Search Results (4,060)

Fiber interferometers are widely used in precision measurement fields such as seismic observation, gravitational-wave detection, and aerospace guidance. However, phase noise in the Hz–kHz range has become an important factor limiting further improvement in measurement accuracy. In this work, a solid-core photonic crystal fiber (PCF) and a hollow-core photonic bandgap fiber (HC-PBGF) were introduced into the sensing arms of a fiber interferometer to reduce phase noise in this frequency range. Theoretical analysis showed that, compared with a conventional solid-core fiber, the PCF and the 19-cell HC-PBGF used in this study could reduce the phase noise by approximately 3 dB and 7 dB, respectively. The experimental results agreed well with the theoretical predictions, confirming that both fibers can effectively suppress high-frequency phase noise, with HC-PBGF showing superior noise reduction performance. This work provides a feasible approach for improving the performance of fiber interferometers in precision measurement. Full article

Quantum image transmission over noisy communication channels remains a challenge due to the fragility of quantum states and their susceptibility to channel impairments. Existing quantum encoding schemes often exhibit limited noise resilience, while advanced approaches introduce computational and implementation complexity. To address these limitations, this paper proposes a circular polarization-based quantum encoding framework for image transmission over error-prone channels. In the proposed approach, source images are compressed and source-encoded using standard image coding formats, including the joint photographic experts group (JPEG) standard and the high-efficiency image file format (HEIF), and converted into classical bitstreams. The resulting bitstreams are protected using channel coding and mapped onto quantum states via circular polarization representations, where left- and right-hand circularly polarized states encode binary information. The encoded quantum states are transmitted over noisy quantum channels to model channel impairments. At the receiver, appropriate quantum decoding and channel decoding operations are applied to recover the classical bitstream, followed by source decoding to reconstruct the image. The performance of the proposed framework is evaluated using image quality metrics, including peak signal-to-noise ratio (PSNR), structural similarity index measure (SSIM), and universal quality index (UQI). Simulation results demonstrate that the proposed circular polarization-based encoding scheme outperforms existing quantum image encoding techniques, achieving channel SNR gains of 4 dB over state-of-the-art Hadamard-based encoding and 3 dB over frequency-domain quantum encoding methods under severe noise conditions. These results indicate that circular polarization-based quantum encoding provides improved noise robustness and reconstruction fidelity for practical quantum image transmission systems. Full article

A 0.3 V nanowatt CCII⁻ is presented in 0.18 $\mathsf{\mu }$m TSMC CMOS, targeting ultra-low-power current-mode interfaces. Post-layout extracted simulations demonstrate correct conveying operation with a total DC power consumption of less than 2.40 nW. The low-frequency tracking factors evaluated at 1 Hz are ${\beta }_0=0.9452$ (−0.48 dB) and ${\alpha }_0=0.9609$ (≈−0.35 dB), with $-3$ dB bandwidths of 22.95 kHz and 63.95 kHz for the voltage and current transfers, respectively. Small-signal extraction confirms the intended impedance profile, yielding $R_X=46.73$ M$\mathsf{\Omega }$, $R_Z=1.204$ G$\mathsf{\Omega }$, and a very high input resistance $R_Y=392$ G$\mathsf{\Omega }$. Robustness is verified through full PVT and mismatch analyses, showing stable functionality across process corners, a 0–80 °C temperature range, and 270–330 mV supply variations while maintaining nanowatt-level dissipation. Full article

Compared to antennas bearing a single port, MIMO antennas with several ports enable higher data throughput by exploiting spatial diversity. This capability is essential for next-generation implantable medical devices, where high channel capacity is a key requirement. A quad-element implantable MIMO antenna is designed and practically validated at 1420 MHz in this paper. It occupies a compact volume of $7\times 8\times 0.1 {\mathrm{mm}}^3$ ($5.6 {\mathrm{mm}}^3$). The compactness is realized by combining high-permittivity substrate (Rogers 3010 with relative permittivity of 10.2) with meandered radiator paths, which increase the effective current length while maintaining a small physical size. All antennas have very small mutual coupling with isolation of more than $31.78$ dB, which is mainly due to the spacing of 1 mm between the elements and the substrate, which is thin. The peak realized gain for each antenna element is $-27.3$ dBi. The simulation is performed within a capsule-like structure, which is embedded in the stomach tissue model. The experimental verification is carried out by embedding antenna within minced meat. The ECC, channel capacity, and link margin are also evaluated and found to be satisfactory. The proposed antenna ensures reliable communication performance, with the transmission range being as high as $2.5$ m, link margin being 15 dB, and the data rate being 120 Mb/s. The proposed antenna ensures a good level of ECC, which is less than $0.1$. The SAR is $52.3$ W/kg at 1420 MHz. This design is favorable for implants because of the small size, good impedance matching, high isolation, low correlation, good level of gain, and good link performance. Full article

This paper presents two broadband four-way power dividers based on a novel T-coil topology, operating in the 22–32 GHz band (covering the K/Ka bands). Type I adopts a cascaded power division structure, while Type II employs a direct-feed integrated architecture. The innovation lies in the introduction of isolating capacitors at the input and output ports, which significantly shortens the critical transmission line lengths in both topologies. This effectively reduces the equivalent inductance and raises the self-resonant frequency, achieving wideband response while maintaining structural simplicity, compact size, and ease of integration. Both circuits were fabricated using a standard 45 nm CMOS process. The measured core chip areas (excluding pads) are only 0.125 mm² for Type I and 0.066 mm² for Type II, demonstrating excellent integration density. Through even-mode and odd-mode theoretical analysis and full-wave electromagnetic simulation verification, both power dividers exhibit good impedance matching and port isolation across the target frequency band. Measurement results further confirm their performance: across the entire 22–32 GHz band, both power dividers achieve a return loss better than 11 dB and isolation exceeding 15 dB; the insertion loss is 1.1–1.4 dB for Type I and 0.8–1.3 dB for Type II; the amplitude imbalance is below ±0.3 dB and ±0.1 dB, respectively; and the phase imbalance is less than ±5° and ±3°, respectively. All measured data show good agreement with simulation results. In summary, Type I offers advantages in layout flexibility and isolation performance, while Type II excels in insertion loss and chip size. Both provide practical circuit solutions for broadband, high-performance, and compact power division systems. Full article

This paper presents the performance analysis of a 100 Gbps long-reach passive optical network (LR-PON) based on intensity modulation and direct detection (IM-DD). The LR-PON is designed for low-complexity environments that reuse previously deployed infrastructure and extend coverage to rural areas. It features a point-to-multipoint PON topology with a 1:64 split and links up to 100 km long. The paper analyzes the impact of the booster amplifier, preamplifier, and chromatic-dispersion-compensating module on the bit error rate (BER) using OptSim simulations. The results demonstrate that the LR-PON, operating at 100 Gbps over a 100 km link and with losses over 3 dB over a legacy network, maintains acceptable BER levels in the order of ${10}^{-6}$, validating its viability as a scalable, efficient, and economical solution for optical access networks in suburban or rural areas in locations such as Quito city (Ecuador). Full article

Objectives: Obesity remains a global health challenge, and promoting white adipose tissue browning has emerged as a promising anti-obesity strategy. This study aimed to investigate the anti-obesity effects of denatonium benzoate (DB) and elucidate its underlying mechanisms. Methods: In order to study the anti-obesity effects of DB and its mechanisms, we used in vivo and in vitro obesity models to study whether DB has anti-obesity effects by participating in fat browning. We investigated the role of DB in high-fat diet (HFD)-induced obese C57BL/6J mice using 36 male animals (8 weeks old, 25 ± 2 g), and evaluated the expression of the adipogenic marker genes Fatty acid-binding protein 4 (Fabp4) and Peroxisome Proliferator-Activated Receptor gamma (PPAR-γ); the thermogenic genes uncoupling protein 1 (Ucp1), Transcription Factor A, Mitochondrial (TFAM), Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Alpha (Pgc1α), and Adrenergic receptor beta 3 (Adrb3); as well as the adipose browning marker genes Deiodinase, Iodothyronine, Type II (Dio2), PR domain containing 16 (PRDM16), and Peroxisome Proliferator-Activated Receptor alpha (PPAR-α) in 3T3-L1 cells and primary adipocytes with DB treatment. Conclusions: These results indicate that the anti-obesity effects of DB may be related to the browning of white fat, providing a novel potential candidate for anti-obesity drug development. Full article

Background: The effect of fluid thickening in older patients with oropharyngeal dysphagia (OD) is not settled in the case of mild OD or OD caused by structural abnormalities. Objective: To assess the therapeutic effect and mechanism of action of the xanthan-gum-based thickener Tsururinko Quickly in older patients with structural OD and those with mild OD (Penetration–Aspiration Score < 3). Patients and Methods: We included 25 participants in each group (81.8 ± 7.1 vs. 77.4 ± 7.2 yr, respectively). Participants underwent videofluoroscopy (VFS) while swallowing 10 mL boluses at <50 mPa·s, 100, 200, 400, 800, and 1600 mPa·s to evaluate the safety and efficacy of swallowing and the biomechanics of the swallowing response at each viscosity level. After 30 s oral incubation, the effect of salivary α-amylase on shear viscosity was assessed using viscometer measurements. Results: (a) For the <50 mPa·s liquid series, no aspirations occurred in either group; however, 44% of patients with structural OD and 30% of patients with mild OD showed PAS 2 penetrations. (b) Fluid thickening reduced prevalence of penetrations with a maximal effect at 800 mPa·s and without affecting oral or pharyngeal residue in either group. (c) Increasing shear viscosity did not affect timing of airway protection mechanisms nor bolus kinematics. (d) Oral incubation decreased viscosity by 1.7–1.8% at 800 mPa·s. Conclusions: Fluid thickening with TQ enhances swallowing safety in older patients with structural causes of OD and those with mild OD through compensatory mechanisms and without a consistent increase in pharyngeal residue across the tested viscosity range. Full article

Multispectral remote sensing image super-resolution (RSISR) aims to reconstruct high-frequency details while preserving cross-band structural consistency under strict computational budgets. However, real-world satellite imagery exhibits heterogeneous distortions, ranging from band-dependent noise to spatially varying texture degradation, rendering uniform restoration strategies suboptimal. To address these challenges, we propose a unified framework that integrates cue extraction, expert specialization, and efficiency-aware restoration. Specifically, a Distortion-Aware Feature Extractor (DAFE) explicitly encodes distortion cues by synthesizing fixed frequency bases, learnable residual components, lightweight spatial edge representations, and noise proxies. Subsequently, a Distortion-Aware Expert Choice (DAEC) router utilizes these cues to establish distortion-conditioned affinities and performs capacity-constrained, load-balanced expert assignment. Finally, a parameter-shared Mixture-of-Experts (PS-MoE) architecture employs shared expert parameters across spectral bands, augmented by band-wise low-rank adapters, to enable coarse-to-fine restoration with minimal computational overhead. Extensive experiments on the SEN2VENμS and OLI2MSI datasets demonstrate that the proposed method achieves a PSNR of 49.38 dB on SEN2VENμS 2×, 45.91 dB on SEN2VENμS 4×, and 45.94 dB on OLI2MSI 3×. Compared to the strongest baseline for each task, our method yields PSNR improvements of 0.12 dB, 0.10 dB, and 0.09 dB, respectively, while simultaneously reducing FLOPs and parameter counts. These results confirm that explicit distortion modeling and parameter-shared expert specialization provide an effective and computationally efficient solution for multispectral remote sensing image super-resolution. Full article

This study aimed to evaluate the impact of coenzyme Q10 (CoQ10) supplementation during in vitro maturation (IVM) and/or vitrification of immature dromedary camel oocytes on their subsequent in vitro developmental competence. Additionally, total antioxidant capacity (TAC) and malondialdehyde (MDA) concentrations were assessed in the IVM spent medium. In experiment 1, cumulus–oocyte complexes (COCs, n = 808) collected from slaughtered dromedary camel ovaries were cultured in IVM media supplemented with either 0, 25, 50, or 100 μM CoQ10 for 36 h. Matured oocytes were then fertilized in vitro with epididymal camel spermatozoa. Eighteen hours post-insemination (pi), presumptive zygotes were cultured in vitro for 7 days. In experiment 2, a total of 875 COCs were randomly allocated to one of four experimental groups, namely (a) Vit−/IVM− (control) group, where COCs were vitrified in vitrification solution (VS; 25% DMSO + 25% EG) and matured in IVM media without CoQ10 supplementation; (b) Vit+/IVM− group, in which COCs were vitrified in a VS supplemented with 50 µM CoQ10 and matured in IVM media without CoQ10 supplementation; (c) Vit−/IVM+ group, where COCs were vitrified in VS without CoQ10 supplementation and matured in IVM media supplemented with 50 µM CoQ10; and (d) Vit+/IVM+ group, where COCs were vitrified in VS and matured in IVM media, both supplemented with 50 µM CoQ10. Following vitrification and warming, oocyte viability was evaluated morphologically and by trypan blue staining. Viable oocytes were then matured, fertilized, and cultured in vitro. In experiment 3, TAC and MDA concentrations in the IVM spent media were analyzed. Results showed that 50 µM CoQ10 supplementation to IVM media enhanced cumulus expansion, nuclear maturation, cleavage, and blastocyst rates (experiment 1). Adding 50 µM CoQ10 to the VS enhanced (p ≤ 0.05) oocyte viability compared to those vitrified in CoQ10-free media. Cumulus cell expansion and nuclear maturation rates were higher (p ≤ 0.05) in Vit−/IVM+ than in Vit+/IVM+ and Vit−/IVM− groups. Furthermore, cleavage and blastocyst rates were the highest (p ≤ 0.05) in Vit−/IVM+ group (experiment 2). The concentrations of TCA were higher, and the concentrations of MDA were lower (p ≤ 0.05) in Vit−/IVM+ than in other groups (experiment 3). In conclusion, supplementation of CoQ10 in the maturation medium of vitrified–warmed immature dromedary camel oocytes may enhance their in vitro developmental competence. Full article

This study proposes a high-isolation four-port wideband MIMO antenna array designed for sub-6 GHz 5G, IoT, and radar applications. The array is fabricated on a polycarbonate substrate with overall dimensions of 500 × 500 mm² (ε_r = 2.8, h = 1 mm). Four orthogonally arranged modified circular patches with triangular ground planes and optimized inter-element spacing (D₁ = 90 mm) are employed in the antenna’s design to achieve an impedance bandwidth of 0.7–7.0 GHz (Fractional Bandwidth (FBW) > 163.63%) with |S_ii| < −10 dB across all ports. The measurement results indicate that the inter-port isolation is better than 15 dB (worst-case) across the 0.7–7 GHz band, exceeding 25 dB over 63.5% of the bandwidth (with a peak of approximately 50 dB); the envelope correlation coefficient (ECC) is ultra-low (<0.008); the total active reflection coefficient (TARC) is less than −10 dB for primary multi-port excitations; the mean effective gain (MEG) is balanced (≈−3 dB); and the group delay is consistent (~0.5 ns). With a maximum realized gain of 10 dBi, the antenna exhibits omnidirectional radiation patterns, showing a significant correlation between the simulation (CST Microwave Studio) and measurement results. The proposed antenna is particularly well-suited for use in high-throughput sub-6 GHz 5G base stations and wideband wireless systems, offering superior port isolation through multi-mode resonance without the need for metamaterials and outperforming existing four-port designs. Full article

Background/Objectives: The association between ABO/Rh blood groups and knee osteoarthritis (OA) remains controversial, with inconsistent findings reported across different populations. This study aimed to evaluate the distribution of ABO and Rh(D) blood groups in patients undergoing primary total knee arthroplasty (TKA) for primary knee OA and to compare these distributions with a regional external reference population. Methods: This retrospective, single-center, observational study reviewed hospital records of patients who underwent primary TKA between January 2011 and October 2024. After applying predefined exclusion criteria (different ethnic background, age < 50 years, secondary knee OA, and missing blood group data), 4969 patients with primary knee OA were included. ABO/Rh(D) data were obtained from the institutional electronic hospital information system and transfusion/laboratory records. The external reference population consisted of a previously published dataset of regional blood donors (10,867 unique donors). Observed blood group frequencies in the study cohort were compared with expected frequencies derived from the reference distribution using chi-square goodness-of-fit tests for (1) 8-category ABO/Rh(D) distribution, (2) ABO-only distribution, and (3) Rh(D)-only distribution. Results: Among 4969 patients, 4096 (82.4%) were female and 873 (17.6%) were male. Mean age was 66.8 ± 7.0 years (range, 50–94) in females and 68.8 ± 7.3 years (range, 50–88) in males. The most frequent blood groups were A Rh (+) (39.3%), O Rh (+) (30.0%), and B Rh (+) (14.5%). The sex-specific ABO/Rh distribution did not differ significantly (p = 0.052). Compared with the regional reference distribution, the overall 8-category ABO/Rh(D) distribution showed a borderline difference (χ² (7) = 14.04, p = 0.050; Cramér’s V = 0.020). However, neither the ABO-only distribution (χ² (3) = 5.26, p = 0.153; Cramér’s V = 0.019) nor the Rh(D)-only distribution (χ² (1) = 0.11, p = 0.737; Cramér’s V = 0.005) differed significantly from the regional reference. The observed deviations were numerically small and not suggestive of a clinically meaningful difference. Conclusions: In this large single-center cohort of patients undergoing primary TKA for primary knee OA, the ABO and Rh(D) blood group distributions were largely comparable to those of the regional population. Although the overall 8-category ABO/Rh(D) comparison showed a borderline difference, separate ABO-only and Rh(D)-only analyses were not significant. These findings do not support a strong association between blood group status and surgically treated primary knee OA in this population. Full article

Background: Low-THC Cannabis sativa L. extracts are commonly believed to offer potential alternatives to non-steroidal anti-inflammatory drugs (NSAIDs) for inflammatory pain management. This study evaluated the anti-inflammatory effects of two C. sativa extracts (Tygra, Dora) and pure cannabidiol (CBD) compared with acetylsalicylic acid (ASA) in a carrageenan-induced rat paw inflammation model. Materials and Methods: Fifty male Wistar rats were randomized into five groups: control, ASA (200 mg/kg), CBD (20 mg/kg), Extract B (Tygra), and Extract D (Dora). Treatments were administered intragastrically 30 min after carrageenan injection. Paw volume was measured at 0, 1, 3, 6, and 10 h, and mRNA levels of COX-1, COX-2, TNFα, NFκB, CB1, and CB2 were quantified by qPCR. Results: Unlike ASA, which reduced paw edema and NFκB expression at 10 h, CBD and both extracts increased edema compared to control. Specifically, Extract D induced greater edema than ASA, upregulated CB1 and CB2 (surpassing ASA CB2 levels), decreased TNFα, and reduced right-paw COX-2. Extract B increased edema (3 h vs. ASA), increased TNFα, and showed a positive COX-2/paw volume correlation. Furthermore, paw volume correlated negatively with CB2 under CBD treatment (which also lowered right-paw COX-2) and positively with COX-1 under ASA treatment. Conclusions: The results indicate that ASA has a clear anti-inflammatory effect, whereas CBD and the hemp extracts fail to inhibit—and may even exacerbate—the inflammatory response. Differences in endocannabinoid and inflammatory gene expression suggest extract composition–dependent modulation mechanisms. Full article

FAM3A, FAM3B, FAM3C and FAM3D are members of the “family with sequence similarity 3” (FAM3) gene family, an emerging class of cytokine-like proteins with a unique structural globular β-β-α fold and distinct biological functions. With widespread expression in tissue, organs and in many cell types, their specific roles in human diseases have been the focus of much research. FAM3A acts as a positive regulator of metabolic health, typically activating canonical pro-survival and metabolic pathways. FAM3B, also called PANDER (PANcreatic DERived Factor), exerts critical physiological functions in the regulation of glycemic levels via promotion of hepatic glucose production and pancreatic β-cell insulin secretion. FAM3C, also named ILEI (Interleukin-like EMT inducer), is involved as an inducer of epithelial–mesenchymal transition (EMT) and cancer metastasis, as well as osteoblast differentiation and bone mineralization. FAM3D is a gut-secreted protein and potential regulator of gastrointestinal homeostasis and microbiota-induced inflammation. Here we provide an overview of previous studies supporting that FAM3 proteins act through putative membrane receptors and co-partners, including fibroblast growth factor receptor (FGFR), leukemia inhibitory factor receptor (LIFR), formyl peptide receptor (FPR1/2), to activate diverse downstream signaling pathways on different cellular contexts. Basic and clinical studies suggest that the FAM3 family influences both obesity, diabetes, and other metabolic disorders; thus, its expression may have diagnostic potential. The differential and often cancer-specific expression patterns make members of the FAM3 family promising candidates for biomarkers and therapeutic targets of some types of neoplasia. Full article

Background and Objectives: Optic disc drusen (ODD) are deposits in the optic nerve head that can look like true swelling, and in some patients, slowly damage the optic nerve and cause visual field loss. We aimed to identify which eyes are most likely to worsen over time using common clinic tests. Methods: We studied 131 adults with OCT-confirmed ODD who also had OCT-angiography (a scan that measures small blood vessels around the optic nerve) and repeated visual field tests over at least 18 months. We measured (1) the size of the drusen (maximum drusen height), (2) blood vessel density around and inside the optic nerve, and (3) change in visual field performance over time. “Fast progression” was defined as visual field worsening of ≥0.5 dB per year. Results: Eyes with superficial ODD had larger drusen than buried ODD (382.6 ± 110.9 vs. 247.2 ± 92.8 µm; p < 0.001) and more frequent visual field defects (78.6% vs. 58.7%; p = 0.02). When blood vessel density around the optic nerve was low, fast progression was much more common (52.3%) than in the middle (16.3%) or highest groups (13.6%; p < 0.001). In the adjusted model, fast progression was more likely with superficial ODD (OR 6.3) and larger drusen (OR 2.0 per 100 µm), and less likely when the vessel density was higher (OR 0.8 per 1% increase). Adding the vessel measurements improved the prediction accuracy (AUC 0.8 → 0.9; p = 0.011). Conclusions: Combining drusen size and blood vessel measurements helps identify ODD patients at higher risk of faster visual field loss and may guide closer follow-up. Full article