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3 Results Found

  • Review
  • Open Access
3 Citations
12,124 Views
23 Pages

Familial Pancreatic Cancer

  • Henry T. Lynch,
  • Jane F. Lynch and
  • Stephen J. Lanspa

10 November 2010

Pancreatic cancer’s high mortality rate equates closely with its incidence, thereby showing the need for development of biomarkers of its increased risk and a better understanding of its genetics, so that high-risk patients can be better targeted for...

  • Article
  • Open Access
26 Citations
6,274 Views
16 Pages

Pancreatic Cancer with Mutation in BRCA1/2, MLH1, and APC Genes: Phenotype Correlation and Detection of a Novel Germline BRCA2 Mutation

  • Maria Teresa Vietri,
  • Giovanna D’Elia,
  • Gemma Caliendo,
  • Luisa Albanese,
  • Giuseppe Signoriello,
  • Claudio Napoli and
  • Anna Maria Molinari

9 February 2022

Pancreatic ductal adenocarcinoma (PDAC) is the seventh leading cause of cancer death worldwide; most of cases are sporadic, however about 5% to 10% report a hereditary predisposition. Several hereditary syndromes have been associated with familial pa...