Acute-Phase Proteins in Animals

Dear Colleagues, 

Inflammation is one of the key biological defense responses to pathogenic microorganism infections, physical irritation, and chemical contact. Acute-phase proteins are important indicators of acute inflammation. Acute-phase proteins, such as C-reactive protein (CRP), serum amyloid A (SAA), a₁ acid glycoprotein (AAG), haptoglobin (Hp), and a₂-maccroglobilin (a2M), have been used as biomarkers of acute inflammation. The serum levels of these acute-phase proteins are known to increase in a variety of diseases or conditions, such as Bordetella bronchiseptica or Ehrlichia canis infection, surgical trauma, and gastrointestinal bleeding. Acute-phase protein fluctuations reflect the animal’s condition and are widely used in veterinary medicine. Furthermore, acute-phase proteins are also useful for assessing inflammatory changes in candidate substances in toxicity assessments. In this way, acute-phase proteins are useful markers in various situations. The purpose of this Special Issue is to clarify the usefulness of acute-phase proteins in nonclinical studies or veterinary clinical practices. Such studies can significantly improve their role as indicators of acute inflammation and may provide benefits in the treatment of more diseases. In particular, by accumulating evidence in veterinary clinical practice, it is possible to further increase the usefulness of these acute proteins.

We look forward to receiving your contributions.

Dr. Takashi Kuribayashi
Dr. Eiichi Momotani
Guest Editors

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• acute inflammation
• acute-phase protein
• CRP
• SAA
• AAG
• dogs
• felines
• cattle
• equines
• marine mammals