Gene Regulation and Immunity
A special issue of Vaccines (ISSN 2076-393X).
Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 359
Special Issue Editors
Interests: host-microbe interactions; mucosal immunity; immunometabolism; infectious disaseses; cancer; host defense peptides; metabolits
Interests: peptide; cancer; protein engineering; biomarker; infectious diseases
Special Issue Information
Dear Colleagues,
The identity and function of immune cells, such as other cells, rely heavily on the programming of transcripts during development and differentiation. Gene expression is regulated by regulatory circuits consisting of cis-acting promoters and enhancers that respond to many external and internal cues through the action of transcription factors. In this regard, transcription factors drive epigenetic changes in remodeling chromatin landscapes and direct contacts between enhancer–distal combinations. In immune cells, the regulatory circuits for effector genes are particularly complex and flexible, employing distinct sets of transcription factors and enhancers, depending on the signals each cell type receives during and after injury. Additionally, the gut microbiota that resides in the gastrointestinal tract provides essential health benefits to its host, particularly by regulating immune homeostasis. Moreover, it has recently become obvious that alterations of these gut microbial communities can cause immune dysregulation, leading to autoimmune disorders. Hence, in this Special Issue, major players in the coordination of gene regulatory programs within immune cells during hemostasis and diseases are invited.
Dr. Rasoul Mirzaei
Dr. Yaghoub Ahmadyousefi
Guest Editors
Saba Jalalifar
Guest Editor Assistant
Manuscript Submission Information
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Keywords
- epigenetic
- histone deacetylases (HDAC)
- gene regulation
- non-coding RNAs
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