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2,284 Results Found

  • Article
  • Open Access
5 Citations
5,086 Views
11 Pages

Introduction: Air pollution is a significant risk factor for a range of diseases and leads to substantial disease burden and deaths worldwide. This study aimed to investigate the burden of disease in Afghanistan attributed to air pollution in 2019. M...

  • Article
  • Open Access
8 Citations
5,175 Views
13 Pages

Schistosomiasis Burden and Trend Analysis in Africa: Insights from the Global Burden of Disease Study 2021

  • Dandan Peng,
  • Yajing Zhu,
  • Lu Liu,
  • Jianfeng Zhang,
  • Peng Huang,
  • Shaowen Bai,
  • Xinyao Wang and
  • Kun Yang

Schistosomiasis remains a major public health concern in Africa, despite global efforts to eliminate the disease by 2030. This study estimates the burden, trends, and inequalities of schistosomiasis in Africa from 1990 to 2021, and projects future pr...

  • Article
  • Open Access
1 Citations
2,095 Views
16 Pages

26 September 2025

Background: Psoriasis is a chronic immune-mediated disease affecting approximately 43 million individuals worldwide. While previous studies provide certain insights, there remains different conclusions and a lack of a comprehensive analysis regarding...

  • Article
  • Open Access
36 Citations
10,422 Views
17 Pages

Global, Regional, and National Burden of Protein–Energy Malnutrition: A Systematic Analysis for the Global Burden of Disease Study

  • Xu Zhang,
  • Lu Zhang,
  • Yuanchun Pu,
  • Min Sun,
  • Yan Zhao,
  • Dan Zhang,
  • Xin Wang,
  • Yarui Li,
  • Dan Guo and
  • Shuixiang He

22 June 2022

Background: Statistical data on the prevalence, mortality, and disability-adjusted life years (DALYs) of protein–energy malnutrition are valuable for health resource planning and policy-making. We aimed to estimate protein–energy malnutri...

  • Article
  • Open Access
19 Citations
3,900 Views
13 Pages

14 November 2022

The aim of this study was to explore the most updated changing trends of non-rheumatic calcific aortic valve disease (nrCAVD) and reveal possible improvements. We analyzed the age-standardized rates (ASRs) of prevalence, incidence, disability-adjuste...

  • Article
  • Open Access
3 Citations
3,139 Views
15 Pages

Background/Objectives: Vertebral fractures (VFs) are a global health issue caused by traumatic or pathological factors that compromise spinal integrity. The burden of VFs is increasing, particularly in older adults. Methods: Data from the Global Burd...

  • Article
  • Open Access
22 Citations
7,952 Views
19 Pages

The Global Burden of Type 2 Diabetes Attributable to Dietary Risks: Insights from the Global Burden of Disease Study 2019

  • Alina Ioana Forray,
  • Mădălina Adina Coman,
  • Ruxandra Simonescu-Colan,
  • Andreea Isabela Mazga,
  • Răzvan Mircea Cherecheș and
  • Cristina Maria Borzan

30 October 2023

The Global Burden of Disease Study (GBD) 2019 reveals an increasing prevalence of Type 2 Diabetes Mellitus (T2DM) from 1990 to 2019. This study delves into the role of dietary risk factors across different demographic and socioeconomic groups. Utiliz...

  • Article
  • Open Access
15 Citations
4,403 Views
15 Pages

27 February 2023

Uterine cancer (UC) is the most common gynecologic malignancy, and high body mass index (BMI) is a poor prognostic factor for UC. However, the associated burden has not been fully assessed, which is crucial for women’s health management and the...

  • Review
  • Open Access
1 Citations
2,020 Views
12 Pages

The Global Disease Burden of Hypertensive Heart Disease from 1990 to 2019: A Gender-Stratified Joinpoint Analysis

  • Noman Khalid,
  • Hasan Munshi,
  • Abdullah Ahmad,
  • Muhammad Abdullah,
  • Muhammad Adil Afzal,
  • Sarshaar Qadir,
  • Yezin Shamoon,
  • Rahul Vasudev and
  • Fayez E. Shamoon

13 June 2025

This study aimed to examine global hypertensive heart disease (HHD) trends (1990–2019). Methods: We extracted data from the Global Burden of Disease (GBD) 2019 Study, encompassing 204 countries and territories. We analyzed the age-adjusted mort...

  • Article
  • Open Access
2,302 Views
23 Pages

26 June 2025

Background: Rheumatic heart disease (RHD) remains a major contributor to childhood cardiovascular morbidity and mortality globally, particularly in low-resource settings. This study offers a thorough evaluation of the global, regional, and national b...

  • Article
  • Open Access
105 Citations
9,295 Views
19 Pages

Background: To inform global health policies and resources planning, this paper analyzes evolving trends in physical rehabilitation needs, using data on Years Lived with Disability (YLDs) from the Global Burden of Disease Study (GBD) 2017. Methods: S...

  • Article
  • Open Access
809 Views
19 Pages

The Burden of Inflammatory Bowel Disease in Gulf Cooperation Council Countries from 1990 to 2021 with Forecasting Projections to 2030: A Global Burden of Disease Study

  • Ahmed K. Alsaif,
  • Jawad S. Alnajjar,
  • Faisal A. Al-Harbi,
  • Ahmed A. Alsirhani,
  • Sultan S. Alruqaie,
  • Abdulaziz T. Alturki,
  • Mohammed A. Basuhail,
  • Abdulrhman K. Alabdulqader,
  • Ahmed A. Albadrani and
  • Ahmed Y. Azzam

28 November 2025

Background: Inflammatory bowel disease (IBD) represents a growing health challenge in regions undergoing socioeconomic transition. This study characterized IBD epidemiology across Gulf Cooperation Council (GCC) countries, forecasted future burden, an...

  • Article
  • Open Access
11 Citations
3,421 Views
11 Pages

22 August 2023

Background: Endometriosis is a common nonfatal gynecological disease, and infertility is one of its main dangers. Endometriosis-related infertility causes serious damage to women’s health and places a burden on women of reproductive age. The ai...

  • Article
  • Open Access
40 Citations
6,935 Views
17 Pages

The Burden of Early-Onset Colorectal Cancer and Its Risk Factors from 1990 to 2019: A Systematic Analysis for the Global Burden of Disease Study 2019

  • Wan-Jie Gu,
  • Jun-Peng Pei,
  • Jun Lyu,
  • Naohiko Akimoto,
  • Koichiro Haruki,
  • Shuji Ogino and
  • Chun-Dong Zhang

19 July 2022

Background: The incidence of early-onset colorectal cancer (CRC) diagnosed before age 50 has been increasing over the past decades. Hence, we examined the global, regional, and national burden of early-onset CRC and its risk factors from 1990 to 2019...

  • Article
  • Open Access
50 Citations
5,077 Views
13 Pages

Background: Oral cancer (OC) is a common tumour that poses a threat to human health and imposes a heavy burden on countries. This study assessed the burden imposed by OC on the 10 most populous countries from 1990 to 2019 on the basis of gender, age...

  • Article
  • Open Access
11 Citations
3,716 Views
10 Pages

The prevalence of type 2 diabetes mellitus (T2DM) and the burden of complications are increasing worldwide. Chronic kidney disease (CKD) is one serious complication. Our aim was to investigate the trends and inequalities of the burden of CKD due to T...

  • Article
  • Open Access
8 Citations
11,798 Views
17 Pages

Assessing Global Frailty Scores: Development of a Global Burden of Disease-Frailty Index (GBD-FI)

  • Mark O’Donovan,
  • Duygu Sezgin,
  • Zubair Kabir,
  • Aaron Liew and
  • Rónán O’Caoimh

Frailty is an independent age-associated predictor of morbidity and mortality. Despite this, many countries lack population estimates with large heterogeneity between studies. No population-based standardised metric for frailty is available. We appli...

  • Viewpoint
  • Open Access
101 Citations
22,192 Views
13 Pages

Occupational stress and high workload are being increasingly recognized as significant contributors to the diseases and disorders constituting major components of the global burden of disease. A more detailed definition of burn-out was recently inclu...

  • Feature Paper
  • Article
  • Open Access
1 Citations
5,289 Views
18 Pages

Background: Sudden Infant Death Syndrome (SIDS) remains an important global health concern despite its decline in recent decades. This research assesses the global, regional, and national tendencies in SIDS mortality and DALYs from 1991 to 2021, high...

  • Article
  • Open Access
3 Citations
5,091 Views
28 Pages

Burdens of Breast Cancer and Projections for 2030 Among Women in Asia: Findings from the 2021 Global Burden of Disease Study

  • Feng Wang,
  • Sixuan Liu,
  • Jianwei Li,
  • Yuzhen Shi,
  • Zhaohui Geng,
  • Yajie Ji and
  • Jie Zheng

Background: Employing the most recent dataset from the Global Burden of Disease (GBD) Study 2021, this report sought to delineate the current epidemiologic landscape of breast cancer in Asian women. Methods: We examined the evolving trends in disease...

  • Article
  • Open Access
3 Citations
3,978 Views
23 Pages

10 April 2025

Background: An unhealthy diet is a major risk factor for colorectal cancer (CRC). This study assessed the diet-related CRC burden from 1990 to 2021 in Organisation for Economic Co-operation and Development (OECD) nations and estimated the burden unti...

  • Article
  • Open Access
10 Citations
6,086 Views
14 Pages

The global epidemic of noncommunicable diseases (NCDs), such as cardiovascular disease and diabetes, is creating unsustainable burdens on health systems worldwide. NCDs are treatable but not curable. They are less amenable to top-down prevention and...

  • Article
  • Open Access
436 Views
26 Pages

26 November 2025

Background: While tobacco smoke remains a leading modifiable risk factor for urologic cancers, comprehensive assessments in BRICS countries are scarce. We aimed to quantify the burden of kidney, prostate, and bladder cancers attributable to tobacco e...

  • Article
  • Open Access
1 Citations
2,233 Views
12 Pages

This study assesses the feasibility of hepatitis B (HBV) and C (HCV) elimination using an analysis of trends of epidemiology data (1990–2019) from the Global Burden of Disease Study. Joinpoint regression analysis was used to identify significan...

  • Article
  • Open Access
2 Citations
1,361 Views
13 Pages

Rehabilitation Needs Across Heterogenous Brazilian Regions: Secondary Analysis of the Global Burden of Disease Study

  • Rogério Olmedija de Araújo,
  • Tiótrefis Gomes Fernandes and
  • Tiago Silva Jesus

Aim: This study aimed to determine the evolving rehabilitation needs in Brazil, considering five main impairment categories for nationwide health-service planning, stratified per age groups, as well as Brazilian regions with inequitable development....

  • Article
  • Open Access
3 Citations
2,435 Views
15 Pages

To investigate the trend of healthcare needs among elders in low-income countries (LICs) and how changes in healthcare access and quality (HAQ) have correlated with these changes from 1990 to 2019, this study used estimates from the global burden of...

  • Article
  • Open Access
17 Citations
11,045 Views
14 Pages

5 October 2018

Disability adjusted life years (DALYs) is a health burden metric that combines years of life lost due to disease disability and premature mortality. The Global Burden of Disease (GBD) has been using DALYs to determine the health burden associated wit...

  • Article
  • Open Access
4 Citations
3,084 Views
16 Pages

Trends of the Global Burden of Disease Linked to Ground-Level Ozone Pollution: A 30-Year Analysis for the Greater Athens Area, Greece

  • Kleopatra Ntourou,
  • Kyriaki-Maria Fameli,
  • Konstantinos Moustris,
  • Nikolaos Manousakis and
  • Christos Tsitsis

20 March 2024

The Greater Athens Area (GAA), situated in the southern part of the European continent (in Greece), has a Mediterranean climate characterized by hot, dry summers and mild, wet winters. As a result of increased sunshine and high temperatures, exceedan...

  • Article
  • Open Access
30 Citations
4,918 Views
20 Pages

Physical Rehabilitation Needs in the BRICS Nations from 1990 to 2017: Cross-National Analyses Using Data from the Global Burden of Disease Study

  • Tiago S. Jesus,
  • Michel D. Landry,
  • Helen Hoenig,
  • Yi Zeng,
  • Sureshkumar Kamalakannan,
  • Raquel R. Britto,
  • Nana Pogosova,
  • Olga Sokolova,
  • Karen Grimmer and
  • Quinette A. Louw

Background: This study analyzes the current and evolving physical rehabilitation needs of BRICS nations (Brazil, Russian Federation, India, China, South Africa), a coalition of large emergent economies increasingly important for global health. Method...

  • Article
  • Open Access
3 Citations
2,690 Views
9 Pages

20 September 2024

The incidence of prostate, breast, and thyroid cancers has increased in China over the past few decades. Whether and how much these increases can be attributed to overdiagnosis are less understood. This study aimed to estimate the proportion of overd...

  • Article
  • Open Access
1 Citations
3,161 Views
21 Pages

The aims of this study were (1) to develop a comprehensive risk-of-death and life expectancy (LE) model and (2) to provide data on the effects of multiple risk factors on LE. We used data for Canada from the Global Burden of Disease (GBD) Study. To c...

  • Article
  • Open Access
8 Citations
3,994 Views
13 Pages

Magnitude, Temporal Trends, and Inequalities in the DALYs and YLDs of Nutritional Deficiency among Older Adults in the Western Pacific Region: Findings from the Global Burden of Disease Study 1990–2019

  • Doris Y. P. Leung,
  • Hui-Lin Cheng,
  • Stefanos Tyrovolas,
  • Angel S. K. Tang,
  • Justina Y. W. Liu,
  • Mimi M. Y. Tse,
  • Claudia K. Y. Lai and
  • Alex Molassiotis

10 December 2021

The population in the Western Pacific region is aging rapidly. Nutritional deficiency is prevalent in older adults; however, information regarding nutritional deficiency in this population is scarce. Using the 2019 Global Burden of Disease (GBD) resu...

  • Article
  • Open Access
2 Citations
2,176 Views
22 Pages

Global Epidemiology of Vector-Borne Parasitic Diseases: Burden, Trends, Disparities, and Forecasts (1990–2036)

  • Cun-Chen Wang,
  • Wei-Xian Zhang,
  • Yong He,
  • Jia-Hua Liu,
  • Chang-Shan Ju,
  • Qi-Long Wu,
  • Fang-Hang He,
  • Cheng-Sheng Peng,
  • Mao Zhang and
  • Sheng-Qun Deng

25 August 2025

Vector-borne parasitic diseases (VBPDs), including malaria, schistosomiasis, leishmaniasis, Chagas disease, African trypanosomiasis, lymphatic filariasis, and onchocerciasis, impose a significant global health burden. This study analyzes the global d...

  • Article
  • Open Access
23 Citations
5,689 Views
12 Pages

Global Air Quality: An Inter-Disciplinary Approach to Exposure Assessment for Burden of Disease Analyses

  • Gavin Shaddick,
  • James M. Salter,
  • Vincent-Henri Peuch,
  • Giulia Ruggeri,
  • Matthew L. Thomas,
  • Pierpaolo Mudu,
  • Oksana Tarasova,
  • Alexander Baklanov and
  • Sophie Gumy

31 December 2020

Global assessments of air quality and health require comprehensive estimates of the exposures to air pollution that are experienced by populations in every country. However, there are many countries in which measurements from ground-based monitoring...

  • Article
  • Open Access
98 Citations
11,962 Views
11 Pages

The Burden of Rheumatoid Arthritis: Findings from the 2019 Global Burden of Diseases Study and Forecasts for 2030 by Bayesian Age-Period-Cohort Analysis

  • Yuanqing Cai,
  • Jianan Zhang,
  • Jialin Liang,
  • Mofan Xiao,
  • Guangyang Zhang,
  • Zhaopu Jing,
  • Leifeng Lv,
  • Kai Nan and
  • Xiaoqian Dang

6 February 2023

Background: Rheumatoid arthritis (RA) is a key health issue worldwide. Due to early identification and effective treatment strategies, the disease pattern of RA has also changed. However, the most comprehensive and up-to-date information about the bu...

  • Article
  • Open Access
24 Citations
18,863 Views
19 Pages

29 August 2024

(1) Background: Depression and anxiety are the most common and severe mental disorders. This research estimated the prevalence and disease burden of depression and anxiety from 1990 to 2044. (2) Methods: Data on disease burden, population, and risk f...

  • Feature Paper
  • Article
  • Open Access
46 Citations
14,117 Views
9 Pages

Impact of Air Pollution on Global Burden of Disease in 2019

  • Meghnath Dhimal,
  • Francesco Chirico,
  • Bihungum Bista,
  • Sitasma Sharma,
  • Binaya Chalise,
  • Mandira Lamichhane Dhimal,
  • Olayinka Stephen Ilesanmi,
  • Paolo Trucillo and
  • Daniele Sofia

25 September 2021

Air pollution consisting of ambient air pollution and household air pollution (HAP) threatens health globally. Air pollution aggravates the health of vulnerable people such as infants, children, women, and the elderly as well as people with chronic d...

  • Article
  • Open Access
21 Citations
5,363 Views
15 Pages

Background: Cystic echinococcosis (CE) is a neglected tropical parasitic disease that poses huge disease, social and economic burdens worldwide; however, there has been little knowledge on the global morbidity, mortality and disability-adjusted life...

  • Article
  • Open Access
6 Citations
2,958 Views
19 Pages

Global Burden of Esophageal Cancer and Its Risk Factors: A Systematic Analysis of the Global Burden of Disease Study 2019

  • Irena Ilic,
  • Ivana Zivanovic Macuzic,
  • Ana Ravic-Nikolic,
  • Milena Ilic and
  • Vesna Milicic

28 December 2024

Background: Esophageal cancer is a major public health issue, yet risk factors for its occurrence are still insufficiently known. This study aimed to estimate the global burden of esophageal cancer and its risk factors. Methods: This ecological study...

  • Article
  • Open Access
66 Citations
16,408 Views
11 Pages

The Global Burden of Glaucoma: Findings from the Global Burden of Disease 2019 Study and Predictions by Bayesian Age–Period–Cohort Analysis

  • Yi Lin,
  • Bingcai Jiang,
  • Yuanqing Cai,
  • Wangdu Luo,
  • Xiaomin Zhu,
  • Qianyi Lin,
  • Min Tang,
  • Xiangji Li and
  • Lin Xie

24 February 2023

This study aims to report the most up-to-date information about the global disease burden of glaucoma from 1990 to 2019 and to forecast trends in the next few years. Publicly available data from the Global Burden of Diseases, Injuries, and Risk Facto...

  • Article
  • Open Access
1 Citations
2,722 Views
17 Pages

28 March 2025

Background/Objectives: Child growth failure is a manifestation of chronic malnutrition expressed in stunting, wasting, and underweight in children. This study aimed to analyze global trends in child growth failure disease burden and mortality across...

  • Article
  • Open Access
162 Citations
20,083 Views
10 Pages

Alcohol use is a major risk factor for burden of mortality and morbidity. Alcoholic liver disease (ALD) and alcohol use disorders (AUDs) are important disease outcomes caused by alcohol use. We will describe the global mortality and burden of disease...

  • Article
  • Open Access
27 Citations
6,035 Views
13 Pages

Forecasting and Analyzing the Disease Burden of Aged Population in China, Based on the 2010 Global Burden of Disease Study

  • Chengzhen Bao,
  • Mamat Mayila,
  • Zhenhua Ye,
  • Jianbing Wang,
  • Mingjuan Jin,
  • Wenjiong He and
  • Kun Chen

Background: Forecasting the disease burden of the elderly will contribute to make a comprehensive assessment about physical and mental status of the elderly in China and provide a basis for reducing the negative consequences of aging society to a min...

  • Article
  • Open Access
9 Citations
4,150 Views
12 Pages

Global Population Exposure to Extreme Temperatures and Disease Burden

  • Yajie Du,
  • Ming Jing,
  • Chunyu Lu,
  • Jingru Zong,
  • Lingli Wang and
  • Qing Wang

The frequency and duration of extreme temperature events continues to increase worldwide. However, the scale of population exposure and its quantitative relationship with health risks remains unknown on a global scale, limiting our ability to identif...

  • Review
  • Open Access
25 Citations
15,445 Views
35 Pages

The Global Burden of Periodontal Disease: A Narrative Review on Unveiling Socioeconomic and Health Challenges

  • Nada Tawfig Hashim,
  • Rasha Babiker,
  • Vivek Padmanabhan,
  • Azza Tagelsir Ahmed,
  • Nallan C. S. K. Chaitanya,
  • Riham Mohammed,
  • Sivan Padma Priya,
  • Ayman Ahmed,
  • Shadi El Bahra and
  • Muhammed Mustahsen Rahman
  • + 2 authors

Periodontal disease is a prevalent chronic inflammatory condition that impacts over a billion people worldwide, leading to substantial tooth loss, reduced quality of life, and heightened systemic health risks. This narrative review synthesizes curren...

  • Article
  • Open Access
8 Citations
4,164 Views
17 Pages

Objective: Pancreatic cancer poses a serious medical problem worldwide. Studies have reported the relationship between smoking and cancer. This study aimed to evaluate the burden of pancreatic cancer attributable to smoking and its global, regional a...

  • Review
  • Open Access
74 Citations
13,668 Views
9 Pages

With the rise of global migration, international trade, and global environmental challenges such as climate change, it is not surprising that the interactions between humans and other animals are shifting. Salient infectious diseases, such as malaria...

  • Article
  • Open Access
2 Citations
1,762 Views
15 Pages

Background: Lower respiratory infections (LRIs) are the leading cause of the global disease burden, accounting for millions of deaths each year. Methods: Data on LRIs, including deaths, disability-adjusted life years (DALYs), and incidence, were obta...

  • Article
  • Open Access
1,848 Views
16 Pages

Trends in the Burden of Headache Disorders in Europe, 1990–2021: A Systematic Analysis from the Global Burden of Disease Study 2021

  • Terry Jung,
  • Yoonkyung Chang,
  • Moon-Kyung Shin,
  • Sohee Wang,
  • Seyedehmahla Hosseini,
  • Joonho Kim,
  • Min Kyung Chu and
  • Tae-Jin Song

1 October 2025

Background/Objectives: Headache disorders, including migraine and tension-type headache (TTH), are among the most prevalent and disabling neurological conditions globally. This study aimed to evaluate temporal changes, demographic disparities, and so...

  • Article
  • Open Access
1,235 Views
14 Pages

A Three-Decade Analysis of Ischemic Stroke in India: Mortality, Morbidity, and Risk Factors Using the Global Burden of Diseases Study from 1990 to 2019

  • Aditya D. Goyal,
  • Avi A. Gajjar,
  • Najib Muhammad,
  • Albert Q. Wu,
  • Hanish Polavarapu,
  • Oliver Tang,
  • Mohamed M. Salem,
  • Ethan D. Paliwoda,
  • Nithin Gupta and
  • Jan-Karl Burkhardt
  • + 3 authors

3 November 2025

Background/Objectives: India has experienced a sharp increase in stroke burden over the last half-century. The diverse geographical conditions and developing health infrastructure warrant an investigation into changes in mortality and morbidity due t...

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