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Keywords = H-spectral radius

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13 pages, 588 KB  
Article
A Linearly Convergent Algorithm for the H-Spectral Radius of Index-Cyclic Symmetric Positive Tensors
by Xincun Wang and Hongbin Lyu
Symmetry 2026, 18(6), 1054; https://doi.org/10.3390/sym18061054 - 18 Jun 2026
Viewed by 38
Abstract
A class of index-cyclic symmetric positive tensors is defined, and a diagonal similarity algorithm is proposed to compute the H-spectral radius of such tensors. The linear convergence of the algorithm is rigorously proven. The computational efficiency of the proposed method is compared [...] Read more.
A class of index-cyclic symmetric positive tensors is defined, and a diagonal similarity algorithm is proposed to compute the H-spectral radius of such tensors. The linear convergence of the algorithm is rigorously proven. The computational efficiency of the proposed method is compared with that of the classical power method by numerical examples. The results indicate that the proposed algorithm achieves reliable linear convergence and offers competitive computational performance for index-cyclic symmetric positive tensors. Full article
(This article belongs to the Section Mathematics)
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11 pages, 906 KB  
Article
Optical Variability and Evidence for a Changing-Look Event in the Galaxy Mrk 6 (IC 450)
by Saule Shomshekova, Gaukhar Aimanova, Nazim Huseynov, Ayazhan Temirzhanova, Diana Nasirova, Inna Reva, Daulet Anarbek and Alexander Serebryanskiy
Universe 2026, 12(4), 104; https://doi.org/10.3390/universe12040104 - 2 Apr 2026
Viewed by 545
Abstract
In this work, the light curve of the Seyfert galaxy Mrk 6 constructed from photometric observations in the B, V, and Rc filters over the period from 5 April 2016 to 1 February 2026 is presented and analyzed. Over the [...] Read more.
In this work, the light curve of the Seyfert galaxy Mrk 6 constructed from photometric observations in the B, V, and Rc filters over the period from 5 April 2016 to 1 February 2026 is presented and analyzed. Over the entire monitoring interval (2016–2026), the variability amplitude of the light curve reaches ΔB=1.9 mag, ΔV=1.5 mag, and ΔRc=1.4 mag. During 2024–2026, the galaxy exhibits synchronous photometric variability in the B, V, and Rc filters with an amplitude of ∼0.3 mag. The study also uses spectroscopic observations obtained on 15 and 22 November 2025 and 16 February 2026 at the Shamakhy Astrophysical Observatory (Azerbaijan), as well as on 9 January 2026 at the Fesenkov Astrophysical Institute (Kazakhstan). The fluxes in the Hβ emission line were calibrated using the [O III] λ5007 Å line, ensuring consistent relative calibration of the spectral data. A comparison of the optical spectra reveals a pronounced transformation of the Hβ line profile between November 2025 and January 2026. The broad component, clearly present in November 2025, becomes strongly suppressed and nearly disappears in January 2026, while the narrow emission lines remain stable. This behavior is consistent with a changing-look transition, indicating a temporary weakening of the broad-line region emission. The radius of the broad-line region RBLR was taken to be equal to the average time delays (lags), amounting to ≈20 light days for the Hβ emission and ≈28 light days for the Hα. Full article
(This article belongs to the Special Issue Seyfert Galaxies: Probing the Active Nuclei of Nearby Galaxies)
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22 pages, 5394 KB  
Article
Unveiling the Variability and Chemical Composition of AL Col
by Surath C. Ghosh, Santosh Joshi, Samrat Ghosh, Athul Dileep, Otto Trust, Mrinmoy Sarkar, Jaime Andrés Rosales Guzmán, Nicolás Esteban Castro-Toledo, Oleg Malkov, Harinder P. Singh, Kefeng Tan and Sarabjeet S. Bedi
Galaxies 2025, 13(4), 93; https://doi.org/10.3390/galaxies13040093 - 14 Aug 2025
Viewed by 1496
Abstract
In this study, we present analysis of TESS photometry, spectral energy distribution (SED), high-resolution spectroscopy, and spot modeling of the α2 CVn-type star AL Col (HD 46462). The primary objective is to determine its fundamental physical parameters and investigate its surface activity [...] Read more.
In this study, we present analysis of TESS photometry, spectral energy distribution (SED), high-resolution spectroscopy, and spot modeling of the α2 CVn-type star AL Col (HD 46462). The primary objective is to determine its fundamental physical parameters and investigate its surface activity characteristics. Using TESS short-cadence (120 s) SAP flux, we identified a rotational frequency of 0.09655 d1 (Prot=10.35733 d). Wavelet analysis reveals that while the amplitudes of the harmonic components vary over time, the strength of the primary rotational frequency remains stable. A SED analysis of multi-band photometric data yields an effective temperature (Teff) of 11,750 K. High-resolution spectroscopic observations covering wavelengthrange 4500–7000 Å provide refined estimates of Teff = 13,814 ± 400 K, logg = 4.09 ± 0.08 dex, and υsini = 16 ± 1 km s−1. Abundance analysis shows solar-like composition of O ii, Mg ii, S ii, and Ca ii, while helium is under-abundant by 0.62 dex. Rare earth elements (REEs) exhibit over-abundances of up to 5.2 dex, classifying the star as an Ap/Bp-type star. AL Col has a radius of R=3.74±0.48R, with its H–R diagram position estimating a mass of M=4.2±0.2M and an age of 0.12±0.01 Gyr, indicating that the star has slightly evolved from the main sequence. The TESS light curves were modeled using a three-evolving-spot configuration, suggesting the presence of differential rotation. This star is a promising candidate for future investigations of magnetic field diagnostics and the vertical stratification of chemical elements in its atmosphere. Full article
(This article belongs to the Special Issue Stellar Spectroscopy, Molecular Astronomy and Atomic Astronomy)
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18 pages, 10314 KB  
Article
Multispectral and Thermal Imaging for Assessing Tequila Vinasse Evaporation: Unmanned Aerial Vehicles and Satellite-Based Observations
by Jesús Gabriel Rangel-Peraza, Sergio Alberto Monjardin-Armenta, Osiris Chávez-Martínez and José de Anda
Processes 2025, 13(7), 2281; https://doi.org/10.3390/pr13072281 - 17 Jul 2025
Cited by 1 | Viewed by 968
Abstract
This work aims to assess the droplets produced by a novel evaporation process, proposed as an alternative for managing tequila vinasses, using a spectral camera with three spectral bands and a thermal camera mounted on an unmanned aerial vehicle (UAV). High-resolution satellite images [...] Read more.
This work aims to assess the droplets produced by a novel evaporation process, proposed as an alternative for managing tequila vinasses, using a spectral camera with three spectral bands and a thermal camera mounted on an unmanned aerial vehicle (UAV). High-resolution satellite images with seven spectral bands complemented this characterization. The spectral characterization was conducted by comparing three experimental conditions: the background of the study area without droplets, the droplets generated from purified water, and the droplets produced from tequila vinasses. Two monitoring campaigns, conducted in November 2024 and January 2025, revealed that the tequila vinasse droplets exhibited a maximum influence radius of 16 m, primarily regulated by wind speed conditions (6–16 km/h). Thermal analysis identified the droplet plume as a zone with a lower temperature, creating a thermal contrast of up to 6.6 °C against the average background temperature of 36.6 °C. No significant difference was observed in the influence radius between the droplets generated from vinasse and those from potable water. Spectral analysis of the UAV and satellite images showed significant (p < 0.05) differences in reflectance when the droplets were present (e.g., the coastal blue band increased from an average of 14.43 to 95.59 when vinasse droplets were present). This suggests that the presence of chemical compounds altered light absorption and reflection. However, the instrument’s sensitivity limited the detection of organic compounds at concentrations below its detection limit. The monitoring data presented in this manuscript is crucial for developing strategies to mitigate the potential environmental impacts of the droplets emitted by this novel process. Full article
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15 pages, 914 KB  
Article
Spectral and Photometric Studies of NGC 7469 in the Optical Range
by Saule Shomshekova, Inna Reva, Ludmila Kondratyeva, Nazim Huseynov, Vitaliy Kim and Laura Aktay
Universe 2025, 11(7), 227; https://doi.org/10.3390/universe11070227 - 10 Jul 2025
Viewed by 1040
Abstract
The galaxy NGC 7469 is a bright infrared source with an active galactic nucleus (AGN) and an intense star-forming region with a radius of approximately 500 parsecs, where the star formation rate is estimated to be 20–50 Myr1. [...] Read more.
The galaxy NGC 7469 is a bright infrared source with an active galactic nucleus (AGN) and an intense star-forming region with a radius of approximately 500 parsecs, where the star formation rate is estimated to be 20–50 Myr1. This study presents the results of spectral and photometric observations carried out during the period from 2020 to 2024 at the Fesenkov Astrophysical Institute (Almaty, Kazakhstan) and the Nasreddin Tusi Shamakhy Astrophysical Observatory (Shamakhy, Azerbaijan). Photometric data were obtained using B, V, and Rc filters, while spectroscopic observations covered the wavelength range of λ 4000–7000 Å. Data reduction was performed using the IRAF and MaxIm DL Pro6 software packages. An analysis of the light curves revealed that after the 2019–2020 outburst, the luminosity level of NGC 7469 remained relatively stable until the end of 2024. In November–December 2024, an increase in brightness (∼0.3–0.5 magnitudes) was recorded. Spectral data show variations in the Ha fluxes and an enhancement of them at the end of 2024. On BPT diagrams, the emission line flux ratios [OIII]/H β and [NII]/H α place NGC 7469 on the boundary between regions dominated by different ionization sources: AGN and star-forming regions. The electron density of the gas, estimated from the intensity ratios of the [SII] 6717, 6731 Ålines, is about 9001000cm3. Continued observations will help to determine whether the trend of increasing brightness and emission line fluxes recorded at the end of 2024 will persist. Full article
(This article belongs to the Special Issue 10th Anniversary of Universe: Galaxies and Their Black Holes)
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32 pages, 443 KB  
Article
Spectral and Sharp Sufficient Conditions for Graphs to Admit a Strong Star Factor
by Fengyun Ren, Shumin Zhang and He Li
Mathematics 2025, 13(10), 1640; https://doi.org/10.3390/math13101640 - 16 May 2025
Viewed by 776
Abstract
LetGbe a graph. An odd [1,k]-factor of a graph G is a spanning subgraph H of G such that degH(v) is odd and [...] Read more.
LetGbe a graph. An odd [1,k]-factor of a graph G is a spanning subgraph H of G such that degH(v) is odd and 1degH(v)k for every vV(G) where k is a positive odd integer. We call a spanning subgraph H of a graph G a strong star factor if every component of H is isomorphic to an element of the stars K1,1,K1,2,,K1,r and is an induced subgraph of G where r2 is an integer. In a {K1,1,K1,2,Cm:m3}-factor of G, each component is isomorphic to a member in {K1,1,K1,2,C3,C4,Cm}. A graph G is a strong star factor deleted graph if Ge has a strong star factor for each edge e of G. In this paper, through the typical spectral techniques, we obtain the respective necessary and sufficient conditions defining a strong star factor deleted graph, an odd [1,k]-factor deleted graph, and a {K1,1,K1,2,Cm:m3}-factor deleted graph. We determine a lower bound on the size to guarantee that G is a {K1,1,K1,2,Cm:m3}-factor deleted graph. We establish the upper bound of the signless Laplacian spectral radius (resp. the spectral radius) and the lower bound of the distance signless Laplacian spectral radius (resp. the distance spectral radius) to determine whether G admits a strong star factor. Furthermore, by constructing extremal graphs, we show that all the bounds obtained in this contribution are the best possible. Full article
17 pages, 313 KB  
Article
On the Extended Adjacency Eigenvalues of a Graph
by Alaa Altassan, Hilal A. Ganie and Yilun Shang
Information 2024, 15(10), 586; https://doi.org/10.3390/info15100586 - 26 Sep 2024
Cited by 3 | Viewed by 2119
Abstract
Let H be a graph of order n with m edges. Let di=d(vi) be the degree of the vertex vi. The extended adjacency matrix Aex(H) of H is an [...] Read more.
Let H be a graph of order n with m edges. Let di=d(vi) be the degree of the vertex vi. The extended adjacency matrix Aex(H) of H is an n×n matrix defined as Aex(H)=(bij), where bij=12didj+djdi, whenever vi and vj are adjacent and equal to zero otherwise. The largest eigenvalue of Aex(H) is called the extended adjacency spectral radius of H and the sum of the absolute values of its eigenvalues is called the extended adjacency energy of H. In this paper, we obtain some sharp upper and lower bounds for the extended adjacency spectral radius in terms of different graph parameters and characterize the extremal graphs attaining these bounds. We also obtain some new bounds for the extended adjacency energy of a graph and characterize the extremal graphs attaining these bounds. In both cases, we show our bounds are better than some already known bounds in the literature. Full article
(This article belongs to the Special Issue Feature Papers in Information in 2024–2025)
16 pages, 298 KB  
Article
Quasi-Double Diagonally Dominant H-Tensors and the Estimation Inequalities for the Spectral Radius of Nonnegative Tensors
by Xincun Wang and Hongbin Lv
Symmetry 2023, 15(2), 439; https://doi.org/10.3390/sym15020439 - 7 Feb 2023
Cited by 2 | Viewed by 1948
Abstract
In this paper, we study two classes of quasi-double diagonally dominant tensors and prove they are H-tensors. Numerical examples show that two classes of H-tensors are mutually exclusive. Thus, we extend the decision conditions of H-tensors. Based on these two [...] Read more.
In this paper, we study two classes of quasi-double diagonally dominant tensors and prove they are H-tensors. Numerical examples show that two classes of H-tensors are mutually exclusive. Thus, we extend the decision conditions of H-tensors. Based on these two classes of tensors, two estimation inequalities for the upper and lower bounds for the spectral radius of nonnegative tensors are obtained. Full article
21 pages, 363 KB  
Article
A New Seminorm for d-Tuples of A-Bounded Operators and Their Applications
by Najla Altwaijry, Kais Feki and Nicuşor Minculete
Mathematics 2023, 11(3), 685; https://doi.org/10.3390/math11030685 - 29 Jan 2023
Cited by 9 | Viewed by 2041
Abstract
The aim of this paper was to introduce and investigate a new seminorm of operator tuples on a complex Hilbert space H when an additional semi-inner product structure defined by a positive (semi-definite) operator A on H is considered. We prove the equality [...] Read more.
The aim of this paper was to introduce and investigate a new seminorm of operator tuples on a complex Hilbert space H when an additional semi-inner product structure defined by a positive (semi-definite) operator A on H is considered. We prove the equality between this new seminorm and the well-known A-joint seminorm in the case of A-doubly-commuting tuples of A-hyponormal operators. This study is an extension of a well-known result in [Results Math 75, 93(2020)] and allows us to show that the following equalities rA(T)=ωA(T)=TA hold for every A-doubly-commuting d-tuple of A-hyponormal operators T=(T1,,Td). Here, rA(T),TA, and ωA(T) denote the A-joint spectral radius, the A-joint operator seminorm, and the A-joint numerical radius of T, respectively. Full article
(This article belongs to the Special Issue Mathematical Inequalities, Models and Applications)
10 pages, 268 KB  
Article
On the Sum and Spread of Reciprocal Distance Laplacian Eigenvalues of Graphs in Terms of Harary Index
by Saleem Khan, Shariefuddin Pirzada and Yilun Shang
Symmetry 2022, 14(9), 1937; https://doi.org/10.3390/sym14091937 - 17 Sep 2022
Cited by 11 | Viewed by 2769
Abstract
The reciprocal distance Laplacian matrix of a connected graph G is defined as RDL(G)=RT(G)RD(G), where RT(G) is the diagonal matrix of [...] Read more.
The reciprocal distance Laplacian matrix of a connected graph G is defined as RDL(G)=RT(G)RD(G), where RT(G) is the diagonal matrix of reciprocal distance degrees and RD(G) is the Harary matrix. Clearly, RDL(G) is a real symmetric matrix, and we denote its eigenvalues as λ1(RDL(G))λ2(RDL(G))λn(RDL(G)). The largest eigenvalue λ1(RDL(G)) of RDL(G), denoted by λ(G), is called the reciprocal distance Laplacian spectral radius. In this paper, we obtain several upper bounds for the sum of k largest reciprocal distance Laplacian eigenvalues of G in terms of various graph parameters, such as order n, maximum reciprocal distance degree RTmax, minimum reciprocal distance degree RTmin, and Harary index H(G) of G. We determine the extremal cases corresponding to these bounds. As a consequence, we obtain the upper bounds for reciprocal distance Laplacian spectral radius λ(G) in terms of the parameters as mentioned above and characterize the extremal cases. Moreover, we attain several upper and lower bounds for reciprocal distance Laplacian spread RDLS(G)=λ1(RDL(G))λn1(RDL(G)) in terms of various graph parameters. We determine the extremal graphs in many cases. Full article
13 pages, 500 KB  
Article
Spectral and Timing Properties of H 1743-322 in the “Faint” 2005 Normal Outburst
by Aijun Dong, Chang Liu, Qijun Zhi, Ziyi You, Qibin Sun and Bowen Du
Universe 2022, 8(5), 273; https://doi.org/10.3390/universe8050273 - 6 May 2022
Cited by 2 | Viewed by 2943
Abstract
H 1743-322 is a well-known black hole X-ray binary (BH XRBs) that has been observed in several outbursts over the past. In this work, we have performed the spectral and timing analysis of H 1743-322 during the “faint” 2005 outburst for the first [...] Read more.
H 1743-322 is a well-known black hole X-ray binary (BH XRBs) that has been observed in several outbursts over the past. In this work, we have performed the spectral and timing analysis of H 1743-322 during the “faint” 2005 outburst for the first time with the RXTE/PCA data. In this outburst, the spectral and timing parameters (e.g., Tin, Γ, Rin, rms and QPOs, etc.) presented an obvious change and a q-like pattern was found in the Hardness Intensity Diagram (HID), which often named as the hysteresis effect of BH XRBs. The radius of the innermost stable circular orbit was constrained as RISCO∼3.50 Rg, which predicts that H 1743-322 is a lower-spin black hole. We further explored the correlation between timing and spectral properties. The relation of photon index Γ and X-ray flux, F325keV, presented a transition between negative and positive correlation when the X-ray luminosity, L325keV, is above and below a critical X-ray luminosity, LX,crit2.55×103 LEdd, which can be well explained by the Shakura-Sunyaev disk–corona model (SSD-corona) and advection-dominated accretion flow (ADAF). We also found the tight linear, negative correlation between photon index Γ and the total fractional rms. Since the amount of soft photons from the accretion disk seems invariable, an increase of the number of soft photons will dilute the variability from the harder photons. Therefore, the softer the X-ray spectra will result in the smaller total fractional rms. The above results suggested that the 2005 outburst of H 1743-322 was a normal outburst and H 1743-322 represented similar properties with other black hole X-ray binaries. Full article
(This article belongs to the Special Issue Multi-Messengers of Black Hole Accretion and Emission)
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22 pages, 6352 KB  
Article
Albumin Binds Doxorubicin via Self–Assembling Dyes as Specific Polymolecular Ligands
by Anna Jagusiak, Katarzyna Chłopaś, Grzegorz Zemanek, Izabela Kościk, Paweł Skorek and Barbara Stopa
Int. J. Mol. Sci. 2022, 23(9), 5033; https://doi.org/10.3390/ijms23095033 - 1 May 2022
Cited by 6 | Viewed by 4846
Abstract
Congo red (CR) type self–assembled ribbon–like structures (SRLS) were previously shown to interact with some proteins, including albumin. SRLS also complex with some drugs with a flat, ring–shaped structure with aromatic characteristics, intercalating them into their ribbon structure. The combination of interaction with [...] Read more.
Congo red (CR) type self–assembled ribbon–like structures (SRLS) were previously shown to interact with some proteins, including albumin. SRLS also complex with some drugs with a flat, ring–shaped structure with aromatic characteristics, intercalating them into their ribbon structure. The combination of interaction with proteins and drug binding by SRLS enables the use of such systems for immunotargeting. It is especially interesting in the case of chemotherapeutic agents. The present experiments aimed to show that the model carrier system composed of supramolecular albumin and Congo red efficiently binds doxorubicin (Dox) and that the drug can be released at reduced pH. The presented results come from the studies on such complexes differing in the molar ratio of CR to Dox. The following methods were used for the analysis: electrophoresis, dialysis, gel filtration, spectral analysis, and analysis of the size of the hydrodynamic radius using the dynamic light scattering method (DLS). The applied methods confirmed the formation of the CR–Dox complex, with large dimensions and changed properties compared with free CR. The presented results show that albumin binds both CR and its complex with Dox. Various CR–Dox molar ratios, 5:1, 2:1, and 1:1, were analyzed. The confirmation of the possibility of releasing the drug from the carriers thus formed was also obtained. The presented research is important due to the search for optimal solutions for the use of SRLS in drug immunotargeting, with particular emphasis on chemotherapeutic agents. Full article
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20 pages, 3153 KB  
Article
Chitosan-Hyaluronan Nanoparticles for Vinblastine Sulfate Delivery: Characterization and Internalization Studies on K-562 Cells
by Carmela Cannavà, Federica De Gaetano, Rosanna Stancanelli, Valentina Venuti, Giuseppe Paladini, Francesco Caridi, Corneliu Ghica, Vincenza Crupi, Domenico Majolino, Guido Ferlazzo, Silvana Tommasini and Cinzia Anna Ventura
Pharmaceutics 2022, 14(5), 942; https://doi.org/10.3390/pharmaceutics14050942 - 26 Apr 2022
Cited by 24 | Viewed by 4085
Abstract
In the present study, we developed chitosan/hyaluronan nanoparticles (CS/HY NPs) for tumor targeting with vinblastine sulfate (VBL), that can be directed to the CD44 transmembrane receptor, over-expressed in cancer cells. NPs were prepared by coating with HY-preformed chitosan/tripolyphosphate (CS/TPP) NPs, or by polyelectrolyte [...] Read more.
In the present study, we developed chitosan/hyaluronan nanoparticles (CS/HY NPs) for tumor targeting with vinblastine sulfate (VBL), that can be directed to the CD44 transmembrane receptor, over-expressed in cancer cells. NPs were prepared by coating with HY-preformed chitosan/tripolyphosphate (CS/TPP) NPs, or by polyelectrolyte complexation of CS with HY. NPs with a mean hydrodynamic radius (RH) of 110 nm, 12% polydispersity index and negative zeta potential values were obtained by a direct complexation process. Transmission Electron Microscopy (TEM) images showed spherical NPs with a non-homogeneous matrix, probably due to a random localization of CS and HY interacting chains. The intermolecular interactions occurring between CS and HY upon NPs formation were experimentally evidenced by micro-Raman (µ-Raman) spectroscopy, through the analysis of the spectral changes of characteristic vibrational bands of HY during NP formation, in order to reveal the involvement of specific chemical groups in the process. Optimized NP formulation efficiently encapsulated VBL, producing a drug sustained release for 20 h. In vitro studies demonstrated a fast internalization of labeled CS/HY NPs (within 6 h) on K-562 human myeloid leukemia cells. Pre-saturation of CD44 by free HY produced a slowing-down of NP uptake over 24 h, demonstrating the need of CD44 for the internalization of HY-based NPs. Full article
(This article belongs to the Special Issue Polymer-Based Micro- and Nanocarriers for Drug Delivery and Targeting)
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23 pages, 9864 KB  
Article
Large-Eddy Simulation Study of Flow and Heat Transfer in Swirling and Non-Swirling Impinging Jets on a Semi-Cylinder Concave Target
by Liang Xu, Xu Zhao, Lei Xi, Yonghao Ma, Jianmin Gao and Yunlong Li
Appl. Sci. 2021, 11(15), 7167; https://doi.org/10.3390/app11157167 - 3 Aug 2021
Cited by 7 | Viewed by 4169
Abstract
Swirling impinging jet (SIJ) is considered as an effective means to achieve uniform cooling at high heat transfer rates, and the complex flow structure and its mechanism of enhancing heat transfer have attracted much attention in recent years. The large eddy simulation (LES) [...] Read more.
Swirling impinging jet (SIJ) is considered as an effective means to achieve uniform cooling at high heat transfer rates, and the complex flow structure and its mechanism of enhancing heat transfer have attracted much attention in recent years. The large eddy simulation (LES) technique is employed to analyze the flow fields of swirling and non-swirling impinging jet emanating from a hole with four spiral and straight grooves, respectively, at a relatively high Reynolds number (Re) of 16,000 and a small jet spacing of H/D = 2 on a concave surface with uniform heat flux. Firstly, this work analyzes two different sub-grid stress models, and LES with the wall-adapting local eddy-viscosity model (WALEM) is established for accurately predicting flow and heat transfer performance of SIJ on a flat surface. The complex flow field structures, spectral characteristics, time-averaged flow characteristics and heat transfer on the target surface for the swirling and non-swirling impinging jets are compared in detail using the established method. The results show that small-scale recirculation vortices near the wall change the nearby flow into an unstable microwave state, resulting in small-scale fluctuation of the local Nusselt number (Nu) of the wall. There is a stable recirculation vortex at the stagnation point of the target surface, and the axial and radial fluctuating speeds are consistent with the fluctuating wall temperature. With the increase in the radial radius away from the stagnation point, the main frequency of the fluctuation of wall temperature coincides with the main frequency of the fluctuation of radial fluctuating velocity at x/D = 0.5. Compared with 0° straight hole, 45° spiral hole has a larger fluctuating speed because of speed deflection, resulting in a larger turbulence intensity and a stronger air transport capacity. The heat transfer intensity of the 45° spiral hole on the target surface is slightly improved within 5–10%. Full article
(This article belongs to the Section Mechanical Engineering)
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16 pages, 2464 KB  
Article
Rutin-Loaded Solid Lipid Nanoparticles: Characterization and In Vitro Evaluation
by Federica De Gaetano, Maria Chiara Cristiano, Valentina Venuti, Vincenza Crupi, Domenico Majolino, Giuseppe Paladini, Giuseppe Acri, Barbara Testagrossa, Alessia Irrera, Donatella Paolino, Silvana Tommasini, Cinzia Anna Ventura and Rosanna Stancanelli
Molecules 2021, 26(4), 1039; https://doi.org/10.3390/molecules26041039 - 16 Feb 2021
Cited by 50 | Viewed by 5580
Abstract
This study was aimed at preparing and characterizing solid lipid nanoparticles loading rutin (RT-SLNs) for the treatment of oxidative stress-induced diseases. Phospholipon 80H® as a solid lipid and Polysorbate 80 as surfactant were used for the SLNs preparation, using the solvent emulsification/diffusion [...] Read more.
This study was aimed at preparing and characterizing solid lipid nanoparticles loading rutin (RT-SLNs) for the treatment of oxidative stress-induced diseases. Phospholipon 80H® as a solid lipid and Polysorbate 80 as surfactant were used for the SLNs preparation, using the solvent emulsification/diffusion method. We obtained spherical RT-SLNs with low sizes, ranging from 40 to 60 nm (hydrodynamic radius) for the SLNs prepared starting from 2% and 5% (w/w) theoretical amount. All prepared formulations showed negative zeta-potential values. RT was efficiently encapsulated within SLNs, obtaining high encapsulation efficiency and drug content percentages, particularly for SLNs prepared with a 5% theoretical amount of RT. In vitro release profiles and analysis of the obtained data applying different kinetic models revealed Fickian diffusion as the main mechanism of RT release from the SLNs. The morphology of RT-SLNs was characterized by scanning electron microscopy (SEM), whereas the interactions between RT and the lipid matrix were investigated by Raman spectroscopy, evidencing spectral modifications of characteristic bands of RT due to the establishment of new interactions. Finally, antioxidant activity assay on human glioblastoma astrocytoma (U373) culture cells showed a dose-dependent activity for RT-SLNs, particularly at the highest assayed dose (50 μM), whereas the free drug showed the lesser activity. Full article
(This article belongs to the Special Issue Nanosystems in Pharmaceutical Technology)
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