Mycotoxin Contamination in Food and Feed

A special issue of Toxins (ISSN 2072-6651). This special issue belongs to the section "Mycotoxins".

Deadline for manuscript submissions: 15 March 2026 | Viewed by 571

Special Issue Editor


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Guest Editor
State Key Laboratory of Animal Nutrition, College of Animal Science and Technology, China Agricultural University, Beijing 100193, China
Interests: mycotoxin; analytical technique; feed quality and safety; risk assessment
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Special Issue Information

Dear Colleagues,

Mycotoxin contamination in animal feed reduces the feed’s nutritional value, affects animal productivity, and can cause animals’ death. Moreover, the carry-over of mycotoxin from animal feed to animal-derived food can pose potential hazards to human health. Thus, it is of great significance to develop detection technology to monitor mycotoxin contamination in animal feed and food, and to clarify the toxicological effects and mechanisms of mycotoxins in animals and humans. This Special Issue focuses on recent advances in the analytical approaches and toxicology of mycotoxins, including but not limited to the following research topics: novel immunoassays, biosensors, instrumental analytical methods for mycotoxins in animal feed and food; the level or prevalence of mycotoxins in animal feed and food; and the toxicological effects and potential mechanisms of mycotoxins on domestic and model animals. As mycotoxins generally co-contaminate animal feed, and masked mycotoxins account for a large part of mycotoxin contamination, research works about the multiplex analytical approaches, the toxicokinetics of masked mycotoxins, and the combined toxicological effect and mechanism of co-contaminated mycotoxins are especially welcomed in this Special Issue.

Prof. Dr. Yiqiang Chen
Guest Editor

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Keywords

  • mycotoxin
  • feed
  • food
  • analytical approach
  • toxicological effect
  • toxicological mechanism

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Published Papers (1 paper)

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Research

24 pages, 15660 KB  
Article
Low-Dose Deoxynivalenol Induces Subclinical Multi-Organ Toxicity in Weaned Piglets
by Ying Liu, Sunlin Luo, Xinchun Zou, Wenjun He, Ruiqi Tan, Yongpeng Jin, Gaoyi Liu, Qiaomin Duan, Wenjun Yang and Yiqiang Chen
Toxins 2026, 18(2), 75; https://doi.org/10.3390/toxins18020075 - 2 Feb 2026
Viewed by 144
Abstract
Deoxynivalenol (DON) is a common mycotoxin in cereal crops such as corn, wheat, and their processed products. It can cause feed refusal and growth retardation in piglets. This study systematically evaluated the effects of dietary exposure to purified DON at low doses of [...] Read more.
Deoxynivalenol (DON) is a common mycotoxin in cereal crops such as corn, wheat, and their processed products. It can cause feed refusal and growth retardation in piglets. This study systematically evaluated the effects of dietary exposure to purified DON at low doses of 0.25, 0.5, 1.0, and 2.0 mg/kg on growth performance, blood biochemistry, antioxidant capacity, immune function, intestinal health, and reproductive development in female weaned piglets over a 42-day period. Although dietary exposure to 0.25–2.0 mg/kg of DON did not significantly affect growth performance, it induced subclinical multi-organ toxicity. Notably, decreased platelet count (PLT) at 0.25–2.0 mg/kg and increased serum alanine aminotransferase (ALT) activity at 2.0 mg/kg were observed. DON exposure also impaired antioxidant function with reduced serum total antioxidant capacity (T-AOC) at 0.25–2.0 mg/kg, and elevated malondialdehyde (MDA) content in the jejunum and ileum at 0.5–2.0 mg/kg. Furthermore, at all doses tested (0.25–2.0 mg/kg), DON suppressed anti-inflammatory cytokine interleukin-10 (IL-10) levels in both serum and intestine, reduced duodenal villus height (VH), and decreased serum follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels. Additionally, histopathological injuries of liver, kidney, duodenum, jejunum, ileum, uterus and ovaries were also observed at doses of 1.0–2.0 mg/kg. In summary, this study confirms the multi-organ toxicity of low-dose DON in piglets. Our findings suggest that DON concentrations in pig feed should be more strictly controlled and highlight the importance of considering subclinical health endpoints, such as oxidative stress markers and immune parameters, in future risk assessments of mycotoxin exposure. Full article
(This article belongs to the Special Issue Mycotoxin Contamination in Food and Feed)
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