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Veterinary Sciences
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Extraintestinal Pathogenic Escherichia coli
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Extraintestinal Pathogenic Escherichia coli

A special issue of Veterinary Sciences (ISSN 2306-7381). This special issue belongs to the section "Veterinary Microbiology, Parasitology and Immunology".

Deadline for manuscript submissions: closed (30 April 2023) | Viewed by 4570

Special Issue Editors

Prof. Dr. Shaohui Wang

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Guest Editor
Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai 200241, China
Interests: Escherichia coli; Salmonella; epidemiology; detection; pathogenic mechanism; innate immunity; vaccines; bacteriophage
Prof. Dr. Jian Tu

E-Mail Website
Guest Editor
Anhui Province Key Laboratory of Veterinary Pathobiology and Disease Control, Anhui Province Engineering Laboratory for Animal Food Quality and Bio-safety, College of Animal Science and Technology, Anhui Agricultural University, Hefei, China
Interests: avian pathogenic E. coli; outer membrane vesicles; small non-coding RNAs; pathogenicity; toxicity; cell signaling pathways; protein interactions

Special Issue Information

Dear Colleagues, 

Extraintestinal pathogenic Escherichia coli (ExPEC) are important pathogens causing various extraintestinal diseases in humans and animals, which differ from intestinal pathogenic E. coli (IPEC) in terms of the anamnestic clinical diseases and virulence features. ExPEC strains are distributed widely not only in a variety of animals, such as birds, swine, and cattle, but also in patients with sepsis, leading to excessive morbidity and mortality. Increasing evidence indicates that the ExPEC strains involved in animal and human infections have a similar range of phylogenetic and pathogenic mechanisms, indicating the zoonotic potential of ExPEC infections. However, the epidemiology, pathogenic mechanism, and interaction between host and ExPEC remain poorly understood.

This Special Issue aims to provide a comprehensive overview of ExPEC infections. Research areas may include but are not limited to epidemiological characteristics, occurrence of antibiotic resistance, pathogenic mechanism, host–pathogen interaction, and control strategies of ExPEC. In this Special Issue, original research articles and reviews are welcome. All researchers working in the field are cordially invited to contribute relevant articles on this topic.

We look forward to receiving your contributions.

Prof. Dr. Shaohui Wang
Prof. Dr. Jian Tu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Veterinary Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ExPEC
  • epidemiology
  • virulence factors
  • pathogenic mechanism
  • host–pathogen interaction
  • vaccines
  • bacteriophage
  • antibiotic resistance

Published Papers (2 papers)

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Research

13 pages, 591 KiB  
Article
Antibiotic-Resistant Escherichia coli Strains Isolated from Captive Giant Pandas: A Reservoir of Antibiotic Resistance Genes and Virulence-Associated Genes
by Siping Fan, Shaoqi Jiang, Lijun Luo, Ziyao Zhou, Liqin Wang, Xiangming Huang, Haifeng Liu, Shaqiu Zhang, Yan Luo, Zhihua Ren, Xiaoping Ma, Suizhong Cao, Liuhong Shen, Ya Wang, Liping Gou, Yi Geng, Guangneng Peng, Yanqiu Zhu, Wei Li, Yalin Zhong, Xianpeng Shi, Ziqi Zhu, Keyun Shi and Zhijun Zhongadd Show full author list remove Hide full author list
Vet. Sci. 2022, 9(12), 705; https://doi.org/10.3390/vetsci9120705 - 18 Dec 2022
Cited by 4 | Viewed by 1961
Abstract
Recent studies showed that Escherichia coli (E. coli) strains isolated from captive giant pandas have serious resistance to antibiotics and carry various antibiotic resistance genes (ARGs). ARGs or virulence-associated genes (VAGs) carried by antibiotic-resistant E. coli are considered as a potential [...] Read more.
Recent studies showed that Escherichia coli (E. coli) strains isolated from captive giant pandas have serious resistance to antibiotics and carry various antibiotic resistance genes (ARGs). ARGs or virulence-associated genes (VAGs) carried by antibiotic-resistant E. coli are considered as a potential health threat to giant pandas, humans, other animals and the environment. In this study, we screened ARGs and VAGs in 84 antibiotic-resistant E. coli strains isolated from clinically healthy captive giant pandas, identified the association between ARGs and VAGs and analyzed the phylogenetic clustering of E. coli isolates. Our results showed that the most prevalent ARG in E. coli strains isolated from giant pandas is blaTEM (100.00%, 84/84), while the most prevalent VAG is fimC (91.67%, 77/84). There was a significant positive association among 30 pairs of ARGs, of which the strongest was observed for sul1/tetC (OR, 133.33). A significant positive association was demonstrated among 14 pairs of VAGs, and the strongest was observed for fyuA/iroN (OR, 294.40). A positive association was also observed among 45 pairs of ARGs and VAGs, of which the strongest was sul1/eaeA (OR, 23.06). The association of ARGs and mobile gene elements (MGEs) was further analyzed, and the strongest was found for flor and intI1 (OR, 79.86). The result of phylogenetic clustering showed that the most prevalent group was group B2 (67.86%, 57/84), followed by group A (16.67%, 14/84), group D (9.52%, 8/84) and group B1 (5.95%, 5/84). This study implied that antibiotic-resistant E. coli isolated from captive giant pandas is a reservoir of ARGs and VAGs, and significant associations exist among ARGs, VAGs and MGEs. Monitoring ARGs, VAGs and MGEs carried by E. coli from giant pandas is beneficial for controlling the development of antimicrobial resistance. Full article
(This article belongs to the Special Issue Extraintestinal Pathogenic Escherichia coli)
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13 pages, 6393 KiB  
Article
Isolation, Characterization and Whole Genome Analysis of an Avian Pathogenic Escherichia coli Phage vB_EcoS_GN06
by Leping Wang, Yizhou Tan, Yuying Liao, Lei Li, Kaiou Han, Huili Bai, Yajie Cao, Jun Li, Yu Gong, Xiaoye Wang and Hao Peng
Vet. Sci. 2022, 9(12), 675; https://doi.org/10.3390/vetsci9120675 - 05 Dec 2022
Cited by 1 | Viewed by 1591
Abstract
Escherichia coli (O78) is an avian pathogenic Escherichia coli (APEC). It can cause perihepatitis, pericarditis, septicemia and even systemic infections in the poultry industry. With the incidence of antibiotic resistance reaching a crisis point, it is important to find alternative treatments for multidrug-resistant [...] Read more.
Escherichia coli (O78) is an avian pathogenic Escherichia coli (APEC). It can cause perihepatitis, pericarditis, septicemia and even systemic infections in the poultry industry. With the incidence of antibiotic resistance reaching a crisis point, it is important to find alternative treatments for multidrug-resistant infections. The use of phages to control pathogens is a promising therapeutic option for antibiotic replacement. In this study, we isolated a lytic phage called vB_EcoS_GN06 from sewage. It lysed APEC GXEC-N22. Transmission electron microscopy showed that the phage belongs to family Siphoviridae. Phage GN06 has a 107,237 bp linear double-stranded DNA genome with 39.2% GC content and 155 coding sequences. It belongs to the genus Tequintavirus, subfamily Markadamsvirinae. The multiplicity of infection of 0.01 and the one-step growth showed that the latent time is 60 min and the burst size is 434 PFU/cell. Temperature and pH stability tests showed that phage GN06 was stable in the range of 4 °C–60 °C and pH 5–9. GN06 showed significant inhibition of APEC both within the liquid medium and in biofilm formation. These results suggest that phage GN06 has the potential to control bacterial pathogens. Thus, GN06 has the potential to be a new potential candidate for phage therapy. Full article
(This article belongs to the Special Issue Extraintestinal Pathogenic Escherichia coli)
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