Recent Advances in Raman and IR Spectroscopy: Biology and Medicine
A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 3
Special Issue Editors
Interests: biomedical Raman spectroscopy; biomedical IR spectroscopy; chemometrics; biophotonics; data science
Interests: biomedical spectroscopy; clinical spectroscopy; Alzheimer's disease; breast cancer; nanomedicine; Raman spectroscopy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Raman spectroscopy has become a potential technique for noninvasive diagnostic applications, providing high specificity and sensitivity in disease detection. This technique utilizes the unique vibrational signatures of biomolecules, which allows for the differentiation between healthy and diseased tissues at the molecular level. In biomedical research, Raman spectroscopy has proven effective for diagnostics in tissues and biofluids, enabling early detection of metabolic disorders and infectious diseases. Additionally, Surface-enhanced Raman spectroscopy (SERS) has further increased its potential to facilitate trace-level detection of biomarkers. As a versatile tool, Raman spectroscopy continues to transform biomedical science, offering a rapid, label-free, and non-invasive alternative to human health research.
Infrared (IR) spectroscopy complements Raman spectroscopy by providing additional insights into biological samples' molecular composition and structure. IR can detect biochemical changes associated with diseases by measuring the absorption of infrared light by molecular bonds within the biological sample. It is particularly effective in identifying functional groups and chemical bonds, allowing for the analysis of lipids, proteins, nucleic acids, and carbohydrates. Advancements in IR spectroscopy, such as FTIR and ATR-FTIR, have further improved its ability to identify disease biomarkers, monitor treatment responses, and investigate noninvasive tissue pathology.
While IR and Raman spectroscopy are highly sensitive to molecular vibrations, they operate based on different principles of light interaction, making them complementary techniques.
Raman and IR spectroscopies provide a synergistic approach to biomedical diagnostics, delivering a comprehensive molecular fingerprint of health and disease states.
SCOPE:
- Development of IR and Raman spectroscopic techniques for non-invasive diagnostics.
- Applications in disease detection, including cancer, neurodegenerative diseases, metabolic disorders, and infectious diseases.
- Raman and IR imaging of biological tissues, cells, and biomolecules.
- Integration of machine learning, deep learning, and chemometric approaches for vibrational spectroscopy data analysis.
- Research focusing on in vivo, ex vivo, and in vitro applications.
- Novel instrumentation and fiber-optic probes for clinical use.
- IR and Raman studies on disease biomarkers in cells, tissues, and biofluids.
- Microplastics detection using vibrational spectroscopy on biological samples.
- Raman and IR spectroscopy for plant disease detection.
Prof. Dr. M. G. Ramírez-Elías
Dr. Carlo Morasso
Guest Editors
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Keywords
- Raman spectroscopy
- infrared spectroscopy
- biology
- medicine
- diagnostics
- biomarkers
- tissue
- biofluids
- biomedical
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