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Search Results (21)

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Authors = Ahmed Fouly ORCID = 0000-0002-0358-0392

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13 pages, 3921 KiB  
Article
Design and Fabrication of Nanofiber-Coated Antenna with Electrospun Polyacrylonitrile (PAN) for Tissue Cancer Ablation
by Mohamed S. Abdo, Ashraf Maher, Ahmed Fouly, Saud M. Almotairy, Muhammad A. Shar and Hany S. Abdo
Coatings 2023, 13(10), 1767; https://doi.org/10.3390/coatings13101767 - 13 Oct 2023
Cited by 1 | Viewed by 1776
Abstract
Hepatocellular carcinoma (HC) is a common liver cancer often associated with chronic liver diseases such as hepatitis B and C-induced cirrhosis. Multiple treatments are available, including microwave ablation (MWA), which has proven effective. This is attributed to its proved ability to eliminate liver [...] Read more.
Hepatocellular carcinoma (HC) is a common liver cancer often associated with chronic liver diseases such as hepatitis B and C-induced cirrhosis. Multiple treatments are available, including microwave ablation (MWA), which has proven effective. This is attributed to its proved ability to eliminate liver tumors with a successful rate of more than 85%. However, in order to maintain healthy tissues and establish good ablation practicability, the temperature involved should be controlled. This can be achieved by monitoring different parameters including thermal conductivity, heat capacity, and blood perfusion. For this purpose, an antenna probe is usually employed to localize heat distributions and identify heating efficiency. Many types and shapes of antenna probes for MWA have been reported in different studies. Thus, in the current study, a numerical model is established to investigate the performance of the antenna based on its shape. A finite element model (FEM) was developed to examine the specific absorption rate (SAR), distribution of temperature, and coefficient of reflection. Closed and conventional single-slot antennas were targeted via this model. The antenna was then designed to have a reflection coefficient lower than 10 dB and heating of a spherical shape profile. The findings of the study can aid in determining the optimal parameters required for the highest effectiveness of MWA in the treatment of HC at early stages with the lowest amount of invasiveness and collateral harm. Full article
(This article belongs to the Special Issue Nanostructures for Biomedical Applications)
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15 pages, 3540 KiB  
Article
Investigation of the Mechanical and Tribological Behavior of Epoxy-Based Hybrid Composite
by Thamer Albahkali, Ahmed Fouly, Ibrahim A. Alnaser, Mahmoud B. Elsheniti, Ahmed Rezk and Hany S. Abdo
Polymers 2023, 15(19), 3880; https://doi.org/10.3390/polym15193880 - 25 Sep 2023
Cited by 11 | Viewed by 2393
Abstract
The main target of this study is to evaluate the impact of hybrid reinforcement using Al2O3 nanoparticles and graphite on the epoxy nanocomposites’ mechanical and tribological properties. Various weight fractions of the reinforcement materials, ranging from 0 to 0.5 wt.%, [...] Read more.
The main target of this study is to evaluate the impact of hybrid reinforcement using Al2O3 nanoparticles and graphite on the epoxy nanocomposites’ mechanical and tribological properties. Various weight fractions of the reinforcement materials, ranging from 0 to 0.5 wt.%, were incorporated into the epoxy. The aim is to enhance the characteristics and durability of the polymers for potential utilization in different mechanical applications. The addition of hybrid additives consisting of Al2O3 nanoparticles and graphite to the epoxy resin had a noticeable effect on the performance of the epoxy nanocomposites. The incorporation of these additives resulted in increased elasticity, strength, toughness, ductility, and hardness as the concentration of reinforcement increased. The enhancement in the stiffness, mechanical strength, toughness and ductility reached 33.9%, 25.97%, 25.3% and 16.7%, respectively. Furthermore, the frictional tests demonstrated a notable decrease in both the coefficient of friction and wear with the rise of the additives’ weight fraction. This improvement in the structural integrity of the epoxy nanocomposites led to enhanced mechanical properties and wear resistance. The SEM was utilized to assess the surfaces of tested samples and provide insights into the wear mechanism. Full article
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18 pages, 5716 KiB  
Article
Enhancing the Tribo-Mechanical Performance of LDPE Nanocomposites Utilizing Low Loading Fraction Al2O3/SiC Hybrid Nanostructured Oxide Fillers
by Ibrahim A. Alnaser, Ahmed Fouly, Muhammad Omer Aijaz, Jabair A. Mohammed, Mahmoud B. Elsheniti, Sameh A. Ragab and Hany S. Abdo
Inorganics 2023, 11(9), 354; https://doi.org/10.3390/inorganics11090354 - 29 Aug 2023
Cited by 6 | Viewed by 2054
Abstract
This research work highlights the tribomechanical investigations of using a low loading fraction of two ceramics combinations, Alumina (Al2O3) and Silicon Carbide (SiC) as reinforcement for Low-density Polyethylene (LDPE) matrix. The hybrid additives with different weight percentages (0.1 + [...] Read more.
This research work highlights the tribomechanical investigations of using a low loading fraction of two ceramics combinations, Alumina (Al2O3) and Silicon Carbide (SiC) as reinforcement for Low-density Polyethylene (LDPE) matrix. The hybrid additives with different weight percentages (0.1 + 0.1, 0.25 + 0.25 and 0.5 + 0.5 wt%) were mixed with LDPE matrix and the degree of homogeneity was controlled using double-screw extruder prior to fabricating the composite samples via the injection molding machine. The nanoparticles fillers were characterized by field emission scanning electron microscope (FESEM), EDX and particle size analyzer to check its morphology, composition and size distribution. Thermogravimetric analyzer (TGA) and melting flow index (MFI) were performed for the fabricated nanocomposites samples. The mechanical properties of the nanocomposite were evaluated by performing tensile test, bending test and Shore-D hardness test, while the tribological performance was investigated using a ball on desk apparatus under different applied loads and sliding times. Moreover, in order to confirm the load-carrying capability of the composite, contact stresses was measured via finite element model using ANSYS software. The results show that the incorporation of low fraction hybrid ceramic nanoparticles can contributed positively in the tribological and mechanical properties. Based on the experimental results, the maximum improvement in the tensile strength was 5.38%, and 8.15% for hardness LDPE with 0.5 Al2O3 and 0.5 SiC, while the lowest coefficient of friction was noticed under normal load of 10 N, which was approximately 12.5% for the same composition. The novel approach of incorporating low fraction hybrid ceramic nanoparticles as reinforcement for LDPE matrix is investigated, highlighting their positive contributions to the tribological and mechanical properties of the resulting nanocomposites. Full article
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17 pages, 5937 KiB  
Article
Investigating the Mechanical Properties of Annealed 3D-Printed PLA–Date Pits Composite
by Ahmed Fouly, Thamer Albahkali, Hany S. Abdo and Omar Salah
Polymers 2023, 15(16), 3395; https://doi.org/10.3390/polym15163395 - 13 Aug 2023
Cited by 12 | Viewed by 2884
Abstract
Biomedical applications are crucial in rehabilitation medicine, assisting individuals with disabilities. Nevertheless, materials failure can sometimes result in inconvenience for users. Polylactic Acid (PLA) is a popular 3D-printed material that offers design flexibility. However, it is limited in use because its mechanical properties [...] Read more.
Biomedical applications are crucial in rehabilitation medicine, assisting individuals with disabilities. Nevertheless, materials failure can sometimes result in inconvenience for users. Polylactic Acid (PLA) is a popular 3D-printed material that offers design flexibility. However, it is limited in use because its mechanical properties are inadequate. Thus, this study introduces an artificial intelligence model that utilizes ANFIS to estimate the mechanical properties of PLA composites. The model was developed based on an actual data set collected from experiments. The experimental results were obtained by preparing samples of PLA green composites with different weight fractions of date pits, which were then annealed for varying durations to remove residual stresses resulting from 3D printing. The mechanical characteristics of the produced PLA composite specimens were measured experimentally, while the ANSYS model was established to identify the composites’ load-carrying capacity. The results showed that ANFIS models are exceptionally robust and compatible and possess good predictive capabilities for estimating the hardness, strength, and Young’s modulus of the 3D-printed PLA composites. The model results and experimental outcomes were nearly identical. Full article
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16 pages, 8718 KiB  
Article
Adaptive Neuro-Fuzzy-Based Models for Predicting the Tribological Properties of 3D-Printed PLA Green Composites Used for Biomedical Applications
by Thamer Albahkali, Hany S. Abdo, Omar Salah and Ahmed Fouly
Polymers 2023, 15(14), 3053; https://doi.org/10.3390/polym15143053 - 15 Jul 2023
Cited by 7 | Viewed by 1833
Abstract
Tribological performance is a critical aspect of materials used in biomedical applications, as it can directly impact the comfort and functionality of devices for individuals with disabilities. Polylactic Acid (PLA) is a widely used 3D-printed material in this field, but its mechanical and [...] Read more.
Tribological performance is a critical aspect of materials used in biomedical applications, as it can directly impact the comfort and functionality of devices for individuals with disabilities. Polylactic Acid (PLA) is a widely used 3D-printed material in this field, but its mechanical and tribological properties can be limiting. This study focuses on the development of an artificial intelligence model using ANFIS to predict the wear volume of PLA composites under various conditions. The model was built on data gathered from tribological experiments involving PLA green composites with different weight fractions of date particles. These samples were annealed for different durations to eliminate residual stresses from 3D printing and then subjected to tribological tests under varying normal loads and sliding distances. Mechanical properties and finite element models were also analyzed to better understand the tribological results and evaluate the load-carrying capacity of the PLA composites. The ANFIS model demonstrated excellent compatibility and robustness in predicting wear volume, with an average percentage error of less than 0.01% compared to experimental results. This study highlights the potential of heat-treated PLA green composites for improved tribological performance in biomedical applications. Full article
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15 pages, 4982 KiB  
Article
Unveiling the Potential of Rice Straw Nanofiber-Reinforced HDPE for Biomedical Applications: Investigating Mechanical and Tribological Characteristics
by Mohamed Taha, Ahmed Fouly, Hany S. Abdo, Ibrahim A. Alnaser, Ragab Abouzeid and Ahmed Nabhan
J. Funct. Biomater. 2023, 14(7), 366; https://doi.org/10.3390/jfb14070366 - 12 Jul 2023
Cited by 13 | Viewed by 1989
Abstract
The efficient utilization of rice waste has the potential to significantly contribute to environmental sustainability by minimizing the waste impact on the environment. Through repurposing such waste, novel materials can be developed for various biomedical applications. This approach not only mitigates waste, but [...] Read more.
The efficient utilization of rice waste has the potential to significantly contribute to environmental sustainability by minimizing the waste impact on the environment. Through repurposing such waste, novel materials can be developed for various biomedical applications. This approach not only mitigates waste, but it also promotes the adoption of sustainable materials within the industry. In this research, rice-straw-derived nanofibers (RSNFs) were utilized as a reinforcement material for high-density polyethylene (HDPE). The rice-straw-derived nanofibers were incorporated at different concentrations (1, 2, 3, and 4 wt.%) into the HDPE. The composites were fabricated using twin-screw extrusion (to ensure homogenous distribution) and the injection-molding process (to crease the test samples). Then, the mechanical strengths and frictional performances of the bio-composites were assessed. Different characterization techniques were utilized to investigate the morphology of the RSNFs. Thermal analyses (TGA/DTG/DSC), the contact angle, and XRD were utilized to study the performances of the HDPE/RSNF composites. The study findings demonstrated that the addition of RSNFs as a reinforcement to the HDPE improved the hydrophilicity, strength, hardness, and wear resistance of the proposed bio-composites. Full article
(This article belongs to the Special Issue Nanoparticles: Fabrication, Properties and Biomedical Application)
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17 pages, 12474 KiB  
Article
Developing PMMA/Coffee Husk Green Composites to Meet the Individual Requirements of People with Disabilities: Hip Spacer Case Study
by Ahmed Fouly, Ibrahim A. Alnaser, Abdulaziz K. Assaifan and Hany S. Abdo
J. Funct. Biomater. 2023, 14(4), 200; https://doi.org/10.3390/jfb14040200 - 5 Apr 2023
Cited by 7 | Viewed by 2253
Abstract
When replacing a damaged artificial hip joint, treatment involves using antibiotic-laced bone cement as a spacer. One of the most popular materials used for spacers is PMMA; however, it has limitations in terms of mechanical and tribological properties. To overcome such limitations, the [...] Read more.
When replacing a damaged artificial hip joint, treatment involves using antibiotic-laced bone cement as a spacer. One of the most popular materials used for spacers is PMMA; however, it has limitations in terms of mechanical and tribological properties. To overcome such limitations, the current paper proposes utilizing a natural filler, coffee husk, as a reinforcement for PMMA. The coffee husk filler was first prepared using the ball-milling technique. PMMA composites with varying weight fractions of coffee husk (0, 2, 4, 6, and 8 wt.%) were prepared. The hardness was measured to estimate the mechanical properties of the produced composites, and the compression test was utilized to estimate the Young modulus and compressive yield strength. Furthermore, the tribological properties of the composites were evaluated by measuring the friction coefficient and wear by rubbing the composite samples against stainless steel and cow bone counterparts under different normal loads. The wear mechanisms were identified via scanning electron microscopy. Finally, a finite element model for the hip joint was built to investigate the load-carrying capacity of the composites under human loading conditions. The results show that incorporating coffee husk particles can enhance both the mechanical and tribological properties of the PMMA composites. The finite element results are consistent with the experimental findings, indicating the potential of the coffee husk as a promising filler material for enhancing the performance of PMMA-based biomaterials. Full article
(This article belongs to the Special Issue Advances in Biomaterials and Biopolymers)
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15 pages, 4899 KiB  
Article
Effect of Synthesized Titanium Dioxide Nanofibers Weight Fraction on the Tribological Characteristics of Magnesium Nanocomposites Used in Biomedical Applications
by Ibrahim A. Alnaser, Hany S. Abdo, Mohamed S. Abdo, Mohamed Alkalla and Ahmed Fouly
Nanomaterials 2023, 13(2), 294; https://doi.org/10.3390/nano13020294 - 10 Jan 2023
Cited by 5 | Viewed by 2183
Abstract
Biomedical applications, such as artificial implants, are very significant for the disabled due to their usage in orthopedics. Nevertheless, available materials in such applications have insufficient mechanical and tribological properties. The current study investigated the mechanical and tribological properties of a biomedical metallic [...] Read more.
Biomedical applications, such as artificial implants, are very significant for the disabled due to their usage in orthopedics. Nevertheless, available materials in such applications have insufficient mechanical and tribological properties. The current study investigated the mechanical and tribological properties of a biomedical metallic material, magnesium (Mg), after incorporating titanium dioxide nanofibers (TiO2) with different loading fractions. The TiO2 nanofibers were synthesized using the electrospinning technique. The ball-milling technique was utilized to ensure the homogenous distribution of TiO2 nanofibers inside the Mg matrix. Then, samples of the mixed powder with different loading fractions of TiO2 nanofibers, 0, 1, 3, 5, and 10 wt.%, were fabricated using a high-frequency induction heat sintering technique. The physicomechanical and tribological properties of the produced Mg/TiO2 nanocomposites were evaluated experimentally. Results showed an enhancement in mechanical properties and wear resistance accompanied by an increase in the weight fraction of TiO2 nanofibers up to 5%. A finite element model was built to assess the load-carrying capacity of the Mg/TiO2 composite to estimate different contact stresses during the frictional process. The finite element results showed an agreement with the experimental results. Full article
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39 pages, 2953 KiB  
Article
Energy and Environment-Aware Path Planning in Wireless Sensor Networks with Mobile Sink
by Fatma H. El-Fouly, Ahmed B. Altamimi and Rabie A. Ramadan
Sensors 2022, 22(24), 9789; https://doi.org/10.3390/s22249789 - 13 Dec 2022
Cited by 11 | Viewed by 2511
Abstract
With the advances in sensing technologies, sensor networks became the core of several different networks, including the Internet of Things (IoT) and drone networks. This led to the use of sensor networks in many critical applications including military, health care, and commercial applications. [...] Read more.
With the advances in sensing technologies, sensor networks became the core of several different networks, including the Internet of Things (IoT) and drone networks. This led to the use of sensor networks in many critical applications including military, health care, and commercial applications. In addition, sensors might be mobile or stationary. Stationary sensors, once deployed, will not move; however, mobile nodes can move from one place to another. In most current applications, mobile sensors are used to collect data from stationary sensors. This raises many energy consumption challenges, including sensor networks’ energy consumption, urgent messages transfer for real-time analysis, and path planning. Moreover, sensors in sensor networks are usually exposed to environmental parameters and left unattended. These issues, up to our knowledge, are not deeply covered in the current research. This paper develops a complete framework to solve these challenges. It introduces novel path planning techniques considering areas’ priority, environmental parameters, and urgent messages. Consequently, a novel energy-efficient and reliable clustering algorithm is proposed considering the residual energy of the sensor nodes, the quality of wireless links, and the distance parameter representing the average intra-cluster distance. Moreover, it proposes a real-time, energy-efficient, reliable and environment-aware routing, taking into account the environmental data, link quality, delay, hop count, nodes’ residual energy, and load balancing. Furthermore, for the benefit of the sensor networks research community, all proposed algorithms are formed in integer linear programming (ILP) for optimal solutions. All proposed techniques are evaluated and compared to six recent algorithms. The results showed that the proposed framework outperforms the recent algorithms. Full article
(This article belongs to the Special Issue The Sensor Location-Allocation Problem for Environmental Sensing)
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19 pages, 9846 KiB  
Article
Evaluating the Mechanical and Tribological Properties of 3D Printed Polylactic-Acid (PLA) Green-Composite for Artificial Implant: Hip Joint Case Study
by Ahmed Fouly, Abdulaziz K. Assaifan, Ibrahim A. Alnaser, Omar A. Hussein and Hany S. Abdo
Polymers 2022, 14(23), 5299; https://doi.org/10.3390/polym14235299 - 4 Dec 2022
Cited by 32 | Viewed by 4456
Abstract
Artificial implants are very essential for the disabled as they are utilized for bone and joint function in orthopedics. However, materials used in such implants suffer from restricted mechanical and tribological properties besides the difficulty of using such materials with complex structures. The [...] Read more.
Artificial implants are very essential for the disabled as they are utilized for bone and joint function in orthopedics. However, materials used in such implants suffer from restricted mechanical and tribological properties besides the difficulty of using such materials with complex structures. The current study works on developing a new polymer green composite that can be used for artificial implants and allow design flexibility through its usage with 3D printing technology. Therefore, a natural filler extracted from corn cob (CC) was prepared, mixed homogeneously with the Polylactic-acid (PLA), and passed through a complete process to produce a green composite filament suit 3D printer. The corn cob particles were incorporated with PLA with different weight fractions zero, 5%, 10%, 15%, and 20%. The physical, mechanical, and tribological properties of the PLA-CC composites were evaluated. 3D finite element models were constructed to evaluate the PLA-CC composites performance on a real condition implant, hip joints, and through the frictional process. Incorporating corn cob inside PLA revealed an enhancement in the hardness (10%), stiffness (6%), compression ultimate strength (12%), and wear resistance (150%) of the proposed PLA-CC composite. The finite element results of both models proved an enhancement in the load-carrying capacity of the composite. The finite element results came in line with the experimental results. Full article
(This article belongs to the Special Issue Advanced Polymer Composites for Medical Applications)
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17 pages, 2779 KiB  
Article
ERCP: Energy-Efficient and Reliable-Aware Clustering Protocol for Wireless Sensor Networks
by Fatma H. El-Fouly, Ahmed Y. Khedr, Md. Haidar Sharif, Eissa Jaber Alreshidi, Kusum Yadav, Huseyin Kusetogullari and Rabie A. Ramadan
Sensors 2022, 22(22), 8950; https://doi.org/10.3390/s22228950 - 18 Nov 2022
Cited by 9 | Viewed by 2342
Abstract
Wireless Sensor Networks (WSNs) have been around for over a decade and have been used in many important applications. Energy and reliability are two of the major problems with these kinds of applications. Reliable data delivery is an important issue in WSNs because [...] Read more.
Wireless Sensor Networks (WSNs) have been around for over a decade and have been used in many important applications. Energy and reliability are two of the major problems with these kinds of applications. Reliable data delivery is an important issue in WSNs because it is a key part of how well data are sent. At the same time, energy consumption in battery-based sensors is another challenge. Therefore, efficient clustering and routing are techniques that can be used to save sensors energy and guarantee reliable message delivery. With this in mind, this paper develops an energy-efficient and reliable clustering protocol (ERCP) for WSNs. First, an efficient clustering technique is proposed for sensor nodes’ energy savings considering different clustering parameters, including the link quality metric, the energy, the distance to neighbors, the distance to the sink node, and the cluster load metric. The proposed routing protocol works based on the concept of a reliable inter-cluster routing technique that saves energy. The routing decisions are made based on different parameters, such as the energy balance metric, the distance to the sink node, and the wireless link quality. Many experiments and analyses are examined to determine how well the ERCP performs. The experiment results showed that the ECRP protocol performs much better than some of the recent algorithms in both homogeneous and heterogeneous networks. Full article
(This article belongs to the Special Issue Learning Technology Based on Navigation Sensors)
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20 pages, 6795 KiB  
Article
Evaluating the Performance of 3D-Printed PLA Reinforced with Date Pit Particles for Its Suitability as an Acetabular Liner in Artificial Hip Joints
by Ahmed Fouly, Ibrahim A. Alnaser, Abdulaziz K. Assaifan and Hany S. Abdo
Polymers 2022, 14(16), 3321; https://doi.org/10.3390/polym14163321 - 15 Aug 2022
Cited by 23 | Viewed by 3080
Abstract
Off-the-shelf hip joints are considered essential parts in rehabilitation medicine that can help the disabled. However, the failure of the materials used in such joints can cause individual discomfort. In support of the various motor conditions of the influenced individuals, the aim of [...] Read more.
Off-the-shelf hip joints are considered essential parts in rehabilitation medicine that can help the disabled. However, the failure of the materials used in such joints can cause individual discomfort. In support of the various motor conditions of the influenced individuals, the aim of the current research is to develop a new composite that can be used as an acetabular liner inside the hip joint. Polylactic acid (PLA) can provide the advantage of design flexibility owing to its well-known applicability as a 3D printed material. However, using PLA as an acetabular liner is subject to limitations concerning mechanical properties. We developed a complete production process of a natural filler, i.e., date pits. Then, the PLA and date pit particles were extruded for homogenous mixing, producing a composite filament that can be used in 3D printing. Date pit particles with loading fractions of 0, 2, 4, 6, 8, and 10 wt.% are dispersed in the PLA. The thermal, physical, and mechanical properties of the PLA–date pit composites were estimated experimentally. The incorporation of date pit particles into PLA enhanced the compressive strength and stiffness but resulted in a reduction in the elongation and toughness. A finite element model (FEM) for hip joints was constructed, and the contact stresses on the surface of the acetabular liner were evaluated. The FEM results showed an enhancement in the composite load carrying capacity, in agreement with the experimental results. Full article
(This article belongs to the Special Issue Structure and Properties of Polymer Composites)
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13 pages, 7024 KiB  
Article
Investigation of the Mechanical Behavior of Synthesized Al6061/TiO2 Microcomposites Using an Innovative Stir Casting Method
by A. H. Badran, Turki Alamro, Rabeea W. Bazuhair, Ahmed Ali Gad El-Mawla, S. Z. El-Adben and Ahmed Fouly
Nanomaterials 2022, 12(10), 1646; https://doi.org/10.3390/nano12101646 - 12 May 2022
Cited by 21 | Viewed by 3056
Abstract
Aluminum composites are preferred in many kinds of applications such as aviation, space, automotive, and marine, owing to their outstanding properties, high strength, and corrosion resistance. The main objective of the current study is to evaluate the mechanical properties of aluminum alloy 6061/titanium [...] Read more.
Aluminum composites are preferred in many kinds of applications such as aviation, space, automotive, and marine, owing to their outstanding properties, high strength, and corrosion resistance. The main objective of the current study is to evaluate the mechanical properties of aluminum alloy 6061/titanium dioxide (micro-TiO2) microcomposite synthesized using the stir casting method. The effects of changes in stir casting parameters, such as stirring speed and tiring durations, were studied. Al6061 matrix was reinforced with micro-TiO2 particles with weight fractions of 1, 2, 3, 4, and 5 wt.%. Microstructural and chemical analyses were conducted to explore microstructural transformation resulting from the presence of the TiO2 microparticles. The mechanical characteristics were evaluated, and the results showed a considerable enhancement in the mechanical strength and hardness resulting from the incorporation of micro-TiO2 into Al606. The additions of 2 wt.% and 5 wt.% of micro-TiO2 recorded the highest ultimate tensile strength and hardness, respectively. Full article
(This article belongs to the Special Issue Metal-Matrix Nanocomposites and Their Applications)
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19 pages, 5515 KiB  
Article
Nanoparticles Loaded Thermoresponsive In Situ Gel for Ocular Antibiotic Delivery against Bacterial Keratitis
by Muhammad Naseer Abbas, Saeed Ahmad Khan, Sajid Khan Sadozai, Islam A. Khalil, Asem Anter, Marwa El Fouly, Ahmed H. Osman and Mohsin Kazi
Polymers 2022, 14(6), 1135; https://doi.org/10.3390/polym14061135 - 11 Mar 2022
Cited by 38 | Viewed by 4698
Abstract
Antibiotics delivered through conventional dosage against ophthalmic infections show lower therapeutic efficacy due to their low residence time. Therefore, there is a great need to design and develop novel dosage forms that would increase the ocular residence time of antibiotics at the site [...] Read more.
Antibiotics delivered through conventional dosage against ophthalmic infections show lower therapeutic efficacy due to their low residence time. Therefore, there is a great need to design and develop novel dosage forms that would increase the ocular residence time of antibiotics at the site of infection. This study describes the development of nanoparticles laden in situ gelling solution, intended to sustain antibiotic release for improved therapeutic efficiency. Oxytetracycline-loaded gelatin-polyacrylic acid nanoparticles were prepared and incorporated in poloxamer-N407 solution. The rheological properties of the system were studied concerning time and temperature. Moreover, in vivo biocompatibility of the system was ascertained using the Draize test and histological studies. Finally, the optimized formulation was evaluated for in vitro antibacterial activity against one of the most common keratitis causing bacteria, Pseudomonas aeruginosa. Additionally, the in vivo efficacy was evaluated on the rabbit’s eye conjunctivitis model. The formulation showed a sustained effect against keratitis; furthermore, the antibacterial activity was comparable with the commercial product. Full article
(This article belongs to the Special Issue Polymer-Based Materials for Ophthalmic Applications)
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10 pages, 3056 KiB  
Article
Tribo-Behavior and Corrosion Properties of Welded 304L and 316L Stainless Steel
by Hany S. Abdo, Asiful H. Seikh, Hamad F. Alharbi, Jabair Ali Mohammed, Mahmoud S. Soliman, Ahmed Fouly and Sameh A. Ragab
Coatings 2021, 11(12), 1567; https://doi.org/10.3390/coatings11121567 - 20 Dec 2021
Cited by 7 | Viewed by 3709
Abstract
The present study investigates the electrochemical corrosion response and tribo-behavior of 304L and 316L stainless steel welded by gas metal arc welding (GMAW), which offered a high deposition rate. During this research, the metallurgically prepared welded samples were subjected to a tribological test [...] Read more.
The present study investigates the electrochemical corrosion response and tribo-behavior of 304L and 316L stainless steel welded by gas metal arc welding (GMAW), which offered a high deposition rate. During this research, the metallurgically prepared welded samples were subjected to a tribological test and a corrosion test. The wear results were favorable for 316L steel, and it showed a lower coefficient of friction than the 304L specimen. These samples also underwent characterization studies, such as X-ray diffractometry (XRD) and scanning electron microscopy (SEM), to identify the different phases obtained on the cooling of the weld pool. Finally, both specimens were compared against their mechanical properties. Owing to the above properties, the 316L sample showed lasting durability, as compared to the 304L steel. The primary compositional difference is the higher presence of molybdenum and chromium in the 316L steel, compared to the 304L stainless steel. Full article
(This article belongs to the Special Issue Environmental Corrosion of Metals and Its Prevention)
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