Search Results (338)

Aim: To analyze the burden of road injuries in Colombia from 1990 to 2021, disaggregated by sex, age groups, and road injury category. Methods: Observational study based on the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2021. National data on prevalence, incidence, mortality, years of life lost (YLL), years lived with disability (YLD), and disability-adjusted life-years (DALY) were obtained. Data are reported in years and age-standardized and age-specific rates per 100,000 inhabitants. A log-linear segmented regression model was employed to analyze trends in DALY rates of road injuries from 1990 to 2021. Results: From 1990 to 2021, the age-standardized prevalence and incidence rates (per 100,000 inhabitants) due to road injury decreased by −30.6% (95% UI: −34.3; −26.4) and −27.5% (95% UI: −30.7; −24.4), respectively. The age-standardized mortality rate trend of road injuries decreased by −40.6% (95% UI: −50.0; −31.0). Meanwhile, the age-standardized DALY rate decreased by −39.7% (95% UI: −47.9; −31.3) during the study period. In all indicators, men’s rates were higher than women’s. By road injury category, the age-standardized rates increased significantly for motorcyclist road injuries, particularly among men. Conclusions: Road injuries in Colombia have declined but remain significant, especially for young men. Motorcycle injuries show alarming increases in mortality and DALY rates. Full article

Background: Adolescents in Ethiopia, particularly in rural areas, face significant barriers to accessing comprehensive sexual and reproductive health (SRH) services, resulting in poor health outcomes. The youth-friendly health services (YFHS) initiative addresses these challenges by training Health Extension Workers (HEWs) to deliver tailored, age-appropriate care at the primary care level. This study evaluates the cost-effectiveness of YFHS implementation in rural health posts in the Jimma Zone, Ethiopia. Methods: Using an ingredient-based costing approach, costs were analyzed across six health posts, three implementing YFHS and three offering routine services. Health outcomes were modeled using disability-adjusted life years (DALYs) averted, and incremental cost-effectiveness ratios (ICERs) were calculated. Results: Results showed that YFHS reached 9854 adolescents annually at a cost of USD 29,680, compared to 2012.5 adolescents and USD 7519 in control sites. The study showed the ICER of USD 25.50 per DALY averted. The intervention improved health outcomes, including a 27% increase in antenatal care uptake, a 34% rise in contraceptive use, and a 0.065% reduction in abortion-related mortality, averting 52.11 DALYs versus 26.42 in controls. Conclusions: The ICER was USD 25.50 per DALY averted, well below Ethiopia’s GDP per capita, making it highly cost-effective by WHO standards. Scaling YFHS through HEWs offers a transformative, cost-effective strategy to advance adolescent SRH equity and achieve universal health coverage in Ethiopia. Full article

Objective: This study aimed to explore the burden attributable to different groups of risk factors (environmental/occupational, behavioral, and metabolic) in Saudi Arabia that were stratified by gender and year and measured by summary exposure values (SEVs) and disability-adjusted life years (DALYs) per 100,000. Design: This study was structured as a systematic analysis. Methods: Using the GBD 2021 data, we extracted information on different risk factors attributed to the disease burden in Saudi Arabia to quantify the differences in exposure value (SEV) and disability-adjusted life year (DALY) rates (per 100,000) between females and males across different years. Results: Over the years, sustained progress in reducing the number of DALYs attributable to specific environmental and occupational risks has been observed, as well as a slight decrease in some behavioral risks. The highest disease burden was attributed to metabolic and behavioral risk factors, with body mass index being the leading risk factor for both genders. Between 1990 and 2021, the age-standardized DALY rate in those with high body mass indices increased by 168.4% and reached 3436.23 (95% UI 1878.7–5031.5) in males and increased by 125.2% to reach 2952.6 (95% UI 1456.9–4.407) in females. The age-standardized SEVs were the highest in females with a high body mass index, reaching an SEV of 57.98 (95% UI: 64.1–49.2), and in males, an SEV of 50.75 (95% UI: 57.1–42.3) was achieved. Regarding their attributable deaths in 2021, metabolic risk factors were identified as the primary contributors to NCD mortality in 2021. Conclusions: These results reveal persistent health disparities between males and females, underscoring the urgent need for gender-specific research, policies, and interventions. Strategies aimed at promoting health and reducing disease burden should acknowledge the unique health challenges encountered by males and females. Full article

Background: Development Assistance for Health (DAH) plays a vital role in health financing across Sub-Saharan Africa, particularly in tackling communicable diseases such as HIV/AIDS, malaria, and tuberculosis. Despite its importance, the efficiency and equity of DAH allocation remain contested. Objectives: The study aims to evaluate the cost-effectiveness of DAH in Sub-Saharan Africa from 1995 to 2018, as well as to explore differences in efficiency across diseases and country contexts. Methods: Data were drawn from the Institute for Health Metrics and Evaluation and applied Generalized Cost-Effectiveness Analysis in conjunction with the Gross Domestic Product-based thresholds. Averted Disability-Adjusted Life Years were analyzed across countries and diseases, and countries were categorized by the Human Development Index (HDI) level to assess differential DAH performance. Results: DAH cost-effectiveness showed similar patterns across HDI groups, with roughly equal proportions of cost-effective and dominated outcomes in both low- and middle-HDI countries. Thirteen countries were identified as very cost-effective, nine as cost-effective, and two as non-cost-effective. Twenty-one countries were dominated, reflecting persistent inefficiencies in aid impact that transcends the various levels of development. Conclusions: Tailoring DAH allocation to specific disease burdens and development levels enhances its impact. The study underscores the need for targeted investment and a strategic shift toward integrated health system strengthening. Additionally, microinsurance is highlighted as a key mechanism for improving healthcare access and financial protection in low-income settings. Full article

Despite the well-documented health risks of noise pollution, its impact remains overlooked mainly in life cycle assessment (LCA). This study introduces a methodological innovation by integrating both traffic and construction noise into the LCA framework for concrete construction, providing a more holistic and realistic evaluation of environmental and health impacts. By combining building information modeling (BIM) with LCA, the method automates material quantification and assesses both environmental and noise-related health burdens. A key advancement is the inclusion of health-based indicators, such as annoyance and sleep disturbance, quantified through disability-adjusted life years (DALYs). Two scenarios are examined: (1) a comparative analysis of concrete versus timber flooring and (2) end-of-life options (reuse vs. landfill). The results reveal that concrete has up to 7.4 times greater environmental impact than timber, except in land use. When noise is included, its contribution ranges from 7–33% in low-density regions (Darwin) and 62–92% in high-density areas (NSW), underscoring the critical role of local context. Traffic noise emerged as the dominant source, while equipment-related noise was minimal (0.3–1.5% of total DALYs). Timber slightly reduced annoyance but showed similar sleep disturbance levels. Material reuse reduced midpoint environmental impacts by 67–99.78%. Sensitivity analysis confirmed that mitigation measures like double glazing can cut noise-related impacts by 2–10% in low-density settings and 31–45% in high-density settings, validating the robustness of this framework. Overall, this study establishes a foundation for integrating noise into LCA, supporting sustainable material choices, environmentally responsible construction, and health-centered policymaking, particularly in noise-sensitive urban development. Full article

Background/Objectives: Climate change is a major factor exacerbating non-communicable diseases (NCDs) such as cardiovascular diseases, neoplasms, respiratory diseases, and diabetes, especially in vulnerable Latin American regions. This study analyzes the impact of environmental exposures related to climate change on the NCD burden in eight Latin American countries by quantifying the disability-adjusted life years (DALYs) attributable to these factors. Using Global Burden of Disease (GBD) data (1990–2021), we performed multiple linear regression to assess associations between DALYs and environmental risk factors—air pollution (particulate matter, nitrogen dioxide), radon, lead, and extreme temperatures—in Argentina, Brazil, Chile, Colombia, Costa Rica, Mexico, Peru, and Uruguay. The study included major NCDs, and the population was stratified by age and sex. Results: Ischemic heart disease was the leading cause of DALYs in most countries. Particulate matter pollution was the main environmental risk factor contributing to the NCD burden, mainly affecting cardiovascular and respiratory diseases. Mexico showed the highest DALYs from particulate and ozone pollution; temperature and lead exposure also contributed in some countries. Nitrogen dioxide was the primary risk factor for asthma. Statistically significant relationships between environmental factors and DALYs were confirmed. Conclusions: Climate change-related exposures significantly increase the burden of NCDs in Latin America. Targeted interventions in industry, transportation, and energy, along with sustainable urban policies, are essential to mitigate health impacts and reduce disparities. Integrating environmental health into public policies can improve health outcomes amid ongoing climate challenges. Full article

Colorectal cancer (CRC) is ranked as the third most lethal of all cancers in the USA, following prostate and lung malignancy in men, and breast and lung malignancy in women, respectively. The risk factors for developing colorectal cancer fall into two categories: modifiable risk factors (obesity and physical inactivity, diet, smoking, alcohol, medications, diabetes, and insulin resistance) and non-modifiable risk factors (race and ethnicity, sex, age, and inflammatory bowel disease). The standard therapeutic approaches to the treatment of colorectal cancer have led to a reduction in the burden of colorectal cancer in the USA, with national statistics revealing a reduction in both the incidence and death rates. At the same time, five-year survival rates have also greatly improved. However, associated with these standard treatments are complications, which have become a burden (physical and emotional, financial, and economic burdens, and disability-adjusted life years), affecting the quality of life of CRC patients. This paper discusses the standard therapeutic approaches to managing colorectal cancer, the associated complications, and their management. In addition, a summary of the newly introduced therapeutic approaches for treating CRC, reported improvement in effectiveness over existing strategies and corresponding reduction in therapeutic complications will be discussed. Full article

Background: Clostridioides difficile infection (CDI) poses substantial clinical and economic challenges worldwide. This study aimed to evaluate the global burden, trends, and inequalities of CDI from 1990 to 2021, with projections extending to 2040. Methods: We conducted a systematic analysis of the Global Burden of Disease Study 2021 data for 204 countries and territories. CDI-related mortality and disability-adjusted life years (DALYs) were analyzed from 1990 to 2021. Joinpoint regression assessed the trends, a decomposition analysis identified the contributing factors, and cross-country inequalities were measured with slope and concentration indices. A log-linear age–period–cohort model projected future burden to 2040. Results: Global CDI-related deaths increased from 3047 (95% uncertainty interval [UI], 2550–3609) in 1990 to 15,598 (95% UI, 13,418–18,222) in 2021. The age-standardized mortality rate rose from 0.10 to 0.19/100,000 population (average annual percent change [AAPC], 2.26%; 95% confidence interval [CI], 1.77–2.76%), and the age-standardized DALY rate increased from 1.83 to 3.46/100,000 (AAPC, 1.94%; 95% CI, 1.43–2.45%). Epidemiological changes were the primary driver of this burden, contributing 45.46%. Inequalities were intensified, particularly in high sociodemographic index countries, evidenced by increases in the slope index from 2.00 to 4.17 and concentration index from 0.52 to 0.69. The projections suggest that mortality and DALY rates among populations aged ≥80 years will continue to rise through 2040. Conclusions: The global CDI burden has increased significantly over three decades, disproportionately affecting high sociodemographic index countries. The projected rise in CDI burden among older adults through 2040 underscores the urgent need for targeted interventions and strategic planning. Full article

Background: Lower respiratory infections (LRIs) are the leading cause of the global disease burden, accounting for millions of deaths each year. Methods: Data on LRIs, including deaths, disability-adjusted life years (DALYs), and incidence, were obtained from the Global Burden of Disease Study 2021. Joinpoint regression was employed to assess temporal trends in the LRIs’ burden, while the age–period–cohort model was used to evaluate age, period, and cohort effects. Pearson’s correlation coefficients were calculated to examine the relationship between DALYs attributable to risk factors and the socio-demographic index (SDI). Results: Over recent decades, the average annual percentage change in age-standardized mortality rate, age-standardized DALYs rate, and age-standardized incidence rate of LRIs globally were −2.4%, −3.5%, and −1.3%, respectively. Notably, the LRIs’ burden dropped considerably from 2019 to 2021. The disease burden was higher among children under five and individuals over 60 compared to other age groups. In terms of gender, males had a higher burden. The age-standardized DALYs rate of LRIs was strongly and negatively correlated with SDI (r = −0.84; p < 0.05). Streptococcus pneumoniae remained the leading pathogen, followed by Staphylococcus aureus, and Klebsiella pneumoniae. Conclusions: In recent years, the global burden of LRIs has declined, but regional, gender, and age disparities persist. Targeted measures are needed to address high-risk populations and major risk factors. Full article

Background: Rheumatic heart disease (RHD) remains a major contributor to childhood cardiovascular morbidity and mortality globally, particularly in low-resource settings. This study offers a thorough evaluation of the global, regional, and national burden of RHD among children aged 0–14 years, from 1990 to 2021, utilizing data from the 2021 Global Burden of Disease (GBD) study. Methods: We analyzed age-standardized incidence, prevalence, mortality, and disability-adjusted life years (DALYs) for RHD in 204 countries and territories. Novel methodological approaches included APC analysis to decompose temporal trends into age, period, and cohort effects, and inequality analysis to assess socioeconomic disparities. We calculated age-standardized rates and average annual percentage changes (AAPC) by sex, region, and socio-demographic index (SDI) level. Results: From 1990 to 2021, the global age-standardized death rate due to RHD in children declined by approximately 74%, from 1.24 to 0.32 per 100,000 (AAPC: −4.27%). Similarly, DALY rates dropped from 117.22 to 41.56 per 100,000 (AAPC: −3.30%). Despite this progress, the global age-standardized incidence rate increased modestly from 55.84 to 66.76 per 100,000 (AAPC: 0.58%), and prevalence rates also rose (AAPC: 0.53%). Females consistently experienced higher burden across all metrics. Inequality analysis demonstrated a concerning divergence: while mortality and DALY inequalities narrowed substantially (mortality slope index of inequality (SII) improved from −1.35 to −0.31), incidence and prevalence inequalities widened (incidence SII worsened from −112.60 to −131.90), indicating growing disparities in disease occurrence despite improved survival. Conclusions: While global mortality and DALYs from childhood rheumatic heart disease have declined substantially over the past three decades, a troubling paradox has emerged: rising incidence rates alongside widening socioeconomic inequalities in disease occurrence. This represents a critical public health challenge demanding targeted intervention strategies. The divergent trends in health outcomes, namely, improved survival rates but increased disease burden, reveal that while access to treatment has advanced, upstream prevention efforts remain critically inadequate among socioeconomically disadvantaged populations. Full article

Background: The burden of type 2 diabetes mellitus (T2DM) in Tabasco from 2013 to 2023 has led to a significant loss in quality of life and life years. This study aims to analyze the impact of T2DM on the population of Tabasco, Mexico, during this period. Methods: A descriptive, observational, longitudinal, and retrospective study was conducted in Tabasco, following Feinstein’s guidelines. The study included 2,402,598 individuals, covering the adult study population of Tabasco (n = 927,047) based on National Institute of Statistics and Geography (INEGI) data. Data were gathered from the General Directorate of Health Information and the Ministry of Health and analyzed using Microsoft Excel, applying central tendency and dispersion measures, and calculating Disability-Adjusted Life Years (DALYs) with validated formulas. Results: DALYs in Tabasco’s adult population from 2013 to 2023 were 23,049 in 2013, 24,576 in 2014, 25,193 in 2015, 34,361 in 2016, 29,771 in 2017, 29,309 in 2018, 29,959 in 2019, 28,087 in 2020, 26,451 in 2021, 23,502 in 2022, and 30,523 in 2023, totaling 304,781 DALYs for the period. Conclusions: T2DM has shown an increase in incidence and mortality, especially in recent years, leading to a significant rise in DALYs. This reflects a higher disease burden in Tabasco compared to other regions in Mexico and the Americas, resulting in a considerable loss of quality of life and life years. Full article

Background/Objectives: Colorectal cancer (CRC) is a leading cause of cancer-related morbidity and mortality worldwide, posing a substantial health and economic burden. Despite advances in screening and treatment, significant socioeconomic and healthcare-related disparities persist across European Union (EU) member states. This study aims to identify trends and inequality in CRC burden over time and to explore the relationship between country-level socioeconomic and healthcare indicators and CRC burden across EU member states. Methods: Age-standardized mortality, years lived with disability (YLD), years of life lost (YLL), and disability-adjusted life years (DALY) rates were extracted from Global Burden of Diseases Study 2021 for 24 EU countries. Socioeconomic and healthcare indicators were extracted from Eurostat between 2005 and 2021. The Gini index was calculated to evaluate CRC-related health inequality, and generalized linear mixed models were used to assess the link between indicators and disease burden. Results: The Gini index for age-standardized YLDs declined from 0.19 to 0.12 between 1990 and 2021, while inequality in YLL (from 0.11 to 0.16), DALY (from 0.11 to 0.15), and mortality rates (from 0.12 to 0.14) increased. The number of practicing physicians (p < 0.05) and higher levels of education (p < 0.001) were related to lower death, DALY, YLD, and YLL rates. Conversely, greater income inequality was linked to higher mortality, DALY, and YLL rates (p < 0.05). Conclusions: Our findings underscore that, in addition to expanding organized screening programs, enhancing physician availability and addressing socioeconomic inequalities are essential for reducing the burden of CRC. Full article

This study aimed to examine global hypertensive heart disease (HHD) trends (1990–2019). Methods: We extracted data from the Global Burden of Disease (GBD) 2019 Study, encompassing 204 countries and territories. We analyzed the age-adjusted mortality rates (AAMRs), crude mortality, prevalence, years lived with disability (YLD), years of life lost (YLL), and disability-adjusted life years (DALY). Joinpoint Regression Analysis was used to calculate the Annual Percentage Change (APC), with p < 0.05 indicating statistical significance. Results were stratified by region, Socio-Demographic Index (SDI), and gender. Results: Globally, the crude mortality rate for HHD rose from 12.2 (95% UI 9.9–13.6) to 14.9 (95% UI 16.5–11.1) deaths/100,000 population (1990–2019), whereas the AAMR declined from 19.3 (95% UI 5.8–21.6) to 15.1 (95% UI 11.1–16.7). A Joinpoint Analysis revealed significant APC shifts: a decrease of −1.53% (p < 0.05) from 1990 to 2006, an increase of +0.60% (p < 0.05) from 2006 to 2015, and a subsequent decrease of −1.28% (p < 0.05) from 2006 to 2019. Eastern Europe showed the highest annual rate of change in AAMR at 0.9 (95% UI: −0.1 to 1.2), whereas the high-income Asia Pacific region experienced the largest decline at −0.66 (95% UI −0.27–−0.72). Central Asian males had an AAMR of 31.1 (95% UI 35.3–22.9) in 2019, and Sub-Saharan African females reached 38.5 (95% UI 48.4–26.3). YLL trended downward in both sexes (APC: −1.94, p < 0.05 in males; −1.81, p < 0.05 in females), yet YLD rose steadily in recent years, underscoring a growing chronic burden. The AAMR was highest in 2019 among Sub-Saharan African females, which is a particularly important area. Conclusions: Targeted strategies are essential to mitigate the escalating HHD burden. Full article

Background/Objectives: Chronic kidney disease (CKD) is a major global public health issue, affecting over 690 million individuals worldwide. The prevalence, diagnosis, and treatment of kidney disease vary considerably across different geographical regions. However, comprehensive and in-depth research on CKD remains limited due to its diverse etiologies. Methods: This study provides a detailed assessment of the disease burden of CKD, considering its etiological basis and utilizing the latest data reflecting changing trends. This research synthesizes findings from previous studies, with the necessary literature sourced from online platforms such as Google Scholar, EMBASE, and PubMed/MEDLINE databases, as well as Global Burden of Disease (GBD), to compare visualizations of the world’s CKD levels and trends from 1990 to 2021. Results: The study results demonstrated that eating patterns are affected by historical and industrial factors, which likely contribute to the high prevalence of CKD in Western countries. The data also indicated that the global number of new CKD cases increased from just over 7.8 million in 1990 to nearly 19 million after 30 years. Additionally, the results showed that age and sex together accounted for the observed prevalence and disease-attributable disability-adjusted life year (DALY) rates in CKD, with the highest rates seen in older age groups, except for CKD attributed to type 1 diabetes, where the incidence was higher in children, and the burden was greater in middle-aged adults. Conclusions: Overall, these findings are a valuable addition to the existing literature and provide evidence that CKD studies over a similar time frame reveal notable global trends and regional differences in highlighting this increasing burden. Full article

Background/Objectives: Lip and oral cavity cancer (LOC) remains a critical public health challenge in Asia. This study evaluated spatiotemporal trends and risk factor contributions to LOC-related disability-adjusted life years (DALYs) from 1990 to 2021 to inform evidence-based healthcare policies. Methods: Using Global Burden of Disease (GBD) 2021 data, we analyzed LOC DALYs stratified by age, gender, risk factors (smoking, alcohol use, tobacco chewing), and subregions in Asia. Temporal trends were quantified via estimated annual percentage change (EAPC) across five geographic regions and sociodemographic index (SDI) categories. Age–period–cohort (APC) modeling was used to assess age-specific risk distributions. Results: From 1990 to 2021, Asia’s age-standardized DALY rate (ASDR) for LOC marginally increased (EAPC: 0.0883, 95% CI: 0.0802–0.0963). The alcohol-related ASDR increased sharply (EAPC: 1.033, 95% CI: 1.00–1.06), whereas decreases were detected in the smoking- and tobacco chewing-attributable ASDRs. Pronounced upward trends were observed in South Asia and low/low-middle-SDI regions. Tobacco chewing was the primary risk factor for women and for the populations in South Asia and lower-SDI regions, whereas smoking dominated among men and those in other geographic regions and in higher-SDI areas. APC analysis revealed age-driven increases in ASDR, with alcohol use and tobacco chewing risk increased with age. Notably, the steepest ASDR increase occurred in individuals aged 20–25 years. Conclusions: The LOC burden in Asia reflects divergent risk factor dynamics. Policy strategies must prioritize geographic and demographic targeting: alcohol control in rapidly developing areas and intensified tobacco cessation programs in endemic zones. Early prevention efforts focusing on adolescents and tailored to subregional risk profiles are essential to mitigate future disease burden. Full article