Search Results (467)

Background: Type 2 diabetes (T2D) is a global health epidemic with rising prevalence within Asian populations, particularly amongst individuals with high visceral adiposity and ectopic organ fat, the so-called Thin-Outside, Fat-Inside phenotype. Metabolomic and microbiome shifts may herald T2D onset, presenting potential biomarkers and mechanistic insight into metabolic dysregulation. However, multi-omics datasets across ethnicities remain limited. Methods: We performed cross-sectional multi-omics analyses on 171 adults (99 Asian Chinese, 72 European Caucasian) from the New Zealand-based TOFI_Asia cohort at 4-years follow-up. Paired plasma and faecal samples were analysed using untargeted metabolomic profiling (polar/lipid fractions) and shotgun metagenomic sequencing, respectively. Sparse multi-block partial least squares regression and discriminant analysis (DIABLO) unveiled signatures associated with ethnicity, glycaemic status, and sex. Results: Ethnicity-based DIABLO modelling achieved a balanced error rate of 0.22, correctly classifying 76.54% of test samples. Polar metabolites had the highest discriminatory power (AUC = 0.96), with trigonelline enriched in European Caucasians and carnitine in Asian Chinese. Lipid profiles highlighted ethnicity-specific signatures: Asian Chinese showed enrichment of polyunsaturated triglycerides (TG.16:0_18:2_22:6, TG.18:1_18:2_22:6) and ether-linked phospholipids, while European Caucasians exhibited higher levels of saturated species (TG.16:0_16:0_14:1, TG.15:0_15:0_17:1). The bacteria Bifidobacterium pseudocatenulatum, Erysipelatoclostridium ramosum, and Enterocloster bolteae characterised Asian Chinese participants, while Oscillibacter sp. and Clostridium innocuum characterised European Caucasians. Cross-omic correlations highlighted negative correlations of Phocaeicola vulgatus with amino acids (r = −0.84 to −0.76), while E. ramosum and C. innocuum positively correlated with long-chain triglycerides (r = 0.55–0.62). Conclusions: Ethnicity drove robust multi-omic differentiation, revealing distinctive metabolic and microbial profiles potentially underlying the differential T2D risk between Asian Chinese and European Caucasians. Full article

Hyperlipidemia (HLP) is a disorder of human lipid metabolism or transport, primarily characterized by abnormally elevated levels of total cholesterol (TC), triglycerides (TGs), and low-density lipoprotein cholesterol (LDL-C) in the blood. It is a key factor contributing to the development of non-alcoholic fatty liver disease, obesity, diabetes, atherosclerosis, and cardiovascular and cerebrovascular diseases. Statistics show that the prevalence of dyslipidemia among Chinese adults is as high as 35.6%, and it has shown a trend of younger onset in recent years, posing a serious threat to public health. Therefore, the prevention and treatment of dyslipidemia carry significant social significance. The pathogenesis of hyperlipidemia is complex and diverse, and currently used medications are often accompanied by side effects during treatment, making the research and development of new therapeutic approaches a current focus. Numerous studies have shown that flavonoids, which are abundant in most medicinal plants, fruits, and vegetables, exert effects on regulating lipid homeostasis and treating hyperlipidemia through a multi-target mechanism. These compounds have demonstrated significant effects in inhibiting lipid synthesis, blocking lipid absorption, promoting cholesterol uptake, enhancing reverse cholesterol transport, and suppressing oxidative stress, inflammation, and intestinal microbiota disorders. This article reviews the latest progress in the mechanisms of flavonoids in the treatment of hyperlipidemia, providing a theoretical basis for future research on drugs for hyperlipidemia. Full article

Highway construction in China has bolstered Chinese claims of having the longest highways in the world, yet it has led to the involuntary relocation and resettlement of millions of people all over China. This study examines the interplay of power relationships in modernity and ethnic cultures. Using interviews with 201 Zhuang ethnic minority people and participant observations from two years in the Southwest of China, this paper presents findings that show both the positive and negative effects of urbanization and modernization as the consequence of highway expansion. By discussing the removal of a religious Sacred Rock which was in the way of the highway construction, the authors reveal the subtleties of the power interplay of majority–minority relations and the meanings of cultures and rituals in the face of modernity. In the process of modernization, highway construction reconstructs new communities while deconstructing the old one. The authors argue that recognizing the meanings of ethnic cultures as defined by ethnic people themselves is the first step to the reconciliation of social relationships between the majority and minority people in created new communities. To enhance social integration, religion has an important role to play in Chinese society. Full article

Bupleurum scorzonerifolium Willd. is a perennial herbaceous plant of the genus Bupleurum in the Apiaceae family. Also known as red Bupleurum, it is mainly distributed in Northeast China, North China and other regions and is a commonly used medicinal plant. It is difficult for the wild plant resources of Bupleurum scorzonerifolium Willd. to meet the market demand. In artificial cultivation, there are problems such as a low yield per plant, low quality, weakened stress resistance and variety degradation. The contents of bioactive components and metabolites in traditional Chinese medicinal materials vary significantly across different growth years. The growth duration directly impacts their quality and clinical efficacy. Therefore, determining the optimal growth period is one of the crucial factors in ensuring the quality of traditional Chinese medicinal materials. In this study, Gas Chromatography–Mass Spectrometry (GC-MS) and High-performance liquid chromatography (HPLC) were comprehensively applied to analyze the metabolically differential substances in different parts of Bupleurum scorzonerifolium Willd. By comparing the compositions and content differences of chemical components in different growth years and different parts, the chemical components with significant differences were accurately screened out. In order to further explore the dynamic change characteristics and internal laws of metabolites, a metabolic network was constructed for a visual analysis and, finally, to see the optimal growth years of Bupleurum scorzonerifolium Willd. This result showed that with the accumulation of the growth cycle, the height, root width, fresh mass and saikosaponins content of Bupleurum scorzonerifolium Willd. increased year by year. Except for sodium and calcium elements in the main shoot, the other elements were significantly reduced. In addition, 59 primary metabolites were identified by GC-MS, with the accumulation of the growth cycle, the contents of organic acids, sugars, alcohols and amino acids gradually decreased, while the contents of alkyl, glycosides and other substances gradually increased. There were 53 positive correlations and 18 negative correlations in the triennial Bupleurum scorzonerifolium Willd. grid, all of which were positively correlated with saikosaponins. Therefore, the triennial Bupleurum scorzonerifolium Willd. was considered to be the suitable growth year. It not only provided a new idea and method for the quality evaluation of Bupleurum scorzonerifolium Willd., but also provided a scientific basis for the quality control of Chinese herbs. Full article

This study investigates how climate-resilient city construction (CRCC) influences the Environmental, Social, and Governance (ESG) performance of Chinese listed firms, employing a difference-in-differences (DID) model with firm-year data from 2012 to 2023. The empirical results demonstrate that CRCC exerts a significant positive effect on firms’ ESG performance, with particularly pronounced improvements in the environmental and social dimensions. The mechanism analysis reveals that strengthening government environmental guidance and stimulating firms’ environmental response strategies are the key channels via which CRCC improves firms’ ESG performance. The heterogeneity tests show more pronounced effects for the central–eastern regions, state-owned firms, non-regulated industries, and non-heavily polluting sectors. A further analysis indicates that better ESG performance drives firms to increase their environmental investment, upgrade their value chains, and enhance new quality productive forces. This study extends the framework of ESG determinants by integrating climate adaptation policies, offering insights for urban climate governance and firms’ low-carbon transitions. Full article

Identifying the key factors influencing agricultural carbon emissions and accurately predicting future trends are essential for achieving carbon peak and carbon neutrality goals. This study aims to assess carbon emissions in agriculture from 1997 to 2022, construct an accurate model to identify the key influencing factors, and predict carbon emissions in agriculture from 2023 to 2030 with an intelligent prediction system to discuss risk management. Additionally, the Dagum method was employed to explore regional differences in agricultural carbon emissions across China. The results reveal that China’s agricultural carbon emissions exhibited a fluctuating trend from 1997 to 2022, peaking in 2015, followed by a period of decline and a moderate rebound in recent years. Elastic Net Regression identified eleven key variables, including Agricultural Machinery Level (MA), Numbers of Agricultural Tools (AT), and Agricultural Industrial Structure Upgrading (AICE), as major determinants of agricultural carbon emissions. Furthermore, the RF-PSO method demonstrated the highest predictive accuracy, forecasting a minor peak in agricultural carbon emissions in 2027, followed by stabilization. Regionally, imbalances in emissions were observed, with the intensity of transvariation accounting for 37.078% of the disparity. Therefore, the Chinese government is advised to implement region-specific strategies for controlling agricultural carbon emissions, cultivate new high-quality agricultural productivity, and promote advanced technologies. Full article

In recent years, the rapid development of the agricultural product e-commerce and logistics industry has generated a large amount of express packaging waste. The way in which to promote the reuse of express packaging and reduce carbon emissions has become an important issue, and the current research on consumers’ willingness to express packaging recycling is still in its infancy. This study, based on the theory of Extended Planned Behavior, constructed a factor model observing the influence of consumers’ willingness to participate in the e-commerce of agricultural products’ recyclable packaging recovery. Using partial least squares structural equation modeling to process and analyze 659 questionnaire data, the results show that policy promotion and perceived benefits had the highest degree of positive influence on recycling willingness, and there was a relatively weak positive effect of packaging performance and subjective norm on consumers’ willingness to recycle in terms of packaging performance and the subject norm of recycling willingness. The attitude towards recycling had the smallest impact on the willingness to recycle. Therefore, in order to promote the production and use of recyclable packaging, government policies should be strengthened, and consumers’ perceived benefits and subjective norm should be improved, as well as the packaging performance of recyclable packaging. This study provides new insights into Chinese consumers’ participation in the recycling and promotion of recyclable packaging for e-commerce agricultural products. Full article

Seahorse (Hippocampus spp.) is popular in the markets of traditional Chinese medicine, aquarium, and curio. In order to protect wild stocks and still meet the market demand, China attempted the large-scale cultivation of seahorses in the early 21st century and achieved it in the 2010s. However, in recent years, two new issues have gradually emerged in Chinese seahorse cultivation. One is that the juveniles are prone to disease during diet conversion, and the other is that the reproductive performance of broodstocks is significantly reduced. With the aim to provide some measures that can alleviate these issues, in the present study, we used lined seahorse (Hippocampus erectus, a species widely cultured in China) as the experimental subject and Astragalus polysaccharides (APSs) as the immunostimulant to test whether APSs could improve the immune-health status and reproductive performance of seahorses. The measured indices for reproductive performance included ovarian lipid content, assessment time required before mating for paired male and female seahorses, mating success rate, brood size, and newborn body height. The results showed that for juveniles during diet conversion, their body weight, survival rate, plasma immunocytokine contents (interleukin-2, interferon-α, and immunoglobulin M), and alpha diversity indices (Simpson and Pielou’s-e) of the intestinal microbiota were significantly higher than those of the control group after dietary APSs. For broodstocks, compared with the control group, the expression of lipid substances in the ovary was significantly upregulated, the assessment time was significantly shortened, and the body height of their newborns was significantly increased in the APS group. These results demonstrate that APSs could indeed improve the immune-health status and reproductive performance of seahorses, providing guidance for addressing existing issues in seahorse cultivation. Full article

Background/Objectives: Although several studies have examined the importance of social capital to individual health, the relationship between social capital and family well-being remains unclear. This study examines the relationships among social capital, parental depressive symptoms, and family well-being, and evaluates whether parental depressive symptoms mediate the association between social capital and family well-being in immigrant Chinese and native Japanese families. Methods: A cross-sectional study using Google questionnaires was conducted between January and April 2024 among parents of local Japanese and immigrant Chinese families with children. The survey assessed demographics and social capital using the PSCS-16 and K6 Scale, family well-being using the General Functioning Index of the Family Assessment Device, and family life satisfaction using the New Brief Job Stress Questionnaire. Multiple-group structural equation modeling clarified the association between bonding and bridging social capital and family well-being. Results: The survey data was collected from 133 parents (75 Japanese and 58 Chinese) of preschool children aged six years and under. About 81.2% of respondents were mothers and 18.8% were fathers, with the majority aged between 30 to 39 years (63.9%). Bonding social capital was positively associated with family well-being among Japanese families. In Chinese families, bonding social capital was indirectly associated with family well-being by reducing parental depressive symptoms. Conclusions: These findings highlight the importance of enhancing bonding social capital to benefit both native and immigrant families. Besides, policymakers should consider tailored strategies that reflect the differing needs of both groups. Full article

Low-carbon restructuring serves as a critical strategy for enterprises to achieve the “dual-carbon” target and foster sustainable development, whereas supply chain resilience is essential for maintaining competitiveness in complex environments. Based on the data of Chinese A-share listed companies in the manufacturing industry from 2011 to 2023, this paper empirically examines the relationship between low-carbon restructuring, R&D investment, and supply chain resilience. This study reveals a U-shaped relationship between low-carbon restructuring and supply chain resilience, with an inflection point at approximately 2.34. R&D investment significantly strengthens supply chain resilience and positively moderates the relationship by accelerating technological synergies and optimizing resource allocation. Further analysis shows that heavily polluted industries face more pressure in the early stage of low-carbon restructuring compared to non-heavily polluted industries, but R&D investment has a more significant moderating effect on heavily polluted industries. The prediction results based on the Holt–Winters model show that the level of low-carbon restructuring in China’s manufacturing industry will increase steadily in the next seven years, with an average annual growth rate of about 0.021. These new findings are important for managers and researchers to improve supply chain resilience during the low-carbon transition process. Full article

Against the background of the vigorous development of materials science and the deep cross-infiltration in many fields, a new medicine food homology, carbon dots (herein combined and abbreviated as MFH-CDs), has sprung up, showing great potential. This review used ChatGPT 4.0 to collect background information related to carbon dots, focusing on the common rich medicinal and food resources such as Lycium barbarum, Chinese yam, honeysuckle, and Ganoderma lucidum. These carbon dots are synthesized by hydrothermal synthesis, microwave radiation, and pyrolysis, which have the advantages of small particle size, high quantum yield, and low cytotoxicity. Recent studies have found that MFH-CDs have great application potential in biosensors, biological imaging, and drug delivery. In this paper, the characteristics of preparing carbon dots from different medicinal and edible resources and their applications in biology in recent years are reviewed, which provides in-depth guidance for the research and application of carbon dots from medicinal and edible biomass, helps it shine in multidisciplinary fields, and opens a brand-new journey from traditional medicinal and edible culture to cutting-edge technology application. Full article

Ancient paintings are an intangible window to the economy, politics, and customs of the past. Their characteristics have evolved or were made obsolete, with only limited contemporary connections remaining. This research aims to preserve and to interact with characters in 2D paintings to evolve their cultural identity through combining AI and AR. The scope of this research covers traditional Chinese paintings archived by the National Palace Museum in digital collections, mainly “New Year’s Market in a Time of Peace”. About 25 characters were used for training and 3D reconstruction in RODIN^®. The models were converted into Augment^® and Sketchfab^® platforms as reactivated AR characters to interact with new urban fabrics and landscapes. Stable Diffusion^® and RODIN^® were successfully integrated to perform image training and reconstruct 3D AR models of various styles. As a result, interactions were conducted in two ways: in a mixed context with mixed characters in a painting and in a familiar context in the real world with mixed characters. It was found that AR facilitated the interpretation of how the old urban fabric was arranged. Using AI and AR is a current issue. Combining AI and AR can activate ubiquitous preservation to perform recursive processing from diffused images in order to reconstruct 3D models. This activated heritage preservation method is a reasonable alternative to redefining intangible subjects with a new and evolved contemporary cultural identity. Full article

Almost 70 years after the surprise discovery of a cache of textile-wrapped relics inside an early 13th-century reliquary bust, the St Eustace head reliquary (accession number 1850,1127.1), four of the textile relic wrappings were analysed by combining multiband imaging and fibre-optic reflectance spectroscopy (FORS), as well as dye analysis by high-pressure liquid chromatography coupled to mass spectrometry (HPLC-MS) and fibre analysis by scanning electron microscopy—energy dispersive X-ray spectroscopy (SEM-EDX). In all cases, the use of silk was confirmed, in line with the idea that these precious textiles were purposefully chosen for reuse in a sacred setting. Additionally, dye analysis was able to point to the possible geographic origins of the textile fragments. For 1850,1127.1.a, a mixture of sappanwood (Biancaea sappan) and flavonoid yellow dyes was commensurate with a Chinese or Central Asian origin. Mediterranean origins were thought likely for 1850,1127.1.c and 1850,1127.1.f, from the mixture of kermes (Kermes vermilio) and cochineal (likely Porphyrophora sp.), found in the mauve band of the former, and the combination of weld (Reseda luteola), madder (Rubia tinctorum) and an indigoid dye found in the latter. Finally, the unusual combination of sappanwood, orchil and a yellow dye containing flavonoid glucuronides suggested a less straightforward origin for textile 1850,1127.1.g. The other textile fragments from the reliquary were only investigated using FORS without removing them from their Perspex glass mounts. Nonetheless, indications for the presence of insect-red anthraquinone dyes, safflower (Carthamus tinctorius) and an indigoid dye were obtained from some of these fragments. The study provides a window into the landscape of availability, use and re-use in sacred contexts of precious textiles in the 13th century and evidences the geographic reach of these silks, allowing a new perspective on the St Eustace head reliquary. Full article

In the context of global climate change and the escalating energy crisis, the development of new energy vehicles (NEVs) has become a critical strategy for China to foster green transformation and achieve its carbon neutrality goals. This study focuses on A-share-listed NEV companies in China from 2015 to 2023, specifically those listed on the Shanghai or Shenzhen Stock Exchange and subject to domestic regulatory standards and disclosure requirements. These firms were selected due to the representativeness, availability, and quantifiability of their data. A super-efficient-network SBM model based on undesirable outputs and the Malmquist index were employed to assess the static and dynamic green technology innovation efficiency of 260 NEV enterprises. Additionally, the Tobit regression model was applied to analyze the influencing factors. The findings reveal that the overall green technology innovation efficiency of Chinese NEV enterprises is relatively low and has exhibited a declining trend over the years. Furthermore, the efficiency of enterprises in the western regions surpasses that of those in the eastern and central regions. Key factors, including government support, enterprise scale, and R&D investment, significantly inhibit the green technology innovation efficiency of firms. Based on these findings, this paper recommends prioritizing the innovation of core technologies, addressing regional disparities in development, and implementing tailored policies to enhance the green technology innovation efficiency and economic performance of NEV enterprises. Full article

Background: Motor Function Disorders (MFDs) are common conditions in children with cerebral palsy and closely related to muscle spasticity. Catgut Embedment in Acupoint (CEA) has shown promise as an important adjunctive therapy but current evidence remains insufficient. The aim of this study was to evaluate the efficacy and safety of CEA in Pediatric-Cerebral-Palsy Motor Function Disorders (PCPMFDs). Methods: PubMed, Cochrane Library, Embase, Web of Science, four Chinese databases and two clinical trial registries were searched to include randomized controlled trials of patients with PCPMFDs treated with CEA combined with conventional rehabilitation. Meta-analysis was performed using Review Manager 5.4, Stata 18 and R Studio software 2025, and risk of bias was assessed for the included studies using the Cochrane Collaboration Network tool. Results: A total of 17 papers were included, including 1106 PCPMFDs patients with a wide range of conditions, age ≤ 9 years, and rehabilitation training mostly using Bobath/Vojta therapy. Meta-analysis showed that CEA was effective in improving MFDs with the Gross Motor Function Measure Scale (SMD, 0.90 [95% CI, 0.57 to 1.23], p < 0.0001) and the modified Ashworth Scale (MD, −0.40 [95% CI, −0.58 to −0.23], p < 0.0001). Preliminary results suggested that a treatment regimen, which consisted of three monthly sessions and lasted for one to two months, was most effective. Conclusions: CEA is an effective complementary treatment for patients with PCPMFDs with mild adverse effects. However, due to the relatively new perspective of this study, only a small number of researchers have focused on this area and conducted studies, resulting in fewer included studies meeting requirements, which is a direct result of the fact that this study, although informative, still requires a significant amount of research before clear evidence-based recommendations can be developed. Full article