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Article

21 Citations

4,280 Views

22 Pages

Design of Polymeric Nanocapsules for Intranasal Vaccination against Mycobacterium Tuberculosis: Influence of the Polymeric Shell and Antigen Positioning

Lara Diego-González,
José Crecente-Campo,
Matthew John Paul,
Mahavir Singh,
Rajko Reljic,
María José Alonso,
África González-Fernández and
Rosana Simón-Vázquez

Pharmaceutics2020, 12(6), 489;https://doi.org/10.3390/pharmaceutics12060489

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28 May 2020

Tuberculosis (TB) is the leading cause of death from a single infectious microorganism and Bacillus Calmette Guerin (BCG), the only authorized vaccine, does not confer protection against pulmonary TB. Based on the hypothesis that mucosal protection c...

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Article

12 Citations

3,091 Views

13 Pages

Microbial Antigen-Presenting Extracellular Vesicles Derived from Genetically Modified Tumor Cells Promote Antitumor Activity of Dendritic Cells

Tomoko Ito,
Kikuya Sugiura,
Aya Hasegawa,
Wakana Ouchi,
Takayuki Yoshimoto,
Izuru Mizoguchi,
Toshio Inaba,
Katsuyuki Hamada,
Masazumi Eriguchi and
Yoshiyuki Koyama

Pharmaceutics2021, 13(1), 57;https://doi.org/10.3390/pharmaceutics13010057

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4 January 2021

Tumor-derived extracellular vesicles (EVs), as tumor vaccines, carry tumor-associated antigens (TAAs), and were expected to transfer TAAs to antigen-presenting cells. However, treatment with tumor-derived EVs exhibited no obvious antitumor effect on...

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