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Next-Generation Diagnostics for Infectious Diseases: Microfluidics, BioMEMS for Pathogen Detection and Antimicrobial Susceptibility Testing

A special issue of Sensors (ISSN 1424-8220). This special issue belongs to the section "Biosensors".

Deadline for manuscript submissions: 1 February 2026 | Viewed by 3

Special Issue Editors


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Guest Editor
Department of Clinical Laboratory, Peking University People’s Hospital (PKUPH), Beijing 100044, China
Interests: bioMEMS for clinical diagnostics and mechanism study of tumor-microorganism-host interactions

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Guest Editor
School of Integrated Circuits, Peking University, Beijing 100871, China
Interests: microfluidics; bacteria detection

Special Issue Information

Dear Colleagues,

Infectious diseases account for over four million deaths worldwide each year (WHO), with antimicrobial resistance (AMR) emerging as a mounting global health crisis. Notable examples include methicillin-resistant Staphylococcus aureus (MRSA) and multidrug-resistant Mycobacterium tuberculosis. Current diagnostic approaches suffer from two major shortcomings: traditional culture-based methods are unable to detect the majority of unculturable pathogens, and molecular techniques such as PCR cannot distinguish between viable and non-viable microorganisms. These limitations hinder the effective monitoring of water safety, foodborne pathogens, and timely clinical decision making.

Microfluidics and BioMEMS technologies offer a transformative solution to these challenges. By integrating pathogen enrichment, viability assessment, and antimicrobial susceptibility testing into compact, unified platforms, these systems enable rapid and precise diagnostics. Innovations in multiplexed biosensing, AI-powered signal interpretation, and portable design make such technologies particularly impactful in resource-limited settings, where timely intervention is critical.

This Special Issue seeks to highlight cutting-edge advances in multiplexed pathogen detection, biosensing devices and modalities, and clinical decision-support platforms. We invite original research articles and reviews covering a broad range of topics including, but not limited to, the following:

  • Novel Pathogen-Sensing Mechanisms;
  • Microfluidic Systems and Components (e.g., droplet-based microfluidic platforms, centrifugal lab-on-disc systems, paper-based viability assays, and devices for pathogen detection and AST);
  • BioMEMS Devices, Methods, and Integration (e.g., impedance microarrays, mechanical biosensors);
  • AI-Enhanced Diagnostics;
  • Multidisciplinary Pathogen Detection Applications (e.g., wearable sepsis monitors, environmental AMR surveillance, foodborne outbreak tracking).

We warmly invite you to contribute your latest research or reviews to this Special Issue and join us in advancing the frontiers of pathogen detection and diagnostics.

Prof. Dr. Wei Wang
Dr. Yaoping Liu
Dr. Shitao Shen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Prof. Dr. Wei Wang
Dr. Yaoping Liu
Dr. Shitao Shen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sensors is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pathogen detection
  • microfluidics
  • BioMEMS
  • antimicrobial resistance
  • AMR
  • AI-enhanced diagnostics
  • multiplexed biosensing

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Published Papers

This special issue is now open for submission.
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