Search Results (1,191)

Increased hepatic triacylglycerol (TG) storage in lipid droplets (LDs) is a hallmark of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH). Human carboxylesterase 1 (CES1) regulates TG storage and secretion in hepatocytes, but the mechanism remains to be elucidated. We performed studies in rat hepatoma McArdle RH7777 cells stably transfected with CES1 cDNA and in Ces1d-deficient mice using a variety of biochemical, pharmacological and cell biology approaches including the assessment of gene expression, confocal immunofluorescence microscopy, lipid synthesis measurements and quantitative mass spectrometry. CES1-expressing cells accrued more TG compared to cells lacking CES1 when incubated with oleic acid. CES1 increased the expression of Srebf1c, Nr1h3 and Nr1h2 encoding transcription factors (SREBP1c and LXRα and LXRβ, respectively) that regulate the expression of lipogenic genes. Additionally, CES1 increased the expression of Acsl1 encoding an enzyme catalyzing fatty acid activation and the expression of Dgat1 and Dgat2 encoding enzymes catalyzing TG synthesis. Treatment of CES1-expressing cells with PPARγ antagonist (GW9662), LXR antagonist (GSK2033) or CYP27A1 inhibitor Felodipine prevented CES1-mediated fatty acid esterification into TG. Ces1d-deficient mice fed high-fat diet (HFD) presented with decreased expression of Nr1h3, Nr1h2, Srebf1c and reduced hepatic TG content. Felodipine and GSK2033 treatment eliminated the differential effects on TG concentration between wild-type and Ces1d-deficient hepatocytes. The results suggest that CES1/Ces1d activates PPARγ, LXR and SREBP1c pathways, thereby increasing TG synthesis and LD storage by augmenting fatty acid esterification. Full article

Cu₂S has wide-ranging applications in the energy field, particularly as electrode materials and components of energy storage devices. However, the migration of copper ions is prone to component segregation and copper precipitation, impairing long-term thermal stability and service performance. Ce₂S₃ not only possesses the unique 4f electron layer structure of Ce but also has high thermal stability and chemical inertness. Here, we report for the first time that the thermal stability and mechanical properties of Cu₂S can be significantly enhanced by introducing the dispersed phase Ce₂S₃. Thermogravimetry—differential scanning calorimetry (TG-DSC) results show that the addition of 6 wt% Ce₂S₃ improves the thermal stability of Cu₂S sintered at 400 °C. X-ray diffraction (XRD) results indicate that the crystal structure of Cu₂S gradually transforms to tetragonal Cu_1.96S and orthorhombic Cu_1.8S phase at 400 °C with the increase of Ce₂S₃ addition. Scanning electron microscopy (SEM) results show that the particle size gradually decreased with the increase of Ce₂S₃ amount, indicating that the Ce₂S₃ addition increased the reactivity. The Ce content in Cu₂S increased gradually with the increase of Ce₂S₃ amount at 400–600 °C. The 7 wt% Ce₂S₃-Cu₂S exhibits paramagnetic behavior with a saturation magnetization of 1.2 µ_B/Ce. UV-Vis analysis indicates that the addition of Ce₂S₃ can reduce the optical energy gap and enrich the band structure of Cu₂S. With increasing addition of Ce₂S₃ and rising sintering temperature, the density of Ce₂S₃-Cu₂S gradually increases, and the hardness of Ce₂S₃-Cu₂S increases by 52.5% at 400 °C and by 34.2% at 600 °C. The friction test results show that an appropriate addition amount of Ce₂S₃ can increase the friction coefficients of Cu₂S. Ce₂S₃ modification offers a novel strategy to simultaneously enhance the structural and service stability of Cu₂S by regulating Cu ion diffusion and suppressing compositional fluctuations. Full article

This work investigated the effect of cerium (Ce) addition on the wear behavior of commercially pure titanium (CP-Ti) by varying the Ce content to 0.8, 1.4, and 2.0 wt.%. Alloys were fabricated using plasma arc melting, and wear resistance was evaluated under loads of 1 N and 5 N dry sliding condition. Microstructural characterization confirmed the formation of CeO₂ precipitates, whose size and distribution varied with the Ce content. The Ti-0.8Ce alloy exhibited the highest hardness (203 HV), showing a 35% increase compared to CP-Ti, and the lowest wear rate reduced by approximately 47% and 22% under 1 N and 5 N loads, respectively. In contrast, Ti-1.4Ce and Ti-2.0Ce formed coarse CeO₂ precipitates, which acted as third-body abrasives. Although these alloys showed lower average friction coefficients than CP-Ti (up to 22% reduction), the enhanced abrasive interaction promoted material removal and increased wear rates. Notably, Ti-2.0Ce exhibited the most severe degradation in wear resistance, with wear rates increases of 21% and 27% under 1 N and 5 N loads, respectively. These findings demonstrate that while CeO₂ precipitates reduce friction by suppressing direct metal–metal contact, their abrasive nature adversely affects wear resistance when the particle size and volume fraction are excessive. Therefore, 0.8 wt.% Ce was identified as the optimal composition for improving the wear resistance, achieving the best combination of high hardness, low wear rate without excessive third-body abrasion. Full article

The long-term corrosion behavior of Al₂O₃-3%TiO₂ (AT3) coatings doped with1%, 5% and 8% CeO₂ prepared by plasma spraying was studied in 5% NaCl solution. The results showed that the protective performance of CeO₂-doped coatings was significantly higher than that of undoped coatings, primarily due to the reduction in coating porosity caused by the addition of rare-earth elements. Among the doped coatings, the 5% CeO₂-doped coating exhibited the best protective performance. The addition of rare-earth oxides CeO₂ reduced the content of γ-Al₂O₃ in the coating, but when the concentration of CeO₂ increased to 8%, the Ce element was rich in the gap of the coating. Excessive CeO₂ enriched in the gaps and coexisted more with Ti, and prevented the formation of the AlTi phase, which affected the performance of the coating. Electrochemical and XPS results revealed that an appropriate amount of Ce atoms or CeO₂ particles could fill the pores of the coating. During long-term immersion, Ce (IV) was converted to Ce (III), which demonstrated that Ce atoms have high chemical activity in coatings. The thermodynamic calculation results show that more CeO₂ particles improved the adsorption of corrosive ions. It indicated that the content of doped rare-earth oxides exceeding 5% would be utilized as an active material in the corrosive process. Full article

We report here, for the first time on the Nubian Shield, the western half of the Arabian–Nubian Shield (ANS), pegmatite-hosted pockets with a unique mineralogy, including pyroxmangite. It represents the second discovery on the ANS, where the first one was at Jabal Aja on the Arabian Shield, the eastern half of the ANS. One of the most remarkable aspects of pyroxmangite is its rarity and the potential economic value of its use in jewelry and decorative applications. Pegmatites are associated with A-type granites of the Gabal El-Bakriya intrusion (GEBI), Eastern Desert, Egypt. Mineralized pegmatites occur at the margin of the alkali-feldspar granite and exhibit gradational contacts with the host rocks. The pegmatites were emplaced as plugs and dikes within the intrusion and along its periphery. Pyroxmangite appears as coarse-grained, massive black aggregates or as disseminated crystals. The pegmatites are composed of K-feldspars and quartz, with subordinate amounts of albite, micas, and mafic minerals. Accessory phases include monazite-(Ce), zircon, fergusonite, xenotime, fluorite, pyrochlore, allanite, thorite, bastnäsite, samarskite, cassiterite, beryl, and pyrochlore. Pyroxmangite-bearing assemblages consist essentially of pyroxmangite and garnet, with accessory pyrochroite, quartz, zircon, magnetite, and fluorite. Geochemically, the pegmatites are highly evolved, with elevated SiO₂ content (76.51–80.69 wt.%) and variable concentrations of trace elements. They show significant enrichment in Nb (Nb > Ta), Y, REE, Zr, Th, U, and F, consistent with NYF-type pegmatites. REE contents range from 173.94 to 518.21 ppm, reflecting diverse accessory mineral assemblages. Tectonically, the pegmatites crystallized in a post-collisional setting, representing a late-stage differentiate of the A-type GEBI magma. Mineralization is concentrated in the apical and marginal zones of the granitic cupola and is dominated by barite, fluorite, Nb-Ta oxides, REE minerals, and uranium-bearing phases. The highly evolved granites, greisens, pegmatites, and quartz-fluorite veins of the GEBI have a high economic potential, deserving further exploration. Full article

This study investigates the concentrations and geochemical behaviour of strategic elements—including Li, Co, Ni, Cu, Ga, Ge, rare earth elements (REEs), and yttrium (Y)—in bottom ash samples from the Afşin–Elbistan thermal power plant, Türkiye. Thirty bottom ash samples were analysed, revealing average ∑LREE and ∑HREE concentrations of 86.3 µg/g and 3.3 µg/g, respectively, resulting in an L/H ratio of 24.9, indicating pronounced enrichment in light REEs. The total ∑REE + Y concentration (111 µg/g) is comparable to the background value for coal but approximately 1.5 times lower than those reported for average Chinese coals and the upper continental crust (UCC). REE contents significantly exceed those of sedimentary (5.36 µg/g), mafic (16.77 µg/g), and felsic (3.60 µg/g) rocks. Elevated Li (30.5 µg/g) and Ni (114.4 µg/g) concentrations point to a mafic magmatic source, whereas Cu (28.7 µg/g) likely originates from basic volcanic rocks such as those of the Dağlıca Complex and the Kemaliye Formation. Chondrite-normalised REE patterns show Dy depletion relative to mafic rocks and Ho depletion compared to sedimentary rocks. Positive δEu anomalies (>1) support a mafic or UCC provenance, while slightly positive δCe values indicate hydrothermal leaching influences. The co-precipitation of Ce with Ca–Mg hydroxides and clay minerals in coal-bearing lacustrine sediments is suggested. Ga enrichment is attributed to aluminium-rich clay minerals and organic matter. Overall, these geochemical signatures reflect combined inputs from hydrothermal leaching and volcanic weathering within a coal-bearing lacustrine environment. Full article

Background: Carrimycin is a mixture of spiramycin derivatives with antibacterial functions. However, recent studies have shown that it possesses certain anticancer properties. The specific mechanism of the anticancer activity is unknown. Methods: To study the anticancer mechanism of carrimycin, we synthesized a derivative of spiramycin, n-hexyl spiramycin (h-SPM), and used a combination of metabolomics and transcriptomics methods. Capillary electrophoresis–mass spectrometry (CE-MS) was used to detect polar small molecule metabolites, and liquid chromatography–mass spectrometry (LC-MS) was used to detect lipid metabolites in cells. Transcriptomics was used to measure mRNA content in cells. Finally, by processing these data using specific bioinformatics methods, the mechanism underlying anticancer effect of carrimycin was determined. Results: Metabolomics and transcriptomic results showed that lipid metabolism and mitochondrial biogenesis pathways in the cells changed after hSPM treatment, NR1D1 genes and ceramide were enriched from these pathways, implicating the involvement of ROS and pro-inflammatory response. Western blotting verified that the protein levels of NR1D1 decreased after h-SPM treatment, and ROS stating and qPCR demonstrated that ROS levels and the mRNA levels of pro-inflammatory genes were greatly induced by h-SPM. Conclusions: h-SPM reduced the protein level of NR1D1, disrupted metabolic regulation, accumulating ceramide, and the subsequent increased ROS generation promoted apoptosis and pro-inflammatory-like response of cells. Our findings unveiled the anticancer mechanism of a potent anticancer derivative of spiramycin and unveiled its mechanism of action. Full article

Kimberlite has attracted considerable interest among geologists as the primary source of natural gem-quality diamonds. The term “transitional kimberlite” was previously introduced to categorize rocks that exhibit bulk geochemical and Sr–Nd isotopic characteristics intermediate between those of archetypal kimberlite (formerly Group-I) and orangeite (formerly Group-II). Nevertheless, the petrogenesis of transitional diamond-bearing kimberlites remains poorly understood due to limited research. The diamondiferous transitional Wafangdian kimberlite in the North China Craton (NCC) thus provides a valuable opportunity for a detailed case study. We investigated fresh hypabyssal transitional Wafangdian kimberlites using bulk-rock major and trace element geochemistry to constrain near-primary parental magma compositions and decipher their petrogenesis. Geochemical compositions identify samples affected by crustal contamination based on elevated SiO₂, Pb, heavy rare earth element (HREE) concentrations, and Sr isotopic ratios. Compositional variations among macrocrystic samples (MgO: 29.7–31.5 wt.%; SiO₂: 30.6–34.7 wt.%; CaO: 3.9–7.5 wt.%; Mg^# [atomic Mg/(Mg + Fe²⁺) × 100]: 85–88) result from substantial entrainment and partial assimilation of peridotite xenoliths (up to 35%). In contrast, variations within aphanitic samples (MgO: 24.0–29.7 wt.%; SiO₂: 27.7–30.9 wt.%; CaO: 6.0–11.8 wt.%; Mg^#: 81–85) are attributed to fractional crystallization of olivine and phlogopite (~1–32%). Based on these constraints, the near-primary parental magma composition for the Wafangdian kimberlite is estimated as ~29.7 wt.% SiO₂, ~29.7 wt.% MgO, and Mg^# 85. Trace element concentrations in the transitional Wafangdian kimberlites resemble those of archetypal kimberlites globally (e.g., Nb/U > 26, La/Nb < 1.4, Ba/Nb < 16, Th/Nb < 0.25), indicating a shared convective mantle source. However, the Wafangdian kimberlites exhibit distinct characteristics: ε_Nd(t) values ranging from −3.44 to −1.77, higher Al₂O₃ and K₂O contents, and lower Ce/Pb ratios (10–20) compared to archetypal kimberlites. These features suggest the mantle source region was profoundly influenced by deeply subducted oceanic material. Full article

Ensiling high-moisture alfalfa with peanut vine not only avoids alfalfa nutrient loss during the wilting stage but also maximizes the use of agricultural waste peanut vine. The appropriate mixed ratio of high-moisture alfalfa and peanut vine has been studied in our previous study. However, the effect of additives on improving the nutrition and fermentation quality of the mixed silage of alfalfa and peanut vine has not been investigated. This study aimed to assess the adaptation and association of Lactiplantibacillus plantarum, cellulase and tannin in the mixed silage of alfalfa and peanut vine alone or in combination on fermentation quality, chemical composition, and microbial communities. The harvested fresh alfalfa and dry peanut vine were cut into 2 cm lengths by a crop chopper and they were thoroughly mixed at a ratio of 7:3. The mixtures were treated with no addition (CK), L. plantarum (Lp, 1 × 10⁶ CFU/g fresh weight), cellulase (Ce, 5 g/kg fresh weight), tannin (Ta, 40 g/kg dry matter), and their combinations (LpCe, LpTa, CeTa, LpCeTa). After 45 days of fermentation, silage treated with Lp, Ce, and Ta had lower pH and ammonia-N (NH₃-N) content and higher concentrations of lactic acid compared with the CK group. LpCeTa-treated silage inhibited protein degradation by reducing pH value and ammonia-N concentrations during ensiling processes. The LpCeTa group increased (p < 0.05) water-soluble carbohydrate (WSC) content and reduced (p < 0.05) acid detergent fiber and neutral detergent fiber contents in mixed silage. Furthermore, the LpCeTa group increased the relative abundance of Lactobacillus and decreased the relative abundance of Enterococcus and Weissella as compared with the CK group. Results of the current study indicated that the combined use of L. plantarum, cellulase, and tannin could serve as a promising strategy for the preservation of ensiling fresh alfalfa mixed with peanut vine and provide a reference for the re-utilization of by-product. Full article

Inducible forms of chronic urticaria are characterized by an early age of onset and a long duration of disease. In addition, cold and cholinergic urticaria have a risk of developing systemic, sometimes life-threatening, reactions. Determining the pathogenetic mechanisms and laboratory and clinical predictors of their development is an open question in the understanding of these diseases. This literature review demonstrates the current known facts that allow the identification of patients with cold and cholinergic urticaria in high-risk groups of anaphylaxis development and, therefore, the possibility to prevent emergency situations and to manage them in time. For cold and cholinergic urticaria, observations of Kounis syndrome–acute coronary syndrome (myocardial infarction or unstable angina) have been described. A series of trials, including the large international multicenter COLD-CE study of anaphylaxis in cold urticaria, have identified early age of urticaria onset, severe clinical symptoms, shortening of the critical temperature threshold, comorbid bronchial asthma, concomitant angioedema, and pruritus of the earlobes as warning signs. No such large-scale studies have been conducted for cholinergic urticaria. Among the few high-risk factors for systemic reactions in cholinergic urticaria described in the literature is the occurrence of angioedema. Thus, it is possible to identify some patients in the high-risk group already at the stage of initial anamnesis collection, and additional data can be collected during the examination. Laboratory biomarkers, clinical predictors, understanding the mechanisms of anaphylaxis by physical triggers or their consequences, and optimal options for pathogenetic therapy are still unresolved issues that require further research. The aim of this review is to provide a content analysis of current knowledge about chronic inducible urticarias in order to increase clinicians’ awareness and, consequently, reduce the risk of urgent conditions associated with them. Full article

The Xifanping Cu–(Au) deposit, a small-scale porphyry system in the central Jinshajiang–Red River tectonic belt (JSRR), formed in a Cenozoic collisional setting. This study integrates zircon U–Pb geochronology, Lu–Hf isotopes, whole-rock geochemistry, and zircon trace element analyses of ore-bearing and barren porphyries, combined with regional comparisons, to constrain magma sources, metallogenic controls, and genetic processes. Ore-bearing biotite quartz monzonite porphyries were emplaced at 32.15 ± 0.43 Ma and 32.49 ± 0.57 Ma, post-dating barren quartz monzonite porphyry (33.15 ± 0.51 Ma). These ages are consistent with molybdenite Re–Os ages (32.1 ± 1.6 Ma), indicating near-synchronous magmatism and mineralization. Both porphyry types belong to the shoshonitic, peraluminous series, enriched in LILE, depleted in HFSE, enriched in LREE, and lacking significant Eu anomalies. Their εHf (t) values (–2.94 to +3.68) and crustal model ages (TDM2 = 0.88–1.30 Ga) indicate derivation from Neoproterozoic subduction-modified lower crust. Ore-bearing porphyries, however, exhibit higher zircon Ce⁴⁺/Ce³⁺ ratios (average = 584 vs. 228 for barren porphyries) and elevated hydrous mineral contents (>10 vol.% amphibole + biotite), indicating more oxidized and water-rich parental magmas. Compared with large-scale porphyry systems (e.g., Dexing, northern Chile), the absence of adakitic signatures and only moderate oxidation limited the scale of mineralization. Overall, the Xifanping deposit formed through partial melting of Neoproterozoic subduction-modified lower crust in a post-collisional extensional regime: at ~33.2 Ma, melting of metasomatized ancient lower crust generated barren porphyries; at ~32 Ma, further evolution and differentiation of this lower crust magmas led to the extraction and enrichment of ore-forming materials from the thicken lower crust, producing hydrated, oxidized, ore-bearing magmas that intruded at shallow levels to form base and precious metal mineralizations. These results underscore the distinctive metallogenic characteristics of small-scale porphyry systems in collisional settings and provide new insights into how source composition and magma oxidation state constrain mineralization potential. Full article

The stability of ceramic suspensions is a key factor in the preparation and shaping of ceramic bodies. The presented work offers an experimental determination of ceramics suspensions stability using the LUMiSizer analytical centrifuge, focusing on kinetic behaviour using transmission profiles and instability indexes. Multiple ceramic systems comprising corundum, metakaolin, and zirconia suspensions were experimentally examined under varying solid contents, dispersant dosages, and additive concentrations. Results showed that highly loaded corundum suspensions with dispersant (Dolapix CE64) achieved excellent stability, with an instability index below 0.05. Compared to classical sedimentation tests, which are time-consuming and not highly sensitive, LUMiSizer offers a suitable alternative by guaranteeing correct kinetic data and instability indexes indicating suspension behaviour using centrifugal force. Comparisons of the LUMiSizer results and data obtained using the modified Stokes law confirmed increased terminal velocities in experiments with metakaolin suspensions, indicating the sensitivity of the centrifuge to the effect of dispersion medium shape. The influence of porogen (waste coffee grounds) on the stability of corundum suspensions was also investigated, followed by slip casting to create and characterize a ceramic body, confirming the possibility of shaping based on stability results. Furthermore, instability indices are suggested as a rapid, quantitative method for comparing system stability and as an auxiliary criterion to the rheological measurements. Optimal dispersant concentration for zirconia-based photocurable suspensions was identified as 8.5 wt.%, which minimized viscosity and, at the same time, assured maximal kinetic stability. Integrating the LUMiSizer analytical centrifuge with standard methods, including sedimentation tests and rheological measurements, highlights its value as a powerful tool for characterizing and optimizing ceramic suspensions. Full article

Functional foods are gaining heightened popularity in diet modifications. Green bananas contain a significant quantity of resistant starch, dietary fibre, and phytochemicals that demonstrate strong antioxidant properties, particularly due to the high concentration of polyphenols. The community demand for incorporating these essential components into food products, such as bread, has increased. Therefore, the aim of this study was to evaluate the differences in the content and bio-accessibility of phenolic compounds in bread enriched with 5, 10, and 15% of Australian green banana powder (GBF) from (Cavendish “Musa acuminata”, Ladyfinger “Musa paradisiaca L.”, and Ducasse “Musa balbisiana”), as well as their antioxidant capabilities and the generation of short-chain fatty acids (SCFAs) after in vitro gastrointestinal digestion and colonic fermentation. The 15% Cavendish bread exhibited significant TPC and TFC at 1.31 mg GAE/g and 0.05 mg QE/g, respectively, along with substantial antioxidant activity (DPPH, 0.40 mg TE/g), observed following stomach and intestinal phases. However, the 15% Ladyfinger bread exhibited the highest TTC following the stomach digestion, with 17.4 mg CE/g. The bio-accessibility of most phenolic components from 10% GBF-bread was elevated following the gastric and intestinal phases. Nonetheless, a substantial total phenolic content (50.3% in Ladyfinger bread) was still observable in the residue during colonic fermentation. The highest SCFAs production occurred in Cavendish and Ducasse bread after 24 h of fermentation. Overall, the consumption of GBF bread can positively influence intestinal health and provide antioxidant properties, facilitating future advancements in the creation of nutrient-dense and health-enhancing bakery products. Full article

Sauerkraut (SK) is a fermented food of plant origin recognised for its nutritional properties and health benefits. It is traditionally produced through spontaneous fermentation, carried out by the native microflora of fresh cabbage, which includes Gram-negative bacteria, moulds, yeasts and finally lactic acid bacteria (LAB), responsible for transforming natural sugars into lactic acid. However, spontaneous fermentation can also promote the growth of undesirable microorganisms, leading to risks of sensory or food safety alterations, such as the production of biogenic amines. To prevent these limitations, the use of LAB starter cultures is presented as a promising alternative. This study evaluated the fermentation of cabbage at 18 °C and 25 °C, comparing spontaneous fermentation with controlled fermentations using probiotic cultures (Lactiplantibacillus plantarum 229v and Lacticaseibacillus rhamnosus GG). Due to its nutritional importance, the folate content of different types of SK has been studied. Spontaneous fermentation showed positive results in all studied parameters; however, L. plantarum 229v was the inoculum with the highest and fastest acidifying efficacy, reducing the pH to below 4.0 after 7 days at both temperatures. At 25 °C, L. plantarum 229v achieved LAB counts higher than those of L. rhamnosus GG (7.02 vs. 6.00 log CFU·g⁻¹) and exerted the most effective control over enterobacteria and moulds/yeasts, reaching undetectable values (0 log CFU·g⁻¹) on day 7 under both conditions. Antioxidant activity after 42 days of fermentation was higher at 18 °C with L. rhamnosus GG, which showed the highest values (up to 3.50 mg CE·g⁻¹ FW), followed by L. plantarum 229v and spontaneous fermentation. In terms of total folate content (TFC) retention, spontaneous fermentation was particularly effective at both temperatures after 42 days of fermentation (794.741 µg/100 g TFC at 18 °C and 586.542 µg/100 g TFC at 25 °C). In sensory analysis, spontaneous fermentation, in general acceptance, was rated highest (6.2), followed by L. plantarum 229v (5.5) and L. rhamnosus GG (5.3). Considering all the factors studied, SK fermentation with the probiotic strain L. plantarum 229v has proven to be the most suitable. Full article

This study reports the hydrothermal synthesis, characterization, and Fenton-like catalytic performance of CeO₂–CoFe₂O₄ nanocomposites for degrading Congo Red (CR) dye and the oxytetracycline (OTC) antibiotic. A series of Ce-doped cobalt ferrite samples was prepared using a hydrothermal reaction. Additionally, the 50Ce-CFO sample was further activated with H₂O₂ treatment. XRD, FTIR, and SEM analyses confirmed the formation of a spinel phase alongside segregated CeO₂, which acts as a grain-growth inhibitor. The increased Ce content promotes particle amorphization. FTIR showed changes in the intensity of the M–O stretching band, indicating Ce-induced bond polarization in the spinel lattice. In H₂O₂ decomposition tests, the 50Ce-CFO catalyst fully decomposes H₂O₂ in 160 min, while the activated sample completes it in 125 min. Fenton-like degradation of CR and OTC by untreated and activated 50Ce-CFO sample followed pseudo-first-order kinetics. Catalyst stability was confirmed using post-reaction XRD, FTIR, and SEM analyses. Incorporation of CeO₂ into CoFe₂O₄ refines the crystallite size, increases the BET surface area, and enhances adsorption capacity, while the Ce⁴⁺/Ce³⁺ redox couple promotes reactive oxygen species generation. Owing to this dual structural and catalytic role, the CeO₂-CoFe₂O₄ composites exhibit significantly improved Fenton-like catalytic activity, enabling the efficient degradation of organic pollutants. Full article