Search Results (260)

The article provides an analysis of the geographic origins of Karaites in four areas where Karaite congregations were commonly found after the Middle Ages, namely, Arabic Middle East (territories of modern Iraq, Syria, Israel, and Egypt), Constantinople/Istanbul and its area, the Crimean Peninsula, and Eastern European territories belonging today to Lithuania and Ukraine. It combines available historical, onomastic, and linguistic data revealing the migrations of Karaites to and inside these regions. For the first two regions, no ambiguity exists about the roots of local Karaites. Their ancestors were Jews who adopted the Karaite version of Judaism. For the Crimean communities, various factors favor the hypothesis about the territories of the Byzantine Empire (which later became Ottoman), and more specifically, Constantinople and its area are the only major source for their development. The Karaite communities in such historical Eastern European provinces as Lithuania (properly speaking), Volhynia, and Red Ruthenia were created after migrations from Crimea to these territories. The article also discusses medieval, cultural, and potentially genetic links between Karaites and Rabbanite Jews in the areas in question. It also addresses one phonological feature, the sibilant confusion, shared by the Galician–Volhynian dialect of the Karaim language and the Lithuanian dialect of Yiddish. Full article

The Atlantic Diet (AD) is based on traditional dietary patterns in Galicia (northwestern Spain) and northern Portugal and is known for its health benefits. The AD focuses on fresh, local, and seasonal foods, especially fish, seafood, vegetables, legumes, whole grains, fruit, olive oil, and a moderate consumption of wine. However, it has received less attention from researchers than other dietary patterns. The present study had two main objectives: (i) to evaluate the dietary habits of a Galician population in relation to the AD and (ii) to create a numerical index to measure adherence to the AD. In 2022, a validated food frequency questionnaire was administered to 500 healthy adults living in Galicia. The data on participants’ dietary habits showed notable deviations from the ideal AD, especially regarding consumption of fruits, grains, and seafood. However, an adequate intake of legumes and nuts was observed, along with a reduction in the consumption of processed foods (except among younger participants) relative to that revealed in previous surveys. To assess adherence to the diet, statistical and chemometric analyses were applied, leading to the development of a new index: the Atlantic Diet Scale (ADS). The ADS was compared with three existing tools and proved to be a simple, flexible, and effective method for assessing dietary adherence based on optimal intake levels across food groups. When applied to dietary data, the ADS yielded adherence levels similar to two of the three traditional methods, with some differences relative to the third. These findings highlight the need for standardized evaluation tools, including clear definitions of food groups and consistent scoring systems, to better assess and promote adherence to the Atlantic Diet. Full article

Background/Objectives: Asprosin is the endogenous ligand of the olfactory Olfr734 receptor linked to MASLD and glucose metabolism. Despite the involvement of asprosin in these processes, little has been published on the specific role of Olfr734 in liver function. The aim of this work is therefore to study the specific role of the olfactory Olfr734 receptor in MASLD and glucose metabolism. Methods: To achieve this objective, we performed a genetic inhibition specifically to inhibit Olfr734 in the livers of male mice. We then studied the progression of MASLD in DIO mice. In addition, we studied the glucose metabolism in hypoglycemia states and postprandial glucose production in standard diet-fed mice. Finally, analyses of liver biopsies from patients with obesity and with or without T2DM were conducted. Results: We found that hepatic Olfr734 levels vary according to changes in nutritional status and its knockdown effect in the liver is to increase the hepatic lipid content in DIO mice. Our results also showed that OLFR734 expression is involved in the adaptive response in terms of glucose production to nutrient availability. Finally, the hepatic human Olfr734 ortholog named OR4M1 has been observed to be at significantly higher levels in male patients with T2DM. Conclusions: This study increases understanding of the mechanisms by which the modulation of Olfr734 expression affects liver function. Full article

Background: Understanding the multifactorial determinants of human longevity remains a major scientific challenge. Certain regions of the world—so-called “longevity hotspots”—exhibit a notably high prevalence of centenarians; one such region is the province of Ourense, in north-western Spain. Objectives: This study aimed to analyse, for the first time, the nutritional factors associated with healthy longevity among centenarians, as well as those linked to longevity irrespective of health status, in the province of Ourense. Methods: A cross-sectional, retrospective, observational, mixed-methods study was conducted. A population of 261 individuals aged 100 or over residing in Ourense was identified. A sample of 156 participants was included in the quantitative analysis; from this sample, 25 centenarians were selected for in-depth qualitative analysis through personal interviews. Results: Dietary patterns aligned with the Southern European Atlantic Diet (SEAD), combined with strong social bonds and a culture of self-sufficiency, appear to be key contributors to exceptional longevity in this population. Conclusions: Remarkable longevity in Ourense is associated with a combination of factors: adherence to an SEAD-style dietary pattern, an active and uncomplicated lifestyle, and strong social support networks. Full article

This study focuses on the evolution of the Arousa Island Bridge, a critical infrastructure connecting, in northwestern Spain, the Arousa island to the Galician coast. Since its commissioning in 1985, the bridge has experienced damage due to corrosion, culminating in a major repair intervention in 2011 using hybrid galvanic cathodic protection. This repair was essential in addressing identified pathologies and ensuring the safety of the structure. In 2021, additional repairs needed to be completed, and a thorough study and testing campaign was conducted in 2023 which included the extraction of zinc anode samples from the bridge. The present work evaluates the effectiveness of the repair measures implemented since the intervention, with particular attention to corrosion risk and the durability of the cathodic protection system installed to mitigate corrosion risks in the reinforced concrete exposed to a harsh marine environment. A key aspect of this study is the correlation established between the indirect measurements utilized to evaluate zinc consumption within the cathodic protection system and the direct assessment obtained from the extraction of the anodes, which provides a tangible measure of this consumption. The calculated service life was updated with the measurement, and the integrity of the system was assessed. Full article

Ria de Arousa, one of the Rias Baixas, presents very high economic value for the Galician communities due to its importance for aquaculture, but the changes associated with climate change are expected to have an impact on its hydrodynamics and consequently on the production of cultivated species. The main objective of this work is to study the impact of climate change on the circulation and hydrography of the Ria de Arousa, considering the SSP5-8.5 scenario defined by IPCC. To achieve this goal, the Delft3D hydrodynamic model was implemented three-dimensionally using the results obtained from the CMIP6 MPI-ESM1-2-HR climate model as boundary conditions. Future changes in the hydrodynamic and hydrographic circulation of this coastal system were analysed. The model results were used to assess the impact of climate change on water temperature, salinity, and density patterns of the Ria de Arousa, as well as on stratification, Brunt–Väisälä frequency, and residual circulation. During summer, the water temperature is higher at the surface and lower at the bottom, likely due to the intrusion of water from the Eastern North Atlantic Central Water (ENAWC). In the future, this pattern will continue, albeit with higher temperatures, as the water temperature is expected to increase by around 2.2 °C by 2100. During winter, the water temperature at the bottom is warmer than at the surface, indicating a thermal inversion typical of this season. In the future, the water temperature will also increase, although the increase will be lower compared to summer, with a value of approximately 0.5 °C. Salinity will decrease in the summer and increase in the winter, especially in the areas closest to the rivers. Density analysis shows vertical homogeneity in the water column during winter and stratification during summer. During winter, the Brunt–Väisälä frequency (N) is higher in the region closest to the river’s mouth and lower near the ocean. In the summer, the N value decreases with depth. In the future, the density will increase in winter and decrease in summer, and stratification is expected to decrease. Regarding the residual circulation, it was observed that it will strengthen in the summer and weaken in the winter due to a decrease in freshwater runoff. However, the positive circulation pattern observed in the present will be maintained in the future. Full article

Bread is one of the main symbols of the culinary heritage of Galicia (NW Spain). This study evaluates the nutritional quality of Galician breads made from local wheat varieties, ‘Caaveiro’ and ‘Callobre’, under organic and conventional farming systems. Breads were prepared using 100% local wheat flour and a mixture of 25% local flour with 75% commercial flour, in accordance with the Protected Geographical Indication (PGI) ‘Pan Galego’. Nutritional composition was assessed using official AOAC procedures and validated enzymatic assays, including macronutrients, fiber, starch fractions, sugars and minerals. The results reveal that 100% local wheat breads showed significantly higher levels of protein, carbohydrates and minerals, which are beneficial for human health. Specifically, ‘Caaveiro’ breads were richer in protein, while ‘Callobre’ breads exhibited higher carbohydrate and mineral content. Although the cultivation system had a minor effect, it was still relevant when combined with the proportion of local flour. The study highlights the potential of local wheat varieties to enhance the nutritional value of Galician bread. Full article

Curiosity lies at the heart of the sixteenth-century miscellany books, which served as precursors to the essay genre. Among them, a truly exceptional piece stands out: La silva curiosa by Julián de Medrano, published in 1583. This work pushes the boundaries of curiosity to such an extent that it challenges its classification within the genre of miscellany owing to its unconventional and strange nature. Julián de Medrano, the author of this outlandish work, transforms himself into a character and protagonist, defining himself as an “extremely curious” individual. During his extensive travels, he curates a collection of “curious” epitaphs associated with often comical and peculiar deaths, spanning Latin, Spanish, Portuguese, French, Galician, and Italian. In addition to this, La silva curiosa includes an autobiographical narrative, a precursor to the Gothic genre, in which Medrano recounts unsettling encounters with black magic. This work offers a multifaceted exploration of curiosity, taking it to the extreme by narrating the author’s life experiences driven by a relentless pursuit of the curious, which is synonymous with the bizarre, extraordinary, marvelous, and unexpected. La silva curiosa emerges from a time marked by an almost nihilistic void, as the full force of the Baroque era has not yet arrived, and the ideals of humanism are fading away. It stands as a unique document that unveils an unexpected facet of the concept of curiosity within Spanish Renaissance culture. Full article

Background/Objectives: Methadone maintenance treatment (MMT) is widely used in opioid use disorder (OUD). Its efficacy is influenced by its metabolism, primarily mediated by Cytochrome P450 (CYP450) enzymes in the liver. Genetic polymorphisms in CYP450 genes and other factors, such as age, sex, and concomitant treatments, contribute to interindividual variability in methadone response. This article addresses the relevance of pharmacokinetic biomarkers in methadone metabolism and its impact on treatment outcomes in European populations over the past 25 years. Methods: A systematic review was conducted using four databases (PsycINFO, PubMed, Scopus, and Web of Science) for studies published between 2000 and 2024 following the PRISMA 2020 guidelines (CRD42025641373 in PROSPERO). Two independent reviewers screened and assessed the study quality using NHLBI tools. Discrepancies were solved through consensus. Relevant data including sample size, genetic biomarkers, and key findings were extracted for each study. Data were synthesized and described in detail. Results: Fourteen studies on pharmacogenetic biomarkers influencing methadone metabolism in European populations were analyzed, encompassing a total of 3180 subjects. CYP2B6*6 was identified as a key variant associated with increased (S)-methadone plasma levels, potentially leading to cardiac complications, while the role of other pharmacokinetic genes, including ABCB1 and CYP2D6, was inconclusive. Conclusions: Genetic polymorphisms significantly influence methadone metabolism, with the CYP2B6*6 allele playing a key role in (S)-methadone metabolism and associated with cardiac risks. Pharmacogenetic studies integrating co-mediation—the principal cause of phenoconversion—as a potential variable alongside gender differences and encompassing adequate sample sizes could improve outcomes and establish the basis for personalized medicine of MMT. Full article

Cancer survivors face numerous challenges, and digital health interventions can empower them by enhancing self-efficacy and patient activation. This prospective study aimed to assess the impact of a mHealth app on self-efficacy and patient activation in 166 breast and colorectal cancer survivors. Participants received a smart bracelet and used the app to access personalized care plans. Data were collected at baseline and follow-ups, including patient-reported outcomes and clinician feedback. The study demonstrated positive impacts on self-efficacy and patient activation. The overall trial retention rate was 75.3%. Participants reported high levels of activation (PAM levels 1–3: P = 1.0; level 4: P = 0.65) and expressed a willingness to stay informed about their disease (CASE-Cancer factor 1: P = 0.98; factor 2: P = 0.66; factor 3: P = 0.25). Usability of the app improved, with an increase in participants rating the system as having excellent usability (from 14.82% to 22.22%). Additional qualitative analysis revealed positive experiences from both patients and clinicians. This paper contributes significantly to cancer survivorship care by providing personalized care plans tailored to individual needs. The PERSIST platform shows promise in improving patient outcomes and enhancing self-management abilities in cancer survivors. Further research with larger and more diverse populations is needed to establish its effectiveness. Full article

Travel and tourism are essential to global economies, generating social, economic, and environmental impacts. However, there is a lack of standardized methodologies to assess the environmental footprint of tourist destinations beyond carbon footprint analysis. This study introduces the Greentour tool, the first of its kind to evaluate the environmental impact of accommodation, restaurants, and tourism activities using nine environmental indicators from a life cycle assessment (LCA) perspective. The tool applies a hybrid bottom-up and top-down approach, integrating data from tourist establishments and destination managers. The tool was tested in four tourist destinations in Spain and Portugal (Rías Baixas, Camino Lebaniego, Lloret de Mar, and Guimarães), revealing that transportation is the primary contributor to environmental impacts, ranging from 60% to 96% of total emissions, particularly in air-travel-dependent destinations. Food and beverage services are the second-largest contributor, accounting for up to 26% of emissions, while accommodation ranks third (1–14%). This study highlights the significant role of electricity consumption and food choices (e.g., red meat and dairy) in greenhouse gas (GHG) emissions, emphasizing the need for sustainable alternatives. Despite challenges in data collection, particularly for food and transport statistics, the Greentour tool has demonstrated robustness and adaptability across diverse destinations, making it applicable worldwide. This tool provides key insights for policymakers, tourism stakeholders, and businesses, supporting the integration of sustainability strategies into public policies and industry best practices. Future research should focus on expanding its use to additional destinations to foster science-based decision-making and promote more sustainable tourism practices globally. Full article

Background/Objectives: Fluoropyrimidine derivatives, 5-fluorouracil (5-FU) and its prodrugs (capecitabine and tegafur), are widely used in patients suffering from colorectal cancer. The enzyme responsible for their metabolization, dihydropyrimidine dehydrogenase (DPD), is encoded by the DPYD gene, which is highly polymorphic and may contain polymorphisms which could severely compromise its function. This article aims to describe the prevalence of the four main DPYD polymorphisms in the Galician population (Spain) and to compare these frequencies with data obtained from European cohorts in genetic databases and a Spanish study. Methods: Galician data frequencies for the four main DPYD polymorphisms recommended by the European Medicine Agency (EMA) and the Spanish Agency for Medicines and Health Products (AEMPS) (rs3918290 (c.1905+1G>A), rs55886062 (c.1679T>G), rs56038477 (c.1236G>A) and rs67376798 (c.2846A>T)) were collected, as well as data from the genomic databases 1000 Genomes and gnomAD. Additionally, the results from a Spanish DPYD study were included. Results: Significant differences in DPYD variant allele frequencies were observed in the Galician population compared to the frequencies reported in the European population, as well as in the Spanish PhotoDPYD study. Specifically, the rs56038477-T variant (most prevalent) along with the rs3918290-T variant, exhibited significantly lower frequencies than anticipated in the Galician cohort, with a high degree of statistical significance. Conclusions: Observed allele frequencies for the four DPYD variants suggest that Europeans and Spanish frequencies may not be fully applicable to the Galician population. These results emphasize the emerging need for incorporating the genetic information of populations that might be underrepresented into populational databases available worldwide. Full article

Background/Objectives: Shoulder pain is one of the most common injuries among athletes who perform overhead movements. The Athletic Shoulder Test (ASH) has been validated to measure isometric shoulder strength in rugby and baseball players but has not yet been applied to swimmers, where the prevalence of shoulder pathologies reaches up to 91%. The present study aims to validate the ASH and Inverse Athletic Shoulder Test (iASH) in swimmers and establish general values for both tests. Methods: A total of 21 swimmers from the Galician and Asturian Swimming Federation were evaluated using the ASH and iASH tests, measuring strength in three positions (180°, 135°, and 90°). Relative reliability was analysed using the Intraclass Correlation Coefficient (ICC), absolute reliability was assessed through the Standard Error of Measurement (SEM) and Minimal Detectable Change at 90% confidence (MDC90), and variability was determined using the Coefficient of Variation (CV%), applying statistical tests such as Wilcoxon. Results: The ASH and iASH tests demonstrated excellent reliability (ICC = 0.9) across all positions, with acceptable variability (CV% < 35%). No statistically significant differences were found between the preferred and non-preferred side (p > 0.05), except in the iASH test at 180°, where a difference was observed (p = 0.007). The SEM values ranged from 4.39 to 7.39 N, while the MDC90 varied between 10.22 and 17.19 N, ensuring the tests’ sensitivity in detecting real changes in shoulder strength. Conclusions: The ASH and iASH tests are reliable tools for assessing shoulder strength in swimmers and can be used to monitor muscular imbalances and prevent injuries. The symmetry in strength between both sides supports their applicability in preventive programmes. Full article

Assessing water demand is essential for urban planning, aligning with socio-economic and climatic needs. The territorial water footprint identifies water requirements across sectors and detects sources of consumption. This aids in mitigating impacts and evaluating alternative water sources like reclaimed water. In Gavà, water impacts were assessed for residential, commercial, municipal, tourism, industrial, agricultural, and livestock sectors. The total water footprint is 6,458,118 m³, comprising 3,293,589 m³ from blue water, 2,250,849 m³ from green water, and 913,680 m³ from grey water. Agriculture (54.2%), residential (30.9%), and industrial activities (5.8%) are the main water footprint contributors. A key methodological advancement of this study is the refinement of grey water footprint calculations for livestock facilities within the RWF framework, allowing for a more precise assessment of their environmental impact. Integrating geographic information systems with land use mapping helps localize impacts, detect hotspots, and identify infrastructure improvement opportunities. Full article