HPV Genomics

Dear Colleagues, 

There are 13 carcinogenic HPV types that cause more than 600,000 cancers worldwide each year at the cervix and at non-cervical sites. We do not know why there is a large variability in risk of precancer and cancer conferred by different HPV types, or why only a small proportion of carcinogenic HPV infections progress to precancer and subsequently cancer. Sequencing the genomes of HPV specimens from large population-based studies of benign HPV infections and precancer/cancer enables the interrogation of the HPV genetic basis of carcinogenicity and is providing insights into the natural history of an HPV infection. High-throughput HPV whole-genome sequencing using next-generation sequencing technology has enabled the large-scale study of HPV genome variability. Several studies have now uncovered strong associations between HPV genetic variation and cervical carcinogenicity as well as new insights into HPV diversity in the population.

We are excited to dedicate a Special Issue of Viruses to highlight advances in our understanding of HPV genomic variation and how this relates to HPV natural history and carcinogenesis.

Sincerely,

Dr. Lisa Mirabello
Dr. Meredith Yeager
Guest Editors

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