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Review

[URE3] and [PSI] Are Prions of Yeast and Evidence for New Fungal Prions

by
Daniel C. Masison
,
Herman K. Edskes
,
Marie-Lise Maddelein
,
Kimberly L. Taylor
and
Reed B. Wickner
*
National Institutes of Health, Bethesda, MD 20892-0830, USA
*
Author to whom correspondence should be addressed.
Curr. Issues Mol. Biol. 2000, 2(2), 51-59; https://doi.org/10.21775/cimb.002.051
Submission received: 2 November 1999 / Revised: 5 February 2000 / Accepted: 8 March 2000 / Published: 1 April 2000
Versions Notes

Abstract

[URE3] and [PSI] are two non-Mendelian genetic elements discovered over 25 years ago and never assigned to a nucleic acid replicon. Their genetic properties led us to propose that they are prions, altered self-propagating forms of Ure2p and Sup35p, respectively, that cannot properly carry out the normal functions of these proteins. Ure2p is partially protease-resistant in [URE3] strains and Sup35p is aggregated specifically in [PSI] strains supporting this idea. Overexpression of Hsp104 cures [PSI], as does the absence of this protein, suggesting that the prion change of Sup35p in [PSI] strains is aggregation. Strains of [PSI], analogous to those described for scrapie, have now been described as well as an in vitro system for [PSI] propagation. Recently, two new potential prions have been described, one in yeast and the other in the filamentous fungus, Podospora.

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MDPI and ACS Style

Masison, D.C.; Edskes, H.K.; Maddelein, M.-L.; Taylor, K.L.; Wickner, R.B. [URE3] and [PSI] Are Prions of Yeast and Evidence for New Fungal Prions. Curr. Issues Mol. Biol. 2000, 2, 51-59. https://doi.org/10.21775/cimb.002.051

AMA Style

Masison DC, Edskes HK, Maddelein M-L, Taylor KL, Wickner RB. [URE3] and [PSI] Are Prions of Yeast and Evidence for New Fungal Prions. Current Issues in Molecular Biology. 2000; 2(2):51-59. https://doi.org/10.21775/cimb.002.051

Chicago/Turabian Style

Masison, Daniel C., Herman K. Edskes, Marie-Lise Maddelein, Kimberly L. Taylor, and Reed B. Wickner. 2000. "[URE3] and [PSI] Are Prions of Yeast and Evidence for New Fungal Prions" Current Issues in Molecular Biology 2, no. 2: 51-59. https://doi.org/10.21775/cimb.002.051

APA Style

Masison, D. C., Edskes, H. K., Maddelein, M.-L., Taylor, K. L., & Wickner, R. B. (2000). [URE3] and [PSI] Are Prions of Yeast and Evidence for New Fungal Prions. Current Issues in Molecular Biology, 2(2), 51-59. https://doi.org/10.21775/cimb.002.051

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