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Separations
Special Issues
Recent Advances and Trends in Dietary Supplement Analysis
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Recent Advances and Trends in Dietary Supplement Analysis

A special issue of Separations (ISSN 2297-8739). This special issue belongs to the section "Analysis of Natural Products and Pharmaceuticals".

Deadline for manuscript submissions: closed (20 January 2024) | Viewed by 3244

Special Issue Editors

Dr. Daniela Amidžić Klarić

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Guest Editor
Faculty of Pharmacy of Biochemistry, University of Zagreb, A. Kovačića 1, 10000 Zagreb, Croatia
Interests: pharmaceutical analysis; supplement analysis; sample preparation; atomic spectroscopy; chromatography; food analytical chemistry; food control; bioactive compounds; metals
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Ana Mornar

E-Mail Website
Guest Editor
Faculty of Pharmacy of Biochemistry, University of Zagreb, A. Kovačića 1, 10000 Zagreb, Croatia
Interests: drug development; sample preparation; pharmaceutical analysis; biopharmaceutical analysis; food analysis; chromatography; mass spectrometry
Special Issues, Collections and Topics in MDPI journals
Dr. Mario-Livio Jeličić

E-Mail Website
Guest Editor
Faculty of Pharmacy of Biochemistry, University of Zagreb, A. Kovačića 1, 10000 Zagreb, Croatia
Interests: sample preparation; pharmaceutical analysis; drug compatibility; quality control; chromatography; method development; method validation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The number of different dietary supplements and their daily use has increased dramatically worldwide. Because these natural health products have become a matter of great public interest, this Special Issue plans to provide an overview of the application of state-of-the-art scientific methods to explore issues involving the quality, safety, and efficacy of dietary supplements. This Special Issue of Separations titled “Recent Advances and Trends in Dietary Supplement Analysis” will be a collection of research articles, short communications, and reviews related to original and novel analytical methods developed for the evaluation of active and toxic ingredients in various dietary supplement dosage forms. Green and sustainable analytical procedures are more than welcome, as are methods including the pre-treatment of natural health products as samples.

The coverage of this Special Issue includes, but is not limited to:

  • New advances in analytical methods for dietary supplements;
  • Innovation on the separation and characterization of dietary supplements;
  • Dietary supplement assay;
  • Dietary supplement impurities;
  • Green separation science;
  • Supplement quality, safety and efficacy;
  • Regulation of dietary supplements;
  • Role of dietary supplement formulated products in health promotion and disease prevention.

Dr. Daniela Amidžić Klarić
Prof. Dr. Ana Mornar
Dr. Mario-Livio Jeličić
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Separations is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dietary supplements
  • natural health product
  • herbal medicines
  • bioactive compounds
  • nutraceuticals
  • dietary supplement formulation
  • dietary supplements quality analysis
  • analytical methods
  • sample preparation
  • dietary supplement assay
  • dietary supplements impurities
  • regulation of dietary supplements

Published Papers (2 papers)

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Research

15 pages, 1761 KiB  
Article
The Development and Validation of Simultaneous Multi-Component Quantitative Analysis via HPLC–PDA Detection of 12 Secondary Metabolites Isolated from Drynariae Rhizoma
by Jin Sung Ahn and Wan Kyunn Whang
Separations 2023, 10(12), 601; https://doi.org/10.3390/separations10120601 - 18 Dec 2023
Viewed by 1349
Abstract
Drynariae Rhizoma (DR) is a functional food and traditional medicine that has been widely used for bone and joint disorders for thousands of years. In this study, 14 compounds were isolated from DR, and their structures were identified using UPLC/QTOF–MS, UPLC–ESI/LTQ–Orbitrap–HRMS, and 2D [...] Read more.
Drynariae Rhizoma (DR) is a functional food and traditional medicine that has been widely used for bone and joint disorders for thousands of years. In this study, 14 compounds were isolated from DR, and their structures were identified using UPLC/QTOF–MS, UPLC–ESI/LTQ–Orbitrap–HRMS, and 2D NMR and compared with those obtained in previous studies. An HPLC–PDA multi-component simultaneous quantitative determination method was developed for 12 of the 14 DR-derived compounds, excluding compounds with a content <1.5 mg. The developed HPLC method was validated based on linearity (r2 ≥ 0.999), limit of detection (0.01–0.65 μg/mL), limit of quantification (0.04–1.97 μg/mL), intra-day precision and accuracy ranges (0.06–2.85% and 95.03–104.75%, respectively), and inter-day precision and accuracy ranges (0.24–2.83% and 95.75–105.75%, respectively). The developed analysis method improved the resolution of compounds 4 and 5. In addition, this is the first quantitative analysis of compounds 7, 8, and 11 and the first simultaneous quantitative analysis of 12 compounds, including compounds 4, 7, 8, 10, 11, and 14. This study developed a rapid, accurate, and economical HPLC method for performing the simultaneous quantitative analysis of 12 secondary metabolites isolated from DR. Full article
(This article belongs to the Special Issue Recent Advances and Trends in Dietary Supplement Analysis)
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18 pages, 1141 KiB  
Article
The Development and Validation of a Targeted LC-HRAM-MS/MS Methodology to Separate and Quantify p-Synephrine and m-Synephrine in Dietary Supplements and Herbal Preparations
by Celine Vanhee, Sophia Barhdadi, Angélique Kamugisha, Tanika Van Mulders, Kevin Vanbrusselen, Marie Willocx and Eric Deconinck
Separations 2023, 10(8), 444; https://doi.org/10.3390/separations10080444 - 09 Aug 2023
Cited by 1 | Viewed by 1065
Abstract
Dietary supplements containing Citrus aurantium or p-synephrine remain very popular in Europe and the United States of America (USA). They are primarily sold as weight loss enhancers, although their efficacy and the safety are still under scrutiny. To this end, several countries [...] Read more.
Dietary supplements containing Citrus aurantium or p-synephrine remain very popular in Europe and the United States of America (USA). They are primarily sold as weight loss enhancers, although their efficacy and the safety are still under scrutiny. To this end, several countries have set maximum threshold levels of p-synephrine that are permitted in dietary supplements. Moreover, there have also been reports of possible chemical adulteration of these supplements with the synthetic positional isomer, m-synephrine, known to be used as a medicinal product. Therefore, it is pivotal for regulatory agencies to be able to discriminate between the two positional isomers and also quantify the amount of each when encountered in dietary supplements. Here, we present the development and the validation of a simple and fast “dilute and shoot” procedure, employing liquid chromatographic (LC) separation in combination with high-resolution accurate mass (HRAM) tandem mass spectroscopy (LC-HRAM-MS/MS) to separate these two isomers and subsequently quantify them. The quantification methodology has been validated using the “total error approach”, applying accuracy profiles, and is consequently compliant with ISO17025. Moreover, ten real-life samples, either purchased online or encountered by Belgian regulatory agencies, were analyzed using the described procedure. Startlingly, only one sample out of ten was compliant with Belgian legislation in terms of labeling, the presence of a batch number, expiration date and dosage (with a tolerated error of ±20%). Moreover, three samples also contained banned substances such as yohimbine and sibutramine. Full article
(This article belongs to the Special Issue Recent Advances and Trends in Dietary Supplement Analysis)
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