Novel Methods and Applications in Zebrafish as a Model for Mixture Toxicity
A Special Issue of Toxics (ISSN 2305-6304) belonging to the section "Novel Methods in Toxicology Research".
Deadline for manuscript submissions: 1 December 2026 | Viewed by 518
Editor
Interests: computational toxicology; developmental toxicity; zebrafish; high-throughput screening; new approach methods (NAMs)
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Chemical risk assessment has long relied on single-compound testing paradigms, yet real-world exposures are inherently complex—involving simultaneous exposure to multiple chemicals across diverse environmental, occupational, and consumer contexts. This disconnect between laboratory practice and biological reality underscores an urgent need for models and methods capable of capturing the complexity of mixture toxicity.
This Special Issue highlights zebrafish (Danio rerio) as a powerful and versatile platform for advancing mixture toxicity research. As a well-established New Approach Methodology (NAM), zebrafish offer a unique combination of biological complexity, high-throughput compatibility, and translational relevance that makes them ideally suited for studying the additive, synergistic, and antagonistic effects that characterize real-world chemical exposures.
Contributions to this collection will showcase novel methodological approaches and emerging applications—spanning automated phenotypic screening, computational modeling, multi-omics integration, and behavioral analysis—that expand the toolkit available for mixture toxicity evaluation. By bringing together researchers using a common model organism, this Special Issue seeks to foster cross-laboratory learning and methodological harmonization.
Ultimately, this collection aims to accelerate the development of robust, biologically informed frameworks for mixture risk assessment and support the broader transition toward next-generation toxicology.
Dr. Lisa Truong
Guest Editor
Manuscript Submission Information
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Keywords
- zebrafish
- chemical mixture toxicity
- environmental mixture exposures
- synergism, antagonism, and additivity
- new approach methodologies (NAMs)
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