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Current Issues in Molecular Biology is published by MDPI from Volume 43 Issue 1 (2021). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Caister Press.
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Review

The Use of Ribozyme Gene Therapy for the Inhibition of HIV Replication and Its Pathogenic Sequelae

by
Justin E. Rigden
,
Julie A. Ely
,
Janet L. Macpherson
,
Wayne L. Gerlach
,
Lun-Quan Sun
and
Geoff P. Symonds
*
Johnson and Johnson Research Labs, GPO Box 3331, Sydney, NSW 2001, Australia
*
Author to whom correspondence should be addressed.
Curr. Issues Mol. Biol. 2000, 2(2), 61-69; https://doi.org/10.21775/cimb.002.061
Submission received: 5 November 1999 / Revised: 6 February 2000 / Accepted: 9 March 2000 / Published: 1 April 2000
Versions Notes

Abstract

Human immunodeficiency virus (HIV) is a lentivirus, a separate genus of the Retroviridae which are RNA viruses that integrate as DNA copies into the genomes of host cells and replicate intracellularly through various RNA intermediates. Several of these RNA molecules can be targeted by ribozymes and a number of investigators, including our group, have demonstrated the ability of ribozymes to suppress HIV replication in cultured cells. It is argued that the use of this ribozyme gene therapy approach for the treatment of HIV infection may act as an adjunct to chemotherapeutic drugs and may affect not just viral suppression, but also immune restoration. This approach can be tested in Clinical Trials, several of which are currently under way.

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MDPI and ACS Style

Rigden, J.E.; Ely, J.A.; Macpherson, J.L.; Gerlach, W.L.; Sun, L.-Q.; Symonds, G.P. The Use of Ribozyme Gene Therapy for the Inhibition of HIV Replication and Its Pathogenic Sequelae. Curr. Issues Mol. Biol. 2000, 2, 61-69. https://doi.org/10.21775/cimb.002.061

AMA Style

Rigden JE, Ely JA, Macpherson JL, Gerlach WL, Sun L-Q, Symonds GP. The Use of Ribozyme Gene Therapy for the Inhibition of HIV Replication and Its Pathogenic Sequelae. Current Issues in Molecular Biology. 2000; 2(2):61-69. https://doi.org/10.21775/cimb.002.061

Chicago/Turabian Style

Rigden, Justin E., Julie A. Ely, Janet L. Macpherson, Wayne L. Gerlach, Lun-Quan Sun, and Geoff P. Symonds. 2000. "The Use of Ribozyme Gene Therapy for the Inhibition of HIV Replication and Its Pathogenic Sequelae" Current Issues in Molecular Biology 2, no. 2: 61-69. https://doi.org/10.21775/cimb.002.061

APA Style

Rigden, J. E., Ely, J. A., Macpherson, J. L., Gerlach, W. L., Sun, L.-Q., & Symonds, G. P. (2000). The Use of Ribozyme Gene Therapy for the Inhibition of HIV Replication and Its Pathogenic Sequelae. Current Issues in Molecular Biology, 2(2), 61-69. https://doi.org/10.21775/cimb.002.061

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