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Non-Invasive Sensors for Disease Diagnosis

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Physical Sensors".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 951

Special Issue Editors


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Guest Editor
Laboratory of Instrumentation, Biomedical Engineering and Radiation Physics (LIBPhys-UNL), Department of Physics, NOVA School of Science and Technology, NOVA University of Lisbon, 2829-516 Caparica, Portugal
Interests: sensors; ion mobility spectrometry; VOCs; environmental health; VOC biomarkers; toxicology; metabolites; breath analysis
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Laboratory of Instrumentation, Biomedical Engineering and Radiation Physics (LIBPhys-UNL), Department of Physics, NOVA School of Science and Technology, NOVA University of Lisbon, 2829-516 Caparica, Portugal
Interests: biomedical instrumentation; sensors; ion mobility spectrometry; breath biomarkers; air quality assessment
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Nowadays, a key factor for early detection and successful clinical management of diseases, while improving patients' quality of life, is the development of non-invasive and cost-effective biomedical sensors for the measurement of physiological parameters from the human body. Recent developments in sensor materials, electronics, and novel applications of artificial intelligence (AI) technology in the domain of physiological signals could open to healthcare providers new exciting avenues for personalized healthcare monitoring to make better decisions.

This Special Issue addresses the latest advancements in all types of non-invasive sensors designed for human disease diagnosis and health monitoring, as well as the developments in novel sensing techniques for non-invasive measurement of the comprehensive set of biomarkers. Recent achievements in device concepts and sensor fabrication, including wireless and wearable sensors and the engineering of low-cost, miniaturized AI-powered sensing systems that provide continuous, real-time, and long-term monitoring of key biomarkers, are welcomed.

Dr. Valentina Vassilenko
Dr. Pedro C. Moura
Guest Editors

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Keywords

  • non-invasive biomedical sensors
  • wearable sensors
  • wireless sensing devices
  • body-sensor networks
  • optical sensors
  • biochemical sensors
  • infrared detectors
  • breath analysis
  • machine learning
  • artificial intelligence
  • clinical environment
  • portable technology

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Published Papers (1 paper)

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Research

18 pages, 2147 KB  
Article
Implementation, Validation and Clinical Testing of Oximetry Device for Microcirculation Assessment in Oral Tissue
by Hojat Lotfi, Bibiana Falcão and Valentina Vassilenko
Sensors 2025, 25(21), 6604; https://doi.org/10.3390/s25216604 - 27 Oct 2025
Viewed by 508
Abstract
The recent rise in living standards has been accompanied by increased awareness and emphasis on oral health. Non-invasive assessment of gingival microcirculation and accurate evaluation of oxygen supply to oral tissues are critical for the early diagnosis of oral diseases. These factors also [...] Read more.
The recent rise in living standards has been accompanied by increased awareness and emphasis on oral health. Non-invasive assessment of gingival microcirculation and accurate evaluation of oxygen supply to oral tissues are critical for the early diagnosis of oral diseases. These factors also play a pivotal role in optimizing treatment planning and improving outcomes in dental implantology. In this study, we report the development and implementation of a novel pulse oximetry device based on reflective photoplethysmography technology, designed for non-invasive, real-time monitoring of gingival health through the measurement of oxygen saturation levels. A detailed description of the technology, including key aspects of sensor probe design, is provided, with particular emphasis on the calibration process and performance evaluation of the prototype. Furthermore, we present and discuss the first proof-of-concept gingival oxygen saturation measurements obtained in a clinical setting during oral rehabilitation consultations. Full article
(This article belongs to the Special Issue Non-Invasive Sensors for Disease Diagnosis)
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