Advances in Toxoplasma gondii Infection Research

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Guest Editor
Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Fort Lauderdale, FL 33314, USA
Interests: Toxoplasma gondii; host–parasite interaction; toxoplasmosis; neurodevelopment and behavior; drug discovery; treatment efficacy; diagnosis and prevention; co-infections
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Guest Editor
Laboratorio de Parasitología Molecular y Celular-Escuela Profesional de Microbiología y Parasitología, Facultad de Ciencias Biológicas, Universidad Nacional Mayor de San Marcos, Lima, Peru
Interests: parasitology; microbiology; Toxoplasma gondii; Trypanosoma cruzi; Giardia intestinalis; Blastocystis; Taenia solium; Diphyllobothrium

Special Issue Information

Dear Colleagues,

Toxoplasma gondii is an intracellular parasite capable of infecting a wide range of intermediate hosts, some of which allow T. gondii to infect its definitive feline host. Additionally, transmission between intermediate hosts is frequent. Human infection with Toxoplasma gondii is common, but severe disease does not ensue unless the host is immunosuppressed or immunocompromised, or infected congenitally. Due to the latent nature of this parasite, studies investigating host–parasite interactions during infection are important in gaining a better understanding of the biology of the parasite for the design of more effective treatment and the prevention of toxoplasmosis. The predilection of this parasite to infect the brain and heart also remains an area of active investigation. Recent systematic studies suggest an association of toxoplasmosis with neurodevelopmental and neuropsychiatric disorders. At the cellular level, chronic toxoplasmosis has been shown to alter brain connectivity by disrupting neurotransmitter signaling.

Against this research background, this Special Issue focuses on recent advances in the study of Toxoplasma gondii infections.

Dr. Imaan Benmerzouga
Dr. Juan Atilio Jimenez Chunga
Guest Editors

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Keywords

  • Toxoplasma gondii
  • host–parasite interactions
  • toxoplasmosis
  • treatment and prevention
  • pathogenic mechanism

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