Search Results (60)

Cancer therapy is increasingly shaped by the need for agents that are both mechanistically precise and clinically tolerable. Sulforaphane (SFN), a dietary isothiocyanate enriched in cabbage-family vegetables such as cauliflower and Brussels sprouts, has emerged as a pleiotropic modulator of tumor biology. This review synthesizes current evidence that SFN regulates diverse cancer-relevant processes, including redox homeostasis, cell-cycle progression, apoptosis, autophagy and epigenetic remodeling, largely through coordinated effects on transcriptional (for example, Nrf2, MAPK, NF-κB and AP-1), post-transcriptional (microRNAs and messenger RNAs) and epigenetic (DNA methyltransferases and histone deacetylases) networks. We then examine how functional nucleic acids, including aptamers, small interfering RNAs, microRNAs and tetrahedral DNA nanostructures, can be engineered to guide SFN to tumor cells, amplify pathway-specific effects and overcome resistance. Particular emphasis is placed on nanotechnology-enabled delivery platforms that enhance SFN stability, bioavailability and tumor selectivity. Finally, we outline key challenges, such as context-dependent Nrf2 activity, inter-individual variability in metabolism and incomplete clinical validation, and propose priorities for translating SFN-based functional nucleic acid systems into rational, combination-ready strategies for precision oncology. Full article

The Earth’s climate is an open nonlinear system, sustained far from thermodynamic equilibrium by solar radiation and energy and matter exchange among its four major subsystems: atmosphere, ocean, land, and cryosphere. Among these four subsystems, the ocean significantly influences and sustains Earth’s climate over decadal to millennial timescales. Although modern numerical models increasingly capture intricate dynamical details, the fundamental concepts of large-scale ocean variability are less frequently explored. This study revisits ocean circulation through the lens of self-organization theory and synergetics. The key synergetic concepts of mode competition, order parameters, and the slaving principle are interpreted within the framework of general ocean circulation and the Atlantic Meridional Overturning Circulation (AMOC). The Brusselator, a simplified model of a nonlinear dynamical system initially developed in chemical kinetics, serves as a conceptual analog for ocean circulation energy conversion. Despite its high abstraction, this proxy model effectively captures essential bifurcation behaviors, such as Hopf bifurcation transitions and limit-cycle behaviors. This clarifies feedback regulation, instability, and potential regime transitions in the AMOC. The synthesis in this study is intended for an interdisciplinary readership and highlights the broader applicability of synergetic principles to the complex Earth climate system maintained far from equilibrium. Full article

The Wallonia-Brussels Federation is transforming through its education through the ‘Pact for an Education of Excellence’, notably by redefining the post-common core stage. This perspective article proposes a curricular paradigm that reconciles the specialisation of pathways with a shared foundation ensuring informed citizenship for all students. Based on a conceptual analysis of existing literature, we advocate for integrating Socially Acute Questions (SAQs) as a transversal axis of the post-common core curriculum. This shift the system from a ‘retrocognitive’ model—where knowledge is accumulated for uncertain future application—to a ‘procognitive’ model inspired by Chevallard’s ‘questioning of the world’. We outline seven pedagogical approaches to support this: controversy mapping, case studies, reasoned debate, the problematic matrix, researcher–student encounters, moral dilemmas, and role-play simulations. However, implementation faces barriers, including the rigidity of school structures, disciplinary compartmentalisation, teachers’ epistemic vulnerability, and challenges surrounding neutrality when addressing sensitive subjects. Success depends on transforming teaching professionalism through collaborative and interdisciplinary work, adopting ‘committed impartiality’ or ‘active neutrality’, and developing assessment tools that capture complex competencies. This proposal aligns with global curricular renewal movements and suggests a model where common ground rests not on contents, but on a competency to navigate the uncertainty and complexity. Full article

Differential equations have demonstrated significant practical effectiveness across diverse fields, including physics, chemistry, biological engineering, computer science, electrical power systems, and security cryptography. This study investigates the dynamics of a Caputo fractional discrete-time modified Brusselator model. Conditions for the existence and local stability of the fixed point $FP$ are established. Using bifurcation theory, the occurrence of both period-doubling and Neimark–-Sacker bifurcations is analyzed, revealing that these bifurcations occur at specific values of the bifurcation parameter. Maximum Lyapunov characteristic exponents are computed to assess system sensitivity. Two-dimensional diagrams are presented to illustrate phase portraits, local stability regions, closed invariant curves, bifurcation types, and Lyapunov exponents, while the 0-1 test confirms the presence of chaos in the model. Finally, MATLAB simulations validate the theoretical results. Full article

Water Supply and Distribution Networks (WSDNs) offer underexplored potential for energy recovery. While many studies confirm their technical feasibility, few assess the long-term operational compatibility and economic viability of such solutions. This study evaluates the energy recovery potential of the Brussels Capital Region’s WSDN using four years (2019–2022) of operational data. Rather than focusing on available technologies, the analysis examines whether the real behavior of the network supports sustainable energy extraction. The approach includes network topology identification, theoretical power modeling, and detailed flow and pressure analysis. The Brussels system, composed of a Water Supply Network (WSN) and a Water Distribution Network (WDN), reveals strong disparities: the WSN offers localized opportunities for energy recovery, while the WDN presents significant operational constraints that limit economic viability. Our findings suggest that day-ahead electricity markets provide more suitable valorization pathways than flexibility markets. Most importantly, the study highlights the necessity of long-term behavioral analysis to avoid misleading conclusions based on short-term data and to support informed investment decisions in the urban water–energy nexus. Full article

Background: The Spanish Interterritorial Council of the National Health System (a central government body) currently recommends vaccination against meningococcal serogroup C (MenC) at 4 and 12 months of age for prevention of invasive meningococcal disease (IMD). The Advisory Committee on Vaccines of the Spanish Association of Pediatrics (a professional medical association) and numerous Spanish regional bodies instead recommend quadrivalent vaccination against serogroups A, C, W, and Y (MenACWY) at 4 and 12 months of age. The central government and Spanish Association of Pediatrics also recommend MenACWY vaccination at 12 years of age. This study assessed the potential public health effects of replacing the MenC vaccination schedule with different MenACWY vaccination schedules in infants. Methods: Here, a static multi-cohort population model was used to evaluate potential effects on public health of IMD due to meningococcal serogroups C/W/Y, comparing MenC infant vaccination (reference strategy) against four different strategies including quadrivalent tetanus toxoid conjugate vaccine (MenACWY-TT; Nimenrix^®, Pfizer Europe MA EEIG, Brussels, Belgium) infant vaccination; all strategies included MenACWY-TT vaccination at 12 years of age. Results: The most effective strategy for infant vaccination was MenACWY-TT at 2, 4, and 12 months, preventing an estimated additional 103 IMD cases, 17 deaths, and 41 cases with long-term sequelae (LTS) versus the reference strategy in the base-case IMD incidence scenario. When strategies included a two-dose infant schedule, the earlier the infant MenACWY-TT vaccine was administered, the more additional cases, deaths, and cases with LTS were prevented (base-case and high-incidence scenarios). Conclusions: This analysis supports implementation of MenACWY-TT as a replacement for MenC vaccination. Full article

Transitioning to Positive Energy Districts (PEDs) is essential for achieving carbon neutrality in urban areas by 2050. This study presents a multi-objective optimization framework that balances energy, environmental, and economic performance, addressing the diverse priorities of multiple stakeholders. The framework enhances PED design by systematically evaluating technical solutions, including renewable-based electrification, demand-side management (DSM), energy storage, and retrofitting. The framework is applied to the Usquare district in Brussels, Belgium, as a case study. The results indicate that expanding photovoltaic (PV) capacity is crucial for achieving PED targets, with renewable-based electrification potentially reducing carbon emissions by up to 79%. The incorporation of demand-side management (DSM) and battery storage improves system flexibility, reduces grid dependency, and enhances cost-effectiveness. Although slightly more costly, retrofitting existing buildings provides the most balanced approach, offering the lowest CO2 emissions and the highest self-consumption ratio. This study presents a comprehensive decision-making support framework for optimizing PED design and operation, offering practical guidance for urban energy planning and contributing to global efforts toward carbon neutrality. Full article

Background/Objectives: Inadequate dosing and respiratory motion contribute to local recurrence for oligometastatic disease (OMD). While short-term LC rates are well-documented, data on long-term LC remain limited. This study investigated long-term LC after stereotactic body radiotherapy (SBRT), using respiratory motion management techniques. Methods: This retrospective study took place at UZ Brussel with follow-up until Oct 2024. It analyzed oligometastatic patients treated with SBRT between Jul 2012 and Feb 2017. Treatment involved delivering 50 Gy in 10 fractions on the 80% isodose line, building on data from a prior prospective study. Lesion movement was managed using internal target volume (ITV) or dynamic tumor tracking (DTT) with marker. The primary endpoint of the study was long-term LC and identifying variables associated with it using a Cox proportional hazards model. Results: A total of 100 patients were treated for a total of 211 metastatic lesions. Lesions were predominantly in the lungs (74%) and treated using ITV (88%). LC rates at 1, 3, 5, and 10 years were 76.5%, 53.8%, 38.1%, and 36.3%, respectively. Improved LC was observed in locations other than lung and liver (HR: 0.309; p = 0.024) and with increasing age (HR: 0.975; p < 0.010). Worse LC was seen in liver lesions (HR: 1.808; p = 0.103) and systemic therapy post-radiotherapy (HR: 3.726; p < 0.001). No significant associations were found with tumor size or tumor motion, nor between the two motion management strategies used (DTT and ITV). Conclusions: Appropriate motion management is key in LC for OMD. No significant difference in LC was found between both techniques. Lesion location, patient age, and systemic therapy post-radiotherapy were prognostic factors for LC. Full article

The aim of this study was to compare the concentration of phenolic compounds, glucosinolates, proteins, sugars and vitamin C between kohlrabi (Brassica oleracea var. acephala gongylodes), Savoy cabbage (B. oleracea sabauda), Brussels sprouts (B. oleracea gemmifera), cauliflower (B. oleracea botrytis), radish (Raphanus sativus) and garden cress (Lepidium sativum) microgreens for their antioxidant and hypoglycemic potential. In addition, we applied an in vitro-simulated system of human digestion in order to track the bioaccessibility of the selected phenolic representatives, and the stability of the microgreens’ antioxidant and hypoglycemic potential in terms of α-amylase and α-glucosidase inhibition after each digestion phase. Using spectrophotometric and RP-HPLC methods with statistical analyses, we found that garden cress had the lowest soluble sugar content, while Savoy cabbage and Brussels sprouts had the highest glucosinolate levels (76.21 ± 4.17 mg SinE/g dm and 77.73 ± 3.33 mg SinE/g dm, respectively). Brussels sprouts were the most effective at inhibiting protein glycation (37.98 ± 2.30% inhibition). A very high positive correlation (r = 0.830) between antiglycation potential and conjugated sinapic acid was recorded. For the first time, the antidiabetic potential of microgreens after in vitro digestion was studied. Kohlrabi microgreens best inhibited α-amylase in both initial and intestinal digestion (60.51 ± 3.65% inhibition and 62.96 ± 3.39% inhibition, respectively), and also showed the strongest inhibition of α-glucosidase post-digestion (19.22 ± 0.08% inhibition). Brussels sprouts, cauliflower, and radish had less stable α-glucosidase than α-amylase inhibitors during digestion. Kohlrabi, Savoy cabbage, and garden cress retained inhibition of both enzymes after digestion. Kohlrabi antioxidant capacity remained unchanged after digestion. The greatest variability was seen in the original samples, while the intestinal phase resulted in the most convergence, indicating that digestion reduced differences between the samples. In conclusion, this study highlights the potential of various microgreens as sources of bioactive compounds with antidiabetic and antiglycation properties. Notably, kohlrabi microgreens demonstrated significant enzyme inhibition after digestion, suggesting their promise in managing carbohydrate metabolism and supporting metabolic health. Full article

Conceived as institutions funded by the public purse and intended to exist devoid of political influence, the mandate of public service media (PSM) entities is to disseminate reliable news content and high-quality audiovisual productions to all demographic segments, inclusive of marginalized communities and audiences that are typically under-served. Over the previous ten years, the rise in prominence of global platforms in national media systems has precipitated many changes in the media sector, including unique challenges for PSM institutions guided by specific public service values. Using a holistic conceptual framework for assessing the implementation of these values, this article analyzes the impact of platformization on Europe’s PSM and discusses how the Union’s policy approaches affect related challenges to PSM. The analysis indicates that while the European Union (EU) has accorded a high priority to PSM within its media policy framework, the role that Brussels plays in protecting the independence and efficacy of PSM has been circumscribed, given that the onus of regulating PSM entities rests with national governments. This has engendered contrasting experiences wherein certain PSM outlets enjoy political independence and command significant public trust while others function as state-controlled propaganda vehicles, advancing the objectives and interests of governing bodies. The EU has addressed global platform power in recent attempts to safeguard its digital future, including the Digital Services Act (DSA), Digital Markets Act (DMA), and the European Media Freedom Act (EMFA). However, these acts do not adequately address PSM’s two central and often interconnected problems: funding challenges and political pressures. Full article

In recent years, smart water sensing technology has played a crucial role in water management, addressing the pressing need for efficient monitoring and control of water resources analysis. The challenge in smart water sensing technology resides in ensuring the reliability and accuracy of the data collected by sensors. Outliers are a well-known problem in smart sensing as they can negatively affect the viability of useful analysis and make it difficult to evaluate pertinent data. In this study, we evaluate the performance of four sensors: electrical conductivity (EC), dissolved oxygen (DO), temperature (Temp), and pH. We implement four classical machine learning models: support vector machine (SVM), artifical neural network (ANN), decision tree (DT), and isolated forest (iForest)-based outlier detection as a pre-processing step before visualizing the data. The dataset was collected by a real-time smart water sensing monitoring system installed in Brussels’ lakes, rivers, and ponds. The obtained results clearly show that the SVM outperforms the other models, showing 98.38% $F_1$-score rates for pH, 96.98% $F_1$-score rates for temp, 97.88% $F_1$-score rates for DO, and 98.11% $F_1$-score rates for EC. Furthermore, ANN also achieves a significant results, establishing it as a viable alternative. Full article

This paper investigates the effect of a gene expression time delay on the Brusselator model with reaction and diffusion terms in one dimension. We obtain ODE systems analytically by using the Galerkin method. We determine a condition that assists in showing the existence of theoretical results. Full maps of the Hopf bifurcation regions of the stability analysis are studied numerically and theoretically. The influences of two different sources of diffusion coefficients and gene expression time delay parameters on the bifurcation diagram are examined and plotted. In addition, the effect of delay and diffusion values on all other free parameters in this system is shown. They can significantly affect the stability regions for both control parameter concentrations through the reaction process. As a result, as the gene expression time delay increases, both control concentration values increase, while the Hopf points for both diffusion coefficient parameters decrease. These values can impact solutions in the bifurcation regions, causing the region of instability to grow. In addition, the Hopf bifurcation points for the diffusive and non-diffusive cases as well as delay and non-delay cases are studied for both control parameter concentrations. Finally, various examples and bifurcation diagrams, periodic oscillations, and 2D phase planes are provided. There is close agreement between the theoretical and numerical solutions in all cases. Full article

This article examines how and under what conditions Italy’s civil society organizations (CSOs) have resorted to transnational activism and to what extent these efforts translate into impactful political advocacy. The analysis focuses on the action strategies of these civil society actors that have come under considerable pressure through the resurgence of populist–nationalist actors in the domestic arena. Developing an actor-centred perspective from below, this article draws on a series of 27 interviews conducted with these organizations’ representatives working primarily on issues related to migration and refugees in Italy. The empirical study examines some key initiatives that see domestic CSOs as protagonists in the transnational realm and explicates their motivations, approaches, and experiences. Conceptually, the article distinguishes between the vertical and horizontal Europeanization of CSOs. While there are notable opportunities for CSOs to engage in Brussels-centred governance and policy making, the effectiveness of horizontal Europeanization in the form of cross-border networking is—at first sight paradoxically—limited by the EU’s system of multi-level governance. The central argument about Europeanizing civil society activism is that these processes are primarily driven by a pragmatic pursuit of solutions to concrete political challenges that could not be properly addressed in an increasingly hostile domestic environment. Full article

Space and water heating for residential and commercial buildings amount to a third of the European Union’s total final energy consumption. Approximately 75% of the primary energy is still produced by burning fossil fuels, leading to high greenhouse gas emissions in the heating sector. Therefore, policymakers increasingly strive to trigger investments in sustainable and low-emission heating systems. This study forms part of the “Roll-out of Deep Geothermal Energy in North-West-Europe”-project and aims at quantifying the spatial heat demand distribution in the Interreg North-West-Europe region. An open-source geographic information system and selected Python packages for advanced geospatial processing, analysis, and visualization are utilized to constrain the maps. These were combined, streamlined, and optimized within the open-source Python package PyHeatDemand. Based on national and regional heat demand input data, three maps are developed to better constrain heat demand at a high spatial resolution of 100 m × 100 m (=1 ha) for the residential and commercial sectors, and for both together (in total). The developed methodology can not only be applied to transnational heat demand mapping but also on various scales ranging from city district level to states and countries. In addition, the workflow is highly flexible working with raster data, vector data, and tabular data. The results reveal a total heat demand of the Interreg North-West-Europe region of around 1700 TWh. The spatial distribution of the heat demand follows specific patterns, where heat demand peaks are usually in metropolitan regions like for the city of Paris (1400 MWh/ha), the city of Brussels (1300 MWh/ha), the London metropolitan area (520 MWh/ha), and the Rhine-Ruhr region (500 MWh/ha). The developed maps are compared with two international projects, Hotmaps and Heat Roadmap Europe’s Pan European Thermal Atlas. The average total heat demand difference from values obtained in this study to Hotmaps and Heat Roadmap Europe is 24 MWh/ha and 84 MWh/ha, respectively. Assuming the implementation of real consumption data, an enhancement in spatial predictability is expected. The heat demand maps are therefore predestined to provide a conceptual first overview for decision-makers and market investors. The developed methods will further allow for anticipated mandatory municipal heat demand analyses. Full article

Target2 is the Eurozone’s cross-border payment system, which is mandatory for the settlement of euro transactions involving Eurozone central banks. It is being used to save the Eurozone from imploding. A key underlying problem is that the Eurozone does not satisfy the economic conditions for being an Optimal Currency Area, i.e., a geographical area over which a single currency and monetary policy can operate on a sustainable, long-term basis. The different business cycles in the Eurozone, combined with poor labour and capital market flexibility, mean that systematic trade surpluses and deficits will build up because inter-regional exchange rates can no longer be changed. Surplus regions need to recycle the surpluses back into deficit regions via transfers to keep the Eurozone economies in balance. But the largest surplus country—Germany—refuses to formally accept that the European Union is a ‘transfer union’. However, deficit countries, including the largest of these—Italy—are using Target2 for this purpose. Target2 has become a giant credit card for Eurozone members that import more than they export to other members, but with two differences compared with normal credit card debt: neither the debt nor the interest that accrues on the debt ever needs to be repaid. Furthermore, the size of the deficits being built up is causing citizens in deficit countries to lose confidence in their banking systems, leading them to transfer their funds to banks in surplus countries. Target2 is also being used to facilitate this capital flight. However, these are not viable long-term solutions to systemic Eurozone trade imbalances and weakening national banking systems. There are only two realistic outcomes. The first is a full fiscal and political union, with Brussels determining the levels of tax and public expenditure in each member state—which has long been the objective of Europe’s political establishment. The second outcome is that the Eurozone breaks up. Full article