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27 Results Found

  • Review
  • Open Access
98 Citations
21,577 Views
40 Pages

Trafficking of ThermoTRP Channels

  • Clotilde Ferrandiz-Huertas,
  • Sakthikumar Mathivanan,
  • Christoph Jakob Wolf,
  • Isabel Devesa and
  • Antonio Ferrer-Montiel

19 August 2014

ThermoTRP channels (thermoTRPs) define a subfamily of the transient receptor potential (TRP) channels that are activated by changes in the environmental temperature, from noxious cold to injurious heat. Acting as integrators of several stimuli and si...

  • Review
  • Open Access
6 Citations
3,608 Views
30 Pages

Temperature-sensitive transient receptor potential (TRP) channels (so-called “thermoTRPs”) are multifunctional signaling molecules with important roles in cell growth and differentiation. Several “thermoTRP” channels show alte...

  • Article
  • Open Access
1,100 Views
14 Pages

The Impact of a Quinone Scaffold on Thermo-TRPs Modulation by Dimethylheptyl Phytocannabinoids

  • Aniello Schiano Moriello,
  • Aurora Bossoni,
  • Daiana Mattoteia,
  • Diego Caprioglio,
  • Alberto Minassi,
  • Giovanni Appendino,
  • Luciano De Petrocellis,
  • Pietro Amodeo and
  • Rosa Maria Vitale

Phytocannabinoids (pCBs) from Cannabis sativa represent an important class of bioactive molecules, potentially useful for the treatment of a wide range of diseases. Their efficacy is due to their ability to interact with multiple targets of the endoc...

  • Article
  • Open Access
6 Citations
3,012 Views
11 Pages

The Combined Effect of Branching and Elongation on the Bioactivity Profile of Phytocannabinoids. Part I: Thermo-TRPs

  • Daiana Mattoteia,
  • Aniello Schiano Moriello,
  • Orazio Taglialatela-Scafati,
  • Pietro Amodeo,
  • Luciano De Petrocellis,
  • Giovanni Appendino,
  • Rosa Maria Vitale and
  • Diego Caprioglio

The affinity of cannabinoids for their CB1 and CB2 metabotropic receptors is dramatically affected by a combination of α-branching and elongation of their alkyl substituent, a maneuver exemplified by the n-pentyl -> α,α-dimethylheptyl (DMH) swap....

  • Review
  • Open Access
10 Citations
3,850 Views
20 Pages

Progress in the Structural Basis of thermoTRP Channel Polymodal Gating

  • Gregorio Fernández-Ballester,
  • Asia Fernández-Carvajal and
  • Antonio Ferrer-Montiel

The thermosensory transient receptor potential (thermoTRP) family of ion channels is constituted by several nonselective cation channels that are activated by physical and chemical stimuli functioning as paradigmatic polymodal receptors. Gating of th...

  • Article
  • Open Access
13 Citations
3,424 Views
17 Pages

A Systematical Survey on the TRP Channels Provides New Insight into Its Functional Diversity in Zhikong Scallop (Chlamys farreri)

  • Cheng Peng,
  • Zujing Yang,
  • Zhi Liu,
  • Shenhai Wang,
  • Haitao Yu,
  • Chang Cui,
  • Yuqing Hu,
  • Qiang Xing,
  • Jingjie Hu and
  • Xiaoting Huang
  • + 1 author

14 October 2021

Transient receptor potential (TRP) channel plays a significant role in mediating various sensory physiological functions. It is widely present in the vertebrate and invertebrate genomes and can be activated by multiple compounds, messenger molecules,...

  • Article
  • Open Access
9 Citations
3,057 Views
22 Pages

Thermosensitive TRP Channels Are Functionally Expressed and Influence the Lipogenesis in Human Meibomian Gland Cells

  • Melina Keller,
  • Stefan Mergler,
  • Aruna Li,
  • Ingrid Zahn,
  • Friedrich Paulsen and
  • Fabian Garreis

While the involvement of thermosensitive transient receptor potential channels (TRPs) in dry eye disease (DED) has been known for years, their expression in the meibomian gland (MG) has never been investigated. This study aims to show their expressio...

  • Article
  • Open Access
37 Citations
5,955 Views
24 Pages

Human and Mouse TRPA1 Are Heat and Cold Sensors Differentially Tuned by Voltage

  • Viktor Sinica,
  • Lucie Zimova,
  • Kristyna Barvikova,
  • Lucie Macikova,
  • Ivan Barvik and
  • Viktorie Vlachova

24 December 2019

Transient receptor potential ankyrin 1 channel (TRPA1) serves as a key sensor for reactive electrophilic compounds across all species. Its sensitivity to temperature, however, differs among species, a variability that has been attributed to an evolut...

  • Feature Paper
  • Review
  • Open Access
21 Citations
6,157 Views
20 Pages

13 June 2023

Both sensory neurons and immune cells, albeit at markedly different levels, express the vanilloid (capsaicin) receptor, Transient Receptor Potential, Vanilloid-1 (TRPV1). Activation of TRPV1 channels in sensory afferent nerve fibers induces local eff...

  • Review
  • Open Access
25 Citations
4,734 Views
25 Pages

Minor Phytocannabinoids: A Misleading Name but a Promising Opportunity for Biomedical Research

  • Diego Caprioglio,
  • Hawraz Ibrahim M. Amin,
  • Orazio Taglialatela-Scafati,
  • Eduardo Muñoz and
  • Giovanni Appendino

6 August 2022

Despite the very large number of phytocannabinoids isolated from Cannabis (Cannabis sativa L.), bioactivity studies have long remained focused on the so called “Big Four” [Δ9-THC (1), CBD (2), CBG (3) and CBC (4)] because of their e...

  • Review
  • Open Access
4 Citations
2,992 Views
16 Pages

Thermo-Transient Receptor Potential Channels: Therapeutic Potential in Gastric Cancer

  • Gang-Fan Zong,
  • Rui Deng,
  • Su-Yun Yu,
  • Ai-Yun Wang,
  • Zhong-Hong Wei,
  • Yang Zhao and
  • Yin Lu

4 December 2022

Over the last decade, researchers have found abnormal expression of transient receptor potential (TRP) channels. In particular, members of the thermally sensitive subclass (thermo-TRPs) are involved in many disease processes. Moreover, they have a vi...

  • Review
  • Open Access
22 Citations
16,377 Views
33 Pages

New Strategies to Develop Novel Pain Therapies: Addressing Thermoreceptors from Different Points of View

  • Asia Fernández-Carvajal,
  • Gregorio Fernández-Ballester,
  • Isabel Devesa,
  • José Manuel González-Ros and
  • Antonio Ferrer-Montiel

27 December 2011

One approach to develop successful pain therapies is the modulation of dysfunctional ion channels that contribute to the detection of thermal, mechanical and chemical painful stimuli. These ion channels, known as thermoTRPs, promote the sensitization...

  • Article
  • Open Access
2 Citations
2,380 Views
29 Pages

27 September 2023

Temperature sensation involves thermosensitive TRP (thermoTRP) and non-TRP channels. Drosophila larval Class III (CIII) neurons serve as the primary cold nociceptors and express a suite of thermoTRP channels implicated in noxious cold sensation. How...

  • Review
  • Open Access
56 Citations
12,186 Views
17 Pages

TRPV3 in Drug Development

  • Lisa M. Broad,
  • Adrian J. Mogg,
  • Elizabeth Eberle,
  • Marcia Tolley,
  • Dominic L. Li and
  • Kelly L. Knopp

9 September 2016

Transient receptor potential vanilloid 3 (TRPV3) is a member of the TRP (Transient Receptor Potential) super-family. It is a relatively underexplored member of the thermo-TRP sub-family (Figure 1), however, genetic mutations and use of gene knock-out...

  • Article
  • Open Access
14 Citations
6,286 Views
13 Pages

Effect of Capsaicin and Other Thermo-TRP Agonists on Thermoregulatory Processes in the American Cockroach

  • Justyna Maliszewska,
  • Milena Jankowska,
  • Hanna Kletkiewicz,
  • Maria Stankiewicz and
  • Justyna Rogalska

18 December 2018

Capsaicin is known to activate heat receptor TRPV1 and induce changes in thermoregulatory processes of mammals. However, the mechanism by which capsaicin induces thermoregulatory responses in invertebrates is unknown. Insect thermoreceptors belong to...

  • Article
  • Open Access
12 Citations
4,653 Views
8 Pages

TRPA1 Modulating C14 Polyacetylenes from the Iranian Endemic Plant Echinophora platyloba

  • Giuseppina Chianese,
  • Carmina Sirignano,
  • Yalda Shokoohinia,
  • Zeynab Mohammadi,
  • Leili Bazvandi,
  • Fataneh Jafari,
  • Fereshteh Jalilian,
  • Aniello Schiano Moriello,
  • Luciano De Petrocellis and
  • Orazio Taglialatela-Scafati
  • + 1 author

Phytochemical investigation of the apolar extract obtained from aerial parts of the Iranian endemic plant Echinophora platyloba DC (Apiaceae) resulted in the characterization of the polyacetylene fraction of this plant. This resulted to be composed o...

  • Article
  • Open Access
2 Citations
2,892 Views
12 Pages

Genome-Wide Identification and Phylogenetic Analysis of TRP Gene Family Members in Saurian

  • Lin Zhang,
  • Ning Li,
  • Buddhi Dayananda,
  • Lihu Wang,
  • Huimin Chen and
  • Yunpeng Cao

19 December 2022

The transient receptor potential plays a critical role in the sensory nervous systems of vertebrates in response to various mechanisms and stimuli, such as environmental temperature. We studied the physiological adaptive evolution of the TRP gene in...

  • Article
  • Open Access
1 Citations
2,141 Views
14 Pages

Inhibition of Cutaneous TRPV3 Channels by Natural Caffeic Acid for the Alleviation of Skin Inflammation

  • Guoji Zhang,
  • Liqin Wang,
  • Yaxuan Qu,
  • Shilun Mo,
  • Xiaoying Sun and
  • Kewei Wang

6 August 2024

Natural caffeic acid (CA) and its analogues have been studied for their potential applications in the treatment of various inflammatory and infectious skin diseases. However, the molecular mechanism underlying the effects of the CA remains largely un...

  • Article
  • Open Access
15 Citations
4,386 Views
24 Pages

β–Lactam TRPM8 Antagonist RGM8-51 Displays Antinociceptive Activity in Different Animal Models

  • Cristina Martín-Escura,
  • Alicia Medina-Peris,
  • Luke A. Spear,
  • Roberto de la Torre Martínez,
  • Luis A. Olivos-Oré,
  • María Victoria Barahona,
  • Sara González-Rodríguez,
  • Gregorio Fernández-Ballester,
  • Asia Fernández-Carvajal and
  • Antonio R. Artalejo
  • + 2 authors

28 February 2022

Transient receptor potential melastatin subtype 8 (TRPM8) is a cation channel extensively expressed in sensory neurons and implicated in different painful states. However, the effectiveness of TRPM8 modulators for pain relief is still a matter of dis...

  • Article
  • Open Access
29 Citations
4,959 Views
17 Pages

Transmembrane proteins are involved in an array of stress responses, particularly in thermo-sensation and thermo-regulation. In this study, we performed a genome-wide identification and characterization of the Transient Receptor Potential (TRP) genes...

  • Review
  • Open Access
10 Citations
3,734 Views
15 Pages

Role of the TRP Channels in Pancreatic Ductal Adenocarcinoma Development and Progression

  • Gonçalo Mesquita,
  • Natalia Prevarskaya,
  • Albrecht Schwab and
  • V’yacheslav Lehen’kyi

26 April 2021

The transient receptor potential channels (TRPs) have been related to several different physiologies that range from a role in sensory physiology (including thermo- and osmosensation) to a role in some pathologies like cancer. The great diversity of...

  • Article
  • Open Access
9 Citations
4,221 Views
14 Pages

Influence of Cold-TRP Receptors on Cold-Influenced Behaviour

  • Dibesh Thapa,
  • Brentton Barrett,
  • Fulye Argunhan and
  • Susan D. Brain

28 December 2021

The transient receptor potential (TRP) channels, TRPA1 and TRPM8, are thermo-receptors that detect cold and cool temperatures and play pivotal roles in mediating the cold-induced vascular response. In this study, we investigated the role of TRPA1 and...

  • Article
  • Open Access
1 Citations
2,408 Views
14 Pages

TRPA1 Influences Staphylococcus aureus Skin Infection in Mice and Associates with HIF-1a and MAPK Pathway Modulation

  • Manoj Yadav,
  • Prem Prashant Chaudhary,
  • Grace Ratley,
  • Brandon D’Souza,
  • Mahaldeep Kaur,
  • Sundar Ganesan,
  • Juraj Kabat and
  • Ian A. Myles

14 September 2024

Infections caused by methicillin-resistant Staphylococcus aureus (MRSA) are a major public health burden. Emerging antibiotic resistance has heightened the need for new treatment approaches for MRSA infection such as developing novel antimicrobial ag...

  • Article
  • Open Access
1,028 Views
19 Pages

8 August 2025

The transient receptor potential channels TRPM3 and TRPM8 are cation channels that regulate numerous cellular activities, including thermo- and pain sensation. Stimulation of either TRPM3 or TRPM8 channels induces an intracellular signaling cascade t...

  • Article
  • Open Access
14 Citations
3,626 Views
19 Pages

Molecular Characterization of TRPA Subfamily Genes and Function in Temperature Preference in Tuta absoluta (Meyrick) (Lepidoptera: Gelechiidae)

  • Xiao-Di Wang,
  • Ze-Kai Lin,
  • Shun-Xia Ji,
  • Si-Yan Bi,
  • Wan-Xue Liu,
  • Gui-Fen Zhang,
  • Fang-Hao Wan and
  • Zhi-Chuang Lü

To reveal the mechanism of temperature preference in Tuta absoluta, one of the top 20 plant pests in the world, we cloned and identified TaTRPA1, TaPain, and TaPyx genes by RACE and bioinformatic analysis, and clarified their expression profiles duri...

  • Article
  • Open Access
12 Citations
4,124 Views
21 Pages

Calmodulin Supports TRPA1 Channel Association with Opioid Receptors and Glutamate NMDA Receptors in the Nervous Tissue

  • Elsa Cortés-Montero,
  • María Rodríguez-Muñoz,
  • M. Carmen Ruiz-Cantero,
  • Enrique J. Cobos,
  • Pilar Sánchez-Blázquez and
  • Javier Garzón-Niño

28 December 2020

Transient receptor potential ankyrin member 1 (TRPA1) belongs to the family of thermo TRP cation channels that detect harmful temperatures, acids and numerous chemical pollutants. TRPA1 is expressed in nervous tissue, where it participates in the gen...

  • Article
  • Open Access
63 Citations
5,797 Views
19 Pages

Green Bio-Assisted Synthesis, Characterization and Biological Evaluation of Biocompatible ZnO NPs Synthesized from Different Tissues of Milk Thistle (Silybum marianum)

  • Bilal Haider Abbasi,
  • Muzamil Shah,
  • Syed Salman Hashmi,
  • Munazza Nazir,
  • Sania Naz,
  • Waqar Ahmad,
  • Inam Ullah Khan and
  • Christophe Hano

16 August 2019

The purpose of the current study was green synthesis of ZnO-nanoparticles (NPs) from different tissues of Silybum marianum (L.) Gaernt. (i.e., seeds, wild plant, in vitro derived plantlets and callus cultures) followed by extensive characterization a...