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Synthesis and Antiproliferative Evaluation of 3-Chloroazetidin-2-ones with Antimitotic Activity: Heterocyclic Bridged Analogues of Combretastatin A-4
- Azizah M. Malebari,
- Shu Wang,
- Thomas F. Greene,
- Niamh M. O’Boyle,
- Darren Fayne,
- Mohemmed Faraz Khan,
- Seema M. Nathwani,
- Brendan Twamley,
- Thomas McCabe and
- Daniela M. Zisterer
- + 1 author
Antimitotic drugs that target tubulin are among the most widely used chemotherapeutic agents; however, the development of multidrug resistance has limited their clinical activity. We report the synthesis and biological properties of a series of novel...