Search Results (25)

Coronary atherosclerosis in patients with diabetes mellitus is the most significant pathophysiological mechanism responsible for ischemic heart disease. Atherosclerosis in diabetes is premature, more diffuse, and more progressive, and it affects more coronary blood vessels compared to non-diabetics. Atherosclerosis begins with endothelial dysfunction, continues with the formation of fatty streaks in the intima of coronary arteries, and ends with the appearance of an atherosclerotic plaque that expands centrifugally and remodels the coronary artery. If the atherosclerotic plaque is injured, a thrombus forms at the site of the damage, which can lead to vessel occlusion and potentially fatal consequences. Diabetes mellitus and atherosclerosis are connected through several pathological pathways. Among the most significant factors that lead to atherosclerosis in diabetics are hyperglycemia, insulin resistance, oxidative stress, dyslipidemia, and chronic inflammation. Chronic inflammation is currently considered one of the most important factors in the development of atherosclerosis. However, to date, no adequate anti-inflammatory therapeutic measures have been found to prevent the progression of the atherosclerotic process, and they remain a subject of ongoing research. In this review, we summarize the most significant pathophysiological mechanisms that link atherosclerosis and diabetes mellitus. Full article

Background/Objectives: Drug prescribing in elderly people with chronic diseases carries certain risks. The desire to treat several different diseases at the same time increases the risk of inadequate drug prescribing. Prostate cancer is a disease of older men and occurs in most men over the age of 65. With age, the risk of prostate cancer increases, but so does the risk of the inadequate prescription of drugs. Our research aimed to highlight the potential inadequate prescription of drugs in patients with prostate cancer, considering that it is mostly a population of older men in whom a greater number of comorbidities is expected, followed by the use of a greater number of drugs. Methods: Our investigation was designed as an observational, cross-sectional study of 334 male patients who presented at the Multidisciplinary Tumor Board (MDT) for urological cancers at the University Clinical Center Kragujevac, Kragujevac, Serbia, from 1 September to 15 December 2023. Our primary outcome was obtaining the MAI score. Results: Our study showed that a significant number of drugs per patient with a prostate cancer diagnosis were prescribed potentially inadequately. The factors associated with greater risk for PIP were the initial level of PSA, ADT meta (intermittent), and several prescribed drugs; on the other hand, secondary hormonal therapy was the reason for less frequent PIP. Conclusions: In conclusion, patients with prostate cancer are under increased risk of inappropriate prescribing when they are prescribed more medication, have high PSA, and have ADT meta (intermittent). To stop the incidence of inappropriate prescribing and its serious economic and health consequences, clinicians should take special care when prescribing new drugs to such patients. Full article

The limited nature of fossil resources and their unsustainable characteristics have led to increased interest in renewable sources. However, significant work remains to be carried out to fully integrate these systems into existing power distribution networks, both technically and legally. While reliability holds great potential for improving energy production sustainability, the dependence of solar energy production plants on weather conditions can complicate the realization of consistent production without incurring high storage costs. Therefore, the accurate prediction of solar power production is vital for efficient grid management and energy trading. Machine learning models have emerged as a prospective solution, as they are able to handle immense datasets and model complex patterns within the data. This work explores the use of metaheuristic optimization techniques for optimizing recurrent forecasting models to predict power production from solar substations. Additionally, a modified metaheuristic optimizer is introduced to meet the demanding requirements of optimization. Simulations, along with a rigid comparative analysis with other contemporary metaheuristics, are also conducted on a real-world dataset, with the best models achieving a mean squared error (MSE) of just 0.000935 volts and 0.007011 volts on the two datasets, suggesting viability for real-world usage. The best-performing models are further examined for their applicability in embedded tiny machine learning (TinyML) applications. The discussion provided in this manuscript also includes the legal framework for renewable energy forecasting, its integration, and the policy implications of establishing a decentralized and cost-effective forecasting system. Full article

Software is increasingly vital, with automated systems regulating critical functions. As development demands grow, manual code review becomes more challenging, often making testing more time-consuming than development. A promising approach to improving defect detection at the source code level is the use of artificial intelligence combined with natural language processing (NLP). Source code analysis, leveraging machine-readable instructions, is an effective method for enhancing defect detection and error prevention. This work explores source code analysis through NLP and machine learning, comparing classical and emerging error detection methods. To optimize classifier performance, metaheuristic optimizers are used, and algorithm modifications are introduced to meet the study’s specific needs. The proposed two-tier framework uses a convolutional neural network (CNN) in the first layer to handle large feature spaces, with AdaBoost and XGBoost classifiers in the second layer to improve error identification. Additional experiments using term frequency–inverse document frequency (TF-IDF) encoding in the second layer demonstrate the framework’s versatility. Across five experiments with public datasets, the accuracy of the CNN was 0.768799. The second layer, using AdaBoost and XGBoost, further improved these results to 0.772166 and 0.771044, respectively. Applying NLP techniques yielded exceptional accuracies of 0.979781 and 0.983893 from the AdaBoost and XGBoost optimizers. Full article

Respiratory conditions have been a focal point in recent medical studies. Early detection and timely treatment are crucial factors in improving patient outcomes for any medical condition. Traditionally, doctors diagnose respiratory conditions through an investigation process that involves listening to the patient’s lungs. This study explores the potential of combining audio analysis with convolutional neural networks to detect respiratory conditions in patients. Given the significant impact of proper hyperparameter selection on network performance, contemporary optimizers are employed to enhance efficiency. Moreover, a modified algorithm is introduced that is tailored to the specific demands of this study. The proposed approach is validated using a real-world medical dataset and has demonstrated promising results. Two experiments are conducted: the first tasked models with respiratory condition detection when observing mel spectrograms of patients’ breathing patterns, while the second experiment considered the same data format for multiclass classification. Contemporary optimizers are employed to optimize the architecture selection and training parameters of models in both cases. Under identical test conditions, the best models are optimized by the introduced modified metaheuristic, with an accuracy of 0.93 demonstrated for condition detection, and a slightly reduced accuracy of 0.75 for specific condition identification. Full article

Monitoring heart electrical activity is an effective way of detecting existing and developing conditions. This is usually performed as a non-invasive test using a network of up to 12 sensors (electrodes) on the chest and limbs to create an electrocardiogram (ECG). By visually observing these readings, experienced professionals can make accurate diagnoses and, if needed, request further testing. However, the training and experience needed to make accurate diagnoses are significant. This work explores the potential of recurrent neural networks for anomaly detection in ECG readings. Furthermore, to attain the best possible performance for these networks, training parameters, and network architectures are optimized using a modified version of the well-established particle swarm optimization algorithm. The performance of the optimized models is compared to models created by other contemporary optimizers, and the results show significant potential for real-world applications. Further analyses are carried out on the best-performing models to determine feature importance. Full article

This paper addresses the critical security challenges in the internet of things (IoT) landscape by implementing an innovative solution that combines convolutional neural networks (CNNs) for feature extraction and the XGBoost model for intrusion detection. By customizing the reptile search algorithm for hyperparameter optimization, the methodology provides a resilient defense against emerging threats in IoT security. By applying the introduced algorithm to hyperparameter optimization, better-performing models are constructed capable of efficiently handling intrusion detection. Two experiments are carried out to evaluate the introduced technique. The first experiment tackles detection through binary classification. The second experiment handles the task by specifically identifying the type of intrusion through multi-class classification. A publicly accessible real-world dataset has been utilized for experimentation and several contemporary algorithms have been subjected to a comparative analysis. The introduced algorithm constructed models with the best performance in both cases. The outcomes have been meticulously statistically evaluated and the best-performing model has been analyzed using Shapley additive explanations to determine feature importance for model decisions. Full article

Rapid developments in Internet of Things (IoT) systems have led to a wide integration of such systems into everyday life. Systems for active real-time monitoring are especially useful in areas where rapid action can have a significant impact on outcomes such as healthcare. However, a major challenge persists within IoT that limit wider integration. Sustainable healthcare supported by the IoT must provide organized healthcare to the population, without compromising the environment. Security plays a major role in the sustainability of IoT systems, therefore detecting and taking timely action is one step in overcoming the sustainability challenges. This work tackles security challenges head-on through the use of machine learning algorithms optimized via a modified Firefly algorithm for detecting security issues in IoT devices used for Healthcare 4.0. Metaheuristic solutions have contributed to sustainability in various areas as they can solve nondeterministic polynomial time-hard problem (NP-hard) problems in realistic time and with accuracy which are paramount for sustainable systems in any sector and especially in healthcare. Experiments on a synthetic dataset generated by an advanced configuration tool for IoT structures are performed. Also, multiple well-known machine learning models were used and optimized by introducing modified firefly metaheuristics. The best models have been subjected to SHapley Additive exPlanations (SHAP) analysis to determine the factors that contribute to occurring issues. Conclusions from all the performed testing and comparisons indicate significant improvements in the formulated problem. Full article

Maritime vessels provide a wealth of data concerning location, trajectories, and speed. However, while these data are meticulously monitored and logged to maintain course, they can also provide a wealth of meta information. This work explored the potential of data-driven techniques and applied artificial intelligence (AI) to tackle two challenges. First, vessel classification was explored through the use of extreme gradient boosting (XGboost). Second, vessel trajectory time series forecasting was tackled through the use of long-short-term memory (LSTM) networks. Finally, due to the strong dependence of AI model performance on proper hyperparameter selection, a boosted version of the well-known particle swarm optimization (PSO) algorithm was introduced specifically for tuning the hyperparameters of the models used in this study. The introduced methodology was applied to real-world automatic identification system (AIS) data for both marine vessel classification and trajectory forecasting. The performance of the introduced Boosted PSO (BPSO) was compared to contemporary optimizers and showed promising outcomes. The XGBoost model tuned using boosted PSO attained an overall accuracy of 99.72% for the vessel classification problem, while the LSTM model attained a mean square error (MSE) of 0.000098 for the marine trajectory prediction challenge. A rigid statistical analysis of the classification model was performed to validate outcomes, and explainable AI principles were applied to the determined best-performing models, to gain a better understanding of the feature impacts on model decisions. Full article

Polycyclic aromatic hydrocarbons (PAHs) refer to a group of several hundred compounds, among which 16 are identified as priority pollutants, due to their adverse health effects, frequency of occurrence, and potential for human exposure. This study is focused on benzo(a)pyrene, being considered an indicator of exposure to a PAH carcinogenic mixture. For this purpose, we have applied the XGBoost model to a two-year database of pollutant concentrations and meteorological parameters, with the aim to identify the factors which were mostly associated with the observed benzo(a)pyrene concentrations and to describe types of environments that supported the interactions between benzo(a)pyrene and other polluting species. The pollutant data were collected at the energy industry center in Serbia, in the vicinity of coal mining areas and power stations, where the observed benzo(a)pyrene maximum concentration for a study period reached 43.7 $\mathrm{ng}{\mathrm{m}}^{-3}$. The metaheuristics algorithm has been used to optimize the XGBoost hyperparameters, and the results have been compared to the results of XGBoost models tuned by eight other cutting-edge metaheuristics algorithms. The best-produced model was later on interpreted by applying Shapley Additive exPlanations (SHAP). As indicated by mean absolute SHAP values, the temperature at the surface, arsenic, PM${}_{10}$, and total nitrogen oxide (NOx) concentrations appear to be the major factors affecting benzo(a)pyrene concentrations and its environmental fate. Full article

As solar energy generation has become more and more important for the economies of numerous countries in the last couple of decades, it is highly important to build accurate models for forecasting the amount of green energy that will be produced. Numerous recurrent deep learning approaches, mainly based on long short-term memory (LSTM), are proposed for dealing with such problems, but the most accurate models may differ from one test case to another with respect to architecture and hyperparameters. In the current study, the use of an LSTM and a bidirectional LSTM (BiLSTM) is proposed for dealing with a data collection that, besides the time series values denoting the solar energy generation, also comprises corresponding information about the weather. The proposed research additionally endows the models with hyperparameter tuning by means of an enhanced version of a recently proposed metaheuristic, the reptile search algorithm (RSA). The output of the proposed tuned recurrent neural network models is compared to the ones of several other state-of-the-art metaheuristic optimization approaches that are applied for the same task, using the same experimental setup, and the obtained results indicate the proposed approach as the better alternative. Moreover, the best recurrent model achieved the best results with $R^2$ of 0.604, and a normalized MSE value of 0.014, which yields an improvement of around 13% over traditional machine learning models. Full article

An effective energy oversight represents a major concern throughout the world, and the problem has become even more stringent recently. The prediction of energy load and consumption depends on various factors such as temperature, plugged load, etc. The machine learning and deep learning (DL) approaches developed in the last decade provide a very high level of accuracy for various types of applications, including time-series forecasting. Accordingly, the number of prediction models for this task is continuously growing. The current study does not only overview the most recent and relevant DL for energy supply and demand, but it also emphasizes the fact that not many recent methods use parameter tuning for enhancing the results. To fill the abovementioned gap, in the research conducted for the purpose of this manuscript, a canonical and straightforward long short-term memory (LSTM) DL model for electricity load is developed and tuned for multivariate time-series forecasting. One open dataset from Europe is used as a benchmark, and the performance of LSTM models for a one-step-ahead prediction is evaluated. Reported results can be used as a benchmark for hybrid LSTM-optimization approaches for multivariate energy time-series forecasting in power systems. The current work highlights that parameter tuning leads to better results when using metaheuristics for this purpose in all cases: while grid search achieves a coefficient of determination ($R^2$) of 0.9136, the metaheuristic that led to the worst result is still notably better with the corresponding score of 0.9515. Full article

Background and Objectives: The saphenous vein is one of the most common used grafts (SVG) for surgical revascularization. The mechanism of the SVGs occlusion is still unknown. Surgical preparation techniques have an important role in the early and late graft occlusion. Our study analyzed the influence of the three different surgical techniques on the histological and immunohistochemical characteristics of the vein grafts. Methods: Between June 2019 and December 2020, 83 patients who underwent surgical revascularization were prospectively randomly assigned to one of the three groups, according to saphenous vein graft harvesting (conventional (CVH), no-touch (NT) and endoscopic (EVH)) technique. The vein graft samples were sent on the histological (hematoxylin-eosin staining) and immunohistochemical (CD31, Factor VIII, Caveolin and eNOS) examinations. Results: The CVH, NT, and EVH groups included 27 patients (mean age 67.66 ± 5.6), 31 patients (mean age 66.5 ± 7.4) and 25 patients (mean age 66 ± 5.5), respectively. Hematoxylin-eosin staining revealed a lower grade of microstructural vein damage in the NT group (2, IQR 1-2) in comparison with CVH and EVH (3, IQR 2-4), (4, IQR 2-4) respectively (p < 0.001). Immunohistochemical examination revealed a high grade of staining in the NT group compared to the CVH and EVH group (CD 31 antibody p = 0.02, FVIII, p < 0.001, Caveolin, p = 0.001, and eNOS, p = 0.003). Conclusion: The best preservation of the structural vein integrity was in the NT group, while the lowest rate of leg wound complication was in the EVH group. These facts increase the interest in developing and implementing the endoscopic no-touch technique. Full article

In this paper, we explore the computational capabilities of advanced modeling tools to reveal the factors that shape the observed benzene levels and behavior under different environmental conditions. The research was based on two-year hourly data concentrations of inorganic gaseous pollutants, particulate matter, benzene, toluene, m, p-xylenes, total nonmethane hydrocarbons, and meteorological parameters obtained from the Global Data Assimilation System. In order to determine the model that will be capable of achieving a superior level of performance, eight metaheuristics algorithms were tested for eXtreme Gradient Boosting optimization, while the relative SHapley Additive exPlanations values were used to estimate the relative importance of each pollutant level and meteorological parameter for the prediction of benzene concentrations. According to the results, benzene levels are mostly shaped by toluene and the finest aerosol fraction concentrations, in the environment governed by temperature, volumetric soil moisture content, and momentum flux direction, as well as by levels of total nonmethane hydrocarbons and total nitrogen oxide. The types of conditions which provided the environment for the impact of toluene, the finest aerosol, and temperature on benzene dynamics are distinguished and described. Full article

Developing countries have had numerous obstacles in diagnosing the COVID-19 worldwide pandemic since its emergence. One of the most important ways to control the spread of this disease begins with early detection, which allows that isolation and treatment could perhaps be started. According to recent results, chest X-ray scans provide important information about the onset of the infection, and this information may be evaluated so that diagnosis and treatment can begin sooner. This is where artificial intelligence collides with skilled clinicians’ diagnostic abilities. The suggested study’s goal is to make a contribution to battling the worldwide epidemic by using a simple convolutional neural network (CNN) model to construct an automated image analysis framework for recognizing COVID-19 afflicted chest X-ray data. To improve classification accuracy, fully connected layers of simple CNN were replaced by the efficient extreme gradient boosting (XGBoost) classifier, which is used to categorize extracted features by the convolutional layers. Additionally, a hybrid version of the arithmetic optimization algorithm (AOA), which is also developed to facilitate proposed research, is used to tune XGBoost hyperparameters for COVID-19 chest X-ray images. Reported experimental data showed that this approach outperforms other state-of-the-art methods, including other cutting-edge metaheuristics algorithms, that were tested in the same framework. For validation purposes, a balanced X-ray images dataset with 12,000 observations, belonging to normal, COVID-19 and viral pneumonia classes, was used. The proposed method, where XGBoost was tuned by introduced hybrid AOA, showed superior performance, achieving a classification accuracy of approximately 99.39% and weighted average precision, recall and F1-score of 0.993889, 0.993887 and 0.993887, respectively. Full article