Special Issue "HIV-1 Latency: Regulation and Reversal"
Deadline for manuscript submissions: closed (20 December 2019).
Interests: HIV-1 gene expression and latency; viral RNA structure and function; virus evolution; antiviral therapy; patient-related virus studies
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Interests: HIV-1 persistence and reservoirs, HIV-1 curative approaches, novel virological assays
Human immunodeficiency virus type 1 (HIV-1) establishes a persistent infection, resulting in acquired immunodeficiency syndrome (AIDS) if left untreated. Around 37 million people in the world live with HIV-1 with a global HIV-1 prevalence of 0.8% among adults. Combination antiretroviral therapy (ART) has saved millions of lives, as it suppresses HIV-1 replication, blocks transmission, and improves immune responses, preventing the development of AIDS. However, ART has to be taken lifelong, is prone to side-effects, and is unable to eradicate the virus. On top of that, 40% of HIV-infected people in the world still do not have access to ART. Therefore, HIV-1 cure research has flourished in recent years, inspired by an apparent cure in a single individual.
By establishing latent infection, HIV-1 forms long-lived reservoirs in infected individuals that persist despite decades of suppressive ART and are considered the main obstacle to an HIV-1 cure. Depleting the reservoirs is therefore the principal goal of HIV-1 curative strategies. So far, the concept behind most such strategies has been the reversal of HIV-1 latency with specific compounds, which was expected to result in the switch to productive infection, with subsequent elimination of infected cells by immune-mediated clearance and/or viral cytopathic effects. However, this approach has so far demonstrated limited success in clinical trials, mainly attributed to insufficient understanding of HIV-1 latency, which prevents the development of efficient therapeutic strategies for eradication of the reservoirs. Therefore, we need to accumulate much more knowledge about the regulation of HIV-1 latency before we can design a meaningful therapeutic intervention.
In this Special Issue, we seek reviews and original research articles that discuss the latest developments in the establishment and regulation of HIV-1 latency, as well as efficient strategies for its reversal and elimination of latently infected cells.
Prof. Dr. Ben Berkhout
Dr. Alexander Pasternak
Dr. Angela Ciuffi
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- HIV-1 latency
- HIV-1 reservoir
- HIV-1 cure