Children Webinar | Neonatal Clinical Pharmacology, 5 May 2023

Pharmacotherapy is a very powerful intervention to improve outcome, and this is also true in neonates. The prescription of a given drug should result in a safe and effective intervention to treat or prevent a specific disease or risk in an individual patient or population while avoiding disproportional side effects. Clinical pharmacology supports these aims in predicting drug-related (side) effects driven by pharmacokinetics (PK) and pharmacodynamics (PD). The dynamic changes related to maturation and growth in newborns result in a unique setting with extensive variability. Non-maturational changes (such as disease characteristics, drug–drug interactions, pharmacogenetics, and lactation-related exposure) further add to this variability.

This is a growing and active field of clinical research, with several reports on PK, PD, pharmacovigilance and -safety, and pharmaco-epidemiology having been published. This clinical field is further supported by novelties in the methods that are currently available (low-volume sample analysis, population PK analysis, physiology-based PK).

Date: 5 May 2023, at 11:00 a.m. CEST | 5:00 a.m. EST | 5:00 p.m. CST Asia
ID: 880 0570 9862

Chair and Speakers

	Chair: Prof. Dr. Karel Allegaert, 1. Department of Development and Regeneration, KU Leuven, Leuven, Belgium 2. Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium 3. Department of Clinical Pharmacy, Erasmus Medical Center, Rotterdam, The Netherlands
	Speaker: Dr. Robert B. Flint, Department of Pediatrics, Division of Neonatology Erasmus University Medical Center – Sophia Children's Hospital, Rotterdam, The Netherlands
	Speaker: Dr. Nadir Yalcin, Department of Clinical Pharmacy, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey

Program:

Speaker/Presentation	Time in CEST
Prof. Dr. Karel Allegaert Chair Introduction	11:00–11:10
Prof. Dr. Karel Allegaert Presentation: “Neonatal clinical pharmacology: limited in size, extensive in variability”	11:10–11:30
Dr. Robert B. Flint Presentation: “From therapeutic drug monitoring to model informed precision dosing”	11:30–11:50
Dr. Nadir Yalcin Presentation: “New tools to improve pharmacotherapy and safety: Artificial Intelligence approaches”	11:50–12:10
Q&A	12:10–12:25
Prof. Dr. Karel Allegaert Closing of Webinar	12:25–12:30

Relevant SI

Neonatal Clinical Pharmacology
Guest Editor: Prof. Dr. Karel Allegaert, Dr. Nadir Yalcin, Dr. Robert B. Flint and Dr. Sinno H.P. Simons
Deadline for manuscript submissions: 25 August 2023

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