 14 to 26% and Cu precipitation from 5 to 23%, while at 220 °C, Fe extraction reached 33.4% and Cu precipitation 26.8%. XRD confirmed the sequential transformation CuS → Cu_1.8S. SEM/EDS showed that SLS converts localized nucleation of Cu_xS on defect sites into the formation of a fine, loosely packed, and well-dispersed copper sulfide phase. The results demonstrate that lignosulfonate surfactants efficiently suppress passivation and enhance mass transfer, providing a basis for intensifying hydrothermal pretreatment of pyrite-bearing industrial materials. Full article

(This article belongs to the Special Issue Recent Progress in Metal Extraction and Recycling)

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19 pages, 1674 KB

Open AccessReview

Role of Nod-like Receptors in Helicobacter pylori Infection: Insights into Innate Immune Signaling Pathways

by Ah-Ra Jang, Yeong-Jun Kim, In-Su Seo, Wan-Gyu Kim, Sang-Eun Jung and Jong-Hwan Park

Microorganisms 2026, 14(2), 271; https://doi.org/10.3390/microorganisms14020271 - 23 Jan 2026

Abstract

Helicobacter pylori is a prevalent gastric pathogen that establishes chronic infection and contributes to gastritis, peptic ulcer disease, and gastric cancer. Its persistence depends on immune evasion strategies that promote sustained low-grade inflammation in the gastric mucosa. Nucleotide-binding oligomerization domain-like receptors (NLRs) are cytosolic pattern recognition receptors that play key roles in innate immune responses against H. pylori. Nod1 and Nod2 detect bacterial peptidoglycan delivered via the type IV secretion system or outer membrane vesicles, activating NF-κB, MAPK, and interferon signaling pathways that regulate inflammatory cytokine production, epithelial barrier function, autophagy, and antimicrobial defense. The NLRP3 inflammasome mediates the maturation of IL-1β and IL-18 primarily in myeloid cells, thereby shaping inflammatory and immunoregulatory responses during infection. In contrast, NLRC4 functions in a context-dependent manner in epithelial cells and is largely dispensable for myeloid IL-1β production. Emerging evidence also implicates noncanonical NLRs, including NLRP6, NLRP9, NLRP12, NLRX1, and NLRC5, in regulating inflammation, epithelial homeostasis, and gastric tumorigenesis. In addition, genetic polymorphisms in NLR genes influence host susceptibility to H. pylori-associated diseases. This review highlights the interplay between NLR signaling, bacterial virulence, and host immunity and identifies potential therapeutic targets. Full article

(This article belongs to the Section Molecular Microbiology and Immunology)

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22 pages, 63134 KB

Open AccessArticle

The Effects of Laser Shock Peening with and Without Protective Coating on the Corrosion Resistance of Sensitized 304L Stainless Steel

by Richard Chiang and Vijay K. Vasudevan

Metals 2026, 16(2), 136; https://doi.org/10.3390/met16020136 - 23 Jan 2026

Abstract

This study examined the effects of laser shock peening (LSP) and LSP without protective coating (LSPwC) on the microstructure and corrosion behavior of 304L stainless steel using cyclic polarization testing. LSP enhanced corrosion resistance under mild sensitization (650 °C; 5 h) by inducing compressive stress and increasing dislocation density, stabilizing the passive film. Limited improvement was observed under severe sensitization (650 °C; 24 h). Deformation-induced martensite detected by XRD was attributed to mechanical polishing, not LSP. In contrast, LSPwC reduced corrosion resistance across all conditions due to Fe-rich surface oxides that impaired passivation. Full article

(This article belongs to the Special Issue Laser Shock Peening: From Fundamentals to Applications)

21 pages, 1436 KB

Open AccessArticle

Development and Systematic Evaluation of a Low-Irritation PFD-AIS Formulation for Pulmonary-Targeted Therapy

by Xinze Li, Chengcheng Li, Jingxin Sun, Yidong Yan, Yong Jin, Lili Jin and Jishan Quan

Pharmaceuticals 2026, 19(2), 197; https://doi.org/10.3390/ph19020197 - 23 Jan 2026

Abstract

Background: To overcome the gastrointestinal and hepatic toxicity of oral pirfenidone (PFD) in the treatment of idiopathic pulmonary fibrosis (IPF), this study systematically constructed a minimal-component, buffer-free pirfenidone aerosol inhalation solution (PFD-AIS), achieving lung-targeted delivery, reduced systemic exposure, and maintained antifibrotic efficacy. Methods: Analytical methods for PFD-AIS, covering content, related substances, aerodynamic particle size distribution (APSD), and delivered dose uniformity, were established. The prescription and preparation process of the formulation was optimized by evaluating its key quality attributes. Pharmacodynamic and pharmacokinetic evaluations of PFD-AIS were performed in a mouse lung-fibrosis model and SD rats. Results: The final specification of PFD-AIS was set to 40 mg:4 mL, containing 40 mg of PFD, 28 mg of sodium chloride, and 4 mL of injection water with a preparation process of 40 °C for 60 min and a pH range of 4–8. The PFD-AIS exhibited a fine particle fraction (FPF) of 56.1%, meeting the requirements for deep lung deposition. The delivered dose and delivery rate were 17.52 mg and 2.48 mg/min, respectively, both complying with inhalation formulation standards. In the bleomycin-induced IPF mouse model, the PFD-AIS markedly improved pulmonary fibrosis pathology, reduced the lung coefficient, and significantly lowered serum ALT/AST levels, indicating hepatic protection. In the SD rats, compared with oral dosing, PFD-AIS administration resulted in significantly lower AUC_0−t (−63%) and AUC_0–∞ (−67%) values, demonstrating a substantial reduction in systemic drug exposure. Conclusion: This work presents a complete, systematic chain—from formulation, process, and quality control to pharmacodynamics and pharmacokinetics—of a PFD-AIS. The PFD-AIS is effective and feasible, featuring a stable preparation process and controllable quality. Lung-directed drug delivery enhances PFD’s therapeutic efficacy, reduces systemic exposure and liver toxicity, and offers significant clinical advantages. Full article

(This article belongs to the Section Medicinal Chemistry)

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