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Viruses
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Parvoviridae
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Parvoviridae

A topical collection in Viruses (ISSN 1999-4915). This collection belongs to the section "Human Virology and Viral Diseases".

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Editor

Prof. Dr. Giorgio Gallinella

E-Mail Website
Collection Editor
Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy
Interests: parvovirus B19; virus-cell interactions; viral infections; recombinant viruses; virological diagnosis; antiviral strategies
Special Issues, Collections and Topics in MDPI journals

Topical Collection Information

Dear Colleagues,

Viruses in the Parvoviridae family constitute a most diverse group and an ever-intriguing field of research. While all share an ssDNA genome and small dimensions, they can differ widely in structure, genome organization and expression, virus–cell interactions, host range, and impacts on hosts. Within the family, some viruses are human and veterinary pathogens; other viruses have long been studied and engineered as tools for oncolytic therapy, or as sophisticated gene delivery vectors, and can now display their wide and expanding applicative potential. Exploring the biological diversity within the family, the inherent complexity in these apparently simple viruses, and expanding the translational potential, is an ongoing endeavour and commitment for the scientific community.

This Topical Collection on ‘Parvoviridae’ continues the series of collections dedicated to viruses belonging to the Parvoviridae family. The aim is to compile contributions in the field of parvovirus research, encouraging new insights and research on unresolved issues, as well as new approaches exploiting systemic methodologies. Evolution, structural biology, viral replication, virus–host interaction, pathogenesis and immunity, gene therapy, and viral oncotherapy are all topics of relevance to the community involved in parvovirus research and of interest to wider audiences, studies of which may be contributed to this collection.

Prof. Dr. Giorgio Gallinella
Collection Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the collection website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Parvoviridae
  • Parvovirus evolution
  • Parvovirus structure
  • Parvovirus genetics
  • Parvovirus–host interactions
  • Parvovirus pathogenesis and immunity
  • Parvovirus oncolytic therapy
  • Parvovirus viral vectors
  • antiviral strategies

Related Special Issues

Published Papers (2 papers)

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2025

11 pages, 6898 KiB  
Brief Report
Detection and Molecular Characterization of Novel Porcine Parvovirus 8 Strains in China
by Wei Chen, Yanqing Hu, Yan Qin, Yuying Li, Xinyu Zhang, Haixin Huang, Mengjia Liu, Yuping Zheng, Xuelian Lu, Qiaoqiong Wang, Jianuo Yang, Liting Kang, Lulu Xie, Baopeng Zhao, Tian Lan and Wenchao Sun
Viruses 2025, 17(4), 543; https://doi.org/10.3390/v17040543 - 8 Apr 2025
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Abstract
Porcine parvovirus 8 (PPV8), the most recently discovered PPV genotype, was first reported in pigs in Guangdong, China, in 2021. In this study, we assessed 69 lung tissue samples collected from animals with high fever or respiratory syndrome on pig farms in Guangxi [...] Read more.
Porcine parvovirus 8 (PPV8), the most recently discovered PPV genotype, was first reported in pigs in Guangdong, China, in 2021. In this study, we assessed 69 lung tissue samples collected from animals with high fever or respiratory syndrome on pig farms in Guangxi in 2018. Five nearly full-length genome sequences were characterized and analyzed. The percentage of PPV8-positive samples was 13.04% (9/69), and five complete PPV8 sequences were obtained, which were designated PPV8-A, PPV-B, PPV8-G, PPV8-H, and PPV8-I. The genomic sequence homology among the five PPV8 strains and other PPVs was 25.91–98.84%, with the closest genetic relationship to PPV8-GDJM2021 (98.84%), followed by PPV1 (44.64%). For the NS1 protein, phylogenetic analysis revealed that the identified PPV8-I was closely related to PPV8-GDJM2021 and that PPV8-A was closely related to PPV8-H, whereas PPV8-B and PPV8-G were more distantly related to the other PPV8 strains. For the VP1 protein, phylogenetic analysis revealed a close correlation between PPV8-H and PPV8-GMJM2021, whereas PPV8-A, PPV8-B, PPV8-G, and PPV8-I were more distantly related. In conclusion, five nearly full-length sequences were amplified, and the molecular characteristics of PPV8 were analyzed. These findings improve our understanding of the PPV8 genome. Full article
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12 pages, 2827 KiB  
Article
Compelling Increase in Parvovirus B19 Infections: Analysis of Molecular Diagnostic Trends (2019–2024)
by Flora Marzia Liotti, Simona Marchetti, Sara D’Onghia, Lucio Romano, Rosalba Ricci, Maurizio Sanguinetti, Rosaria Santangelo and Brunella Posteraro
Viruses 2025, 17(4), 523; https://doi.org/10.3390/v17040523 - 4 Apr 2025
Viewed by 345
Abstract
Human parvovirus B19 (B19V) follows a well-documented cyclical epidemiology, with peaks occurring every 3–4 years. However, recent reports indicate an unusual resurgence in B19V infections across multiple countries, prompting increased surveillance. This study analyzed molecular diagnostic assay results from 826 unique-patient samples tested [...] Read more.
Human parvovirus B19 (B19V) follows a well-documented cyclical epidemiology, with peaks occurring every 3–4 years. However, recent reports indicate an unusual resurgence in B19V infections across multiple countries, prompting increased surveillance. This study analyzed molecular diagnostic assay results from 826 unique-patient samples tested for B19V DNA between 2019 and 2024 at a large Italian tertiary-care hospital, covering pre-, during, and post-COVID-19 years. Overall, 80 of 826 patients (9.7%) tested positive for B19V DNA. A significant increase in positivity was observed in 2024 (23.4%), with a peak in May, representing an eightfold rise compared to 2019–2020. Despite this surge, the distribution of positive cases across population categories remained consistent with previous years, with 32 of 80 (40.0%) positive samples from pregnant women and 27 of 80 (33.8%) from hematology/oncology patients. Among 66 B19V DNA-positive patients with available serology, 4 of 66 (6.1%)—all immunocompromised—lacked detectable IgM/IgG despite high B19V DNA levels (7.8 log10 IU/mL). These findings highlight the importance of integrating molecular and serological diagnostics, particularly in high-risk populations. Given the potential impact of the COVID-19 pandemic on B19V circulation, continued surveillance is essential to determine whether this resurgence represents a temporary fluctuation or a sustained epidemiological shift. Full article
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