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Brachytherapy Approach Using 177Lu Conjugated Gold Nanostars and Evaluation of Biodistribution, Tumor Retention, Dosimetry and Therapeutic Efficacy in Head and Neck Tumor Model
- Min-Ying Lin,
- Hsin-Hua Hsieh,
- Jyh-Cheng Chen,
- Chuan-Lin Chen,
- Nin-Chu Sheu,
- Wen-Sheng Huang,
- Shinn-Ying Ho,
- Ting-Wen Chen,
- Yi-Jang Lee and
- Chun-Yi Wu
Brachytherapy can provide sufficient doses to head and neck squamous cell carcinoma (HNSCC) with minimal damage to nearby normal tissues. In this study, the β−-emitter 177Lu was conjugated to DTPA-polyethylene glycol (PEG) decorated gold nanostars (1...