Special Issue "Viruses, ERAD, and the Proteasome"
A special issue of Viruses (ISSN 1999-4915).
Deadline for manuscript submissions: closed (31 July 2016).
Interests: Pathogenesis and molecular biology of retroviruses
Interests: Pathogenesis of adenovirus infections
Multiple viruses subvert ERAD to promote their replication. In some cases, ERAD is used for viral delivery into the cytosol, whereas other viruses encode proteins that target specific cellular proteins for degradation to prevent an anti-viral immune response. Viruses also may use the ERAD machinery for trafficking of specific viral proteins without triggering proteasomal degradation.
Degradation of damaged or misfolded proteins is an essential homeostatic process that is largely driven by the activity of the ubiquitin-proteasome system (UPS). UPS activity contributes to numerous critical cellular functions, such as signal transduction, cell signaling, antigen processing, regulation of cell cycle, and apoptosis. UPS activity is required for efficient replication of many viruses, but UPS activity also drives aspects of host defense that may limit viral replication. Not surprisingly, many viruses have evolved mechanisms to exploit or subvert the UPS in ways that provide an advantage for growth/survival.
For this Special Issue of Viruses, we aim to explore the various mechanisms that viruses use to manipulate ERAD and assemble a collection of research papers and reviews that together offer a comprehensive view on this field. Topics may include studies on the UPS and viral replication, host cell interactions, virus persistence and virus-associated oncogenesis, innate and adaptive immune responses to infection and mechanisms of immunoevasion, and other related aspects of proteasome activity and viral pathogenesis. We hope that this work will expand our current understanding of the intimate relationship between Viruses, ERAD, and UPS.
Prof. Jaquelin Dudley
Dr. Jason B. Weinberg
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- proteasomal degradation
- viral entry
- innate immunity
- adaptive immunity
- protein trafficking