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Article

52 Citations

4,296 Views

14 Pages

A Molecular Electron Density Theory Study of the Chemoselectivity, Regioselectivity, and Diastereofacial Selectivity in the Synthesis of an Anticancer Spiroisoxazoline derived from α-Santonin

Luis R. Domingo,
Mar Ríos-Gutiérrez and
Nivedita Acharjee

Molecules2019, 24(5), 832;https://doi.org/10.3390/molecules24050832

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26 February 2019

The [3 + 2] cycloaddition (32CA) reaction of an α-santonin derivative, which has an exocyclic C–C double bond, with p-bromophenyl nitrile oxide yielding only one spiroisoxazoline, has been studied within the molecular electron density the...

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Feature Paper
Article

11 Citations

3,952 Views

10 Pages

Preparation of Sesquiterpene Lactone-Loaded PLA Nanoparticles and Evaluation of Their Antitrypanosomal Activity

Njogu M. Kimani,
Solveig Backhaus,
Josphat C. Matasyoh,
Marcel Kaiser,
Fabian C. Herrmann,
Thomas J. Schmidt and
Klaus Langer

Molecules2019, 24(11), 2110;https://doi.org/10.3390/molecules24112110

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4 June 2019

Human African trypanosomiasis (HAT), also commonly known as sleeping sickness, is a neglected tropical disease affecting millions of people in poorly developed regions in sub-Saharan Africa. There is no satisfactory treatment for this infection. The...

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Article

1,428 Views

25 Pages

Comprehensive GC-MS Profiling and Multi-Modal Pharmacological Evaluations of Haloxylon griffithii: In Vitro and In Vivo Approaches

Iram Iqbal,
Mohamed A. M. Ali,
Fatima Saqib,
Kinza Alamgir,
Mohammad S. Mubarak,
Anis Ahmad Chaudhary,
Mohamed El-Shazly and
Heba A. S. El-Nashar

Pharmaceuticals2025, 18(6), 770;https://doi.org/10.3390/ph18060770

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22 May 2025

Background/Objectives: Haloxylon griffithii is a medicinal plant possessing therapeutic effects in disorders associated with the gastrointestinal (GIT) system. This research aims to study the pharmacological activity of Haloxylon griffithii in a...

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