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Veterinary Sciences
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Innovative Strategies for the Prevention and Control of Animal Infectious...
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Innovative Strategies for the Prevention and Control of Animal Infectious Diseases: Immunology, Vaccines, and Beyond

A special issue of Veterinary Sciences (ISSN 2306-7381). This special issue belongs to the section "Veterinary Microbiology, Parasitology and Immunology".

Deadline for manuscript submissions: 11 June 2026 | Viewed by 3818

Special Issue Editors

Dr. Adriana Soutullo

E-Mail Website
Guest Editor
Facultad de Bioquimica y Ciencias Biologicas, Universidad Nacional del Litoral, Paraje El Pozo, Santa Fe Ciudad 3000, Argentina
Interests: vaccine; EIAV; diagnosis; bovine tuberculosis
Dr. Teresa Freire

E-Mail Website
Guest Editor
Laboratorio de Inmunomodulación y Desarrollo de Vacunas, Unidad Académica de Inmunobiología, Facultad de Medicina, Universidad de la República, General Flores 2125, Montevideo 11800, Uruguay
Interests: immunology; zoonoses; parasite; vaccines
Dr. Cecilia Dogi

E-Mail Website
Guest Editor
Department of Microbiology and Immunology, Faculty of Exact, Chemical, and Natural Sciences, National University of Río Cuarto, Route 36 km. 601, Río Cuarto 5800, Argentina
Interests: veterinary immunology; intestinal health; animal production
Prof. Dr. Nora Lía Padola

E-Mail Website
Guest Editor
Laboratorio de Inmunoquímica, Facultad de Ciencias Veterinarias, Universidad del Centro de la Provincia de Buenos Aires, Buenos Aires, Argentina
Interests: STEC; cattle; vaccine antigens

Special Issue Information

Dear Colleagues,

Veterinary immunology has traditionally provided solutions for the agricultural sector. However, we believe its most significant potential lies in addressing challenges related to human and environmental health within the framework of the One Health concept.

This Special Issue aims to advance veterinary immunology through a truly transdisciplinary perspective, integrating and articulating related fields to comprehensively tackle health threats at the interface of humans, animals and the environment. We are particularly interested in zoonotic infections and infectious diseases in animals that offer valuable insights for understanding and managing similar conditions in human health.

Our goal is to provide future readers with up-to-date and practical knowledge on immune responses, such as novel vaccines, innovative diagnostic approaches, and emerging antibody-based immunotherapies. This Special Issue highlights the importance of fostering multidisciplinary collaboration in the study of infectious diseases affecting livestock and domestic and wild animals by featuring a selection of cutting-edge research.

We hope this Special Issue serves as a valuable resource for researchers, professional in both public and private sectors, for students and scholarship fellows from universities and related institutions, contributing to the advancement of this vital field.

Dr. Adriana Soutullo
Dr. Teresa Freire
Dr. Cecilia Dogi
Prof. Dr. Nora Lía Padola
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Veterinary Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diagnosis
  • vaccine
  • treatment
  • one health
  • animal health
  • integrative strategies

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Review

15 pages, 554 KB  
Review
Helminthic Infections and Vaccine Efficacy in Cattle: Implications for Disease Control and Sustainable Livestock Production
by Teresa Freire and Alejandra V. Capozzo
Vet. Sci. 2026, 13(1), 18; https://doi.org/10.3390/vetsci13010018 - 24 Dec 2025
Viewed by 361
Abstract
Vaccination remains a cornerstone of livestock disease control, yet its effectiveness under field conditions is often compromised by concurrent infections, particularly parasitic helminths. This review explores how infections shape vaccine-induced immunity in cattle, emphasizing the immunoregulatory mechanisms by which helminths interfere with protective [...] Read more.
Vaccination remains a cornerstone of livestock disease control, yet its effectiveness under field conditions is often compromised by concurrent infections, particularly parasitic helminths. This review explores how infections shape vaccine-induced immunity in cattle, emphasizing the immunoregulatory mechanisms by which helminths interfere with protective responses. Chronic infections with Fasciola hepatica and Ostertagia ostertagi induce Th2-biased and regulatory immune environments that suppress antigen presentation, cytokine production, and memory formation and maintenance, leading to reduced vaccine efficacy. Evidence from experimental and field studies is scarce and constitutes a gap in our knowledge on how vaccines work in the field. Available data indicate that infection timing, intensity, and chronicity critically determine the extent of vaccine interference. The review highlights diagnostic approaches that can support targeted deworming before vaccination and proposes integrated management strategies combining parasite control, immunization, and nutritional optimization. Such approaches can mitigate helminth-driven immune suppression, enhance herd protection, and reduce dependence on anthelmintics. However, the impact of helminth infections on vaccine efficacy in cattle should be further assessed in the field. Understanding parasite–vaccine interactions is essential to refine vaccination programs, guide the development of next-generation vaccines, and promote sustainable livestock health in parasite-endemic areas. Full article
(This article belongs to the Special Issue Innovative Strategies for the Prevention and Control of Animal Infectious Diseases: Immunology, Vaccines, and Beyond)
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42 pages, 1647 KB  
Review
Preventive Immunology for Livestock and Zoonotic Infectious Diseases in the One Health Era: From Mechanistic Insights to Innovative Interventions
by Eman Marzouk and Ahmed I. Alajaji
Vet. Sci. 2025, 12(10), 1014; https://doi.org/10.3390/vetsci12101014 - 20 Oct 2025
Viewed by 2951
Abstract
Preventive immunology is emerging as a cornerstone of animal infectious disease control within One Health, shifting emphasis from treatment to prevention. This review integrates mechanistic insights in host immunity with a comparative evaluation of next-generation interventions—mRNA/DNA and viral-vector vaccines, nanovaccines, monoclonal antibodies, cytokine [...] Read more.
Preventive immunology is emerging as a cornerstone of animal infectious disease control within One Health, shifting emphasis from treatment to prevention. This review integrates mechanistic insights in host immunity with a comparative evaluation of next-generation interventions—mRNA/DNA and viral-vector vaccines, nanovaccines, monoclonal antibodies, cytokine modulators, probiotics/postbiotics, bacteriophages, and CRISPR-based approaches—highlighting their immunogenicity, thermostability, delivery, and field readiness. Distinct from prior reviews, we appraise diagnostics as preventive tools (point-of-care assays, biosensors, MALDI-TOF MS, AI-enabled analytics) that enable early detection, risk prediction, and targeted interventions, and we map quantifiable links between successful prevention and reduced antimicrobial use. We embed translation factors—regulatory alignment, scalable manufacturing, workforce capacity, equitable access in LMICs, and public trust—alongside environmental and zoonotic interfaces that shape antimicrobial resistance dynamics. We also provide a critical analysis of limitations and failure cases: gene editing may require stacked edits and concurrent vaccination; phage programs must manage host range, resistance, stability, and regulation; and probiotic benefits remain context-specific. Finally, we present a risk–benefit–readiness framework and a time-bound research agenda to guide deployment and evaluation across animal–human–environmental systems. Coordinating scientific innovation with governance and ethics can measurably reduce disease burden, curb antimicrobial consumption, and improve health outcomes across species. Full article
(This article belongs to the Special Issue Innovative Strategies for the Prevention and Control of Animal Infectious Diseases: Immunology, Vaccines, and Beyond)
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