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Nanomaterial-Based Devices and Biosensors for Diagnostic Applications

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".

Deadline for manuscript submissions: 31 May 2025 | Viewed by 1942

Special Issue Editor


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Guest Editor
The New Zealand Institute for Plant and Food Research, Auckland 1025, New Zealand
Interests: materials engineering; biosensors; biomaterials; thin film deposition; SEM analysis; thin film fabrication; materials processing; material characteristics; surface characterization;

Special Issue Information

Dear Colleagues,

The growing popularity of health monitoring is driven by an increasingly health-conscious society. An ideal sensor is characterized by a superior detection range, high sensitivity, selectivity, resolution, reproducibility, repeatability, and a quick response time. Recently, biosensors incorporating nanomaterials have become highly popular due to their exceptional applications across various scientific and technological fields. Nanomaterials bridge the nanoscale gap between the converter and bioreceptor in biosensors. These features have led to the development of highly sensitive biosensors with excellent decomposition capabilities.

For instance, nanomaterial biowaste is both abundant and possesses interesting physical and chemical properties. More importantly, they are biocompatible and biodegradable, making them ideal for applications in biosensing, wastewater treatment, drug delivery, tissue engineering, and flexible electronics. Material engineering allows the chemical modification of these nanomaterials to enhance the properties needed for smart electronic biosensing and diagnosis applications.

The anticipated outcomes of this special issue could help shape the health industry and improve patient well-being. We will seek to create opportunities where traditional knowledge and modern science converge to drive innovations in biosensing.

Dr. Roshan Khadka
Guest Editor

Manuscript Submission Information

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Keywords

  • health monitoring
  • self-powered electronics
  • environmentally friendly
  • nanomaterials
  • biowaste
  • sustainable technology
  • smart biosensors
  • diagnostic applications

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Published Papers (1 paper)

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Research

11 pages, 4645 KiB  
Article
A Signal-On Microelectrode Electrochemical Aptamer Sensor Based on AuNPs–MXene for Alpha-Fetoprotein Determination
by Xiaoyu Su, Junbiao Chen, Shanshan Wu, Yong Qiu and Yuxiang Pan
Sensors 2024, 24(24), 7878; https://doi.org/10.3390/s24247878 - 10 Dec 2024
Cited by 3 | Viewed by 1077
Abstract
As a crucial biomarker for the early warning and prognosis of liver cancer diseases, elevated levels of alpha-fetoprotein (AFP) are associated with hepatocellular carcinoma and germ cell tumors. Herein, we present a novel signal-on electrochemical aptamer sensor, utilizing AuNPs–MXene composite materials, for sensitive [...] Read more.
As a crucial biomarker for the early warning and prognosis of liver cancer diseases, elevated levels of alpha-fetoprotein (AFP) are associated with hepatocellular carcinoma and germ cell tumors. Herein, we present a novel signal-on electrochemical aptamer sensor, utilizing AuNPs–MXene composite materials, for sensitive AFP quantitation. The AuNPs–MXene composite was synthesized through a simple one-step method and modified on portable microelectrodes. As signal molecules, AFP aptamers were conjugated with methylene blue (MB) and immobilized on the electrode surface. When interacting with AFP, conformational changes in the aptamer–target complex caused MB to approach the electrode, and the electrochemical signal was enhanced through signal-on mechanisms. The developed sensor demonstrated high sensitivity and selectivity for AFP, with a log-linear relationship defined as 1–300 ng/mL, and the LOD was 0.05 ng/mL (S/N = 3). The method was applied to laboratorial and real clinical samples and presented satisfactory selectivity, reproducibility, and long-term stability. The proposed high-performance sensor highlights the potential of electrochemical aptamer sensors in improving the warning capabilities in disease management. Full article
(This article belongs to the Special Issue Nanomaterial-Based Devices and Biosensors for Diagnostic Applications)
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